74 ).20;51 /;),20)4 )+ /; " ## " %!`% " MMM FF H= M F 1,-5 )- +;7 5 )1 1,-5 1! ) 91-+ ) +1- ) 64 -5 1) ,-4)6-20;51+) 64)1 1 / *, )

Size: px

Start display at page:

Download "74 ).20;51 /;),20)4 )+ /; " ## " %!`% " MMM FF H= M F 1,-*5 )- +;*7 5 )1 1,-*5 1! ) 91-+ ) +1- ) 64 -*5 1) ,-4)6-20;51+) 64)1 1 / *, )"

Jonas Owen
5 years ago
Views:

1 74 ).20;51 /;),20)4 )+ /; " ## " %!`% " MMM FF H= M F 1,-*5 )- +;*7 5 )1 1,-*5 1! ) 91-+ ) +1- ) 64 -*5 1) ,-4)6-20;51+) 64)1 1 / *, )41)*1 16;),0-,; ) 1+2) , ;0; * -+65,AF=HJ A J B-NFAHE A J= E E?= 2DOIE CO 6DA A@E?= 7 ELAHIEJO B9=HI=M =JE = 1 IJEJKJA B+=H@E CO =JE = +A JHA B5F HJI A@E?E A! 9=HI=M 2 6DA > A?JELA B KHIJK@OM=IJ? F=HAJDA?=H@E L=I?K =HABBA?JI ANAH?EIAJH=E E CE DA=JDOO K C 65 & ' DOFAHJA IELA DK = IK> A?JI065!! JIEC EBE?= J O@EBBAH>AJMAA CH KFI 065 BIOIJ $ FHAIIKHA,*2&& 0C 65 B5*2 & & " % ' 0CMAHAIK> = E?ANAH?EIAJH=E E C =J=> KJ#8!JE AIFAHMAA B H AD KH LAH! JDI 8 M=I )HJAHE= A=IKHA@MEJD.E =FHAIJA?D EGKA JDAIJH AL K A?=H@E=? MMAHA=IIAIIA@>OE FA@=?AHA CH=FDO 8=HE=>E EJO IAE JAHL= L= KAI21MAHAAIJE =JA@>O? FKJE CJDA MAHIFA?JH==?? H@E CJ..6= C HEJD )BJAHJH=E E IEC EBE?= JE FH LA A JIE 8 MAHA >IAHLA@E 65 >O ' 065 >O! $& C E 1 065IEC EBE?= J O@A?HA=IA@ 5*2>O' ' 0C E,*2>O % 0CJ J= FAHEFDAH= HAIEIJ=?A624>O & #624K EJI 6DAFHAJH=E E CL= KA B MBHAGKA?O? F A JF MAHIFA?JH=5*2. 5*2 M=I IEC EBE?= J OCHA=JAHE 065? F=HA@J 65 21L=HE=?AM=I MAHE 065? F=HA@J 65 )BJAHFDOIE?= JH=E E C E 06521L=HE=?AE?HA=IA@IKCCAIJE C =@A?HA=IAE =JA@IO =JE BDA=HJH=JAE IE ) = C BJDAIJK@OEIJDA IEC EBE?= J@A?HA=IA BHAIJE C MBHAGKA?O? F A J5*2F MAHIFA?JHK =BJAH JH=E E CE 065 6DAL= KA B. 5*2 E JH=E A@DOFAHJA IELAIK> A?JI H = E A@J JDAHAIJE C ALA B. 5*2 E 65 CIIKCCAIJJD=J= JEDOFAHJA IELA = E?ABBA?JI = E?FDOIE?= JH=E E C=HA=II?E=JA@MEJD HA=@ KIJ A J BJDA=KJ E??=H@E L=I?K =H? JH IOIJA AO9 H@I DOFAHJA IE IFA?JH= = = OIEI FDOIE?= JH=E E C = E?I

