Applications. Column Reproducibility. Casein Tryptic Digest. QC Test. Antimalarial. Antipsychotic. Column Reproducibility 7

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1 Column Reproducibility Robust Column Bondings Assured Peak Shapes % Lower Asymmetry Specification % Higher Efficiency Fortis HPLC columns are tested using the industries most rigorous QC test, utilising basic analyte probes as well as neutral efficiency markers ensures that the column reproducibility is first class. Fortis columns are also subject to a % lower peak shape specification than other manufacturers columns. QC Test Fortis stationary phases have been proven to exhibit excellent peak shapes and efficiency for the full range of analyte species. By employing a QC mix that accurately probes silanol activity (the measure of good peak shape) the analyst can be assured of quality time and time again. Gains are also made in: - Sample carry over - Increased Resolution - Increased Sensitivity Fortis C x.mm μ F- : ACN:HO.ml/min. Uracil. Phenol. -Ethylaniline. N,N-Dimethylaniline. Napthalene..... QC HP Casein Tryptic Digest.μm Fortis C x.mm F- A - HO +.% Formic acid B - ACN +.% Formic acid min % B min % B min % B min % B. ml/min C nm. Casein Antipsychotic Antimalarial. Prochlorperazine Maleate. Proguanil Column Reproducibility Fortis columns are subject to tight specification using basic analytes in an unbuffered mobile phase system. If there were residual uncovered hydroxyl groups present then these basic probes would highlight this fact. Fortis Technologies unique bondings combined with the ultra pure silica matrix ensure that the peak shapes achieved are first class. Asymmetry Fortis Diphenyl x.mm μ FPH- : HO +.% Formic acid : MeOH ml/min Fortis Diphenyl x.mm μ FPH- A: HO +.% formic acid B: MeOH +.% formic acid - % in mins ml/min + columns Tel: + Tel: +

2 Adrenergic alpha-antagonist Explosives Proton Pump Inhibitor Antiretroviral - HIV. Doxazosin. -Nitroaniline. -Nitroaniline. Nitrobenzene.,-Dinitrotoluene... Omeprazole Amprenavir Saquinavir. Nelfinavir Lopinvir. Atazanavir. Ritonavir IS Fortis Diphenyl x.mm μ FPH- : HO +.% Formic acid : MeOH ml/min Fortis Cyano x.mm μ FCN- A: : HO : MeOH B: ACN : Isocratic.ml/min Ambient Fortis C x.mm μ F- A: HO +.% Formic acid B: ACN +.% Formic acid - % in mins.ml/min Fortis C x.mm μ F- A: HO + Buffer B: MeOH + ACN.ml/min nm Stereoisomers Decongestant Non Steroid Anti-Inflammatory Anticonvulsant. Isoascorbic acid. Phenylephrine. Diclofenac Sodium. Lamotrigine. Ascorbic acid Fortis HILIC x.mm μ FHI- : ACN : NHOAc ml/min Fortis C x.mm μ F- : HO : MeOH +.% NH.ml/min nm Fortis C x.mm μ F- A: HO +.% Formic acid B: ACN +.% Formic acid - % in mins.ml/min Ambient Fortis C x.mm μ F- A: HO +.% formic acid B: MeOH +.% formic acid - % in mins.ml/min Tel: + Tel: +

3 Asymmetry (%) Theoretical plates / meter Asymmetry (%) Theoretical plates / meter Antihistamine Antipsychotic SSRI Antidepressant Benzodiazepines. Loratadine.. Haloperidol. Paroxetine ACS x- um ml min Run Area. Lorazepam. Temazepam. Diazepam Fortis C x.mm μ F- A: HO +.% Formic acid B: ACN +.% Formic acid - % in mins.ml/min C Fortis C x.mm μ F- A: HO +.% formic acid B: ACN +.% formic acid - % in mins.ml/min Fortis Pace Ho x.mm μ FHO- : HO : ACN +.% Formic acid.ml/min nm Fortis Pace Ho x.mm μ FHO- : ACN : HO.ml/min nm Hypertension Antidepressant Antidepressant Sulfa Drugs.. Diltiazem. Fluoxetine. ACS.. Mirtazapine. Sulfathiazole. Sulfamerazine. Sulfamethoxazole Fortis Ho x.mm μ FHO- A: HO +.% formic acid B: ACN +.% formic acid - % in mins.ml/min Fortis C x.mm μ F- A: HO +.% formic acid B: ACN +.% formic acid - % in mins.ml/min C Fortis Pace C x.mm μ F- : HO : MeOH +.% Formic acid.ml/min Fortis Pace Ho x.mm μ FHO- : HO : ACN +.% Formic acid.ml/min Tel: + Tel: +

