HPLC UHPLC Columns. Dikma Technologies Inc.

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1 Technologies Inc.

2 About HPLC UHPLC Columns has over years of R&D experience in HPLC / UHPLC columns. HPLC / UHPLC columns have been widely used by pharmaceutical manufacturers. We offer columns of ultimate performance and maximum versatility to address the challenges and increasing needs of today's chromatographic laboratories. The quality of packing material is the basis for all good chromatographic separation. is in a unique position to control the manufacturing process from start to finish, from making high-purity (99.999%) raw silica to applying different bonding chemistries. Furthermore, to ensure the high performance and robustness of our columns, we maintain tight specifications during all stages of the manufacturing process and follow rigid, audited ISO 9 procedures to guarantee reproducible products. The end results that get delivered to you are columns that perform at their best and offer you highly reproducible batch-to-batch results without alteration of HPLC / UHPLC conditions. HPLC UHPLC Columns List Brand Chemistry Features Endeavorsil Leapsil Inspire Spursil Platisil Diamonsil Bio-Bond Endeavorsil C8 Leapsil C8 Inspire C8 Inspire C8 Inspire HILIC Inspire Diol Spursil C8 Spursil C8-EP Platisil C8 Platisil NH Platisil CN Platisil PH Platisil Silica Diamonsil C8 Diamonsil C8 Diamonsil AAA Bio-Bond C8 Bio-Bond C8 Bio-Bond C.8 μm UHPLC columns Exceptional speed, resolution, and sensitivity.7 μm, compatible with all HPLC and UHPLC instruments Flexible method development High-end columns to meet high separation demands Rapid separations with outstanding resolutions Superior batch-to-batch reproducibility Polar modification columns with maximal polar retention and selectivity Silanol shielding for excellent peak shape Suitable for highly aqueous mobile phase conditions Universal and cost-effective columns Unique selectivity, excellent peak shape Useful in normal or reversed phase applications Universal reversed phase columns High efficiency and outstanding lifetime Å, designed to analyze and purify proteins, peptides, and biomolecules Direct scale-up to preparative material

3 Endeavorsil.8 μm UHPLC Columns Features of Endeavorsil Columns Combined speed, resolution, and sensitivity Reduced analysis time and solvent waste High efficiency combined with high selectivity and productivity Superior column performance at higher pressure Excellent separation characteristics over a wide ph range Endeavorsil Material Characteristics Bonded phase Particle size Pore size Surface area Purity Phase density Carbon loading ph range Endcapping (Å) (m /g) (%) (μmol/m ) (%) C8.8 > Yes Selectivity * Speed x. mm MeCN:H O = :. ml/min UV nm. Uracil. Caffeine. Phenol. Toluene. Butylbenzene. o-terphenyl 7. Triphenylene 8. Amylbenzene Endeavorsil.8 μm C8 (Cat.# 87) X Resolution MeCN:H O = : UV nm. Uracil. Acetophenone. Methyl benzoate. Toluene. Naphthalene Inspire μm C8, x. mm (Cat.# 8). ml/min 7 s Waters ACQUITY UPLC HSS T.8 μm C8 Inspire μm C8, x. mm (Cat.# 8). ml/min Unseparated 8 s Agilent ZORBAX Eclipse Plus RRHD.8 μm C8 Unseparated 9 s Endeavorsil.8 μm C8, x. mm (Cat.# 87). ml/min 7X faster * ACQUITY UPLC is a registered trademark of Waters Corporation. Technologies Inc. is not affiliated with the above company. * ZORBAX is a registered trademark of Agilent Technologies. Technologies Inc. is not affiliated with the above company. Endeavorsil Ordering Information.8 μm Microbore Columns (. mm ID) Phase x. x. x. x. Endeavorsil C