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

3 %# 57* -+65), -60,5 5K> A?JI EJJAA 0K = 4AIA=H?D BJDA A@E?= 7 ELAHIEJO B9=HI=M -=?DIK> A?JC=LA? IA JJ F=HJE?EF=JAE JDAIJK@O A=IKHA A JIMAHAFAHB H A@!K JHA=JA@ ODOFAHJA JDO H JA IELA = AIK> A?JI 65 6DA H JA IELAIK> A?JIMAHA IJ O A@E?= IJK@A JI ) F=HJE?EF= JIMAHAIJH C O ANFHAII=@AIEHAJ E?HA=IAJDAEHFDOIE?= BEJ AII 0OFAHJA IELAF=JEA JIMAHAE JH=E E CH=JDAHJD= >OFD=H =? CE?= JHA=J A J ) IK> A?JIMAHA? E E?= OAN= E FK =HO HA = +D=H=?JAHEIJE?I B> JDCH KFI=HAID M E 6=> A 2D=H =? CE?= JHA=J A JM=I@EI? JE KA@B H=J A=IJJM MAA I>AB HAJDAIJ=HJ BJDAIJK@O = E AFDOIE?= BEJ AII>OE = NOCA? IK FJE 6H=E E C ) IK> A?JIMAHAE IJHK?JA@ >J=E A@@AJ=E A@ANF = =JE D MJ FAHB H >OJDA IA JH=E E C,KHE C => H=J HO A=IKHA A JI?O? AHC AJAHJDAIK> A?JI >IAHLA@JDA?D= CE C M H =@ ALA IA BDA=HJH=JA04J M H =@ 6DAJH=E E C? = E? =AH >E?ANAH?EIA=J=" # BA=?DIK> A?J8 6DAL= KAI B04?=?K =JA@B HA=?D B H" #8 MAHAAIJ=> EIDA@ JDA?O? AHC AJAHE JDA => H=J M J A=?DIK> A?J 6DAIK> A?JIFAHB H A@= ANAH?EIA!JE AIFAHMAA B H=> KJD KH=?? H@E CJ B=L KHA@ B=?JELEJOHK E C?O? E C JA EI IME E C L AO>= >HEI M= E C 6DAO? JH A@DA=HJH=JA>OJDA IA LAIJ =E J=E JDA ALA BAIJE =JA@DA=HJH=JA=J" #8 2H?A@KHAI 6DAFH?A@KHAIMAHA= M=OI?=HHEA@ KJE JDAI= A A=IKHA@>O AH?KHOIFDOC = AJAH,KHE CJAIJE C A A?JH?=H@E CH= A=@I-+/B HDA=HJH=JA?DAIJM= A H?=H@E=? KJFKJ A=IKHA A JI >OE FA@=?A?=H@E CH=FDO =H A H A=IKHA A J=H M>OE FA@=?A MAHA=JJ=?DA@ 6DA.E =FHAI?KBBM=IFKJ =BE CAHB H? JE A=IKHA A J.E CAH=HJAHE= H@A@>O.E =FHAI D ALA B JHE?KIFE@L= LA J =L E@DO@H IJ=JE?E B KA?AI 6DA L= E@=JA@B HF MAHIFA?JH= = = OIEI B=HJAHE= FHAIIKHAL=HE=>E EJO! 5JH AL K A?=H@E=? KJFKJ+ KI?K =H MMAHAHA? H@A@MEJDJAJH=F =HE FA@=?AHA CH=FDO9=HI=M6A?D E?= 7 ELAHIEJO DA=HJH=JAE JAHL= BH A A=@-+/ JA A AJHO.K K@=,A IDE KI O I= F H@A@? JE KI OMEJDI= F E CBHAGA?O 0 >EJAHAI KJE B H IK>IAGKA J BB E A= = OIEI 5JH AL K M=I?=?K =JA@BH JDABEHIJ@AHEL=JELA BJDA 6=> A *=IA E A?D=H=?JAHEIJE?I BJDAIJK@OCH KFI H JA IELAI & 0OFAHJA IELAI! )CAOA=HI ' ""! F # 9AECDJ C %' & '# &" $ F # 0AECDJ? & $$ & % % F # * 1 " % # $! & F #

