Strength in Technology

Transcription

1 Strength in Technology

2 Fortis C8 Excellent Peak Shapes Superb Quantitation ph Range - Fully Scalable 3,5,0μ C8 7% Fortis C8 is designed to provide characteristics which will aid in increased productivity to the analyst. Whether carrying out simple compound screens or complex metabolite i.d. Fortis C8 will provide the best in qualitative and quantitative data. L Optimised Peak Shape Whatever the compound functionality Fortis C8 is optimised in order to provide the best possible peak shapes. Basic, Acidic and Neutral analyte performance is first class across the ph spectrum. Higher Efficiencies Greater Reproducibility Resolution enhanced F Fortis C8 00x4.6mm 3μ Mobile Phase: A - H 2 O + 0.% Formic acid B - ACN + 0.% Formic acid Gradient: 25-40% in 0min Temp: 20 C. Protriptyline 2. Nortriptyline 3. Amitriptyline 4. Trimipramine 254nm Optimised Resolution Only by optimising all factors of stationary phase design can the analyst be assured of the best possible chromatography. Fortis C8 s unique bonded character ensures that not only is reproducibility and robustness assured, but also that resolution is of the highest level. F Fortis C8 00x4.6mm 5μ Mobile Phase: A - H 2 O + 0.% Formic acid B - ACN + 0.% Formic acid Gradient: 0-50% in 0min Temp: 20 C 254nm. Paracetamol 2. Caffeine 3. Excipient Tel:

3 Fortis H2o Retention of Polars Enhanced Resolution 00% Aqueous Compatible Fully Scalable 3,5,0μ Polar Endcapping 8% Fortis H2o is designed to aid in the separation and retention of polar analytes. Complex mobile phase systems can be bypassed if sufficient retention can be afforded solely from the stationary phase chemistry. Fortis H2o is designed to supply additional interaction with polar molecules which allows their successful retention. L Retention of Polar analytes Fortis H2o is optimised not only to help retain and resolve polar analytes, but also to be complimentary in resolution to Fortis C8. Hydrophilic as well as Hydrophobic interaction s Alternative Selectivity No MS bleed Column : Fortis H2o 50x4.6mm 5μ p/n : FHO Mobile Phase: H 2 O + 0.% Formic acid Flow : 0.8ml/min Temp : 20 C 270nm. Dopamine 2. Serotonin 3. DOPAC 4. 5-HIAA Alternative Selectivity Only by optimising all factors of stationary phase design can the analyst be assured of the best possible chromatography. Fortis H2o s unique bonded character ensures that not only is reproducibility and robustness assured, but also that resolution is of the highest level. Fortis H2o 00x4.6mm 5μ FHO Mobile Phase: A - H 2 O + 0.% Formic acid B - ACN + 0.% Formic acid Gradient: 5-70% in 0min Temp: 20 C 254nm. Chloramphenicol Tel:

4 Fortis Phenyl Unique Selectivity Aromatic Retention and Selectivity Enhanced Polar Retention Excellent Peak shapes 3,5,0μ Diphenyl 3% Fortis Phenyl is designed to provide characteristics which will enhance selectivity. Providing the analyst extra retention of compounds containing aromatic functionality. Extra selectivity and retention can be found for polar substrates, along with metabolite profiling. L Enhanced Selectivity Selectivity of compounds normally difficult to resolve on a hydrophobic alkyl chain stationary phase is simplified by the π-π interactions provided by a phenyl functionality. In this application PK95 a PET (Positron Emission Tomography) tracer exhibits resolution from its dechlorinated metabolite, which is not achievable on alkyl chain phases. High Selectivity Resolution enhanced Sharp Peak Shapes Fortis Phenyl 50x4.6mm 5μ FPH Mobile Phase: 40:60 H 2 O : ACN MS Detection. Dechlorinated PK95 2. PK (.00) (.00) Data Courtesy of : Wolfson Molecular Imaging Centre Doxazosin Quinidine Mobile Phase: Fortis Phenyl 50x4.6mm 5μ FPH : 60 H 2 O + 0.% formic acid MeOH 4 Mobile Phase: Fortis Phenyl 50x4.6mm 5μ FPH : 30 H 2 O + 0.% formic acid MeOH nm 2 235nm Quinidine 2. Dihydroquinidine Tel:

5 Fortis C8 Reduced Hydrophobicity over C8 Excellent Peak Shapes Fully Scalable 3,5,0μ C8 3% Fortis C8 is designed to provide characteristics similar to Fortis C8 but specifically for situations where less hydrophobicity is required. The same gains in peak shape, efficiency, resolution and scalability are available providing increased productivity to the analyst. L7 Optimised Peak Shape Following on from Fortis C8, whatever the compound functionality Fortis C8 is optimised to provide the best possible peak shapes and efficiency. Basic, Acidic and Neutral analyte performance is first class. Higher Efficiencies Greater Reproducibility Resolution enhanced Fortis C8 50x4.6mm 5μ F Mobile Phase: A - H 2 O + 0.% Formic acid B - MeOH + 0.% Formic acid Gradient: 0-90% in 0min. Lamotrigine 254nm Depakote Plavix Fortis C8 50x4.6mm 5μ F Mobile Phase: 40 : 60 H 2 O + 0.% formic acid ACN 220nm Fortis C8 50x4.6mm 5μ F Mobile Phase: 25 : 75 H 2 O : ACN 254nm. Valproate Semisodium. Clopidogrel Tel:

6 Part Number Tables Fortis C F8-0203xx F8-0205xx F8-0207xx - Column Diameter 3.0 F8-0303xx F8-0305xx F8-0307xx F8-0503xx F8-0505xx F8-0507xx F8-0509xx Fortis C8 Guards Length 0 Column Diameter 2. F8-0200xxG 4.6 F8-0500xxG Replace xx - 03 for 3µm - 05 for 5µm - 0 for 0µm Fortis H2o FHO-0203xx FHO-0205xx FHO-0207xx - Column Diameter 3.0 FHO-0303xx FHO-0305xx FHO-0307xx FHO-0503xx FHO-0505xx FHO-0507xx FHO-0509xx Fortis H2o Guards Length 0 Column Diameter 2. FHO-0200xxG 4.6 FHO-0500xxG Replace xx - 03 for 3µm - 05 for 5µm - 0 for 0µm Fortis Phenyl FPH-0203xx FPH-0205xx FPH-0207xx - Column Diameter 3.0 FPH-0303xx FPH-0305xx FPH-0307xx FPH-0503xx FPH-0505xx FPH-0507xx FPH-0509xx Fortis Phenyl Guards Length 0 Column Diameter 2. FPH-0200xxG 4.6 FPH-0500xxG Replace xx - 03 for 3µm - 05 for 5µm - 0 for 0µm Fortis C F xx F xx F xx - Column Diameter 3.0 F xx F xx F xx F xx F xx F xx F xx Fortis C8 Guards Length 0 Column Diameter 2. F xxG 4.6 F xxG Replace xx - 03 for 3µm - 05 for 5µm - 0 for 0µm If you do not see the required geometry above or if you require preparative columns then please contact sales@fortis-technologies.com to discuss your requirements. Fortis Fortis Pace columns are designed with High Throughput Screening (HTS) applications in mind. Optimised for use in LC-MS to provide greatest sensitivity by achieving sharp peak shapes combined with excellent resolution and retention. Fortis Pace 3μ Fxx Fxx Fortis Pace 5μ Fxx Column Diameter Fxx Column Diameter Fxx Replace xx with: 8 for Fortis C8; HO for Fortis H2o; PH for Fortis Phenyl; 08 for Fortis C8 34 Coalbrookdale Road Clayhill Industrial Park Neston Cheshire, UK CH64 3UG t: f: e: info@fortis-technologies.com