Oxygen, Glucose, Ascorbate

Size: px

Start display at page:

Download "Oxygen, Glucose, Ascorbate"

Ruby Eaton
5 years ago
Views:

1 Riordan Clinic IVC Academy 2 Oxygen, Glucose, Ascorbate O

2 e- O:O e- C O 2 Glucose

3 e- O:O e- O 2

4 Life = Electron Flow

5 an electron as seen by the Super K Particle Detector in Kamioka Observatory Hida, Japan

6 On a molecular basis, the whole living process is nothing more than an orderly flow and transfer of electrons... - Irwin Stone The Healing Factor

Latin: Ga (giga-annum) billion years Ma (mega-annum) million years Ka (kilo-annum) thousand years 13,800,000,000

7 Latin: Ga (giga-annum) billion years Ma (mega-annum) million years Ka (kilo-annum) thousand years 13,800,000, x 10 8 Ga Univ. atoms = Earth atoms = Human cells = Cells atoms = Electrons = 10 28

Toxic O 2 released Prokaryotic life grows Anaerobic

8 4.567 Ga Geologic Time 4.6 Ga Prebiotic existence 3.8 Ga CO 2 atmosphere Ribosomes Membranes Photosynthesis Toxic O 2 released Prokaryotic life grows Anaerobic dominates 2.5 Ga O 2 atmosphere Eukaryotes emerge Aerobic Organelles Nanomachines

9 Photocatalytic Water Splitting CO 2 O 2

10 Photons Photo- Synthesis O 2!! The energy of light Splits water H 2 O Hydrogen and Oxygen Oxygen is the 2 nd most electronegative atom

11 Oxygen is the 2 nd most electronegative (electron-attractive) element

12 Electron Flow REDOX Electrons always flow from the anode to the cathode or from the oxidation half cell to the reduction half cell. electronegativity = electro-phyllic Redox = lectron flow

13 Dr. Thomas Levy Curing the Incurable One definition of life is a state in which an optimal degree of electron interchange among cells can take place.

14 Oxygen Oxygen s energy potential The electron-attractive Multicellular Life power of oxygen set the stage for evolution s big jump to Eukaryotic cells

16 Eukaryotic Organelles Evolved Life is a chemical system capable of Darwinian evolution. - Carl Sagan

17 Aerobic Cellular Life Anaerobic cellular regression Eukaryotes Single cells that lived aerobically: Oxygen 19 times more Energy Also capable of anaerobic metabolism when stressed

18 Photosynthesis & Respiration Cycle

20 With O 2 : With no O 2 : 38 ATP s 2 ATP s

21 C Glucose

22 Ascorbate is Synthesized from Glucose GLO

23 L-Gulonolactone Oxidase 1972

24 Comparing Vitamin C Synthesis to Predicted Oral Consumption mg/kg/d Human equivalent humans 1 60 mg/d dog mg/d pig mg/d monkey* 100 7,000 mg/d goat ,000 mg/d sick goat ~ ,000 mg/d

25 Excerpt from The Healing Factor, Part 1 Our Deadly Inheritance, Chapter 8 The Genetic Approach Here we have the classic conditions for a genetic, missing-enzyme disease, and yet for years these simple facts have been ignored and scurvy has continued to be regarded as avitaminosis. In 1966, this author published the paper "On the Genetic Etiology of Scurvy," in which the history and pertinent facts were reviewed and it was pointed out that in scurvy we were dealing with a genetic, liver-enzyme disease and not simply a dietary disturbance. Since it is the prerogative of the discoverer to name a new disease, the author called it "hypoascorbemia" because low levels of ascorbic acid in the blood are characteristic of this disease. This genetic approach now provides a natural rationale for the use of large amounts of ascorbic acid which served so well in the survival of the mammals in the course of evolution. Its implications for health and well-being are vast because it furnishes the basis for the new unexplored fields of preventive medicine and therapeutics (megascorbic prophylaxis and megascorbic therapy). It is hoped that the publication of these new ways of using ascorbic acid will stimulate the flood of research similar to that which occurred when ascorbic acid was discovered in the early 1930s. Let us see how long it will take to break down the "vitamin-barriers" of current orthodox medical dogma. Note The Healing Factor was originally published in years ago!

26 the chronic under-dosing of vitamin C from minimal or no supplementation and from eating depleted food will facilitate the development of nearly all the chronic degenerative disease that affects man. Irwin Stone The Healing Factor

27 C O hexuronic acid from adrenals The antiscorbutic factor Albert Szent-Györgyi

28 e- O:O e- C O 2 Glucose

1937 Nobel Prize C One of the primary substances assuring that a vigorous, continuing electron exchange takes place among the body s tissues and

29 1937 Nobel Prize C One of the primary substances assuring that a vigorous, continuing electron exchange takes place among the body s tissues and molecules e- O:O e- in Medicine for the discovery of vitamin C, in connection with biological respiration Two UNPAIRED electrons e- with parallel spins

30 e- O:O e- Amazing factoid: atmospheric oxygen O2 is relatively unreactive!

31 Pauli Exclusion Principle: Two electrons in the same orbit must have opposite spins in order to react with Glucose and other organic molecules Glucose

32 e- O:O e- O 2 Glucose

33 A Simple Electron Transfer System Elements: 1. Paraffin 2. Wick 3. Activated O2 4. Match is Activator Products: 1. Heat 2. Light 3. CO2 4. H2O

34 When a glass jar is placed over a lighted candle, the flame goes out. Why does this happen?

35 The electro-chemical potential of the hydrocarbon bonds was converted to heat, light, CO2 + H2O but not until an activated electron receiver was available

36 singlet superoxide.- O 2 oxygen 1 O 2 atmospheric oxygen O 2 perhydroxyl radical O 2 H hydrogen peroxide H 2 O 2 hydroxyl radical HO Free Energy Kcal/mol water H 2 O water H 2 O

37 Atmospheric O 2 e- O:O e- exists in the ground state O 2 must be activated to be electron receptive

38 e- O:O e- Activation to Singlet Oxygen O:O e- e- Atmospheric O2 has two single electrons with same-spin e- transfers can only happen one electron at a time low reactivity Activated O2 has two opposite-spin paired electrons e- is now highly reactive with other pairs of electrons especially double bonds

39 Atmospheric Oxygen O:O Relatively Unreactive Activated Oxygen O:O e- O e- e- e- 2 This is NOW an electron receiver is gone

40 :O:O: :O:O: Atmospheric O 2 must be ACTIVATED before it can act as an ELECTRON RECEIVER

41 Electron Storage Redox Molecules Electron Energy Transfer Electron Donors Electron Transfer Electron Receivers

42 Dr. Thomas Levy Curing the Incurable One definition of life is a state in which an optimal degree of electron interchange among cells can take place.

43 e- O:O e- C O 2 Glucose

44 Ascorbate as Redoxome Oil Optimizing Electron Flow Efficiency

Biology Unit 4 Energy and Life. 4:1 Energy All living things require a constant supply of ENERGY.

Biology Unit 4 Energy and Life 4:1 Energy All living things require a constant supply of ENERGY. GLUCOSE: (C 6 H 12 O 6 ) the form of energy used for fuel by ALL living cells It requires energy to form