4 %$ E FA@=?A?D= CA KIE CJDA K>E?A AGK=JE! 624M=I?=?K =JA@E 624K EJI>O@ELE@E C A= =HJAHE= KJFKJ )H HACE = L=I?K =HHAIEIJ=?AM=I?=?K =JA@FAH JEIIKA E E 247K EJI 4AIJE C A=IKHA A JIMAHAFAHB H A@E? B HJ=> AIEJJE C F IEJE A=IKHA A A J BIOIJ EJO 6DAL=HE=?A IAE JAHL= L=HE=?AMAHA?=?K =JA@BH => 2K IA E JAHL= IMAHA?=?K =JA@E E IBH.E =FHAI@=J=>OE LAHIE BDA=HJH=JAL= KAI 6DAHAIFEH=J HOH=JAM=I=IIAIIA@>OE FA@=?A 6DAIFA?JH= = = OIEIM=IFAHB H A@ MEJDJDAFH CH= MHEJJA B HJDAF KHF IA BJDEIIJK@O IAC A JI B#? IAGKJELAF E JI *O LEIK= E IFA?JE IJ=JE =HOIAHEAI BHAA BA?J A?JA@B H BB E A = = OIEI 0= E KHEAHJH= IB H..6? FKJ=JE MAHAKIA@ 6DA M BHAGKA?O? F A J BJDAF MAHIFA?JHK E? K@A@JDAF MAHBH "J #0 BHAGKA?O? F A JJDAF MAHIFA?JHK 0. 5*2 HAIFA?JELA OBH #0 J #0 6DAF MAH =JA@=IE JACH= BF JDABHAGKA?O H= CA. 5*2 5*2 MAHA? FKJA@E =>I KJAK EJIE 0C H = E A@K EJIANFHAIIA@ =I=FAH?A J=CA BJDAJ J= F MAH -NAH?EIA )BJAH? F AJE C@=J=? A?JE E JDA? JH A?JHAIJA@=> KJ E 5K>IAGKA J OD KHANAH?EIA BE?HA=IE CE JA IEJOM=IFAHB H A@ A A?JHE?>E?O? AAHC AJAH =H & '- KFJ JDA ALA B=> KJ" # BA=?DIK> A?JI8 ) F=H= AJAHIMAHA? JE KI OHACEIJAHA@@KHE CANAH?EIA )BJAHANAH?EIAJDAIK> A?JID=@=>HA= B H=J A=IJD KH 6DAHA=BJAHJDAOMAHAIK> EJJA@J JDAI= AIAJI B A=IKHA A JI=I>AB HAANAH?EIA 5J=JEIJE?= H H >OJDA? FKJ=JE B A@I A@ KHJ IEI + F=HEI I>AJMAA =@A >OK F=EHA@J JAIJ H = 9DEJ AOJAIJ 9EJDE CH KFI@EBBAHA?AIMAHAAL= K=JA@>OF=EHA@J JAIJ H9E? N IEC A@H= JAIJB H H = O@EIJHE>KJA@@=J= 8= KAIMAHAANFHAIIA@=I A= 5- E A=HHACHAIIE = = OIEIM=IKIA@J?=?K =JA? HHA =JE I 5J=JEIJE?= IEC EBE?=?AM=I =IIK A@=JF # = NOCA KFJ= AE?HA=IA@E DOFAHJA IELA F=JEA DA= JDO? JH IK> A?JI=BJAH! JD@O = E?ANAH?EIAJH=E E C 6=> A )JHAIJJDADOFAHJA IELAI=I? F=HA@J H JA IELAI@A IJH=JA@ IEC EBE?= J ODECDAHIOIJ E?> 6=> A! 2K IA E JAHL= L=HE=?AM=IIEC EBE?= J O 5*2 IEC EBE?= J ODECDAHE 065? F=HE CJ 656=> A" 6DADOFAHJA IELAIK> A?JIID MA@IEC EBE?= J@A?HA=IAE JH=E E 1 65@A?HA=IAE IEC EBE?= J IEC EBE?= J?D= CAE?=H@E=? KJFKJM=I >IAHLA@E AEJDAHCH KF 624@A?HA=IA@ IEC EBE?= J OE > JDCH KFI )84@A?HA=IA@I ECDJ OOAJ JIEC EBE?= J O 4AIJE C FK IAE JAHL= EBE?= J O=BJAHJH=E E CE > JDCH KFI 6=> A"