4 Leapsil HPLC UHPLC Compatible Columns Features of Leapsil Columns Ultra fast separation without compromising resolution Low operating pressure allows higher flow rates Compatible with all HPLC and UHPLC instruments Method development flexibility Wide ph stability Full spectrum of phases and selectivities Leapsil Material Characteristics Bonded phase Particle size Pore size Surface area Purity Phase density Carbon loading ph range Endcapping (Å) (m /g) (%) (μmol/m ) (%) C8.7 > Yes Speed Selectivity * Cat.No.: Leapsil.7 μm C8, x. mm 8 MeCN:H O = : o C UV nm. Uracil. Acetophenone. Methyl benzoate. Toluene. Naphthalene x. mm MeOH:H O = : o C UV nm. Thiourea. Aniline. Phenol. o, m, p-methyl aniline. N, N-Dimethylaniline. Ethyl benzoate 7. Toluene 8. Ethylbenzene. ml/min Leapsil.7 μm C8 (Cat.# 8).8 ml/min, Pressure:,9 psi. ml/min 7 Agilent ZORBAX Eclipse Plus RRHD.8 μm C8. ml/min, Pressure:,77 psi 8.. Min. High speed without compromising resolution 7 s Min. Unseparated +7 Waters ACQUITY UPLC BEH.7 μm C8. ml/min, Pressure: 8,897 psi Min Min. * ZORBAX is a registered trademark of Agilent Technologies. Technologies Inc. is not affiliated with the above company. * ACQUITY UPLC is a registered trademark of Waters Corporation. Technologies Inc. is not affiliated with the above company. Leapsil Ordering Information.7 μm Microbore Columns (. mm ID) Phase x. x. x. Leapsil C μm Analytical Columns (. mm ID) Phase x. x. x. Leapsil C μm Analytical Columns (. mm ID) Phase x. x. x. Leapsil C

5 Inspire HPLC Columns Features of Inspire Columns High efficiency Longer column lifetime Efficient method development Outstanding selectivity Extreme resolution Excellent batch-to-batch reproducibility Inspire Material Characteristics Bonded phase Particle size Pore size Surface area Purity Phase density Carbon loading ph range Endcapping (Å) (m /g) (%) (μmol/m ) (%) C8,, > Yes C8,, > Yes HILIC,, > No Diol,, > No TCAs at Neutral ph Conditions * Antibacterials * x. mm MeCN: mm phosphate buffer (ph 7) = :. ml/min UV nm. Desipramine. Nortriptyline. Imipramine. Amitriptyline. Trimipramine x. mm.% HCOOH in MeCN:.% HCOOH in H O = :8. ml/min UV nm. Sulfanilamide. Carbadox. Sulfapyridine. Sulfamerazine. Thiamphenicol. Sulfamethoxypyridazine 7. Furazolidone 8. Sulfamethoxazole 9. Sulfisoxazole. Oxolinic acid Inspire μm C8 (Cat.# 8) Inspire μm C8 (Cat.# 8) Waters XBridge μm C8 Waters XBridge μm C8 * XBridge is a trademark of Waters Corporation. Technologies Inc. is not affiliated with the above company.

