ASMPH YL5 MODULE 2: THE CELL MODULE Module Syllabus for the Medical Cluster

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1 ASMPH YL5 MODULE 2: THE CELL MODULE Module Syllabus for the Medical Cluster MODULE DESCRIPTION This module introduces the medical student to the basic unit of the human body, the cell. An understanding of the cell, its structure, substructures and biological processes is essential before any discussion on higher organizational structures (e.g. tissues and organs) is undertaken since this forms the foundation of subsequent discussions on normal and abnormal processes in the human body. This syllabus describes the details of the Medical Cluster of the Curriculum. MODULE OBJECTIVES Upon completion of the module, the learners should be able to explain the following concepts and apply them in the analysis of clinical case studies. 1. The structure and function of components of the cell. 2. The structure and function of the major biomolecules of the cell. 3. The concept of internal environment. 4. The cell membrane and transport processes on it. 5. The structure and function of the cytoskeleton and the extra-cellular matrix. 6. The principles of signal transduction. 7. The generation of membrane electrical potentials and synaptic transmission. 8. The basics of electromyography and nerve conduction velocity. 9. The process of enzyme action and its regulation. 10. The process of heredity and genetics. 11. The proper construction and use of pedigree diagrams. 12. The life cycle of the cell and its differentiation. LEARNING STRATEGIES: Lectures and classroom discussions Laboratory sessions Small group discussions and group reports Individual and group assignments FACULTY COORDINATOR Nina Rosario L. Rojas, Ph.D. (module coordinator): nrojas at ateneo.edu. COURSE OUTLINE AND TIME FRAME (subject to change: please check with the ASMPH office for announcements) Date Day Start End Topic Faculty 3-Jul T 8:00 AM 9:00 AM Introduction to the cell module 9:00 AM 10:00 AM The cell and subcellular structures; Introduction to histology B. Mantaring 1:00 PM 5:00 PM Introduction to histology laboratory; histology of the cell B. Mantaring et al. Cell Module 1

2 3:00 PM 5:00 PM Introduction to histology laboratory; histology of the cell B. Mantaring et al. 4-Jul W 8:00 AM 10:00 AM Lipids: Structure and function 10:00 AM 12:00 PM Lipids: Structure and function 1:00 PM 3:00 PM Membranes: Structure and Function G. Adolor 5-Jul Th 8:00 AM 10:00 AM Carbohydrates: Structure and function 10:00 AM 12:00 PM Proteins: Structure and Function 1 6-Jul F 8:00 AM 10:00 AM Proteins: Structure and Function 2 10:00 AM 12:00 PM Membranes: Transport processes N. Nicodemus G. Adolor 1:00 PM 3:00 PM SGD 1 Facilitators 7-Jul Sa 8-Jul Su 9-Jul M 8:00 AM 10:00 AM Exam 1 (Lec + lab) Proctors 10:00 AM 12:00 PM Exam 1 (Lec + lab) Proctors 1:00 PM 3:00 PM Cell Physiology: Membrane potentials and synapse 3:00 PM 5:00 PM Cell Physiology: Membrane potentials and synapse 10-Jul T 8:00 AM 10:00 AM Electromyography and nerve conduction velocity 10:00 AM 12:00 PM Electromyography and nerve conduction velocity J.P. Reyes J.P. Reyes 11-Jul W 8:00 AM 10:00 AM Reports on membrane 10:00 AM 12:00 PM Reports on membrane 1:00 PM 3:00 PM Reports on membrane 3:00 PM 5:00 PM Reports on membrane 12-Jul Th 8:00 AM 10:00 AM Cell motility and shape 10:00 AM 12:00 PM Cell-cell interactions and the extracellular matrix 13-Jul F 8:00 AM 10:00 AM Cell Cycle 10:00 AM 12:00 PM Nucleic acids A. J. Domingo Cell Module 2