5 %% 6=> A -BBA?J BANAH?EIAJH=E E C 8 HOH=JAE 8 C E JH!$!" '!# " $! )BJAHJH=E E C!& $ '!&!! "',EBBAHA?A ' %$! ' $& '#+1! ##J ' F " $&J % F 9AECDJ C + JH %' & '# &" $ )BJAHJH=E E C %& & ' &! &%,EBBAHA?A "! '# '#+1 %&J " F &#J F 4AIFEH=J HO 4=JA>HA=JD E + JH! "! $!& )BJAHJH=E E C #"!!,EBBAHA?A & ' ' '#+1 "J #' F # "J % F # + JH JDAL= KAIBH FHA JH=E E '#+1 '#? BE@A?AE JAHL= 6=> A! -BBA?JI BANAH?EIAJH=E E C = E?F=JJAH E H JA IELA DOFAHJA IELA065IK> A?JI *2 0C + JH & & " % "&! $ )BJAHJH=E E C $ &! &$,EBBAHA?A & &$ # ' ' '#+1 & #J!" " 5! J " '$ F,*2 0C + JH % ' &%! $ )BJAHJH=E E C $& "& %$ # ",EBBAHA?A "!# &! %# '#+1 #!J! 5 $ $#J " &# F K + JH '!# )BJAHJH=E E C '# % $ %,EBBAHA?A! # & # '#+1!J! F # %J!' F )84 247K + JH $! # & )BJAHJH=E E C # % &%!!,EBBAHA?A "" $ %!! '#+1 # J # '% F % " $#J & %& F #$ + E + JH # % $ #!'!% )BJAHJH=E E C #!'! # #!!,EBBAHA?A! # % '#+1 %&J $ 5 $%J!% 5 F IEC EBE?=?A ALA E HAIFA?JJ?D= CAIMEJDE JDACH KF F #E >AJMAA CH KFI '#+1 '#? BE@A?AE JAHL= )>>HALE=JE I IAAJANJ

6 %& 6=> A" -BBA?JI BANAH?EIAJH=E E C IOIJ I?E =JE H JA IELA IELAIK> A?JI IA? JH & ' # %'& % " )BJAHJH=E E C ' ' "! &' ",EBBAHA?A &! ' ' '#+1 $'J &$ F!J # " F 21L=H IA? + JH #!# #"!"%! "%# )BJAHJH=E E C %&' $#! $&# '"%,EBBAHA?A!!# $'' " $%& '#+1 "# J $" F """&J!# F. 5*2 0C + JH " ' &! % ' )BJAHJH=E E C $ & # ',EBBAHA?A ' " % ' '#+1 $ &J! 5! "J! F. 5*2 B62 + JH %!# & ' )BJAHJH=E E C! $ %! $,EBBAHA?A! # % % ' '#+1 & 'J ' 5! "J! F & 0. 5*2 0C + JH " ' #& # % % )BJAHJH=E E C! #$!%! & ",EBBAHA?A!$ " # $% '#+1 $J &% F # J &% F $ 0.5*2 B62 + JH % ' '! %! )BJAHJH=E E C %!$ ' $,EBBAHA?A!!" $ '! '#+1 J $ $' 5 #!J ' 5 L=H 5*2 0C + JH $! $! $# ' %! )BJAHJH=E E C #' " % " #! # $,EBBAHA?A! %" % &! # % '#+1 'J %! 5 $#J " F!' F IEC EBE?=?A ALA E HAIFA?JJ?D= CAIMEJDE JDACH KF F # F E CH KFI 21L=H 21L=HE=?A JDAH@AI?HEFJE I A 5*2L=HE=?A@A?HA=IA@IEC EBE?= J O OE 065IK> A?JI6=> A" 1? JH 5*2 M=IDECDAHE 065? F=HA@J 65=JHAIJ6=> A".EC )BJAHFDOIE?= JH=E E C. EBE?= J OE DOFAHJA IELAF=JEA JIJ JDAL= KA J@EBBAHA JBH JD=JE H JA IELAIK> A?JI6=> A".EC 1 065=? HHA =JE >AJMAA. 5*2 IEJELA H!& F MDAHA=IE 65= AC=JELA H #F.EC

7 %' LF SBP (mmhg2) NS NTSc NTSt HTSc HTSt # *.EC 6DAABBA?J BFDOIE?= JH=E E C M BHAGKA?O? F A J BIOIJ MAH IFA?JHK. 5*2 E H JA IELAI IELAIK> A?JI065 65? 065? JDAFHA JH=E E CL= KAI B. 5*2 B H O 65J 065J JDAF IJ JH=E E CL= KAI B.5*2 F 65?LI065? F 065?LI065J Log LF SBP HYPERTENSIVE SUBJECTS r = p < SBP mmhg Log LF SBP NORMOTENSIVE SUBJECTS r = p< SBP mmhg.ec 4A =JE IDEF>AJMAA JDA. 5*2 DOFAHJA H JA IELAIK> A?JI

