S E R U M O S M O L A L I T Y. Group B: hypothyroid animals. Group C: hyperthyroid animals

Transcription

1 74 ).20;51 /;),20)4 )+ /; " ## "!`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

2 1 64,7+61 8=I FHAIIE NOJ?E 6 IO JDAIE A@E JDA =C?A K =H AKH I + I BJDAIKFH= FJE?5 JHE?K =H28 DOF JD= = E? K? AE =HAJH= IF HJA@J JDAF IJAHE HA A=IA@ E J JIJE K E B I JE? H I JE??D=H=?JAHF=HJE?EF=JAE JDA A?D= EI I 6HA A=IA B HAN= F A I JE?@EIJKH>=?AI BJDA ANJH=?A K =HB KE@ B= E K IJHAII F=HJKHEJE E C HA LAH = O AKH JDAH AKH HACK =J HI BJDA?A JH= AHL KIIOIJA =JAJDAIA AKH D H AI HA A=IABH JDADOF JD= = AKH DOF FDOIE= IOIJA 0 5# $ ) C JDAHI JDOH JH FE HA A=IE CD H A640EIIKFF IA@J =?J=JJDA ALA B0 5=I= =J H 6HA A=IA -=H EAHIJK@EAIBH KH => H=J HOD=LA@A IJH=JA@JD=J640E A?JA@E JH=?AHA>H LA JHE?K =H OE? L E JDAH=J=?JI=I= E DE>EJ HO =J H B AKH DOF FDOIE= AKH D H AIHA A=IA@KHE C@EBBAHA JIJ=JAI BM=JAH AJ=> EI " #! " E I BDOF L A E=@KAJ JDAD=A HHD=CA#=IMA =IE BA = A H=JI@KHE C E@ =?J=JE $ HA LAH MA JA@JD=J640E LAHJIJDA? KHIA OHDOJD 6HA A=IAE J 640 E A?JA@ E JH=LA KI OE L HAIJHE?JI B> JD AKH D H AIHA A=IA@KHE CJDA@ADO@H=JE # 6HA A=IAE LEJH E I B0 5 E?K>=JE & J JDA@ IAA F OA@' 6DAF IIE> AHA =JE IDEFI>AJMAA JDOH E@C AKH D H AIIA?HAJE =HAJ= A IE@AH=JE 5 A=KJD HIHAF HJA@ JD=JJDA?D= CA BBK?JE = JDOH E@IJ=JAE A JDAIJ=JA BDOF H DOFAHJDOH E@EI =OE B KA?AJDA AKH DOF FDOIE= D H AIHA A=IA # 9=JAHIE '%& "D=IB FHAIIE IA?HAJE E F=JEA JIMEJD DOF JDOH E@EI 5E E =H O =?=H KOEM= #D=LA JA@JDA =KC A J=JE B= JE@EKHAJE?D H A ALA E JDAIJ=JA BDOF JDOH E@EI 2 =I =L=I FHAIIE??A JH=JE D=I>AA HAF HJA@J >AA AL=JA@ $ H H = %@KHE CANFAHE A J= DOF JDOH E@EI HAHA?A J OM=IB DOF JDOH JE B KA?A)82 4 )E F=HL =C?A K =H AKH I BJDAF=H=LA JHE?K =H K? AKI28 =BJAHJDOH E@=> =JE 5E E =H O JDOH E@A?J O@E@ J?D= CADOF JD= = E? E DOFAH =JHA E?H=JI! JDA JDAJHA=J A J BH=JIMEJDJDOH E@ D H AE?HA=IA@DOF JD= = E? 6 4 ) AKH DOF FDOIE= 6? JA J =I MA =I 6 ALA E =I = 1JEI JAM HJDOJD=JE DK = IJDAIJ=JA B? E E?= DOF JDOH E@EI EI M J >A=II?E=JA@MEJD=@E E EIDA@=>E EJOJ MAHF =I = I = ALA & ' JDA? JH=HO JDAIJ=JA BDOFAHJDOH E@EI = EBAIJA@>OF O@EFIE=!! 0 MALAH K E A JDAHIFA?EAI E? K@E C = JDAH=JIJHA=JA@MEJDJDOH NE A ID MA@=HA@K?A@KHE =HO KJFKJ! " "