4 Asymmetry (%) Theoretical plates / meter Statins Drugs of Abuse Tamiflu Neurotransmitters... Rosuvastatin. Atorvastatin (.). (.). (.). (.). (.) MDA/. Amphetamine/. MDMA Ecstasy/. Methamphetamine/. MDEA/.. Oseltamivir. Dopamine. Serotonin.... DOPAC MDA (,-Methylenedioxyamphetamine). Amphetamine. MDMA (Ecstasy). Methaphetamine. MDEA (,-Methylenedioxy-N-ethylamphetamine). -HIAA Fortis Pace C x.mm μ F- : HO:ACN +.% Formic acid.ml/min Fortis C x.mm μ F- A: HO +.% ammonia B: ACN +.% ammonia.ml/min C MS Detection Fortis C x.mm μ F- A: HO +.% ammonia B: ACN +.% ammonia - % in mins.ml/min C Fortis Ho x.mm μ FHO- HO +.% formic acid.ml/min C nm Steriods Hypertension Anti-Diabetic Organic acids. Progesterone. Hydroxyprogesterone. Hydroxyprogesterone. Hydroxy--acetate. Cortisone. Prednisone. Prednisolone. Telmisartan. Gliclazide (x,).. (.). (.). (.) Methylmalonic acid (x,). (.).. (.). (.).. Succinic acid.. Fortis Cyano x.mm.μ FCN- Heptane : THF : MeOH ::.ml/min Fortis C x.mm.μ F- A: HO +.% formic acid B: ACN +.% formic acid - % in min.ml/min C Fortis Diphenyl x.mm.μ FPH- : HO : ACN +.% formic acid.ml/min Fortis Ho x.mm μ FHO- mm Ammonium formate +.% formic acid.ml/min C MS Detection Tel: + Tel: +

5 Protease Inhibitors Diuretic Calcium Channel Blocker Erythromycin. Tenofovir. Erythromycin Apps HP nm ml/min.. Amiloride... Thymidine (IS). Verapamil... Fortis C x.mm μ Fortis Ho x.mm μ Fortis HILIC x.mm μ Fortis C x.mm μ F- FHO- FHI- F- : HO+.% NH:MeOH : mm Ammonium formate ph. : MeOH : ACN : mm ammonium acetate A: HO +.% formic acid.ml/min.ml/min.ml/min B: ACN +.% formic acid - % in min C C C.ml/min nm nm nm C nm Vitamins.. Sotalol Apps HP nm ml/min.. Apps HP nm ml/min. Nicotinamide.. Anti-epileptic Beta-Blockers. Promethazine theoclate.. Nicotinic acid.... Vitamin C Gabapentin Apps HP nm ml/min. Riboflavin. Antihistamine Fortis C x.mm μ Fortis HILIC x.mm μ Fortis C x.mm μ Fortis C x.mm μ F- FHI- F- F- A: HO +.% ammonia B: ACN +.% ammonia - % in mins.ml/min : ACN : mm ammonium acetate A: HO +.% formic acid A: HO +.% formic acid.ml/min B: ACN +.% formic acid - % in min B: ACN +.% formic acid - % in min C nm C.ml/min C nm nm C nm Tel: +.ml/min Tel: +.

