Chicago PET Development and
|
|
|
- Lynette Chapman
- 5 years ago
- Views:
Transcription
1 Chicago PET Development and Recent Progress in Digital i TOFPET 1. Heejong Kim, Chien-Min Kao, Qingguo Xie, Yun Dong, Ming-Chi Shih, Antonio Machado, and Chin-Tu Chen 2. Octavia Biris, Jialin Lin, Fukun Tang, Lin Zhou, and Henry Frisch 3. Robert Wagner, Karen Byrum, and Gary Drake 4. Woon-Seng Choong and William Moses 1. Department of Radiology & Committee on Medical Physics, University of Chicago, IL 2. Enrico Fermi Institute & Department of Physics, University of Chicago, IL 3. High Energy Physics Division, Argonne National Laboratory, Argonne, IL 4. Lawrence Berkeley National Laboratory, Berkeley, CA
2 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
3 Quantitative Imaging Multi-Modality Modality Integration High-Performance Low-Cost Broad-Access
4 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
5 Imaging gof Life and Live Brain Life Processes Dead Brain Patient 1 Patient 2 MR PET MR PET
6 Task-Based Image Quality Assessment Tasks Detection and Estimation
7 2008 IEEE NSS/MIC/RTSD MIC Short Course " Image Quality in Adaptive and Multimodality Imaging" 20 October 2008 Dresden, Germany Organizer: Harrison Barrett, Matthew A. Kupinski, Lars R. Furenlid
8 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
9 Key Characteristics of Biomarker Generator Micro Accelerator Lower cost & much smaller to be located at scanner To be an approved FDA medical device Produce dose of F-18 or C-11 biomarker in 20 minutes Base chemistry system for drug discovery Handling of micro to millicuries, not curies Microchemistry i & Microfluidics idi Courtesy of Nanotek & ABT
10 Multi-Modality Targeting Molecular Imaging & Therapeutic Probes (Phage and Micelle Nanosystem) Ultrasound, MRI, SPECT, PET, X-Ray/CT, Fluorescence & Therapeutics
11 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
12 Image Co-Registration & Integration Fusion of PET, SPECT, MRI, CT, EPRI, Histology Halpern, Pelizzari Karczmar Weichselbaum
13 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
14 600 ps 2 ns
15 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
16 Silicon PM Characterization MPPC: 1x1mm 2 25-μm, 50-μm, or 100-μm Front Back Source: LYSO: F-18 1x1x10mm 3, 2x2x10mm 3
17 F-18/LYSO Sample Pulses PMT 25-μm MPPC 50-μm MPPC 100-μm MPPC
18 A Table-Top Top Prototype HRRT Detector Heads The prototype consists of two HRRT (High Resolution Research Tomograph) detector heads. The spacing between detectors shown is ~6 cm, which is adequate for imaging rodents. A single double-layered, layered, 8 x 8 LSO crystal block affixes onto 4 photomultiplier tubes in the quadrant-sharing configuration. CNMF, September 26, 2008
19 Central Sensitivity (GATE Simulation, 20% ER, 3ns TR) Se ensitiv ity (%) ns 6ns 10ns LLD (kev)
20 Noise-Equivalent Count Rate Comparison with reported NECR peaks Mouse Rat Reported NECR peaks Reported NECR peaks
21 FDG Resolution phantom real data mm 0.75 mm mm 2.4 mm mm mm Modeling the responses by MC simulation Ideal line integral
22 Sample Image real FDG-Rat data Ideal line integral Modeling response 22
23 Initial FDG-Rat Images Transaxial Coronal Sagittal
24 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
25 Digital PET Data Acquisition A Multi-Threshold Approach PMT IN V 1 V 2 discriminators TDC TDC V 3 TDC V 4 TDC
26 Multi-Threshold Approach Sampling pulse at pre-defined voltage levels. Output : only digitized timings. Pulse reconstruction using digitized timings. Remove analog blocks. (Pre-Amp, ADC, CFD) PMT waveform by 20GS/s oscilloscope superimposed with timing readouts by the multi-threshold board + HPTDC Digital it Signal Processing (DSP) technology can be utilized. (event time, energy)
27 Multi-Threshold Board + HPTDC Multi-threshold threshold discriminator board 2 boards with 4channels in each. HPTDC (CERN) 0-700mV of adjustable threshold level. 4 chs output Used ADCMP582 comparators. Timings at leading and falling edges. Threshold Set Input Multi-threshold th h ld board (left) connected to HPTDC module (right). High Performance TDC (HPTDC) 8/32 channels. 25 ps/bit. developed at CERN.