8 %, *2 DOFAHJA IELAIK> A?JIE FHA JH=E E IEIJA JMEJDJDADOF JDAIEIJD=J@OIHACK =JE BJDA =KJ E? AHL KIIOIJA F =OI=H AE JDAF=JD CA AIEI BDOFAHJA IE! ' =C EJK@A B. 5*2 =FFA=HIIO FJ =JE? BE?HA=IA@FH >=>E EJO B?=H@E L=I?K =H? F E?=JE IE DOFAHJA IE & 6DAF IEJELA? HHA =JE >AJMAA. 5*2 DOFAHJA IELAIK> A?JI F=EH A JE E?? JH E DOFAHJA IELAI.EC 6DA AC=JELA? HHA =JE >AJMAA. 5*2 H JA IELAIK> A?JIIKCCAIJI= H = AC=JELABAA@>=? =JE B5*2 ANAHJA@>O>=H HA?AFJ HHAB AN.EC 6DAFHAIA JIJK@OIKFF HJIJDALEAMJD=JANAH?EIAJH=E ECE FH LAIJDA E F=EHA@F=JJAH B?=H@E L=I?K =H=KJ E?HACK =JE E DOFAHJA IELAIK> A?JI,A?HA=IAE JDAIOIJ E J J= FAHEFDAH= L=I?K =HHAIEIJ=?A =IMA =IE?HA=IAE FK IAE IAE JAHL= L=HE=>E EJOB JDAFHAIA JIJK@OHAFHAIA J= >A ABE?E= ABBA?JI BHACK =HFDOIE?= ANAH?EIA =JE E DOFAHJA IE " 6DA JDAHAIF IAJ! JDJH=E E C >AJMAA H JA IELAIB JDAFHAIA JIJK@OEI= IEC EBE?= J 5*2 E 065=I? F=HA@ J 656=> KHIJK@OID MA@B HJDABEHIJJE AJD=JJDA@A?HA=IAE =HJAHE= 624E DOFAHJA IELAIK> A?JIIK> = E?FDOIE?= ANAH?EIA 6=> A!EI=II?E=JA@MEJD=IEC EBE?= J@A?HA=IAE.? F A J B5*2F MAH IFA?JHK 6=> A ".EC. 5*2? HHA =JAIMEJDJDA LAH= IO F=JDAJE?=?JELEJO=@@HAIIA@J L=I?K =H IOIJA " $ 6DA. 5*2? =OAHM=LAI H5*2B K?JK=JE =JA@J?D= CE CIO F=JDAJE?J A! ". 5*2 EI =KC A JA@@KHE C = KALAHIJD=JE?HA=IAIO F=JDAJE?=?JELEJO E A KFHECDJ F IJKHA " # E EIDA@=BJAHα =@HA AHCE?HA?AFJ HI>? =@A H C= C E E?>? AHJHE AJ=FD=! 2=C= EAJ= "HAF HJA@JD=J I?E =JE I E KI? AIO F=JDAJE? AHLA=?JELEJOHA? H@A@>O E?H AKH CH=FDOMAHA EHH HA@>O I?E =JE I B5*2 5O F=JDAJE?=?JEL=JE M=I=II?E=JA@MEJD= E?HA=IA B.? F A J B> KI? AIO F=JDAJE? AHLA=?JELEJO )KC A JA@L= KA B. 5*2 E HAIJE CDOFAHJA IELAIK> A?JI 6=> A"M=I HAF HJA@= I E JDAHIJK@EAI # % 6DAO=HA? IEIJA JMEJDE?HA=IAE J E? IO F=JDAJE?=?JELEJOB =HCA IELAF FK =JE >OKIA B@EHA?J E?H AKH CH=FDE? EA@J IE C AIO F=JDAJE? AHLAK EJI ",A?HA=IAE. 5*2 E 065=BJAHJH=E E CEI BIFA?E= E JAHAIJ >A?=KIAEJ FH LE@AI E L=IELAE IECDJE J JDA A?D= EI BJDAHA@K?JE E FHAIIKHA= =HFDOIE?= =?JELEJOE DOFAHJA IELAIK> A?JI 9AIKCAIJJD=JJH=E E C 5*2 E HA@K?JE B