6 Antihistamine Vitamin. Folic acid Apps HP nm ml/min Angiotensin II Receptor Antaganist Proton Pump Inhibitor Apps HP nm ml/min. Levocetirizine. Lansoprazole Apps HP ml/min nm. Irbesartan Apps HP ml/min Fortis Ho x.mm μ Fortis Ho x.mm μ Fortis C x.mm μ Fortis C x.mm μ FHO- FHO- F- F- : HO : ACN A: HO +.% formic acid A: HO +.% formic acid A: HO +.% formic acid.ml/min B: ACN +.% formic acid - % in min B: ACN +.% formic acid - % in min B: ACN +.% formic acid - % in min C.ml/min.ml/min.ml/min nm C C C nm nm nm Antidepressant. Citalopram s. Amoxicillin Apps HP ML/MIN NM Asymmetry (%) Theoretical plates / meter. Flucloxacillin Apps HP New Std nm ml/min. Chloramphenicol Fortis C x.mm μ Fortis C x.mm μ Fortis C x.mm μ Fortis C x.mm μ F- F- F- F- A: HO +.% formic acid A: HO +.% formic acid A: HO +.% formic acid B: ACN - % in mins.ml/min B: ACN +.% formic acid - % in min B: ACN +.% formic acid - % in min B: ACN +.% formic acid - % in min.ml/min C C C.ml/min C nm nm nm nm A: mm ammonia acetate Tel: +.ml/min Tel:

7 Opioid analgesic Thiazide Diuretic Beta-Blocker ACS -- Run. Tramadol. Phenoxymethylpenicilin Apps HP ml/min nm. Bendroflumethiazide Apps HP Lower injection ml/min nm. Atenolol Fortis C x.mm μ F- A: HO + B: ACN +.% NH - % in mins.ml/min Ambient nm Fortis C x.mm μ F- A: HO +.% formic acid B: ACN +.% formic acid - % in mins ml/min Fortis Ho x.mm μ FHO- A: HO +.% formic acid B: ACN +.% formic acid - % in min.ml/min C Fortis Ho x.mm μ FHO- : HO : ACN +.% formic acid.ml/min C nm Vitamin Antihistamine. Vitamin C. Ciprofloxacin. Co-amoxiclav. Diphenhydramine Fortis Diphenyl x.mm μ FPH- % HO +.% Formic acid.ml/min Fortis Diphenyl x.mm μ FPH- A: HO +.% formic acid B: MeOH +.% formic acid - % in mins ml/min Fortis C x.mm μ Fortis C x.mm μ F- F- A: HO +.% formic acid B: ACN +.% formic acid A: HO +.% NH B: ACN +.% formic acid - % in mins - % in mins.ml/min ml/min nm Tel: + Tel: +