28 Experimental Setup A Block diagram of the setup. Two Hamamatsu R9800 photomultiplier tubes (HV = -1,300V) Coupled with LSO crystals ( 6.25x6.25x25mm3). Separated 5cm apart. Na-22 used for positron source located at the center. Multi-threshold threshold discriminator board setup: Inputs from 2 PMT signals Thresholds : 50, 100, 200, 300mV Timing Readout : TDS6154 oscilloscope20gs/s. (Tektronix) HPTDC. ( 8chs, 25 ps/bit, developed at CERN)
29 Time Resolution of Discriminator χ 2 / ndf / Constant ± 7.4 Mean ± Sigma ± Time(ns) Sent pulse generator signals to two channels. Measured time difference with the TDS6154 oscilloscope. Time resolution of single channel : ~13.3ps(FWHM) Time offset between two channels of the Multi-threshold discriminator.
30 Pulse Reconstruction (HPTDC) 2 χ / ndf / 33 Constant ± Mean ± 0.8 Sigma ± χ / ndf / 31 Constant ± 4.4 Mean ± 0.6 Sigma ± 0.48 PMT Signal Reconstructed Select the gamma coincidence events. events with 2, 3 and 4 hits from each board. Reconstructed pulse shape. Linear fit on the leading edge. (event time) Charge(pC) Exponential fit on the falling edge. (energy, decay constant) Energy distribution of 511keV gamma.
31 Pulse Recontstruction χ 2 / ndf 25 / 20 Constant 150 ± Mean ± 0.11 Sigma ± χ 2 / ndf / 10 Constant ± 10.9 Mean ± 0.04 Sigma ± PMT Signal Reconstructed 20GS waveform Multi-threshold Energy resolution 13%(FWHM) 18% Decay constant 45ns 44ns (4ns width) (9ns width) Time(ns) The decay time constant.
32 Coincidence Timing Resolution χ 2 / ndf / 53 Constant ± 3.9 Mean ± Sigma ± Select the coincidence events. Least square fit to the leading edge timings. Use two leading edges with100, 200mV thresholds. Extrapolated at 0mV Time(ns) Time difference of 511keV gamma coincidence events The time difference, t1-t2. (FWHM) Oscilloscope : 330ps HPTDC : 350ps
33 PET Imaging Chain and UC PET R&D Clinical Outcomes & Biological Discoveries [Cancer, Cardiac, Brain, Drug, etc.] Performance Evaluation [Task-Based Assessment] Cyclotron/ Radiotracer [Multi-Modality Probes] Quantitative Image Analysis [MM QIA & List-Mode Dynamic 4D/5D QIA] Subject (Human/Animal) Integration with Medicine & Biology Detector & System [Panel-PET & SiPM] Electronics [Digital PET] Image Reconstruction [MM-IR & ROI-IR]
34 Motor Activity Study (Stroke)
35 Motor Activity Studies
CHIPP Plenary Meeting University of Geneva, June 12, 2008 W. Lustermann on behalf of the AX PET Collaboration
CHIPP Plenary Meeting University of Geneva, June 12, 2008 W. Lustermann on behalf of the AX PET Collaboration INFN Bari, Ohio State University, CERN, University of Michigan, University of Oslo, INFN Roma,
Development of a High Precision Axial 3-D PET for Brain Imaging
Development of a High Precision Axial 3-D PET for Brain Imaging On behalf of the AX-PET Collaboration SIENA - IPRD08 October 1st 4th, 2008 1 Outline Basics of Positron Emission Tomography (PET); Principle
Timing and Energy Response of Six Prototype Scintillators
Timing and Energy Response of Six Prototype Scintillators CCM Kyba 1, J Glodo 2, EVD van Loef 2, JS Karp 1, KS Shah 2 1 University of Pennsylvania 2 Radiation Monitoring Devices SCINT 2007 June 7, 2007
Prospects for achieving < 100 ps FWHM coincidence resolving time in time-of-flight PET
Prospects for achieving < 100 ps FWHM coincidence resolving time in time-of-flight PET, 28-Feb-2012, ICTR-PHE, Geneva, Switzerland 1 Time-of-flight PET Colon cancer, left upper quadrant peritoneal node
Dual Isotope Imaging with LaBr3:Ce Crystal and H8500 PSPMT
Dual Isotope Imaging with LaBr3:Ce Crystal and H8500 PSPMT Dr. Andrea Fabbri, University of Rome Roma Tre I.N.F.N. (National Institue of Nuclear Physics) γ-ray imaging with scintillator and PSPMT γ-ray
Mayneord-Phillips Summer School St Edmund Hall, University of Oxford July Proton decays to n, e +, ν
Positron Emission Tomography Physics & Instrumentation Dimitra G. Darambara, Ph.D Multimodality Molecular Imaging Joint Department of Physics RMH/ICR Outline Introduction PET Physics overview Types of
Positron Emission Tomography (PET)
Positron Emission Tomography (PET) A radiological technique for functional imaging Please note that this exercise takes place at the Stockholm Centre for Physics, Astronomy and Biotechniques (Alba Nova).