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

4 " $ 6DA>H=E MEJDE J=?JFEJKEJ=HOM=IGKE? OE A J =JAHJD= E =BJAH@A?=FEJ=JE HA LA@ JDAE AKH E JAH A@E=JA >AM=IIAF=H=JA@BH JDA = JAHE H >A.H JDA>H=E H=FE@ OBH A B H=BAM E KJAI=J % + JDADOF JD= = E?>? M=I@EIIA?JA@=IFHALE KI O@AI?HE>A@% 6DAMAJMAECDJ BJDEI>? BJEIIKAM=I & $! 5, 6DA AKH E JAH A@E=JA >AHAIFA?JELA O JDADOF JD= = KIM=ID CA E A@=J " + >OI E?=JE E E?H I 6 7 JH=I E?0 CA E AH =>?=EHA 7 E B #HAIF #=?AJE?=?E@@EII LA@E 'I= E A 6DAJEIIKAIKIFA IE M=IJH= IBAHHA@E J =?A JHEBKCA JDAI= F AM=IDA=JA@B H# E > E E CM=JAH>=JDE H@AHJ E =?JEL=JAJDA FH JA OJE?A O AI? J=E A@E JDAD CA E ANJ?A JHEBKCA@=J HF =J " +B H E 6DAIKFAH =J= JIMAHAHA LA@ BH A HA@=J % +K JE H=@E E K =II=O 4=@E E K =II=OI 6? JA J BJDA AKH DOF FDOIE= JD= = E?ANJH=?JI=IMA =IF =I = 6 ALA IMAHA@AJAH E A@>O@ K> A = E K =II=O=IFHALE KI IA AJ= % ) JE JE 6= A J B 2DOIE EIJHO A@E?= 7 ELAHIEJO 6DA= "B H = JE &B H= JE 6> JDBE KJE I +H IIHA=?JELEJOB H= JE )82= M=IMEJD NOJ?E $ MEJD OIE AL=I FHAIIE 82 % MEJDC =@ JH FE HA A=IE C D H A/ AK?E AA AFD= E AK - = CE JA IE 11) 52 AIIJD= +H IIHA=?JELEJOB H= JE 6= FHAIIE MEJD / AK - ) AIIJD= 6DAIA IEJELEJO B= JE JE 6 = JEIAH=M=I #FC)82 H 6FAHJK>A )HCE E AL=I FHAIIE )HC & 8=I FHAIIE *=?DA )/ J#%!=IMA =I NOJ?E 2A E IK = => J@ J %%'MAHAKIA@B FHAF=H=JE =IMA =IB =JE MEJD # 1KIE CJDA?D H= E A 6 1 JH= =II=O? ABBE?EA J BL=HE=JE?LB 6=II=OM=I % HAIFA?JELA O 2 =I =BHAAJDOH NE A.6 JDOH E A.6!??A JH=JE IMAHA@AJAH E E?=JA>O41) EJIFH LE@A@>O2 )6 *=@=M? 4 M MO1 J F M 4AIA=H?D,ALA F A J= +A JHA B1I J FAI JM? MEAH 2 J % HAIFA?JELA O 6DAE JH= =II=O?LB H.6 " H.6! && HAIFA?JELA O 5J=JEIJE?= AL= K=JE BJDAHAIK JI 6DAL=I FHAIIE NOJ?E? JA JM=IBE = OANFHAIIA@E = CH= IFAH C BJDA DOF JD= = E?JEIIKA E = CH= IB HJDAMD A AKH E JAH A@E=JA >A FE? CH= IFAH E E EJHA BF =I = 6DAF =I =.6 " JH=JE IMAHAANFHAIIA@E FE? IFAH EJAH ) HAIK JI=HAHAF HJA@=IJDA A= H BJDA A= 5 -,=J=MAHA?=?K =JA@>OJDA = = OIEI BL=HE=?A) 8) EB) 8)HALA= A@IEC EBE?= JABBA?JI F IJD?= = OIAIMAHA@ A KIE CJDAJM M=O9E? N JAIJF #M=IKIA@=IJDA E E = ALA BIEC EBE?=?A 5J=JEIJE?= = = OIEI BJDAANFAHE A H A@KIE C56)61561+)8AHIE # I BJM=HA? FOHECDJ5J=5 BJ1? E?A IA@J,AF=HJ A J B2=JD FDOIE CO A@E?= 7 ELAHIEJO AHK I = EJOE AKJDOH E@ DOF JDOH J IJ=JAI BM=JAH AJ=> EI 6=> A 5AHK I = EJOL= KAIIEC EBE?= J OH=EIA@ E AKJDOH E@H=JIE I B@ADO@H=JE HDOFAHJ E?I= E AE A?JE I 6=> A )1LI)11 )1LI)111

5 " % 6=> A 5AHK I = EJOE AKJDOH E@ DOF JDOH JIJ=JAI B M=JAH AJ=> EI E I C0 A= 5 - S E R U M O S M O L A L I T Y Subgroups of animals Group A: euthyroid animals Group B: hypothyroid animals Group C: hyperthyroid animals Statistical significance A versus B A versus C I animals ± ± ± 3.50 NS p<0.02 euhydrated II animals dehydrated for 2 days ± ± ± 2.08 p<0.01 p<0.01 III animals injected i.p. with 2% NaCl solution ± ± ± 2.66 p<0.01 p<0.05 Statistical significance: I versus II II versus III I versus III p<0.02 NS p<0.02 p<0.01 NS p<0.01 NS p<0.01 p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

6 " & 6=> A 0=A AKJDOH E@ DOF JDOH JIJ=JAI B M=JAH AJ=> EI A= 5 - H A E M A T O C R I T E I N D E X Subgroups of animals Group A: euthyroid animals Group B: hypothyroid animals Group C: hyperthyroid animals Statistical significance A versus B A versus C I animals 45.7 ± ± ± 0.76 p<0.01 NS euhydrated II animals dehydrated for 2 days 48.6 ± ± ± 0.55 NS NS III animals injected i.p. with 2% NaCl solution 45.0 ± ± ± 0.47 NS NS Statistical significance: I versus II II versus III I versus III p<0.02 p<0.05 NS p<0.01 NS p<0.01 p<0.02 p<0.01 NS KAI>AJMAA = IK>CH KFI B DOFAHJDOH E@H=JI 0OF JDOH E@H=JI@ADO@H=JA@0OF,AD HE A?JA@MEJD =+ 0OF 5= J ID MA@JDAE?HA=IA HA =JE J DOF JDOH E@AKDO@H=JA@= E = I 0OF + JH6=> A *11LI*1 *111LI*1 5E E =H O I JE?= OIJE K =JA@ DOFAHJDOH E@H=JI0OFAH,ADD=@DECDAHL= KAI M=H@IJ HAIFA?JELA? JH IK>CH KF0OFAH+ JH6=> A +11LI+1 8=I FHAIIE HA A=IAE AKJDOH E@ DOF JDOH JIJ=JAI BM=JAH AJ=> EI.EC 1 AKJDOH E@= E = IJDA AKH DOF FDOIE= L=I FHAIIE? JA JIEC EBE?= J O@A?HA=IA@@KHE C@ADO@H=JE.EC )1LI)11=IMA F JHA=J A J B =+ I KJE.EC )1 LI)111 6DA? BEH =JE BJDEI >IAHL=JE EIJDAE?HA=IA B)82F =I =??A CJDAI= AANFAHE A I.EC! )1LI)11 )1LI )111 0OF JD= = E?)82? JA J@E E EIDA@ OE -KJD5= JH=JI.EC )1 LI)111 5 AIEC EBE?= J@EBBAHA?AIE JDADOF JD= = AKH DOF FDOIE= L=I FHAIIE? JA JMAHAB AKJDOH E@ DOF JDOH DOFAHJDOH E@= E = IHA?AELE CJ=FM=JAH=@ E>EJK + F=HA@MEJDAKJDOH E@ = E = I 0OF + JHH=JIID MA@I AMD=JDECDAH>KJ JIEC EBE?= J AKH DOF FDOIE= )82? JA J.EC )1LI*1MDE ADOFAHJDOH E@ AID=@ IEC EBE?= J O MAH)82= K JIE JDA AKH DOF FDOIEI.EC )1LI+1 JDA? JH=HO DOF JD= = E?)82IJ HAI@E E EIDA@E 0OF + JHH=JI.EC )1 LI*1MEJD KJIEC EBE?= J?D= CAIE 0OFAH+ JHH=JI 6DAIJ=JA B I JE?IJE K =JE M=IJDAHA=I B@EBBAHA JHAIF IA BJDA DOF JD= = AKH DOF FDOIE= IOIJA CDOF JDOH E@EI H