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7 Spursil HPLC Columns Features of Spursil Columns Combine high-purity silica with unique polar modification technology Maintain characteristics of conventional reversed phases Unique selectivity and enhanced resolution Reduced silanol interactions and improved peak shape for basic analytes Stable retention in highly aqueous mobile phase conditions Enhanced retention for polar compounds Extended range ph stability Choose from a variety of selectivities and hardware formats Spursil Material Characteristics Bonded phase Particle size Pore size Surface area Purity Phase density Carbon loading (Å) (m /g) (%) (μmol/m ) (%) ph range Endcapping C8,, > Yes C8-EP,, > Yes Cephalosporin Polar Compounds * Steric Selectivity * Cat.No.: Spursil μm C8, x. mm 8 MeOH:.% TFA in H O = :7. ml/min UV nm. Ceftazidime. Cefadroxil. Cefuroxime st injection. Cefazoline. Cefaclor. Cephalexin x. mm mm HCOONH (ph ). ml/min UV nm. Cytosine. Thiourea. Adenine. Uridine Spursil μm C8-EP (Cat.# 8) Spursil μm C8-EP (Cat.# 8) x. mm MeOH:H O = 8:. ml/min UV nm. N,N-Dimethylaniline. Ethylbenzene. Propylbenzene. Bibenzyl. trans-stilbene After injections + + Phenomenex Luna μm C8() Min. Min. Agilent ZORBAX μm Bonus-RP Min. Min. After, injections + + GL Sciences Inertsil μm ODS- Waters XBridge μm C8 Min. Min. * Inertsil is a registered trademark of GL Sciences Inc.. Technologies Inc. is not affiliated with the above company. * Luna is a registered trademark of Phenomenex. Technologies Inc. is not affiliated with the above company. * ZORBAX is a registered trademark of Agilent Technologies. Technologies Inc. is not affiliated with the above company. * XBridge is a trademark of Waters Corporation. Technologies Inc. is not affiliated with the above company. Spursil Ordering Information μm Microbore Columns (. mm ID) μm Microbore Columns (. mm ID) Phases x. x. x. x. x. x. x. x. x. x. Spursil C Spursil C8-EP μm Analytical Columns (. mm ID) μm Analytical Columns (. mm ID) Phases x. x. x. x. x. x. x. x. x. x. Spursil C Spursil C8-EP μm Analytical Columns (. mm ID) μm Analytical Columns (. mm ID) Phases x. x. x. x. x. x. x. x. x. x. Spursil C Spursil C8-EP EasyGuard Guard Holder: Cat.# 7

8 Platisil HPLC Columns Features of Platisil Columns Universal and cost-effective columns Unique selectivity, excellent peak shape Useful in normal or reversed phase applications High loadability Platisil Material Characteristics Bonded phase Particle size Pore size Surface area Purity Phase density Carbon loading ph range Endcapping (Å) (m /g) (%) (μmol/m ) (%) C8 > Yes NH > No CN > Yes Silica > No PH > Yes Cold Medicine The Active Ingredients of Rhubarb Cat. No.: Platisil μm C8,. mm 99 MeOH:MeCN:% sodium dodecyl sulfate: acetic acid=:::.. ml/min UV nm. Pseudoephedrine hydrochloride. Naphazoline hydrochloride. Chlorpheniramine. Dextromethorphan hydrochloride Cat. No.: Platisil μm C8,. mm 99 MeOH:.% phosphoric acid = 8:. ml/min UV nm o C. Aloe emodin. Rhein. Emodin. Chrysophanol. Physcion Min. Min. Platisil Ordering Information μm Analytical Columns Phases x. x. Platisil C Platisil NH Platisil CN Platisil Silica Platisil PH

9 Diamonsil HPLC Columns Features of Diamonsil Columns Universal reversed phase columns High efficiency and outstanding lifetime Suitable for faster method development Superior batch-to-batch reproducibility Diamonsil Material Characteristics Bonded phase Particle size Pore size (Å) Surface area (m /g) Purity (%) Impurities (mg/kg) Carbon loading (%) ph range Endcapping C8(),, > < 7.-9 Yes C8(),, > < 7.-9 Yes C8 > < 7-7. Yes C8 > < -7. Yes β-blockers at High ph * Water-Soluble Vitamins *. mm MeOH: mm NH HCO (ph ) = 7:. ml/min UV nm. Pindolol. Acebutolol. Metoprolol. Bisoprolol. Propranolol. Alprenolol. mm MeOH: mm HCOONH (ph ) = :9. ml/min UV nm. Pyridoxamine. Orotic acid. L-Ascorbic acid Min.. Pyridoxal. Pyridoxol. Nicotinamide Diamonsil μm C8() (Cat.# 99) 8 Min. Diamonsil μm C8() (Cat.# 99) Min. Min. Poor Resolution + Unseparated Phenomenex Luna μm C8 Agilent μm HC-C8 8 Min. Min. Poor Resolution + + Unseparated + Unseparated + Waters Symmetry μm C8 Waters Symmetry μm C8 8 Min. Min. Min. Min. Min. *Luna is a registered trademark of Phenomenex. Technologies Inc. is not affiliated with the above company. *Symmetry is a registered trademark of Waters Corporation. Technologies Inc. is not affiliated with the above company. *HC is a trademark of Agilent Technologies. Technologies Inc. is not affiliated with the above company. + Min. Min. + 9 Min. +