CT-PET calibration : physical principles and operating procedures F.Bonutti. Faustino Bonutti Ph.D. Medical Physics, Udine University Hospital.
CT-PET calibration : physical principles and operating procedures Faustino Bonutti Ph.D. Medical Physics, Udine University Hospital Topics Introduction to PET physics F-18 production β + decay and annichilation
MEDICAL EQUIPMENT: NUCLEAR MEDICINE. Prof. Yasser Mostafa Kadah
MEDICAL EQUIPMENT: NUCLEAR MEDICINE Prof. Yasser Mostafa Kadah www.k-space.org Recommended Textbook Introduction to Medical Imaging: Physics, Engineering and Clinical Applications, by Nadine Barrie Smith
PET scan simulation. Meysam Dadgar. UMSU, Iran. IFMP, Elbasan, Fig 1: PET camera simulation in gate by cylindrical phantom
PET scan simulation Meysam Dadgar UMSU, Iran IFMP, Elbasan, 2016 Meysamdadgar10@gmail.com 1 Fig 1: PET camera simulation in gate by cylindrical phantom 2 What is PET? Positron emission tomography (PET),
Current Challenges and Opportunities in Positron Emission Tomography. Paul Marsden King s College London
Current Challenges and Opportunities in Positron Emission Tomography Paul Marsden King s College London STFC Particle Physics Department Rutherford Appleton Laboratory - 3 Sept 2014 Current Challenges
A. I, II, and III B. I C. I and II D. II and III E. I and III
BioE 1330 - Review Chapters 7, 8, and 9 (Nuclear Medicine) 9/27/2018 Instructions: On the Answer Sheet, enter your 2-digit ID number (with a leading 0 if needed) in the boxes of the ID section. Fill in
Time-of-Flight PET using Cherenkov Photons Produced in PbF 2
Photons Produced in PbF 2 R. Dolenec a, S. Korpar b,a, P. Križan c,a, R. Pestotnik a, A. Stanovnik d,a a, Ljubljana, Slovenia b Faculty of Chemistry and Chemical Engineering, University of Maribor, Slovenia
Detector technology. Aim of this talk. Principle of a radiation detector. Interactions of gamma photons (gas) Gas-filled detectors: examples
Aim of this tal Detector technology WMIC Educational Program Nuclear Imaging World Molecular Imaging Congress, Dublin, Ireland, Sep 5-8, 202 You can now the name of a bird in all the languages of the world,
Charge collection in PET detectors
University of Wollongong Research Online University of Wollongong Thesis Collection 1954-2016 University of Wollongong Thesis Collections 2007 Charge collection in PET detectors Tony Young University of
A liquid xenon PET camera - Simulation and position sensitive PMT tests
A liquid xenon PET camera - Simulation and position sensitive PMT tests S. Jan, J. Collot, E. Tournefier To cite this version: S. Jan, J. Collot, E. Tournefier. A liquid xenon PET camera - Simulation and
Radionuclide Imaging MII Positron Emission Tomography (PET)
Radionuclide Imaging MII 3073 Positron Emission Tomography (PET) Positron (β + ) emission Positron is an electron with positive charge. Positron-emitting radionuclides are most commonly produced in cyclotron
Development of a new PET detector module with improved Depth of Interaction and Time of Flight capabilities
Development of a new PET detector module with improved Depth of Interaction and Time of Flight capabilities Ana Rita Borrego Instituto Superior Técnico IST, Universidade de Lisboa UL, Lisbon, Portugal