9 % IO F=JDAJE? HAIEIJ=?A=HJAHEAI 6DEIABBA?J=FF=HA J O? > 624E 065 KHIKCCAIJE EI E E AMEJD JDAH >IAHL=JE I =@AMEJDJDAKIA BE L=IELA 5*2 E DOFAHJA IELAF=JEA JI=BJAHFDOIE?= JH=E E CEI? IEIJA J= I MEJDHAF HJA@@A?HA=IAE HAFE AFDHE AF =I = ALA =BJAHFDOIE?= JH=E E CE 065" ' 4A@K?JE E IO F=JDAJE?@HELAJD=JB MIJH=E E C=FFA=HI HAFH K?A@E F=JEA JIMEJDAIIA JE= DOFAHJA IE JD= E H JA IELA I& 4AF HJI JDAABBA?JI BFDOIE?= JH=E E C HAIJE C IO F=JDAJE?L=I? IJHE?J H AHLA KJFKJJ FAHEFDAH= L=I?K =H>A@E DA= JDO FA F A=HA J? IEIJA J!! 1 DA= JDODK = IJH=E E CIJK@EAIHAF HJ?D= CA!" E?HA=IA!# H@A?HA=IA!$E HAIJE C KI? AIO F=JDAJE? AHLA =?JELEJO A?D= EI I BHA@K?A@IO JH=E E CE DOFAHJA IELAIK> A?JI=HAIJE K M $ )JJA K=JE B?=H@E L=I?K =HHAIF IAJ >HEABE =?JEL=JE >ODOFAH NE= B=HJAHE=?DA HA?AFJ HI >IAHLA@@KHE CF IJANAH?EIADOF JA IE IKCCAIJIJD=J?DA HA?AFJ HIO F=JD AN?EJ=J HOHAB ANEIHA@K?A@B ME CFDOIE?= ANAH?EIA!% 1JEIJ >A?DA? A@EBHACK =HFDOIE?= JH=E E A@=JJA K=JE BJDAHAIJE C?DA HA?AFJ HFHAII HHAB ANE DOFAHJA IELAIK> A?JI )KC A JA@?DA HA?AFJ HHAB AN@HELA=FFA=HIJ? JHE>KJAJ A?D= EI I B=HJAHE= DOFAHJA IE!% " ) I =B=?E EJ=JE B>=H HA?AFJ HHAB AN?= >AJ= A IE@AH=JE =I= E?HA=IA@>=H HAB ANIA IEJELEJOM=IHAF HJA@=BJAHFDOIE?= ANAH?EIAE DOFAHJA IELAIK> A?JI!% 1 DOFAHJA IELAI=I? F=HA@J DA= JDO A?=H@E L=C= J AEI@A?HA=IA@=I IKCCAIJA@>O@E E EIDA@FK IAE JAHL= L=HE=?A C? IEIJA JMEJD JDAH HAF HJI% & -NAH?EIAJH=E E H = E AJDADOFAHJA IE HA =JA@@ABE?EJIE F=H=IO F=JDAJE?J A =I21L=HE=?AIEC EBE?= J OE?HA=IA@ 6=> A" ) JD KCDE DOFAHJA IELAIK> A?JIFK IAE JAHL= L=HE=?AM=I MAHJD= E H JA IELAIJDAFK J@EBBAHIEC EBE?= J O 2DOIE?= JH=E E CHAIK JIE E?HA=IAE FK IAE IA E JAHL= L=HE=?A > JDE A" IEC EBE?= J@EBBAHA?AE JDAHAIFA?JELAHAIF IAIJ FDOIE?= JH=E E C>AJMAA JM CH KFIMAHA >IAHLA@ 9A?D E C ALA =IE HA?A JIJK@O & OIK?DJH=E E C A JA@F=H=IO F=JDAJE??=H@E L=I?K =JE E F=H= A MAH B.? F A J B5*2E DA= JDOFA F A 1? JH=IJ DECDE JA IEJOJH=E E C=> LA%# B8 A E?EJA@= E?HA=IAE. 5*2 AKH= =KJ E??=H@E L=I?K =HFH BE ABH L=C= J IO F=JDAJE?FHA@ E =?A & = ABBA?JF JA JE= O@= CAH KIJ DOFAHJA IELA F=JEA JI>OE?HA=IE CFH >=>E EJO BJDA=@LAHIA?EH?K =J HO? IAGKA?AI! )KC A J=JE E F=H=IO F=JDAJE?=?JELEJOMEJD?? EJ= J@A?HA=IE C IO F=JDAJE?=?JELEJOEI@AIEH=> AE DOFAHJA IELAF=JEA H JI# HA LAH CEJK@E = AFE@A E CE?= IJK@EAID=LA ID M JD=J ANAH?EIAEI IJABBA?JELAE HA@K?E C

