Characteristic. Mean ±SD. Mean ±SD

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3 $"'? =E I FDOIE?= DA= A J= DA= JD" # % 6DAI? HAE A=?D?=JAC HO =O>A BH J F E JI A= L= KA?=?K =JA@ JDA>=IEI EJA IA? F=IIA@MEJDE = CELA?=JAC HO MDE?DHAIK JIE = E HA JDADECDAHJDA AL= K=JE B=CELA GK= EJO B EBA?=JAC HO" # %.A = A5ANK=.K?JE K JE@E A IE = IA B AL= K=JE E IJHK A JB H= IFDAHAI BBA = AIANK= BK?JE I IANK= =H KI= HC=I I=JEIB=?JE MEJDE JDAFHALE KI"MAA I &.5.1D=I>AA? BEH E E?= O@?K A JA@MEJDHAC=H@J L= E@EJO IA IEJELEJO HA E=>E EJO E JAH =? IEIJA?O IJ=>E HAJAIJHA E=>E EJOE JDA@E=C IE C B@EI H@AHIE =H KI= & HC=I ' =IMA =IF=E HA H@AHI.5.1EI? F IA@ B'EJA I@ELE@A@E J $? A?JELA@ =E IIK>I?= AI IANK= =H KI= K>HE?=JE HC=I IANK= I=JEIB=?JE &.E = HAIK JI=HA >J=E A@ IAF=H=JA OB HA=?D BJDAIK>I?= AI>OIK E CKFJDAA A A J=HOF E JIA? F=IIA@MEJDE A=?D BJDA$@ =E A?JA@? ABBE?EA J 6DAE JAHFHAJ=JE BF=HJE= HAIK JIEI= JDADECDAHJDAI? HA JDA>AJJAHJDAIANK= BK?JE E CMEJDE =CELA?=JAC HO& + E E?= OIEC EBE?= JBA = I=HA@E=C IA@=JL= KAI MAH HAGK= J $F E JI B.5.1I?= A 1 JDAIJ=JEIJE?= = = OIEI 56)61561+)$ B MIM=IKIA@,EBBAHA?AI= C F=H= AJAHIMAHA? IE@AHA@IEC EBE?= J=J= ALA B # 6DAIJ=JEIJE?= = = OIEI =@AKIA B = 9DEJ B K JEF AHACHAIIE DA A= =CA B=IJD =JE?M A M=I!" $ % %#OA=HI JDA? JH CH KF!# " ' # OA=HI2 #6=> A JH CH KFIMAHA? F=H=> AMEJDHAIFA?JJ =CA J DEFH=JE 904 A@K?=JE =HEJ= IJ=JKI??KF=JE = =?JELEJO JOFA BM H FAHB H A@ HACK =HFDOIE?= =?JELEJO A IJHK=?O? AF=H= AJAHI H= 6=> A /A AH= FH BE A BJDAIJK@OF FK =JE Characteristic Asthmatic women Min Max Healthy women Min Max U Mann- W hitney test Age (years) 34.16± ± NS BMI(kg/m 2 ) 22.11± ± NS W HR 0.81± ± NS Duration ofasthma (years) 7.77± Age ofmenarche 13.48± ± NS Length ofmenstrual cycle (days) 29.00± ± NS Length ofmenstruation (days) 4.96± ± NS Numberofpregnancies 0.97± ± NS Numberofmiscarriages 0.19± ± NS Numberofcigarettes a day 0.16± ± P=0.006 * `M=EIJ J DEFH=JE