8 Index -Hydroxy-midazolam Hydroxyprogesterone Hydroxyprogesterone,-D,-DB,-DCP,-DP,-Dinitrotoluene -Hydroxyestradiol -Nitroaniline -Nitrobenzoic acid -Ethylaniline, -Hydroxyestradiol -Nitroaniline -HIAA -Aminoclonazepam -Aminoflunitrazepam -Aminonitrazepam Abscisic acid Acetic acid Adenine Alanine Alprazolam Amiloride Amitriptyline,, Amoxicillin Amphetamine Amprenavir Arginine Asparagine Aspartic acid Atazanavir Atenolol Atorvastatin Banvel Bendroflumethiazide Benzene Benzyladenine Butylbenzene Casein Cefachlor Cefadroxil Cefalexin Cefradine Chloramphenicol Ciprofloxacin Citalopram Clonazepam CMPP Co-amoxiclav Cortisone Cytosine Dechlorinated PK Desmethyldiazepam Dexamethasone Diazepam, Diclofenac Dihydroquinidine Diltiazem Diphenhydramine DOPAC Dopamine Doxazosin Doxepin Erythromycin Ethylbenzene Fenuron Flucloxacillin Flunitrazepam Fluoxetine Folic acid Gabapentin Gibberellin acid Gliclazide Glutamic acid Gly-Tyr Glycine Guanosine Haloperidol Heptylbenzene Hexylbenzene Histidine Hydroxy--acetate Imipramine Indol--yl acetate Irbesartan Isoascorbic acid Isoleucine Isonicotinamide Kinetin Lamotrigine, Lansaprazole Leucine Levocetirizine Lidocaine Lopinvir Loratadine Lorazepam Lysine MCPA MCPB MDA (,-Methylenedioxyamphetamine) MDEA (,-Methylenedioxy-N-ethylamphetamine) MDMA (Ecstasy) Melamine Methaphetamine Methionine Methylmalonic acid Midazolam Mirtazapine N,N-Dimethylaniline, Napthalene, Nelfinavir Neomycin Sulphate Nicotinamide, Nicotinic acid Nitrazepam Nitrobenzene Nortriptyline,, Norvalin Omeprazole Ornithine Oseltamivir Oxazepam Paroxetine PCOC Pentylbenzene Pesticide Phenoxymethylpenicilin Phenylalanine Phenylephrine PK Prednisolone Prednisone Procaine Prochlorperazine Maleate Progesterone Proguanil Proline Promethazine Propylbenzene Protriptyline, Quetiapine Quinidine Riboflavin Ritonavir Rosuvastatin Saquinavir Sarcosin Serine Serotonin Sotalol Succinic acid Sulfamerazine Sulfamethoxazole Sulfathiazole Sumatriptan Telmisartan Temazepam Tenofovir Theobromine Thiabendazole Threonine Thymidine Toluene Tramadol Trimipramine, Tryptophan Tyrosin Uracil, Uridine Valine Valproate Semisodium Verapamil Vitamin C, Zolpidem Zopiclone Part number tables Fortis C. F-xx F-xx F-xx F-xx F-xx - Column Diameter. - F-xx F-xx F-xx F-xx -. - F-xx F-xx F-xx F-xx F-xx Replace xx - for.μm - for.μm - for μm - for μm - for μm Fortis Diphenyl. FPH-xx FPH-xx FPH-xx FPH-xx FPH-xx - Column Diameter. - FPH-xx FPH-xx FPH-xx FPH-xx -. - FPH-xx FPH-xx FPH-xx FPH-xx FPH-xx Replace xx - for.μm - for.μm - for μm - for μm - for μm Fortis Ho. FHO-xx FHO-xx FHO-xx FHO-xx FHO-xx - Column Diameter. - FHO-xx FHO-xx FHO-xx FHO-xx -. - FHO-xx FHO-xx FHO-xx FHO-xx FHO-xx Replace xx - for μm - for μm Fortis C. F-xx F-xx F-xx F-xx F-xx - Column Diameter. - F-xx F-xx F-xx F-xx -. - F-xx F-xx F-xx F-xx F-xx Replace xx - for μm - for μm Fortis Cyano. FCN-xx FCN-xx FCN-xx FCN-xx FCN-xx - Column Diameter. - FCN-xx FCN-xx FCN-xx FCN-xx -. - FCN-xx FCN-xx FCN-xx FCN-xx F-xx Replace xx - for.μm - for μm - for μm Fortis HILIC. FHI-xx FHI-xx FHI-xx FHI-xx FHI-xx - Column Diameter. FHI-xx FHI-xx FHI-xx FHI-xx -. FHI-xx FHI-xx FHI-xx FHI-xx FHI-xx Replace xx - for.μm - for μm - for μm - for μm μm Fortis Guard Cartridges μm Fortis Guard Cartridges DCGUA- Guard Cartridge Holder DCGUA- Guard Cartridge Holder DCxx-G/ xmm Fortis μm Guard pk DCxx-G/ xmm Fortis μm Guard pk DCxx-G/ xmm Fortis μm Guard pk DCxx-G/ xmm Fortis μm Guard pk DCxx-G/ xmm Fortis μm Guard pk DCxx-G/ xmm Fortis μm Guard pk DCxx-G/ xmm Fortis μm Guard pk DCxx-G/ xmm Fortis μm Guard pk Replace xx for Fortis C PH for Fortis Diphenyl HO for Fortis Ho for Fortis C CN for Fortis Cyano HI for Fortis HILIC Analytical In-line Filters UHPLC In-line Filters -SAV μm In-line filter pk UHPSAV UHPLC In-line filter pk -SAV μm In-line filter pk UHPSAV UHPLC In-line filter pk Tel: + Tel: +