10 DOFAHJA IELAF=JEA JIJD= JH=E E C=J=LEC H KI E JA IEJO! # A JA@E CEJK@E = IJK@EAIJD=J MAHE ALA I = HA@K?AIE?E@A?A HJ= EJOBH?=H@E L=I?K =H@EIA=IAI #,A?HA=IA@FK IAE JAHL= JAHL= L=HE=>E EJO? HHA =JAI IJH C OMEJDBKJKHA?=H@E L=I?K =HALA JI# & ) E?HA=IAE IOIJ FHAIIKHAL=HE=>E EJOEI M FHA@E?J H B?=H@E L=I?K =HHEI E F=JEA JIMEJD AL=JE I"" "# E L=IELA?=H@E L=I?K DOFAHJA IE =HA BFH C IJE?L= KAB HJDA?=H@E L=I?K =HALA FH CHAIIE J =CA! # ' % "" "# 4A?A J O EJD=I>AA ID M IEC EBE?= JHA =JE >AJMAA ID HJJAH CJAH " D KH L=HE=>E J J= FAHEFDAH= FK IA E JAHL= 065IK> A?JI >IAHLA@E KHIJK@O=BJAHFDOIE?= JH=E E C=HA J@EIIE E =HJ JDAHHAF HJI " ) LA C BF IIE> A? E E?= L= KAEI=FH K?A@HA@K?JE B. 5*2 = E L=IELA =H AH B IO F=JDAJE?=?JELEJO=BJAHFDOIE?= JH=E E C=FF EA@E IELAF=JEA JI 1 IK =HOMA?? K@AJD=J= JEDOFAHJA IELAABBA?JI = E? ANAH?EIAJH=E E CE IELAIK> A?JI=HA=II?E=JA@MEJDHA=@ KIJ A J BJDA=KJ E??=H@E L=I?K =H? JH IOIJA MDE?DF IIE> O? JHE>KJAIJ >A ABE?E= ABBA?JI BHACK =HFDOIE?= ANAH?EIAE DOFAHJA IE )? M A@CA A JI 6DEIIJK@OM=IIKFF HJA@>O * /H= J "2#,$& DA J 2 0A 1 0A A A I+0 *KHE C - = I - 4E@ AH 2 A@I + E E?= 6HE= IE +=H@E L=I?K =H,EIA=IA 2DE =@A FDE= ''' /HAA 2 5J AH * =HO,)5/ 5E C A K EJIO F=JDAJE?@EI?D=HCA GK= JEJ=JELA =IIAII A JE DK = DOFAHJA IELA@EIA=IA +EH?K =JE '''!#!! =?E=/ /H=IIE/ /E= =JJ=IE + 5AH=L= A/ 5O F=JDAJE?=?JEL=JE E JDAF=JD CA AIEI BDOFAHJA IE CHAIIE B =CA 0OFAHJA IE '''!" % " % & " 5 EJD2) /H=D= - =? E J ID). 5J AH * =HO,)5/ 4A =JE IDEF>AJMAA?A JH= IO BDK = DOFAHJA IE ) 0 " % % # *H 4, K EKI5 )KJ E?E >= =?A DOFAHJA IE L=I?K =HHEI ) 0! 5 5 $ -I AH 5O F=JDAJE?=?JELEJOE ANFAHE A J= = DOFAHJA IE 1 =?DAJJE) =?E=/ A@I B0OFAHJA IE ) IJAH@= AJDAH - IALEAH5?EA?A 2K> EIDE C+ 1? ''% % % $' % /K AJJE5 2E??= KC=- +=I=JE4 +AHKJJE5 >=H@E. 2=C= E = E= E) 5O F=JDAJE? FHA@ E =?AE AIIA JE= DOFAHJA IE =IJK@OA F OE CIFA?JH= = = OIEI BDA=HJH=JA L=HE=>E EJO 0OFAHJA I '&& $ % %% & 5E CD 2 =HI / 6IK E0 -L= I +, A + ALO, 4A@K?A@DA=HJH=JAL=HE=>E EJO AM IAJDOFAHJA IE 1 IECDJIE J F=JD CA AIEI BDOFAHJA IE 6DA.H= E CD= 0A=HJ5JK@O 0OFAHJA IE ''&! '! '%