7 " '.EC 6DADOF JD= = E?0JDL=I FHAIIE )82? JA JE AKJDOH E@ DOF JDOH E@ JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I $.EC 6DA AKH DOF FDOIE= 0L=I FHAIIE )82? JA JE AKJDOH E@ DOF JDOH DOFAHJDOH JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I $ DOFAHJDOH E@EI 0OF JD= = E?)82? JA JH=EIA@E 0OF 5= JH=JIMDA? F=HA@MEJDJDAHAIFA?JELA? JH L= KAIE IK>CH KF*1.EC *1LI*111 JDA IEC EBE?= J@A?HA=IAE AKH DOF FDOIE= )82? JA JM=I B > 5= JH=JI=I? E C? K JAHF=HJI.EC L=I FHAIIE F =I = ALA

8 "! JDAI= AIK>CH KFI D MALAH JDAHAIFA?JELA@EBBAHA?AIMAHA J IEC EBE?= J.EC! *1LI*11 *1LI*111 1 JDAIJ=JA BDOFAHJDOH E@EI JDA AKH DOF FDOIE= )82IJ HAI@EIJE?J O E?HA=IA@E > JH=JIE HA =JE J DOFAHJDOH E@? JH H=JI0OFAH+ JH.EC IE K J= A KI O DOF JD= = E?)82@A?HA=IA@E 0OFAH5= JH=JI.EC +1LI+111.EC! 2 =I =L=I FHAIIE )82??A JH=JE E AKJDOH E@ DOF JDOH JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I $.EC " 6DADOF JD= = E?0JD NOJ?E 6? JA JE AKJDOH E@ DOF JDOH E@ JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I %

9 "! NOJ?E HA A=IAE AKJDOH J IJ=JAI BM=JAH AJ=> EI.EC " # 1 JDAAKJDOH E@= E = IJDAIJ=JA HDOFAHJ E?I= E AJHA=J A JM=IJDAHA=I B@EIJE?J@A?HA=IA B NOJ?E AKH DOF FDOIE=? JA J.EC # KJJDA HAIFA?JELA?D= CAIE JDADOF JD= = E? 6IJ HAI 6F =I =??A JH=JE E?HA=IA@ OE I BM=JAH@AFHEL=JE.EC $ )1LI)11.EC # 6DA AKH DOF FDOIE= 0 NOJ?E 6? JA JE AKJDOH E@ DOF JDOH E@ JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I %.EC $ 2 =I = NOJ?E 6??A JH=JE E AKJDOH E@ DOF JDOH JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I $

10 "! 6DA AKH DOF FDOIE= 6? JA E DOFAHJDOH E = E CJ=FM=JAH0OFAH+ JH.EC # )1LI+1 F =I = 6??A OH=EIA@E JDAIA= E = I.EC $ )1LI+1 5E E =H O DOF JD= = E? 6? JA J@A?HA=IA@@EIJE?J OE 0OFAH+ JH=IMA =I0OF + JHH=JI=I? F=HA@MEJD-KJD+ JHH=JI.EC " %.HAAJDOH NE A.6"??A JH=JE E =I = BAKJDOH E@ DOF JDOH E@ JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I.EC JDOH E A.6!??A JH=JE E =I = BAKJDOH E@ DOF JDOH DOFAHJDOH JIJ=JAI BM=JAH AJ=> EI A= 5 - K >AH B= E = I

11 "!! 6DAJHA=J A J BDOFAHJ E?I= E AA F OA@E DOF JDOH E@= E = IM=I B MA@>O=IEC EBE?= J@A?HA=IA B AKH DOF FDOIE= 6IJ HAI.EC # *1LI * OF,AD= E = IDOF JD= = E? 6? JA JDECD OE?HA=IA@.EC " *1LI*11 JDA? JH=HO E DOFAHJDOH E@H=JIDOF JD= = AKH DOF FDOIE= 6? JA I BI= J =@E C.EC " +1LI+111 JDA 6F =I = O@E E EIDA@.EC $ +1LI+11 +1LI+111.6! " =I = ALA IE AKJDOH E@ DOF JDOH E@ JIJ=JAI BM=JAH AJ=> EI.EC % 1 AKJDOH IE K J= A KI O@ADO@H=JA@-KJD,ADI= J =@A@-KJD5= J= E = I@EIJE?J A AL=JE B.6! " F =I =??A JH=JE ID=I>AA >IAHLA@.EC % )1LI )111.EC & 6DAIJ=JA BDOF JDOH E@EI M=IJDAHA=I BJDAIEC EBE?= J@E E KJE B > JD.6! " F =I = ALA I=I? F=HA@MEJDAKJDOH E@H=JI.EC % *1 LI)1,ADO@H=JE M=IB MA@>O=@EIJE?JE?HA=IA B.6! " ALA IE F=HEI MEJD0OF + JHH=JI.EC % *1LI*11 1 = IK>CH KFI BDOFAHJDOH E@= E = JH=JE I H=EIA@IALAH= JE AIE HA =JE J AKJDOH E@IK>CH KFI.EC % +1LI)1 +11 LI) LI)111,EIJE?J@EBBAHA?AI= CJDAIAIK>CH KFI@KHE CJDAIJ=JAI B I JE?IJE K =JE MAHA >IAHLA@.6! " F =I = ALA IE?HA=IA@E 0OFAH,ADH=JI.EC % +11LI+1, =I FHAIIE NOJ?E I B I JE?@EIJKH>=?AI 5O JDAIEI =N = JH= IF A=IA BL=I FHAIIE NOJ?E =HA E?HA=IA@E = E = I@AFHELA@ BJ=FM=JAH HE I= J =@A@H=JI" #!" HA LAH JDA>E A BL=I FHAIIE NOJ?E AHCE? AKH I B =C?A K =HDOF JD= = E? K? AEEI M J E I!# 1 E CDOFAHJ E?I= E A E A?JA@E? L H E F MEJDDOFAHJ HE@AI KJE > JD AKH DOF FDOIE= D H AI D=LA>AA ID M AJAE JDA AKH= >A JD= = E? K? AE! " "!$!% HA LAH JDAE?HA=IA 6??A JH=JE E =I =E JDAH=J=BJAHIK?DJHA=J A JD=I>AA >IAHLA@! " "!$!%!&!' " 6DEIFH > >O* +E IA " 1 =CHAA A JMEJDB H AH@=J= = I BH JDEI => H=J HO" #!" JDAFHAIA J HAIK JIID MJD=JJDADOFAH I JE?@ADO@H=JE HJDAJHA=J A JMEJDDOFAHJ E? HE@AI E EIDA@IEC EBE?= J OJDA AKH DOF FDOIE= L=I FHAIIE NOJ?E? JA J 6DEI@E E KJE B AKH DOF FDOIE= L=I FHAIIE NOJ?E? JA JM=I >IAHLA@J >A=?? F= EA@>O= E?HA=IA BJDAEHHA A=IAE J 1JIAA IJD=JJDAE =HJH= IF HJ B> JD