PET. Technical aspects
PET Technical aspects 15 N 15 O Detector 1 β+ Detector 2 e- Evolution of PET Detectors CTI/Siemens 15 N 15 O Detector block 1 β+ Detector block 2 x e- x y y location line of response Constant fraction
Solid State LightBurst New PET Technology GE PET/CT and PET/MR
Solid State LightBurst New PET Technology GE PET/CT and PET/MR Osama Mawlawi PhD. Dept. of Imaging Physics MD Anderson Cancer Center Disclosures SIEMENS Research grant GE research grant Discovery MI LYSO
Sub-Nanosecond Timing for In-Beam PET in hadrontherapy
Sub-Nanosecond Timing for In-Beam PET in hadrontherapy Baptiste Joly Clermont Université, Université Blaise Pascal, CNRS/IN2P3, Laboratoire de Physique Corpusculaire, BP 10448, F-63000 CLERMONT-FERRAND,
Application of Nuclear Physics
Application of Nuclear Physics Frontier of gamma-ray spectroscopy 0.1 IR visible light UV soft X-ray X-ray hard X-ray gamma-ray 1 10 100 1e3 1e4 1e5 1e6 energy [ev] Photoelectric effect e - Compton scattering
Introduction to SPECT & PET TBMI02 - Medical Image Analysis 2017
Introduction to SPECT & PET TBMI02 - Medical Image Analysis 2017 Marcus Ressner, PhD, Medical Radiation Physicist, Linköping University Hospital Content What is Nuclear medicine? Basic principles of Functional
Module of Silicon Photomultipliers as a single photon detector of Cherenkov photons
Module of Silicon Photomultipliers as a single photon detector of Cherenkov photons R. Pestotnik a, H. Chagani a, R. Dolenec a, S. Korpar a,b, P. Križan a,c, A. Stanovnik a,c a J. Stefan Institute, b University
Bioimage Informatics. Lecture 23, Spring Emerging Applications: Molecular Imaging
Bioimage Informatics Lecture 23, Spring 2012 Emerging Applications: Molecular Imaging Lecture 23 April 25, 2012 1 Outline Overview of molecular imaging Molecular imaging modalities Molecular imaging applications
Using new digital SiPM from Philips with AX-PET a new geometrical concept for PET
Using new digital SiPM from Philips with AX-PET a new geometrical concept for PET Matthieu Heller CERN - PH/DT Marie Curie network MC-PAD Matthieu.heller@cern.ch On behalf of the AX-PET collaboration https://twiki.cern.ch/twiki/bin/view/axialpet
Compton Camera with PositionSensitive Silicon Detectors
University of Ljubljana Faculty of mathematics and physics Andrej Studen Compton Camera with PositionSensitive Silicon Detectors Doctoral thesis Supervisor: Professor Marko Mikuž Outline: Motivation Basic
List of Nuclear Medicine Radionuclides. Nuclear Medicine Imaging Systems: The Scintillation Camera. Crystal and light guide
Nuclear Medicine Imaging Systems: The Scintillation Camera List of Nuclear Medicine Radionuclides Tc99m 140.5 kev 6.03 hours I-131 364, 637 kev 8.06 days I-123 159 kev 13.0 hours I-125 35 kev 60.2 days
III. Proton-therapytherapy. Rome SB - 2/5 1
Outline Introduction: an historical review I Applications in medical diagnostics Particle accelerators for medicine Applications in conventional radiation therapy II III IV Hadrontherapy, the frontier
The Role of Silicon Radiation Sensors and Integrated Front-End Electronics In Medical Imaging Instrumentation.