4 $#? JH=?AFJELAI +KIA K >AH BFHAC =?EAI CO A? CE?= FAH=JE IE JDA A@E?= DEIJ HO6=> A A 5J=JEIJE?= OIEC EBE?= J@EBBAHA?AI??AH A@?EC=HAJJAI E ANF IKHA6=> A A 9EJDHAIFA?JJ I E C =DECDAHFAH?A J=CA BI AHIM=I JA@= CJDADA= JDOM A! %E? F=HEI MEJD JDA! BJDA=IJD =JE? AI2 '6=> A 6DA K >AH I IALAH= JE AIDECDAH= CJDA? JH CH KF? F=HA@MEJDJDA =IJD =JE?M A %' $ %LI $ ' HAIFA?JELA O2 $6=> A 6DA=IJD =JE?M A IK> A?JELA OAL= K=JA@JDAEHANF IKHAJ DECDIJHAII=J= ALA B& $E? F=HEI MEJD'# BDA= JDOM A 2 "6=> A,KH=JE B>H?DE= =IJD =H= CA@BH J 'OA=HI MEJD= A= B % %% $ '!OA=HI6=> A 3K= EJO B EBA 6DAGK= EJO B EBAF=H= AJAHIB H=IJD =JE?M A MAHACA AH= O MAHJD= B HJDA? JH CH KF I= IJ=?=JAC HEAI CA AH= DA= JD FDOIE?= BK?JE E C E EJ=JE I@KAJ FDOIE?= DA= JD E EJ=JE I@KAJ A JE = FH > A I I?E= BK?JE E C F=E A AHCO B=JECKA A JE = MA >AE C 5EC EBE?= J@EBBAHA?AIMAHAB BELAF=H= AJAHI B5.!$I?= A E EJ=JE I@KAJ FDOIE?= DA= JD E EJ=JE I@KAJ A JE = FH > A I I?E= BK?JE E C A AHCO B=JECKA A JE = MA >AE C6=> A! 6=> A CH=FDE??D=H=?JAHEIJE?I BJDAIJK@OF FK =JE Marital status Education Characteristic Occupational activity Asthmatic women Healthy women n % n % Fishertest single NS married NS divorced NS vocational NS secondary NS higher NS manual NS white-collar NS not working NS Regularphysical activity NS Smokingwomen P=0.019 High level ofstress exposure P=0.024 Oral contraceptives use NS Irregularmenstrual cycles NS Gynecological operations in medical history NS

5 $# 6=> A! 5D HJ. H!$0A= JD5KHLAO= C=IJD JDOM A SF-36 domains Asthmatic women Min Max Healthy women Min Max U Mann- W hitney test General Health 50.81± ± NS Health Change 50.00± ± NS Physical Functioning 79.19± ± NS Limitations due to Physical Health 59.68± ± P=0.003 Limitations due to Emotional 63.19± ± P=0.047 Problems Social Functioning 63.90± ± P=0.003 Pain 66.35± ± NS Energy/Fatigue 46.77± ± P=0.018 Emotional W ell-being 48.26± ± P= EJDHAIFA?JJ E EJ=JE I@KAJ FDOIE?= DA= E EJ=JE I@KAJ A JE = FH > A I =IJD =JE?M A AL= K=JA@JDAEH?KHHA MAH#' $&! '! %! HAIFA?JELA OE HA =JE J JDA? JH CH KF%' &&! '!!! HAIFA?JELA O7 = 9DEJ AO JAIJ "%6=> A! 6DAIAM A = I ID MA@ HAIEC EBE?= H@AHIE I?E= BK?JE E CJD= DA= JDOM A 2!6=> A! 1 JDA?=JAC HO A AHCO B=JECKA =C >= 5.!$I? HAM=IIEC EBE?= J ODECDAHE JDA? JH CH KF#% $& " "'E? F=HEI MEJDM A MEJD=IJD = "$ %% ' "! 2 & HA LAH JDA=IJD =JE?M A = EBAIJA@ IEC EBE?= J ODECDAH@EI H@AHIE JDAA JE = CE?= IFDAHAE? F=HEI MEJD? JH I2!!6=> A! *=IA@ = K JEF =IEC EBE?= J O AC=JELAABBA?J B* 1 FDOIE?= BK?JE E C2 E EJ=JE I@KAJ FDOIE?= DA= JDI? HAI 2 "&M=I >IAHLA@ HA LAH E EJ=JE I@KAJ A JE = FH > A CMEJDHACK =H??KF=JE = =?JELEJO2 ALA 2 E JDAMD AIJK@OF FK =JE 1 JDA=IJD =CH KF E EJ=JE I@KAJ FDOIE?= DA= JDE?HA=IA@= CMEJD?EC=HAJJAI E C2! J DA= JDIJ=JA? F=HA@MEJDJDA =IJ H=JA@= CMEJDIJHAII ANF IKHA2 & ) I =IEC EBE?= JF IEJELA? HHA =JE M=IB A@K?=JE ALA 5J=JEIJE?= = = OIEI@E@ JHALA= = OIEC EBE?= J? HHA =JE I>AJMAA JDA A J B>H?DE= =IJD EJO B EBA F=H= AJAHI= CIJK@EA@M A 5ANK= BK?JE E C BM A 6DA? FHADA IELAAL= K=JE BJDA.5.1I?= A?JELA@ =E I IANK= =H KI= K>HE?=JE HC=I IANK= I=JEIB=?JE ID MA@JD=JJDA=IJD =JE?M =OE F=EHA@IANK= BK?JE E C=I

