Course Syllabus. Biochemistry 107

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1 Course Syllabus Biochemistry 107 Spring/Summer 2007 University Health Science Antigua On-line 7 May - 6 August UHSA Bioch107 Course description Biochemistry and chemistry of biological materials: water, amino acids, peptides, proteins, enzymes, bases, nucleosides, nucleotides, nucleic acids, carbohydrates, polysaccharides, lipids, complex lipids, vitamins, and cofactors. The structure/function aspect of cells, organelles, tissues & membrane structure will be examined. Calendar May, June, July & August 2007

2 Sun Mon Tue Wed Thur Fri Sat 7 12 WK1 clm 1 & E1 Ch 1 & D1 C2, E2 C clm 3 & 4 WK2 Ch WK3 D2 clm 5 & C3 26 E3 Ch 4 & WK4 D3 clm 7 & C4 2 E4 Ch WK5 D4 clm 9 & C5 9 E6 Ch 7 & 8 10 WK6 11 D5 clm 11 & C6 16 E6

3 12 Ch 9 17 WK7 18 D6 clm 13 & 14 Ch 10 & Midterm Or Sunday class vote WK8 D7 clm 15 & C7 30 E7 Ch WK9 D8 clm 17 & C8 7 E8 Ch 13 & WK10 D9 clm 19 & C9 14 E9 Ch WK11 16 D C10 21 E10

4 22 WK12 29 WK13 clm 21 & 22 Ch D11 clm 23 & D August Final C chat participation date D Forum contribution due E examination date + midterm + final Instructor Franklin R. Leach Home addresses 2304 Fox Glen LN Temple, TX Phones: home (before 10 p.m. Central time zone) cell

5 this course: Other Personal homepage: gory&sectionid=19&id=76&itemid=148 Goals 1. To learn biochemical principles as a foundation for your medical education and to allow you to pass the board examinations. 2. To transform your view of biochemistry from being a required hurdle to being a useful companion in your quest to improve the health of your patients. 3. To learn sufficient chemistry so that we may understand the pervasive structure/function theme. This will entail learning the major players, their structures, and some of their properties. Amino acids and proteins Purines and pyrimidines and nucleic acids Fatty acids, steroids, and lipids Carbohydrates and polysaccharides. 4. To learn the energetic relationships.

6 5. To learn the chemical principles of biochemical conversions. 6. To learn the enzymes and coenzymes involved in metabolism and how they participate in the reactions. 7. To learn how biochemical signals are sent, received, interpreted, and answered. 8. To learn how the structures of cells, tissues, and organs influence function. 9. To learn how the whole living system and subsystems are integrated and controlled. 10. To learn of the errors or defects that occur in biochemical functioning and how they can be treated. 11. To develop effective learning and study habits and a thirst for life-long learning. 12. To develop problem-solving skills. 13. To appreciate the breadth and practical application of biochemical science. 14. To learn how to use the internet for obtaining biochemical information. 15. To develop writing, analysis, and communication skills and ethical scientific perspectives. 16. To learn how biochemical science relates to physiology, the other basic medical sciences, and the clinical medical sciences. 17. To integrate biochemical knowledge into the larger biological system of the human body. 18. To recognize the limitations of biochemical science, its data, and to develop an inquiring mind that sees each patient as a biochemical individual. Grades Components of the Grade:

7 A. On line 2/3 of course grade 1. Two examinations, a mid-term and a final exam will be given June 23 or 24 and August 6 respectively. Each exam will be worth 100 points. These exams will have multiple choice questions. The final is comprehensive. 2. Forum. Twelve contributions worth 5 points each required by Monday morning of each class week. These are to be contributed on the Bb discussion site. They may consist of: the posing of a question, answering a question of another, discovering a new resource or important finding in biochemistry, and must include links or references. 3. On line chat. Participation in Bb's chat site for this course 10 times (5 points each), usually on Fridays unless I have a conflict between 9:00-11:00 pm eastern, 8:00-10:00 pm central, 7:00-9:00 pm mountain, and 6:00-8:00 pm pacific times. Depending on work schedules adjustments may be required. B. On-campus 1/3 of final grade 1. Laboratory in Antigua. A grade of 70 is required to pass the course. Students consistently receiving 70 or below on exams are in serious difficulty and should seek help from the instructor. Texts Primary Text:

8 Biochemistry by Jeremy M. Berg, John L. Tymoczko, and Lubert Stryer (2007) Sixth Edition, W.H. Freeman, New York, pp. ISBN Supplemental materials Web site Slice of Life, Integrated Biochemistry Learning Series, by James Baggott Other current text books Biochemistry by Reginald H. Garrett and Charles M. Grisham, Third Edition, Thompson Brooks/Cole, Belmont, CA, 2005, 1086+pp. ISBN o This is an excellent text. See text books section. See for biochemimages. Biochemistry, by C. Matthews, K.E. vanholde, and K. Ahern, Third Edition, Benjamin/Cummings, Redwood City, 2000, 1186 pp. ISBN o This is an excellent text. Lehninger Principles of Biochemistry, by D.L. Nelson, & M.M. Cox, Fourth edition, Worth, New York, 2005, 1119 pp. ISBN This is an excellent text. See text books section. The Metabolic & Molecular Bases of Inherited Disease, edited by C.R. Scriver, A.L. Beaudet, W.S. Sly, & D. Valle, McGraw Hill, New York, 7 th edition, Three volumes, 1995, 4605 pp. ISBN This version is on CD.

9 o and The Metabolic & Molecular Bases of Inherited Disease, edited by C.R. Scriver, A.L. Beaudet, W.S. Sly, & D. Valle, McGraw Hill, New York, 8 th edition, Three volumes, 2001, 5568 pp. has been released. $495 ISBN Biochemistry, Third Edition by o o Donald Voet and Judith G. Voet (2004) John Wiley & Sons ( X.html), New York, pp. ISBN Biochemistry, Fourth Edition by G.L. Zubay, Wm. Brown Publishers, Dubuque, IA, 1998, 990+ pp [Your instructor reviewed some of the chapters for the previous edition.] Course Reading Assignments based on Biochemistry, Sixth Edition Berg, Tymoczko, & Stryer Week Chapter # Title Biochemistry: An Evolving Science Protein Composition & Structure

10 2 3 Exploring Proteins & Proteomes DNA, RNA, and the Flow of Genetic Information Exploring Genes & Genomes Exploring Evolution & Genomes Hemoglobin: Portrait of a Protein in Action Enzymes: Basic Concepts and Kinetics 6 9 Catalytic Strategies Regulatory Strategies Carbohydrates Lipids and Cell Membranes Membrane Channels and Pumps Signal-Transduction Sensory Systems Molecular Motors 12 On-line Lecture Organization UHSA

11 Biochemistry 1 Bioch107 Online/Outline 2007 Note: this section will evolve as the course occurs. I. Introduction A. Biochemistry B. Biochemistry, Basic Sciences, Medicine, and Teaching/Learning C. Cellular Environment II. Cellular Biochemicals A. Proteins B. Nucleic Acods III. Information A. Genomics B. Proteomics C, Bioinformatics IV. Protein Details A. Hemoglobin B. Enzymes V. More Cellular Biochemicals A. Carbohydrates B. Lipids VI. Functions A. Transport B. Digestion C. Hormones D. Nutrition

12 FRL 5/06/07 E. Signal Transduction F. Physiological Processes G. Proteins in Motion

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