The Role of Silicon Radiation Sensors and Integrated Front-End Electronics In Medical Imaging Instrumentation. SLAC Seminar 2. May 2007 P. Weilhammer INFN Perugia/CERN 3. 05. 2007 Seminar SLAC 1 OUTLINE
PoS(TIPP2014)033. Upgrade of MEG Liquid Xenon Calorimeter. Ryu SAWADA. ICEPP, the University of Tokyo
ICEPP, the University of Tokyo E-mail: sawada@icepp.s.u-tokyo.ac.jp The MEG experiment yielded the most stringent upper limit on the branching ratio of the flavorviolating muon decay µ + e + γ. A major
arxiv: v2 [physics.ins-det] 8 Feb 2013
![arxiv: v2 [physics.ins-det] 8 Feb 2013](/thumbs/91/107598870.jpg "arxiv: v2 [physics.ins-det] 8 Feb 2013")
Preprint typeset in JINST style - HYPER VERSION arxiv:1302.0278v2 [physics.ins-det] 8 Feb 2013 Investigation of gamma ray detection performance of thin LFS scintillator with MAPD readout E.Guliyev a, F.Ahmadov
Simulation of triple coincidences in PET
136 Institute of Physics and Engineering in Medicine Physics in Medicine & Biology doi:10.1088/0031-9155/60/1/117 Simulation of triple coincidences in PET J Cal-González 1,4, E Lage 2, E Herranz 1, E Vicente
Nuclear Instruments and Methods in Physics Research A
Nuclear Instruments and Methods in Physics Research A () Contents lists available at ScienceDirect Nuclear Instruments and Methods in Physics Research A journal homepage: www.elsevier.com/locate/nima The
Radiation Detectors. How do we detect ionizing radiation? What are these effects? Types of Ionizing Radiation Detectors
Radiation Detectors 1 How do we detect ionizing radiation? Indirectly, by its effects as it traverses matter? What are these effects? Ionization and excitation of the atoms and molecules Heat 2 Types of
Design of a Lanthanum Bromide Detector for TOF PET
Design of a Lanthanum Bromide Detector for TOF PET A. Kuhn, S. Surti, Member, IEEE, J. S. Karp, Senior Member, IEEE, P. S. Raby, K. S. Shah, A. E. Perkins, Member, IEEE, G. Muehllehner, Fellow Member,
Positron-Electron Annihilation
Positron-Electron Annihilation Carl Akerlof September 13, 008 1. Introduction This experiment attempts to explore several features of positron-electron annihilation. One of the attractive aspects of e
Introduction to Medical Physics
Introduction to Medical Physics Ab branch of applied physics concerning the application of physics to medicine or, in other words The application of physics techniques to the human health Marco Silari,
1st Faculty of Medicine, Charles University in Prague Center for Advanced Preclinical Imaging (CAPI)
Radioation Resolution and Sensitivity Nuclear Imaging PET + SPECT Radioactive Decay (EC,Ɣ), (β -,Ɣ), (I.T.,Ɣ) β + Projection imaging collimator needed one angular view Projection imaging coincidence imaging,
PoS(TIPP2014)093. Performance study of the TOP counter with the 2 GeV/c positron beam at LEPS. K. Matsuoka, For the Belle II PID group
Performance study of the TOP counter with the 2 GeV/c positron beam at LEPS, For the Belle II PID group KMI, Nagoya University E-mail: matsuoka@hepl.phys.nagoya-u.ac.jp The TOP (Time-Of-Propagation) counter
A dual scintillator - dual silicon photodiode detector module for intraoperative gamma\beta probe and portable anti-compton spectrometer
University of Wollongong Research Online Faculty of Engineering - Papers (Archive) Faculty of Engineering and Information Sciences 2008 A dual scintillator - dual silicon photodiode detector module for
Technical University of Denmark
Technical University of Denmark Page 1 of 11 pages Written test, 9 December 2010 Course name: Introduction to medical imaging Course no. 31540 Aids allowed: none. "Weighting": All problems weight equally.
A RICH Photon Detector Module with G-APDs
A RICH Photon Detector Module with G-APDs S. Korpar a,b, H. Chagani b, R. Dolenec b, P. Križan b,c, R. Pestotnik b, A. Stanovnik b,c a University of Maribor, b J. Stefan Institute, c University of Ljubljana
Multi-Photon Time Resolution and Applications
FAST Action WG3 meeting Multi-Photon Time Resolution and Applications. 1 E. POPOVA, 1,2 S. VINOGRADOV, 1 D. PHILIPPOV, 1 P. BUZHAN, 1 A. STIFUTKIN, 13th June 2018 Schwetzingen, Germany 1 National Research
www.aask24.com www.aask24.com www.aask24.com P=Positron E= Emission T=Tomography Positron emission or beta plus decay (+ ) is a particular type of radioactive decay, in which a proton inside a radionuclide
Tomography is imaging by sections. 1
Tomography is imaging by sections. 1 It is a technique used in clinical medicine and biomedical research to create images that show how certain tissues are performing their physiological functions. 1 Conversely,
Introduction to Medical Physics
Introduction to Medical Physics Ab branch of applied physics concerning the application of physics to medicine or, in other words The application of physics techniques to the human health Marco Silari,
Advances in PET technology
Advances in PET technology Jostein Sæterstøl September 15th 2009 Outline Introduction Detectors Time-of-flight PET PET / MRI Conclusions Introduction Fluor-18; FDG β + decay p n + e + + ν Annihilation
hν' Φ e - Gamma spectroscopy - Prelab questions 1. What characteristics distinguish x-rays from gamma rays? Is either more intrinsically dangerous?