10 Diamonsil Ordering Information μm Microbore Columns (. mm ID) Guard Cartridges, /pk Phases x. x. x. x. x. x. Diamonsil C8() Diamonsil C8() μm Analytical Columns (. mm ID) Phases x. x. x. x. x. x. Diamonsil C8() Diamonsil C8() μm Analytical Columns (. mm ID) Phases x. x. x. x. x. x. x. Diamonsil C8() Diamonsil C8() μm Microbore Columns (. mm ID) Phases x. x. x. x. x. x. Diamonsil C8() Diamonsil C8() μm Analytical Columns (. mm ID) Phases x. x. x. x. x. x. Diamonsil C8() Diamonsil C8() μm Analytical Columns (. mm ID) Phases x. x. x. x. x. x. x. Diamonsil C8() Diamonsil C8() Diamonsil C Diamonsil C EasyGuard Guard Holder: Cat.# Amino Acid Analysis (AAA) Column Phases Particle Size. Diamonsil AAA 997 μm and μm Semi-preparative Columns Guard Cartridges, /pk Phases Particle Size x. x. x. x. x. x. Diamonsil C8() Diamonsil C8() Diamonsil Diol Diamonsil Silica Diamonsil C8() Diamonsil C8() Diamonsil Diol Diamonsil Silica mm Guard Holder: Cat. #;. mm Guard Holder: Cat.#

11 Bio-Bond Protein and Peptide Separation Columns Features of Bio-Bond Columns Designed to analyze and purify proteins, peptides, and biomolecules Available with C8, C8 and C bonded phases Direct scale-up to preparative material Outstanding reproducibility, efficiency, and column lifetime Bio-Bond Material Characteristics Bonded phase Particle size Pore size (Å) Surface area (m /g) Purity (%) Phase density (μmol/m ) Carbon loading (%) ph range Endcapping C8,, > Yes C8,, > Yes C,, > Yes Insulin Genetic Variant Chemotactic Peptide Cat. No.:. Bovine Insulin. Human Insulin. Porcine Insulin Bio-Bond μm C8, x. mm 8 A:.% TFA in H O B:.% TFA in MeCN A:B = 7: to A:B = : in min. ml/min UV nm Cat. No.: Bio-Bond μm C, x. mm 8 A:.% TFA in H O B:.% TFA in MeCN:.% TFA in H O = 9: A:B = : to A:B = :7 in 8 min. ml/min UV nm. N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys. Lle-Val-Pro-Phe-Lyl-Pro-Leu-Thr-Amide Bio-Bond Ordering Information μm Analytical Columns Guard Cartridges, /pk For. ID Column For. ID Column Phases x. x. x. x. x. x. x. Bio-Bond C Bio-Bond C Bio-Bond C μm Analytical Columns Phases x. x. x. x. x. x. x. Bio-Bond C Bio-Bond C Bio-Bond C EasyGuard Guard Holder: Cat.# μm & μm Semi-preparative Columns Phases Particle Size x. x. x. x. x. x. Bio-Bond C Bio-Bond C Bio-Bond C Bio-Bond C Bio-Bond C Bio-Bond C mm Guard Holder: Cat.# ;. mm Guard Holder: Cat.#

12 About Technologies Inc., established in 99, is a global technology leader committed to developing novel separation and purification solutions for life sciences and related industries. Our core technology portfolio includes products for liquid chromatography, gas chromatography, sample preparation, and bulk purification chromatographic media. We also provide related chromatography accessories. Quality Technologies Inc. is an ISO 9: Standard Quality Assessed Company to ensure the quality and reliability of our products and services. We are dedicated to the highest standards of production, quality assurance and quality control. Value Technologies Inc. is committed to bringing maximum value to its customers. Technologies Inc. Literature No. USA Orchard Road, Suite Lake Forest, CA 9, USA Tel: Fax: Toll-Free: Canada Vogell Road, Unit 7 Richmond Hill, ON LB N, Canada Tel: Fax: Toll-Free:

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