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

12 % "! K>E?A 9/ 2=JAHI 42 9EJI A,) 1 FA@=?A?=H@E CH=FDO=I= E L=IELA B EJ HE C?=H@E=?BK?JE JDAHF=H= AJAHI BJDA?=H@E L=I?K =HIOIJA ) ;)?=@ 5?E '%> % % " %!!,EA@HE?D) H@= 6= 5D= 4 4 >AHJI 4 KBJ.+ 4 >AHJI, *E=CCE E1 6DA IO F=JDAJE? AHL KIIOIJA E DOFAHJA IE =IIIAII A C= C E E?>? =@A 0OFAHJA I! $%% $&$!! =H EAME? 5 AHI8 E CE IE ABBA?JI = >K =J AKH=?EH?K =J HO? JH EJ ''% '!#!" 4=O+ 5O F=JDAJE?=@=FJ=JE IJ A ACCA@JH=E E C )FF 2DOIE ''' &$# #!& #&%!# C ) 8 4 += EIJAH, / D I 4 5A= I E CEI=II?E=JA@ MEJDA AL=JA@>=I= IO F=JDAJE? AHLA=?JELEJOE DA= = I )FF 2DOIE ''" %%!$$!%"!$ /H=IIE / / 5AH=L= A, ) += D K =?E= 2DOIE?= JH=E E HA?AFJ H? JH BIO F=JDAJE? AHLA=?JELEJOE DK = I 0OFAHJA IE! '"! ''"!% =- +O>K I =1 5=ME? E E 6H A>I E) 2 IJANAH?EIA@A?HA=IAE =HJAHE= J J= FAHEFDAH= =J HOHAIF IAIJ >HEABDOFAH NE=E IK> A?JIMEJD JE= DOFAHJA IE 0K 0OFAHJA I ''&,A? &## &$!& 6H A>I E) )HJAHE=?DA HA?AFJ HHAB IE 0OFAHJA IE '' K ' $2J #$ #$$!' 6H A>I E) 6=BE J MI E 2H O>O I E 1?HA=IA@IA IEJELEJO BJDA=HJAHE=?DA HA?AFJ H@HELAE O K C A MEJD IE +=H@E L=I?4AI '& $ $! % " =- E 6H A>I E) = E?HAIF IAIJ >HEABDOFAH NE=E DA= E IELADK = IK> A?JIE C@O = E?ANAH?EIA 2DOIE 2D=H =? ''$ "% "! #$ " 6=BE =MA 6H A>I E) =MA 2= 6 )KC A JA@?DA HA?AFJ HHAB ANJ E?@HELAE A=H ODK = DOFAHJA IE H JA IELAIK> A?JIMEJDB= E O>=? CH B DOFAHJA IE )?J=2DOIE 2 '&#!$ # & " 0AHE AMI E =H=6 H - 5 AHI8 9O O MI E* 4KJ MI E* =H EAME? 6 E??DA HAB AN=?JEL=JE? JHE>KJAIJ JDAA AL=JA@ KI? AIO F=JDAJE? AHLA=?JELEJOE F=JEA JIMEJD?DH E?HA = B=E KHA 0OFAHJA I " 5KFF 5&2 "! =- +O>K I =1 E = MEA? = +EA = 5? OF=? AMI = * H M =- 6H A>I E) -BBA?JI F IJANAH?EIA>=H HAB ANIA IEJELEJOE DOFAHJA IE 0OFAHJA I! IKFF " 5 #$ "" 2=H=JE/ 7 E= 5= JK??EK+ > E5 =?E=/ EJO?=H@E L=I?K =HHEI JEDOFAHJA IELAJHA=J A J 0OFAHJA I5KFF ''#,A?! 5 %!" "# 4=C J5 0AHFE, 5E?DA 2 2?A AJ2 = E 4A =JE IDEF>AJMAA ID HJ JAH C JAH EJEAIE AIIA JE= DOFAHJA IELAI 0K = 0OFAHJA I # " "& 4A?AELA@ )KCKIJ# " )??AFJA@ LA >AH$ " )KJD =,AF=HJ A J B-NFAHE A J= E E?= 2DOIE CO 6DA A@E?= 7 ELAHIEJO B9=HI=M ' %9=HI=M 2

Rick Van Kooten, Indiana Univ., FNAL Users Meeting, HEPAP Session, June 27, 2000

Rick Van Kooten, Indiana Univ., FNAL Users Meeting, HEPAP Session, June 27, 2000 HEACC 2001 Eric Colby Stanford Linear Accelerator Center 2575 Sand Hill Road MS 07 Menlo Park, CA 94025 ecolby@slac.stanford.edu 9D=J FDOIE?I GKAIJE I JEL=JA JDA ANJ E A=H + E@AH Rick Van Kooten, Indiana