Gamma spectroscopy - Prelab questions 1. What characteristics distinguish x-rays from gamma rays? Is either more intrinsically dangerous? 2. Briefly discuss dead time in a detector. What factors are important
Positron Annihilation in Material Research
Positron Annihilation in Material Research Introduction Positron sources, positron beams Interaction of positrons with matter Annihilation channels: Emission of 1, 2 or 3 γ-quanta Annihilation spectroscopies:
Recent Advances of Planar Silicon APD Technology
Recent Advances of Planar Silicon APD Technology M. McClish 1, R. Farrell 1, R. Myers 1, F. Olschner 2, G. Entine 1, K.S. Shah 1 1 Radiation Monitoring Devices Inc., Watertown, MA 2 Cremat Inc., Newton,
Overview of Nuclear Medical Imaging Instrumentation and Techniques*
Overview of Nuclear Medical Imaging Instrumentation and Techniques* William W. Moses Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720 USA Abstract. Nuclear medical imaging
Outline Chapter 14 Nuclear Medicine
Outline Chapter 14 uclear Medicine Radiation Dosimetry I Text: H.E Johns and J.R. Cunningham, The physics of radiology, 4 th ed. http://www.utoledo.edu/med/depts/radther Introduction Detectors for nuclear
Molecular Imaging:the role of radionuclides techniques
High resolution and high efficiency multimodal detector for Molecular Breast Imaging F. Garibaldi NDIP 2014 Tours July 1 2014 Molecular Imaging:the role of radionuclides techniques Breast cancer diagnosis
Radioisotopes in action. Diagnostic application of radioisotopes. Steps of diagnostic procedure. Information from various medical imaging techniques
Radioisotopes in action Diagnostic application of radioisotopes Steps of diagnostic procedure - Radioactive material introduced into the patient - Distribution and alteration of activity is detected -
Readout of LYSO using a new silicon photodetector for positron emission tomography
University of Wollongong Research Online Faculty of Engineering - Papers (Archive) Faculty of Engineering and Information Sciences 23 Readout of LYSO using a new silicon photodetector for positron emission
Performance of the MCP-PMT for the Belle II TOP counter
Performance of the MCP-PMT for the Belle II TOP counter a, S. Hirose b, T. Iijima ab, K. Inami b, Y. Kato a, Y. Maeda a, R. Mizuno b, Y. Sato a and K. Suzuki b a Kobayashi-Maskawa Institute, Nagoya University
TIMEPIX3 First measurements and characterization of a hybrid pixel detector working in event driven mode
TIMEPIX3 First measurements and characterization of a hybrid pixel detector working in event driven mode Erik Fröjdh 1,2, Michael Campbell 2, Massimiliano de Gaspari 2, Szymon Kulis 2, Xavier Llopart 2,
Laboratory of Radiation Detectors and
(2 staff, 8 PhD students and post-doc, 6-8 master thesis positions) Topics for Master Thesis: (for both ELN and BIO strudents) Detectors, electronics and instrumentation for X and gamma rays applications
Measurements of the Minimum Bending Radius of Small Diameter Scintillating Plastic Fibres
LHCb-PUB-218-8 May 8, 218 Measurements of the Minimum Bending Radius of Small Diameter Scintillating Plastic Fibres LHCb SciFi Project L. Gavardi 1, L. Gruber 2, C. Joram 2, M. Väänänen 3 1 TU Dortmund,
Procesamiento de Imágenes y Bioseñales
Procesamiento de Imágenes y Bioseñales Dr. Víctor Castañeda Agenda Physical basis of X-ray- CT, NMR, Ultrasound, Nuclear Medicine Sensors (cameras, gamma probes, microphone) Computational Tomography (CT)
Physics in Nuclear Medicine
SIMON R. CHERRY, PH.D. Professor Department of Biomedical Engineering University of California-Davis Davis, California JAMES A. SORENSON, PH.D. Emeritus Professor of Medical Physics University of Wisconsin-Madison
Tests of the BURLE 64-anode MCP PMT as the detector of Cherenkov photons
