GASTRIC ULCER Veh + ASA (30 mg/kg-d i.g.) Initial (0 day) + NO-ASA (50 mg/kg-d i.g.)

Transcription

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5 %%% BBA?J OJHA=J A J )5) JDADA= E CH=JA BC=IJHE? F= OE C?D= CAIE JDA/.=JK?AH =HCE K E = HA A=IA B.EC ID MIJDAABBA?JI BJDA56 C=IJHE? K? I= M=JK?AH =HCE HA? H@A@MEJD KJ H MEJDJDAJHA=J A JMEJD)5) H CK?AHIE JDAIA = E = IMEJD=B=IJE K? IA ALA B!!& EBE?= JE?HA=IAE JDA=HA= =?? F= EA@>O=IEC EBE?= J@A?HA=IAE JDA/.=JK?AH =HCE 6HA=J A J MEJD)5)! C C BKHJDAHIEC EBE?= J OE?HA=IA@JDA=HA= BC=IJHE? K?AHIE H=JIMEJD HMEJD =HCE =I? F=HA@J JD IAE LADE? 1? JH=IJ GASTRIC ULCER 9 2 LESION AREA (mm ) GBF ATULCER MARGIN (% control) Initial ( day) Veh Diabetes Veh Diabetes ASA ( mg/kg-d i.g.) Veh Diabetes NO-ASA (5 mg/kg-d i.g.).ec -BBA?J BJDAJHA=J A JMEJDLADE? AI= E A =IFEHE )5)! C C )5) # C C JDA=HA= F= OE C?D= CAIE JDAC=IJHE? K? I= M/.E KJ IJHAFJ?E 56 % C CE F A EJKI A= 5- BH $ &H=JIFAHCH KF )IJAHEI A= I=IEC EBE?= J?D= CABH JDA? CL= KAE LADE? A H=JI H II@A JAI=IJ=JEIJE?= OIEC EBE?= J@EBBAHA?ABH JDA? CL= H=JIMEJD KJ)5)=@ E EIJH=JE, K> A?H EBE?= J?D= CA=I? F=HA@MEJDJDA? CL=

6 OJHA=J A JMEJD )5)# C C B=E A@J A D=?AJDA=HA= B JIEC EBE?= J OE B KA?AJDA/.=JK?AH =HCE =I? F=HA@J JDAL= KAIHA? H@A@E LADE? A )IID M E.EC JDA K E = HA A=IA B M=IIEC EBE?= J OHA@K?A@E LADE? A JHA=JA@H=JIMEJDJDA@E=>AJAI= CMEJDJDA =H A@@A =OE K?AHDA= E C EBE?= JB= E JDA/.=JK?AH =HCE =I? F=HA@J JD IA J IK> A?JA@J ANFAHE A 6HA=J A MDE?D =H A@ O@A =OA@K?AHDA= E EBE?= J O@A?HA=IA@JDA/.=JK?AH =HCE EBE?= J@A?HA=IAE JDA K E =? JA J=I? F=HA@J JD=J=JJ=E A 1? JH=IJ JHA=J A JMEJD )5) MDE?DB=E =OJDAK?AHDA= E I HALAHIA@ JDAB= E JDA/.=JK?AH =HCE?=KIA@>O =JELA)5) H=EIA@JDA K E = GASTRIC ULCER 9 LESION AREA (mm ) LUMINAL NO (µm/ L) GBF AT ULCER MARGIN (% control) Initial ( day) Veh Veh ASA ( mg/kg-d i.g.) NO-ASA (5 mg/kg-d i.g.) DIABETES ASA SNAP (5 mg/kg-d i.g.).ec -BBA?J BJDAJHA=J A JMEJDLADE? AI= E A =IFEHE )5)! C C )5)# C C >E A@MEJD5 EJH I =?AJO, FA E?E = E A5 )2 # C E C H JDA=HA= F= OE C?D= CAIE JDAC=IJHE? K? I= K E =??A JH=JE E C AE A?JE BIJHAFJ?E 56 % C CE F A= 5- BH $ &H=JIFAHCH KF )IJAHEI A= I=IEC EBE?= J?D= CABH JDA? C L= KAE LADE? A H II@A JAI=IJ=JEIJE?= OIEC EBE?= J@EBBAHA?ABH JDA? CL= KJ)5)=@ E EIJH=JE, K> A?H IEC EBE?= J?D= CA=I? F=HA@MEJDJDA? CL= A H)5), K> A=IJAHEI EBE?= J?D= CA=I? F=HA@MEJDJDA? CL= KAI

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