6 $# 6=> A".5.1I?= A= C=IJD JDOM A FSFI domains Asthmatic women Healthy women U Min Max Min Max Mann-W hitney test FSFI total score 25.96± ± NS Sexual Desire 3.54± ± NS Sexual Arousal 3.65± ± P=0.002 Lubrication 4.33± ± P=0.003 Orgasm 3.69± ± P=0.006 Sexual Satisfaction 3.88± ± P=0.002 Pain 4.52± ± P=0.048 F=HA@MEJDJDA? JH I 6DAJ J=.5.1I? HAIHALA= A@>AJJAHIANK= EBAE DA= JDOM A ' ' # %E? F=HEI MEJD=IJD =JE?F=JEA JI # '$ ' " >KJJDAOMAHA JIJ=JEIJE?= OIEC EBE?= J6=> A" 1 JDA?=JAC HO B IANK= =H KI= 2 K>HE?=JE 2! HC=I 2 $ IANK= I=JEIB=?JE =E 2 "& IEC EBE?= J@EBBAHA?AI>AJMAA JDA =IJD JDOM A MAHA= I B MDE?D? BEH A@ MAHIANK= BK?JE E CE M A MEJD>H?DE= =IJD =6=> A" 1 F A A JE CJDA?KJ BBF E J? E E?= IFHAL=E A@E =IJD =JE?M A # &LI % 6DEIHA =JE IDEF D MALAH M=I J IJ=JEIJE?= OIEC EBE?= J HA LAH JDA@KH=JE B>H?DE= =IJD = AC=JELA O? HHA =JA@MEJDJDAGK= EJO BBA = AIANK= EBA2 " 1 JDA K JEF A HHA =JE I>AJMAA JDA JB=?J HI BK?JE E CMAHAB JDACH KFIIJK@EA@, )IIAII A J BGK= EJO B BK?JE E CFAHB H A@E JDAFHAIA J IJK@OHALA= A@JD=JM A MEJD>H?DE= =IJD =D=@ MAHGK= EJO B EBA F=H= AJAHI E EJ=JE I@KAJ FDOIE?= DA= JE = FH > A I I?E= BK?JE E C A AHCO JE = MA >AE C? F=HA@MEJDDA= JDO M A )IJD =JE?M A = =OA@M HIAIANK= BK?JE E CE JDA?=JAC HO B IANK= =H KI= K>HE?=JE HC=I IANK= =E + E E?= IFHAL=E A@E =IJD =JE?M A >KJJDAOMAHA J IJ=JEIJE?= OIEC EBE?= JB=?J HI@EHA?J O? A?JA@MEJD=IJD = A J B>H?DE= =IJD =@E@ J=BBA?JJDAGK= EJO B EBA JDA OJDA@KH=JE B>H?DE= =IJD = AC=JELA O? HHA =JA@ MEJDBA = AIANK= EBA 6DA >J=E A@HAIK JI= MJ IJ=JAJD=J>H?DE= =IJD = =BBA?JI> JDCA AH= GK= EJO B BK?JE E C BM A 4ALEAME CJDA=L=E => A EJAH=JKHA A?= = OIJK@EAIJD=J? BEH JDA AC=JELAABBA?J=IJD =D=I F=JEA JI\GK= EJO B EBA %