12 AKH D H AIBH JDADOF JD= = KIJ M=H@IJDA AKH DOF FDOIEI = JD KCD E?HA=IA@E I EIFH >=> OE IKBE?EA JJ? FA 6 GK= JEJEAIHA A=IA@E J JDA?EH?K =JE -BBA?J BJDOH E@IJ=JKI L=I FHAIIE NOJ?E HA A=IA@KHE C I 6DOH E@C B KA?AIJDADOF JD= = FEJKEJ=HOIOIJA BK?JE 1JEI M JD=JJDOH E@D H AI=HAA C=CA@E JDABAA@>=? HACK =JE B640>E IO =JJDA ALA BDOF JD= = E?28 HACE " "! ""MDE?D? JDAJDOH JH FDE?DOF JD= = E?=HA=" "! "# ) =HCA K >AH B640 IO JDAIE E C AKH I=HAFHAIA JE JDA A@E= JHE?K =HF=HL?A K =HIK>@ELEIE I BJDA28 "$ "% +A??=JA EAJ = D=LAID MA@JDABAA@>=? ABBA?J BJDOH E@D H A 640IO JDAIEI >OJDA640 4 )E?HA=IAE JDAIJ=JA BDOF JDOH E@EI E CDOFAHJDOH E@EI 1 JDAIJK@O AJ= "&E JDOH NE JHA=JA@H=JI JDA ALA B640E JDAF IJAHE HFEJKEJ=HOE?HA=IA@MDAHA=IEJ@A?HA=IA@E JDA AJDE = A JDOH E@H=JI 1JD=I>AA DOF JDAIE A@JD=JF IJAHE H FEJKJ=HO640F=HJE?EF=JAIE FH =?JE 24 =IMA 6IA?HAJE "& *KJJDAIAE =O>AGKEJA@EBBAHA JE JDAH>H=E HACE I. H AN= F A E JDAIJK@O B2A =HOAJ= "'DOF JDOH E@EI HA@K?A@JDA? JA J B JDAH640 E AFAFJE@AIE JDAA J HDE =? HJAN 6DOH E@D H AIHACK =JA= I JDAIA?HAJE B JDAHDOF JD= = FEJKEJ=HO D H AI 6DAHA =JE IDEF>AJMAA JDOH E@D H HJE?= BK?JE A JA@ 1JD=I>AA HAF HJA@JD=J)+60HA A=IAEI@E E EIDA@E I BFHE =HODOF JDOH E@EI #>KJE?HA=IA@E JDAIJ=JA B DOFAHJDOH E@EI # 6 DAEAJ= # D=LAID MA@JD=JDOF JDOH E@EI?=KIAI JDADOFAHIA?HAJE B)+60B ME C>OJDAE?HA=IAE IO JDAIEI B? HJE? JH FDE HA A=IE CD H A+40E JDADOF JD= = KI,=J=BH JDA IJK@O B,= E AAJ= #!@A IJH=JAJD=JJDOH NE AH=EIA@ BDOF JD= = E? +40CA AANFHAIIE E JDA A =J= H=JI HA LAH?D= CAIE CH MJDD H A HCH MJDD H A HA A=IE CD H A/040IO A=IA D=LA>AA HAF HJA@E ANFAHE A J= E@@OIBK?JE #" 6DOH E@ D H AANAHJI AC=JELABAA@>=? E B KA?A JDA>=I= AL A@24 IA?HAJE E DK = I## #$ 5JA F E= AJ= #%@A IJH=JA@JD=J24 F =I = ALA IMAHAE HA=IA@E DOF JDOH JHA=JA@H=JI 6DA ALA BC= = E 4 )/= 4 )E F=HL =C?A K =H28 AKH IM=IIEC EBE?= J JDADOF JDOH E@H=JI /=? JA JE DOF JD= = KIM=I@E E EIDA@E I#& HA LAH L=I =?JELA E JAIJE = F HACK =JE >OJDOH E@D H AI )ANFHAIIE E?HA=IA@E JDA28 >OJDOH E@A?J O #' = HA =JE IDEF>AJMAA DOF JD= = FEJKEJ=HO JDOH JD= = AKH DOF FDOIE= IOIJA 5ALAH= BK?JE IB H 640E JDAHACK =JE B AKH DOF FDOIE= =?JELEJOD=LA>AA IKFF IA@ 640D=I >AA JA@J IJE K =JAJDAHA A=IA BL=I FHAIIE NOJ?E E JDAH=>>EJ$ $ 5E E =H O JDAE? L 640JHA=J A JM=IB MA@>O= E?HA=IA B)82 "!"