3 14-Jul Sa 15-Jul Su 16-Jul M 8:00 AM 10:00 AM Exam 2 Proctors 10:00 AM 12:00 PM Exam 2 Proctors 1:00 PM 3:00 PM Nucleic acids 2 17-Jul T 8:00 AM 10:00 AM Replication, mutagenesis and repair 10:00 AM 12:00 PM Replication, mutagenesis and repair 1:00 PM 3:00 PM Transcription and transcriptional regulation 3:00 PM 5:00 PM Transcription and transcriptional regulation 18-Jul W 8:00 AM 10:00 AM Translation, post-translational modification and protein degradation 10:00 AM 12:00 PM Translation, post-translational modification and protein degradation 1:00 PM 3:00 PM Enzyme activity, strategies, and kinetics 3:00 PM 5:00 PM Enzyme activity, strategies, and kinetics A. J. Domingo A. J. Domingo 19-Jul Th 8:00 AM 10:00 AM Signal transduction 20-Jul F 8:00 AM 10:00 AM Research 10:00 AM 12:00 PM Research 1:00 PM 3:00 PM Genetics, heredity, and pedigree analysis E. C. dela Paz 3:00 PM 5:00 PM Genetics, heredity, and pedigree analysis E. C. dela Paz 21-Jul Sa 22-Jul Su 23-Jul M 8:00 AM 10:00 AM Exam 3 Proctors 10:00 AM 12:00 PM Exam 3 Proctors 24-Jul T 8:00 AM 10:00 AM More clinical correlations of the cell module N. Nicodemus 1:00 PM 3:00 PM SGD 2 Facilitators 25-Jul W 8:00 AM 10:00 AM Cell Module Integration Session: Newborn screening 10:00 AM 12:00 PM Cell Module Integration Session: Newborn screening A. Dionisio, E. C. dela Paz et al. A. Dionisio, E. C. dela Paz et al. Cell Module 3

4 26-Jul Th 8:00 AM 10:00 AM Independent study period 10:00 AM 12:00 PM Ethics R. Tanchangco 27-Jul F 8:00 AM 10:00 AM Cell Module Final Exam Proctors 10:00 AM 12:00 PM Cell Module Final Exam and Feedback Proctors EVALUATION PLAN ACTIVITY WEIGHT Written Exam 1 (Lecture) (70 pts) 18% Written Exam 1 (Histology Laboratory) 5% Written Exam 2 (Lecture) (65 pts) 17% Written Exam 3 (Lecture) (100 pts) 25% Small Group Discussions/Reports 15% Final Written Exam 20% Criteria for grading of small group discussions (10-point scale) Active participation and mastery of subject matter as 10 shown by accurate, relevant, and insightful inputs Active participation but some inputs may not be very 8-9 relevant Active participation but some inputs may not be 7 accurate; dependence on notes Participation upon prompting but with accurate input 6 Reading directly from accurate sources 4-5 Minimal participation, inaccurate input 0-3 POLICIES Please refer to the ASMPH Student Handbook for Policies. RESOURCE MATERIALS Main Resource Materials Robert K. Murray, Victor W. Rodwell, David Bender and Kathleen M. Botham Harper's Illustrated Biochemistry, 28th ed. McGraw-Hill. Robert M. Berne, Matthew N. Levy, Bruce M. Koeppen, and Bruce A. Stanton Physiology, 5 th ed. Mosby. Don W. Fawcett and Ronald P. Jensh Bloom and Fawcett: Concise Histology, 2 nd ed. Hodder Arnold. Supplemental Textbooks Boyer, Rodney (2006). Concepts in Biochemistry 3rd Edition. New York: John Wiley and Sons Harvey Lodish, Matthew P. Scott, Paul Matsudaira, James Darnell, Lawrence Zipursky, Chris A. Kaiser, Arnold Berk, Monty Krieger (2003) Molecular Cell Biology, 5th or latest edition. W.H. Freeman. Thomas M. Devlin Textbook of Biochemistry with Clinical Correlations, 6 th ed. Wiley Liss. Pamela C. Champe, Richard A. Harvey, Denise R. Ferrier, Lippincott's Illustrated Reviews: Biochemistry, 4rd ed. Lippincott, Williams & Wilkins. Cell Module 4

5 Robert K. Murray, Darryl K. Granner, Peter A. Mayes, Victor W. Rodwell Harper's Illustrated Biochemistry, 26th ed. McGraw-Hill. Marks, D.B., A.D.Marks, and C.M.Smith, Basic medical biochemistry: a clinical approach. Williams & Wilkins, Baltimore, Maryland. Jeremy M. Berg, John L. Tymoczko and Lubert Stryer (2002) Biochemistry, 5th Edition, W.H. Freeman (or latest edition). Alberts, B. et al. Essential Cell Biology, 2 nd ed, 2004 Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002) Molecular Biology of the Cell, 4th Edition, Garland. Nussbaum, R, et al. Thompson and Thompson Genetics in Medicine, 6th ed, 2001 Benarroch, E et al. Medical Neurosciences: An Approach to Anatomy, Pathology and Physiology by Systems Levels, 1999, 4 th ed. Other resources The National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health USA < or < for scientific literature, online books, genetic and genomic resources, and more links. Other online resources Cell Module 5