7 $#! 9OHME?DAJ= =IIAIIE CJDAGK= EJO B EBA B!'$F=JEA JIMEJD>H?DE= =IJD =5.!$GKAIJE =EHA ID MA@=IK> A?JELA@AJAHE H=JE BJDACA AH= MA >AE C B> JD=BBA?JA@M A A 1 BJDAIJK@O E MDE?DJD=J=IIAII A CFDOIE?E= I JDAHAIK JI >J=E A@ MDE?DMAHA@AHELA@BH F=JEA JI`@E@ JCAJ? BEH A@ F IIE> O@KAJ E =@AGK=JAFDOIE?E= F=JEA JHA =JE IDEFI O? HHA =JE >AJMAA JDAGK= EJO B EBA BF=JEA JIMEJD>H?DE= =IJD F=H= AJAHIMDE?D=HA@EHA?J O E 1 JDAIJK@O>O =HII AJ= JDA>ECCAIJ@EIJKH>=?AIE JDAGK= EJO B EBA=BBA?JA@M A F=JEA JI AJI# $"OA=HI=I? F=HA@MEJD A KHFHAIA JHAIK JI? BEH A@JD IA BA=H EAHIJK@EAI 9AB H=JE E M A \ICA AH= GK= EJO B EBAMEJDHAIFA?JJ E EJ=JE I@KAJ FDOIE?= DA= JE = FH > A I I?E= BK?JE E C A AHCO JE = MA >AE C 9A= I B =? BE F=?J B >H?DE= =IJD = JDAE LAIJEC=JA@F=H= AJAHI *KJMA@E@ OABBA?J BJDA=CA BJDAIJK@EA@M A JDAEHGK= EJO B EBA += BAAAJ=! = = O E CF=H= AJAHI BJDAGK= EJO B EBAE =? D HJ B&$# F=JEA JI2AH?AELA@+ JH B)IJD =3KAIJE =EHA 2+)3E =FH IFA?JELA IJK@O= A@E= B M KFJE A B 'OA=HI ID MA@=IEC EBE?= J OF IEJELA ABBA?J BMA? JH A@=IJD = FDOIE?= DA= JDIJ=JKI =IJD = HA =JA@GK= EJO B EBA MAH=IJD =IALAHEJOI? HAI 1 = JDAHIJK@O =?? H@E CJ )H?DA=AJ = " MI?E A? AC=JELA EBAALA JI? HHA =JA@MEJD= MAHGK= EJO B EBA BF=JEA JIMEJD>H?DE= =IJD =. H? F=HEI JDA FHAIA JIJK@O? BEH A@=>A ABE?E= ABBA?J BA@K?=JE ALA JDA?KHHA J BM A JHA=JA@B H>H?DE= =IJD = =I? F=HA@MEJD JDAEHIJ=JKI=OA=H>AB HA E EJ=JE I@KAJ A JE = FH > A IE JDA?=IA BDECDAHA@K?=JE =H??KF=JE = =?JELEJO -N=?AH>=JE I B>H?DE= =IJD = AIFA?E= OMDA HIALAHA?=? HHA =JA AC=JELA HIA =BBA?JA@F=JEA JI\GK= EJO B EBA F=H= AJAHI MDE?DM=IHAB A?JA@E JDAIJK@EAI>O O@AJ= HI> AHC AJ= $ 5K?DHA =JE IDEFIMAHA J D MALAH? BEH A@>OJDEIIJK@O =IIEI A BJDA J CA E?HEI B=?J HIB H>H?DE= =IJD F A J >KJEJ?= = I E F=EHJDAGK= EJO B EBA BF=JEA JIMEJD@E=C IA@ =IJD = 1 JDAIJK@O>O =L EAAJ= % = AC=JELAABBA?J B* 1 JDACA AH= MA >AE C BIJK@EA@ A A M=ILAHEBEA@ 1 JDAFHAIA JIJK@O =DECDAH * 1= I E F=EHA@JDAGK= EJO BIA A?JA@ EBA@ =E I FDOIE?= BK?JE E E EJ=JE I@KAJ FDOIE?= DA= JD H@AHI? HHA =JAMEJDJDAGK= EJO B EBA BF=JEA JIJHA=JA@B H>H?DE= =IJD = 1 =IJK@O>O K M=J AJ= & EJM=IID M JD=JJDAE?E@A?A B@AFHAIIE E =IJD =F=JEA JIEIGKEJABHAGKA J MDE?DD=I= AC=JELAABBA?J GK= EJO B EBA =CCH=L=JAI=IJD =IO FJ I E?HA=IAIJDA AA@B HJDAKIA BC O?? HJE? IJAH IFEJ= E =JE BF=JEA JI - E?EAJ= '? BEH A@=IEC EBE?= J O AC=JELAABBA?J B@AFHAIIELA

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Rick Van Kooten, Indiana Univ., FNAL Users Meeting, HEPAP Session, June 27, 2000

Rick Van Kooten, Indiana Univ., FNAL Users Meeting, HEPAP Session, June 27, 2000 HEACC 2001 Eric Colby Stanford Linear Accelerator Center 2575 Sand Hill Road MS 07 Menlo Park, CA 94025 ecolby@slac.stanford.edu 9D=J FDOIE?I GKAIJE I JEL=JA JDA ANJ E A=H + E@AH Rick Van Kooten, Indiana