13 "!# HA A=IAE JDAH=J$ 1 JDAHANFAHE A JI?D= CAIE NOJ?E L=I FHAIIE HA A=IA=BJAHE? L E A?JE I B640MAHAHAF HJA@$!?D= CAI E 6 H)82HA A=IAB ME CJDAE JH=LA KIE L =@ E EIJH=JE B640 MAHA JA@E JDAH=J$" -=H EAHIJK@EAIBH KH => H=J HOD=LA@A IJH=JA@ JD=J640E A?JA@E? L E JDAH=JI=?JI=I= E DE>EJ HO =J H B AKH DOF FDOIE= AKH D H AIHA A=IA@KHE C@EBBAHA JIJ=JAI BM=JAH AJ=> EI " #! " I BDOF L A E=@KAJ D=A HHD=CA# =IMA =IE BA = AH=JI@KHE C E@ =?J=JE $ HA LAH MA JA@JD=J640 E LAHJIJDA? KHIA B@=E OHDOJD 6HA A=IAE J 640 E A?JA@E L HAIJHE?JI BJDAJM AKH D H CJDA@ADO@H=JE # 6HA A=IAE LEJH E I B0 5 ANF = JIE?K>=JE & J =@ IA A F OA@' 5 AHAF HJIIKFF =J HOH AB HJDAJDOH E@C L=I FHAIIE NOJ?E HA A=IABH JDA AKH DOF FDOIEI 6DEI? A?JE IJH=JA@ANFAHE A J= OAIFA?E= OE I BJDAJDOH E A E IJ=JAI BDOF JDOH E@EI HDOFAHJDOH E@EI 6DAIJ=JA B DOF JDOH E@EI A J= O>OJDAIKHCE?= JDOH E@A?J O H >O=@ E EIJH=JE B" AJDO JDE KH=?O HFH FO JDE KH=?O $# $$MDAHA=I JDAIJ=JA BDOFAHJDOH E@EI EIKIK= E?JDOH E@D H A =@ E EIJH=JE #! $% $& 1J?= J>AAN? K@A@JDA@EHA?J 67 ABBA?J 6 AJ=> EI 6D KCD EJD=I>AA F IJK =JA@JDAF=H= A O KIA BJDAJDOH E@A?J O HIE K J= A KI O=@ E EIJH=JE B NE =IJDAJAIJ BIKFFHAIIE B 67=?JE E FHAIA JANFAHE A JIE =CHAA A J MEJD IJIJK@EAI JDAIJ=JA BDOF JDOH E@EI 67=FF E?=JE 1 JDAFHAIA JIJK@OF =I = ALA I JDOH E A.6! JDOH NE A.6 " =IJDA>=I= HI BJDAIJ=JAI BDOF HDOFAHJDOH E@EI E A@ 6DABHAA6! " F =I =??A JH=JE IHAFHAIA J=> KJ! H! HAIFA?JELA O BJ J=?EH?K =JE CD H A= K JI 6DAIJ=JA B DOF JDOH E@EI HAIK JA@E IEC EBE?= J@A?HA=IA B.6! " F =I = ALA I = FF IEJAABBA?JIE BJDAJM D H AI ALA M=I CJDADOFAHJDOH E@EI 1 JDEIHAIFA?J KH@=J==HAGKEJA? IEIJA JMEJD FHALE KIHAF HJI"& #% $& 6DAHAIK JI BJDAHAIFA?JELAIJK@EAI??AH E CF IIE> AH A BJDAJDOH E@E HACK =JE 6IA?HAJE =HA JGKEJA? IEIJA J 1 F=JEA JIMEJD ONA@A =@KAJ FHE =HODOF JDOH E@EI F =I =)82 ALA M=IH=EIA@ IEC EBE?= J O " # $' H JDA? JH=HO A HLAHO M % % 5E E =H O ) EAJ= %D=IB E KJE BF =I =L=I FHAIIE ALA E JDAFH FO JDE KH=?E JHA=JA@H=JI 1 FHE =HODOF JDOH E@EI F =I = DOF I = M ALA I B)82D=LA>AA >IAHLA@% 1 =IJK@O B 9 BAJ= $%DOF E@EI E H=JBA = AI@KHE J HAIK JE =IEC EBE?= J?D= CAE L=I FHAIIE NOJ?E? JA J BBAJ= AKH DOF FDOIAI F =I = HFEJKEJ=HOL=I FHAIIE

