DNA. Recombinant DNA Technology. (Gene deletion, replacement, site directed mutagenesis) (Genetically modified organisms)

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4 Recombinant Technology PCR PCR PCR (Gene deletion, replacement, site directed mutagenesis) (Genetically modified organisms) 1- T. Primrose and J. Old, Principle of Gene Manipulation. Blackwell sciences publication, S. Desmond and T. Nicholl, An introduction to Genetic Engineering. Cambridge University Press, T. A. Brown, Genome. Bios Scientific Publishers Ltd, Kreuzer H. and Massey A, Recombinant and Biotechnology. 2 nd ed. ASM Publication, 2001.

5 Advanced Molecular Genetics 1 (Mating type switching) ( rearrengement) 1. B. Lewin, Genes VIII. Oxford Press, M. L. Depampilis, Concepts in eucaryotic replication. Cold Spring Harbor Laboratory, J. D. Watson, Molecular biology of the gene. The Benjamin/Cummings Company, Inc, H. Lodish, Molecular cell biology. Freeman Publisher, 2003.

6 Advanced Molecular Genetics 2 RNA RNA (Post-transcriptional regulation) (RNA splicing) (RNA editing) RNA mrna 1. B. Lewin, Genes VII. Oxford University Press, J. Locker, Transcription Factors. Academic Press, J. D. Watson, Molecular biology of the gene. The Benjamin/Cummings Company, Inc, 2004.

7 Molecular Bases of Genetic Diseases 1) T. Strachan and A.P.Read. "Human molecular genetics" Garland Science, ) R. L., Nussbaum, McInnes R. R. and Willard H. F. Thompson and Thompson, Genetics in medicine. W. B. Saunders company Toronto, ) J. J. Pasternak, An introduction to human molecular genetics: mechanisms of inherited diseases. Fitzgerald Science Press, USA, 1999.

8 Oncogenes microarray 1- G. M. Cooper, Oncogenes. Jones and Bartlett Publishers, J. K. Cowell, Molecular genetics of cancer. Bios Scientific, 2002.

9 Recombination and Repair Poly (ADP-ribose) Polymerase Ageing ADP A. Nickoloff and Hoekstra M. F. damage and repair. Vol.1, repair in prokaryotes and lower eukaryotes. Humana Press, Totowa, New Jersey, A. Nickoloff and Hoekstra M. F. damage and repair. Vol. 2, repair in higher eukaryotes. Humana Press, Totowa, New Jersey, E. C. Friedberg, repair and mutagenesis. ASM Press, Washington, DC, D. S. Henderson, repair protocols, eukaryotic systems. Humana Press. Totowa, New Jersey, T. Lindahl and West S. C. repair and recombination. Chapman and Hall, London, 1995.

10 Advanced Molecular Biology (Development) Signaling (Protein-Targeting) (Chaparones) (Targeting) ER H. Lodish, Molecular cell Biology. Freeman Publisher, B. Gomperts, Signal transduction. Academic Press, 2002.

11 Genetics of Microorganisms Pleiotrophic Global Control Transposition (Bacteriophage) U. N. Streips and Yasbin R. E. Modern microbial genetics, John Wiley and Sons, J. A. Christopher and Edward D. B. Genetically Engineered viruses. Bois Seientific, 2001.

12 Advanced Techniques PCR (Microarray) CHEF 1. L. Davis, Kuehl M. and Battey J. Basic methods in molecular biology. 2 nd Ed. Appleton and Lange, R. I. Freshney, Culture of animal cells, a manual of basic techniques. 3 rd Ed. John Wiley & Sons, Inc, 1999.

13 Biochemistry of Chromatin r (Nucleoskeleton) Nuclear lamina Nuclear matrix Core filaments Nucleoluskeleton Silencing proteins r 1- B.M.Turner, Chromatin and gene regulation, Mechanisms in epigenetics. Blackwell Science Ltd, R. V. Drieb and Otte A.P., Nuclear organization, chromatin structure, and gene expression. Oxford University Press Inc, S.C.R. Elgin, Chromatin structure and gene expression. Oxford University Press Inc, 1997.

14 Genetic Updates sirna RNAi www4.infotrieve.com/newmedline/search.asp

15 Quantitative Genetics Metric character Heritability 1. D. S. Falconer, Introduction to quantitative genetics. 3rd edition. Longman Scientfic and Technical, S. K. Manjit, Quantitative genetics, genomics and plant breeding. Oxford University Press, B. Lewin, Genes VIII. Oxford Press, 2003.

16 Advanced Bioinformatics 1- A. D. Baxevanis and Francis O. B. F. Bioinformatics, John Wiley & Sons, D. M. Webster, Protein structure Prediction. Humana Press, 2000.

17 Cytogenetics (SKY) (FISH) (CGH) 1- R. L. Nussbaum, R. R. McInnes, H. F. Willard, Thompson and Thompson. Genetics in Medicine. W. B. Sannders Company, 2004.

18 2- D. E. Rooney and Czepulkowski B. H., Human chromosome preparation, Essential techniques. John Wiley and Sons, Advanced Population Genetics - - 1) D. A. Hartl and Clark A. G. Principles of population Genetics. Sinecure Associates, Inc, ) D. L. Hartl. A primer of population Genetics. Sinecure Associates, Inc, 2000.

19 -- Advanced Statistical Biology 1) Principles and procedures of Statistics (A Biometrical Approach) Robert G. D. Steel and James H. Torrie.

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