14 ALA C= E JHE= A JDOH E@EI E H=JI 1 =@@EJE JDA DOF JD= = E?)82 4 ) ALA I@E@ J?D= CAE I 5E E =H O E =HAF HJ B+A??=JA EAJ= DOF JDOH J=BBA?J)82 4 ) ANFHAIIE E F=HL =C?A K =H28 AKH I JDA JHA=J A J BH=JIMEJDJDOH E@D H A6! H=EIA@ 6 4 )ANFHAIIE JDA AKH DOF FDOIE= 6? JA J=IMA =I 6 ALA E +=HJAHAJ= %! D=I>AA JA@JD=J)82 4 ) ALA E JDA5 JDA AKH E JAH A@E=JA >A BJDAFEJKEJ=HOIEC EBE?= J OH=EIA@E =IJ=JA B DOF JDOH $ FH FO JDE KH=?E >KJM=I J?D= CA@E? IAGKA?A BIKHCE?= JDOH E@A?J O 1 JDAIJK@OBH KH => H=J HO#%F =I 6??A JH=JE IMAHAHA@K?A@E H=JIMEJDDOF JDOH E@EI >KJ=BJAH6 " =@ E EIJH=JE )82>KJ J 6F =I = OE?HA=IA@ 1 JDAHAF HJ B6 DAEAJ= $#)82HA A=IAE A@E= A E A?AM=I@EIJE?J OE JA IEBEA@E DOF JDOH E@H=JI JDAHAM=I = JAH=JE E DOF JD= = E?)82? JA J 0OFAHJDOH E@EI >IAHLA@E F=JEA JIHAIK JA@E )82F =I = ALA E?HA=IA%" HA??KHE CJ JD=J B? JH I=BJAH H = E =JE BJDOH E@IJ=JKI JDA JDAH E A =J= H=JI E A?JA@MEJD6 " = B)82 4 )E JDA F=HL =C?A K =H?A BJDA28 AKH ID=I>AA >IAHLA@#! 6DA I JE?IJE K KIA F OA@@KHE CJDAJDOH E@C I HAIK JA@E =@EBBAHA J? IAGKA?AI=IJ 6HA A=IA 8=HC=IAJ= %# D=IID MA@JD=JKHE =HOAN?HAJE B)82M=IE?HA=IA@E E EIDA@E DOF JDOH E@H=JIE HAIF IAJ I JE?IJE K EE A H=DOFAHJ E?I= E A =@ 6DOH E@A?J O@E@ DOF JD= = E? 4 )E HAIF IAJ?DH E?DOFAH =JHA E=E = A H=JI! -NFAHE A JI B CK?AJ= $$ %$D=LA>AA ID MA@JD=JE 267 JDOH E@H=JI HE IKHCE?= OJDOH E@A?J E A@H=JIDOFAHJ E? H DOF L A E?JHA=J A J?=KIA@ MAHE?HA=IA B)82F =I = ALA =I? F=HA@ J JDAHAIFA?JELAE J=?J= E = I KHHAIK JIIAA J >AF=HJ O? IEIJA JMEJDI A A JE A@=> LA@=J= 6DA DOF JDOH H=JI>AE CE AGKE E>H=JA@M=JAH AJ=> EI IAA J >AJDAHA=I BJDAHAIJH=E A@L=I FHAIIE HA A=IABH JDA AKH DOF FDOIEI D MALAH MEJD KJ)82F =I = ALA?D= CA 1 KH FE E EJ?= J>A AN? K@A@E DE>EJ HOE B KA?A B640MDE?DEIHA A=IA@E CHA=JAH= K JIE = IJ=JA BJDOH E@DOF BK?JE *=IA@KF JDA >IAHL=JE B KH => H=J HO" #! " # $ &JDEIDOF JD= = E?FAFJE@AEIJD KCDJJ >A= E DE>EJ HO =J HB 6HA A=IA JDA? JH=HO JDA@A?HA=IA BJDA AKH DOF FDOIE= )82IJ H=CAIE =IJ=JA BDOFAHJDOH E@EI =OJAIJEBOJ JDA E JA IEBEA@)82HA A=IA 6DAIA@=J=IAA J >AIE E =HJ I AHAIK JI >J=E A@ BH JDAIJK@EAI B0 M=H@AJ= F E= AJ= #% )IJ NOJ?E EJEI JAM HJDOJD=J> JDIJ=JAI BJDOH E@@OIBK?JE E A DOF DOFAHJDOH E@EI HAIK JA@E = E?HA=IA B 6IA?HAJE E J HDOFAHJ E?I= E A E A?JA@DOF JDOH JDAA 6HA A=IAD=I>AA??KHA@=I? F=HA@MEJDAKDO@H=JA@ "!$

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

16 "!& A L, 5 K J O L 1 6 =HAL,1 *= I2 8EC=I 8=I FHAIIE NOJ?E E IJHAII ) ;)?=@5?E''# %% '! * = MI =- 5JA F E= * 6/ 2 A=IA BL=I FHAIIE NOJ?E BH JDAEI =JA@ H=JDOF JD= = AKH DOF FDOIE= IOIJA ABBA?J B=6/ 2 HA?AFJ H=C J=C EIJ 2DOIE 2D=H =? # %& %'! KI? = AKH E E AKH DOF FDOIE= HAIF IAJ A =J E E LEJH IJK@EAI 2DOIE 2D=H =? #! &! &!"! +E IA /K A 9 6DOH JH FE HA A=IE CD H FHAIIE NOJ?E HA A=IA E LEJH =IMA =IE LEL IJK@EAI -NF+ E '' # #' " +E IA 1 B KA?A BJDOH E>AHE 640 DOF JD= = AKH DOF FDOIE= L=I FHAIIE NOJ?E? JA J BH=JI@HE E C =+ 2 2=JD ''! "" $ # +E IA H MI = 6DOH JH FE HA A=IE CD H A640E DE>EJIJDAHA A=IA B L=I FHAIIE >KJ JJD=J B NOJ?E BH JDADOF JD= = AKH DOF FDOIE= IOIJA E D=A HHD=CA@H=JI ''# ' "% ## $ +E IA /K A 9 6DOH JH FE HA A=IE CD H A=BBA?JIJDA NOJ?E L=I FHAIIE FH =?JE HA A=IAE BA = AH=JI@KHE C E@ =?J=JE HA =JE J IK? E C 2DOIE 2D=H =? ''& "'!# # % +E IA 5JA F E= * 6DOH E>AHE OHDOJD BL=I FHAIIE NOJ?E HA A=IA BH JDADOF JD= = AKH DOF FDOIE= IOIJA 2=JD FDOIE CO ''& #!!' & +E IA 5JA F E= * 6DOH JH FE HA A=IE CD H A640E DE>EJIL=I FHAIIE NOJ?E HA A=IABH H=JDOF JD= = AKH DOF FDOIE= ANF = JIE LEJH )?J= AKH >E -NF ''$ #$!# " ' +E IA 5JA F E= * 6DOH JH FE HA A=IE CD H A=IA B AKH DOF FDOIE= D H AIE JDAH=J 2 ''% "&!!" )@= 4) + N L= =JI 2 *KH>=?D 2 6DOH E@D H AHACK =JAIJDA NOJ?E CA A *E +DA '' $%!%%!%%% +A??=JA E5 /E=H@E += 4AIF IA BDOF JD= = E?FAFJE@A 4 )IJ JDOH E@A?J O AKH CO '' #$ $'" %! 0 M=H@4 5K AH5 4 IIE E 5?DHEAH49 5D HJ JAH DOF JDOH E@EI L=I FHAIIE CA AANFHAIIE E JDAH=J E@,EI '' :1: #%! #%%! 6D =I) E * ) E? ) 6DOH E@A?J O@ AI J= JAHDOF JD= = E? NOJ?E L=I FHAIIE ANFHAIIE E?DH E?= ODOFAH =JHA E?H=JI EBA5?E''# #% "! " " 9=JAHI) 1?HA=IA@L=I FHAIIE AN?HAJE E F=JEA JIMEJDDOF JDOH E@EI '%& && &# ' # =?=H +.= KOEM= 0OF =JHA E= BDOF JDOH E@EI =FFH FHE=JAIKFFHAIE B = JE@EKHAJE?D H A ALA I )H?D1 JAH A@ '%&!& & & $ E 5K AH5 5?DHEAH49 +A K =H=?JE B=HCE E AL=I FHAIIE E JDAEI =JA@HA = JK>K AI BDOF JDOH E@H=JI ) 2DOIE '&% #!.". % 5DE E K AJ= 0OF =JHA E=MEJD KJE =FFH FHE=JAIA?HAJE BL=I FHAIIE E =?=IA B ONA@A =? = F '& '!$!!$& & 0= =.9. 5?=. 0OF =JH=A E= DOF JDOH E@EI A B=HCE E A L=I FHAIE 6DA =?AJ ''%!# %## %#$ ' 5=DK 4= =L=HH )AJ= 9=JAH AJ=> B@EBBAHA JIJ=CAI B FHE =HOJDOH E@B=E KHA $& "!# ""#! 5K =./ 6= - 2BAEBAH; 1 JAH EJJA JDOFAHJDOHA IEI A 0 H AJ=> 4AI'%# % " " " &! AO+6 0EIJ HE?=? E E?= => H=J HOBA=JKHAI B $DOFAHJDOH E@?=JI 8AJ4A? ''! #% $"

17 "!'! 5DK JA 9EIIAH = 0 5JH=K>- -BBA?J B JDOH NE A HA = AN?HAJE A A?JH OJAIE > JD H = AH?KHO E J NE?=JA@H=JI 7H 4AI '& & &' '$!!. HI E C, A=IKHA A J BL=I FHAIIE E KE@ 1 2 IJAHE H2EJKEJ=HO 20*=O EI 2 =H?A,A AH1? '&# FF $ '!" +E IA /K A 9 H MI = 6DOH JH FE HA A=IE CD H =JAI L=I FHAIIE NOJ?E HA A=IABH JDADOF JD= = AKH DOF FDOIE= IOIJA 2DOIE 2D=H =? ''! "" '!!!# A C/ *E? A 4 6DA AKH DOF FDOIEI 1 AKH CO 5 ECDJ = * -LAHEJJ A@I * =? MA 5?EA JEBE?2K> E?=JE I NB -@E >KHCD * IJ 2= ) J A > KH A '&$ FF %% '$!$ 9=@A+- *EA2 AE + 4= I=O, -BBA?JI BDOFAHJ E?E JH=?=H JE@E BKIE I F =I = L=I FHAIIE??A JH=JE ) 2DOIE '& "! -# -# $!% K E?, 1I J E?I= E A=?J=IIJHAIIBK IJE K EB H NOJ?E AHCE? IOIJA BJDAFEJKEJ=HO DOF JD= = =? H@ EBA5?E ''! #! #%' #&"!& AK = 1 K@MEC - CA = 2EJJ = 3 5E K J= A KI NOJ?E FHAIIE HA A=IAE HAIF IAJ?A JH= I JE? IJE K =JE E CE JDAH=J AKH CO ''! #& $!% $"#!' * KHGKA+9 EAJ504 4E?D=H@, I HA?AFJ HI I HA?AFJE I HACK =JE.H J AKH ''" #! %" " 1L= OE6, D= E?I 8AH>= EI / -BBA?J B?DH E?DOF =JHA E=?A JH= NOJ?E FHAIIE IA?HAJE E H=JI AKH CO ''# $ " " " +E IA 8=I FHAIE NOJ?E HA A=IABH JDA AKH DOF FDOIEI JDA?KHHA JIJ=JA B M A@CAE 2 EID HO 2 #!! " 5ACAHI 2 =KAH 9 BA +AJ= 6DOH E@D H AHACK =JAI640>E IO JDAIEIE JDA F=H=LA JHE?K =H K? AKI BJDAH=JDOF JD= = KI 5?EA?A '&%!& %& & "! AH 9 B45 9=H@A A AH46 6DOH E@D H AIHACK =JA ALA I BJDOH JH FE HA A=IE CD H A 4 )E JDAF=H=LA JHE?K =H K? AKI 2H? =J )?=@5?E75) '&% &" %! ' %!!! "" 6=O H6 H@.- * =E A6 9AE JH=K>*, 6DAF=H=LA JHE?K =H K? AKI BJDA DOF JD= = KID=I= = HH AE JDOH E@D H ABAA@>=? HACK =JE BJDOH JH FE IO JDAIEI CO '' $!%! " "# )E =M=6 /HAAH ),A E A=JE BJDADOF JD= = E?=HA=? JH E CJDOH JH FE IA?HAJE E JDAH=J CO '& ' %! %!& "$ 1IDE =M= 6= ECK?DE; 1 KA 1 K?OJ?DA E A=JE BJDOH JH FE?=HA= HECE BJDOH JH FE HA A=IE CD H AE JDA A@E= A E A?A AKH CO '&& "%!&"!&& "% 6 E4 =? I 1, A?D= 4 6DOH JH FE HA A=IE C D H A JK>AH E =H AKH I E H=JDOF JD= = KI = =J E?= >=IEIJ IKCCAIJK JH=ID HJBAA@>=? HACK =JE AKH CO '' # " " & "& JME 9 E A I- L= 0==IJAHA 8EIIAH6 4ACK =JE BJDOH JH FE HA A=IE CD H AE JDAF IJAHE HFEJKEJ=HO AKH CO ''# $ " " ' "' 2A =HO)- 5=JJE ) 4ACK =JE HA =JA@FAFJE@AIE H=J>H=E >OJDOH IJAH E@D H AI 2AFJE@AI $ %! # *EC I4 4E@CAM=O-+ KHE@AI) = B. 5FA?JHK BFEJKEJ=HO= JAH=JE IALAHAJDOH E@E F=EH A J + E AJ=> '%&!%! # # /= =CDAH6. 0A =.E A IJAE AJ= 0OFAHJDOH E@EI HJEI IA?HAJE E = + E AJ=> '%!" '' ' %

18 "" # 6 DAE) 9=J= =>A/ 6=O= 0OFAHIA?HAJE B? HJE? JH FDE HA A=IE CD H =HCE E AL=I FHAIIE E DOF JDOH E@ = AH=JI=IAIJE =JA@MEJDFKID FK FAHBKIE ''& #$!'# " #!,= E A ELAH+ /HE 6DOH NE =JAI? HJE? JH FE HA A=IE CB=?J H>KJ J =HCE E AL=I FHAIE CA AANFHAIIE E JDADOF JD= = E?F=H=LA JHE?K =H K? AKI FE CH=J AKH %%" %&! #" AI2 *KHHE /D=JAE ) 0= H=, AC 5 * 54 6DAE B KA?A BJDOH E@ D H AIJ=JKI JDADOF JD= = DOF FDOIA= CH MJDD H A=NEI CO '' $!%"!%' ## 5 MAHI 5) A AJJ0) *H M 5 5AJD 6 BJ), 2H =?JE HAIF IAJ AJ? FH= E@AE DOFAHJDOH E@EI + E AJ=>'& ## %# %% #$ 9=J= =>A0 5=I= E5 -BBA?J BJDOH E@IJ=JKI JDAFH =?JE HA A=IE C=?JE BL=I =?JELA E JAIJE = FAFJE@AE DK = I? F=HEI MEJDJDA=?JE BJDOH JH FE HA A=IE CD H A + E AKH ''# $ % #% 5JA F E= * =H? O I E), >H MI E4,EI H@AHI BJDOH E@BK?JE H AHA A=IA BH JDAH=JFEJKEJ=HO 2 #!! #& 0 E5+ A EC /=>HEA 5 =EJAH, =HJE * 1 B KA?A BJDOH E@D H A JDA??A JH=JE BC= = E E JDAH=J>H=E AKH CO '' #!#!#$ #' = 5 A?D= 4 E = EJ= E 5ACAHI 62 4AE?D E 5 8=I =?JELAE JAIJE = FAFJE@A E JDA= JAHE HFEJKEJ=HOEIE?HA=IA@E DOF JDOH E@EI CO '&' " %% &" $ 0 HEJ=) +=HE ) +A JH= O=@ E FHAII HHAIF IAE H=>>EJ 2H?9AIJ2D=H =? 5? '%%!!!" $ 9AEJ = 4-.EHA =H / =J 60.EIDAH,) 6DOH JH FE HA A=IE CD H AIJE K =JAI HA A=IA B=HCE E AL=I FHAIIE NOJ?E E LEL CO '%' " '" '% $ 5 MAHI 4 0AHID = 5 MI O94 +=H I 0- -BBA?J B640 IAHK =HCE E A L=I FHAIIE E AKJDOH JDOH E@IK> A?JI 0 H 4AI '%$ %!!% $! =IJE C 9 5E K J= @A JHA A=IA BL=I FHAIIE NOJ?E E JDAH=J += 2DOIE 2D=H =? '&& $$ $ $" 5EHA ) = A+4.AKAHIJAE C/ = AKH= A?D= EI I B=?JE B JDOH JH FE HA A=IE CD H AE JDAH=J +EH?4AI '&& $!' #" $# 6 DAE) 9=J= =>A 6=O= 0OFAHIA?HAJE B? HJE? JH FDE HA A=IE CD H E A L=I FHAIIE E DOF JDOH E@ = AH=JI=IAIJE =JA@MEJDFKID FK FAHBKIE ''& #$!'# " $$ CK?4, C *= J=?E ;E = * A AIJE KH0 1 B KA?A BDOF L A DOFAHJ E?JHA=J A JI F =I =L=I FHAIIE ALA KE@>= =?AE JDAJDOH E@A?J O JDOH E@H=JI AKH AJJ!#!& $% 9 B/ EAIIEC4 ALA I BL=I FHAIIE NOJ?E E AKH DOF F =I = BJDAF IJ =J= O@ALA FE B KA?A BDOF JDOH E@EI H=JBAJKIAI -NF + E '&" &! # ## $& 4 I=J 44 /E A A 5 =D /) -BBA?JI B?DH E?JDOH E@D H A=@ E EIJH=JE FHAC =?O =?J CA =?J=JE E JDAH=J '' % #"% ##" $' 5 MI O94 E K?DE6) 6DAH A BL=I FHAIIE E JDAE F=EHA@M=JAHAN?HAJE E ONA@A = ) A@ '%& $" $! $ % 1M=I= E; EI ; ;= =?DE AJ= I HACK =JE BF =I =L=I FHAIIE E ONA@A = + E AJ=> '' % #!" #!' % ) E /KE / += J= * *= AIJHA +DE? J, + I )? F=H=JELAIJK@O BF =I = L=I FHAIIE L=I FHAIIE HA?AFJ HFH FAHJEAIE? CA EJ= DOF JDOH E@H=J NE A HL=I FHAIIE JDAH=FO 0 H AJ=>4AI '&% ' $ " $ &

19 "" % 5=DK 8E => A+ 4 IA 2AJ= 9=JAH AJ=> JIJ=CAI B FHE =HOJDOH E@B=E KHA $& "!# ""# %! +=HJAH,) 2=H@O KHFDO, 4ACK =JE BL=I FHAIIE CA AANFHAIIE?D= CAIE JDA ALA >KJ JJDAIE A BL=I FHAIIE 4 )B ME A = EFK =JE I +A AKH >E ''!! &% '# %" =H?EI / K?D=H - +D= CAI BF =I ==HCE E A L=I FHAIIE ALA E F=JEA JI MEJDDOFAHJDOH CJHA=J A J A@5?E EJ % "' "" %# 8=HC=I. *= K 0=H 7HE =HOAN?HAJE B@EC NE E A E K HA=?JELAB=?J E A L=I FHAIIE E DOFAH JDOH E@H=JI + E 5?E '' & "% "%$ %$ CK?4 *= J=?E) ;E = * A AIJE KH0 1 B KA?A BDOF L A E? JHA=J A JI F =I =L=I FHAIIE ALA KE@>= =?AE JDAFH FO JDE KH=?E DOF JDOH E@H=JI AKH AJJ '''!!" 4A?AELA@?J >AH! )??AFJA@ =O% " )KJD H\I=@@HAII = =+E IA 2D,, 5?,AF=HJ A J B2=JD FDOIE CO A@E?= 7 ELAHIEJO K =HKJ ME? =$ 2 6A "&" $! $ &% B=N "&" $! '%! - =E = =? (F? J= AJ F