Tests of the BURLE 64-anode MCP PMT as the detector of Cherenkov photons Peter Križan University of Ljubljana and J. Stefan Institute Contents Motivation and requirements BURLE MCP-PMT Beam test results
Radioactivity and Ionizing Radiation
Radioactivity and Ionizing Radiation QuarkNet summer workshop June 24-28, 2013 1 Recent History Most natural phenomena can be explained by a small number of simple rules. You can determine what these rules
First Results and Realization Status of a Proton Computed Radiography Device
First Results and Realization Status of a Proton Computed Radiography Device V. Sipala for the PRIMA collaboration V.Sipalaa,b, D.LoPrestia,b, N.Randazzob, M.Bruzzid,e, D.Menichellie,d, C.Civininid, M.Bucciolinic,d,
PoS(PD07)020. Timing Properties of MCP-PMT. Kenji Inami. Nagoya university, Nagoya, Japan
Nagoya university, Nagoya, Japan E-mail: kenji@hepl.phys.nagoya-u.ac.jp We have studied timing properties of 4 different types of micro-channel-plate photo-multiplier tubes (MCP-PMT) by irradiating with
SCINTILLATION DETECTORS & GAMMA SPECTROSCOPY: AN INTRODUCTION
SCINTILLATION DETECTORS & GAMMA SPECTROSCOPY: AN INTRODUCTION OBJECTIVE The primary objective of this experiment is to use an NaI(Tl) detector, photomultiplier tube and multichannel analyzer software system
AGATA preamplifier performance on large signals from a 241 Am+Be source. F. Zocca, A. Pullia, D. Bazzacco, G. Pascovici
AGATA preamplifier performance on large signals from a 241 Am+Be source F. Zocca, A. Pullia, D. Bazzacco, G. Pascovici AGATA Week - LNL (PD), Italy, 12-15 November 2007 Outline Recalls : Fast reset device
Physics of Novel Radiation Modalities Particles and Isotopes. Todd Pawlicki, Ph.D. UC San Diego
Physics of Novel Radiation Modalities Particles and Isotopes Todd Pawlicki, Ph.D. UC San Diego Disclosure I have no conflicts of interest to disclose. Learning Objectives Understand the physics of proton
Waveform Analysis for DM-Ice17. Zachary Pierpoint University of Wisconsin - Madison October 21, 2013 Yale Weak Interactions Discussions Group
Waveform Analysis for DM-Ice17 Zachary Pierpoint University of Wisconsin - Madison October 21, 213 Yale Weak Interactions Discussions Group DM-Ice17 Energy Spectrum counts / day / kev / kg 1 28 Tl+ 214
Radioisotopes and PET
Radioisotopes and PET 1 Radioisotopes Elements are defined by their number of protons, but there is some variation in the number of neutrons. Atoms resulting from this variation are called isotopes. Consider
Gamma ray coincidence and angular correlation
University of Cape Town Department of Physics Course III laboratory Gamma ray coincidence and angular correlation Introduction Medical imaging based on positron emission tomography (PET) continues to have
What is scintigraphy? The process of obtaining an image or series of sequential images of the distribution of a radionuclide in tissues, organs, or
Let's remind... What is nuclear medicine? Nuclear medicine can be broadly divided into two branches "in vitro" and "in vivo" procedures. There are numerous radioisotopic "in vitro" procedures for genotyping
Recent advances and future perspectives of gamma imagers for scintimammography
3rd International Conference on Imaging Technologies in Biomedical Sciences: ITBS2005 Innovation in Nuclear and Radiological Imaging: From Basic Research to Clinical Application Milos Conference Center,
arxiv: v1 [physics.ins-det] 3 Feb 2011
![arxiv: v1 [physics.ins-det] 3 Feb 2011](/thumbs/86/94571492.jpg "arxiv: v1 [physics.ins-det] 3 Feb 2011")
Nuclear Instruments and Methods in Physics Research A 00 (2018) 1 5 Alogo.pdf Nuclear Instruments and Methods in Physics Research A Scintillation decay time and pulse shape discrimination in oxygenated
A POSITION SENSITIVE ALPHA PARTICLE DETECTOR BASED ON A LYSO CRYSTAL AND A MICRO-PIXEL AVALANCHE PHOTODIODE
A POSITION SENSITIVE ALPHA PARTICLE DETECTOR BASED ON A LYSO CRYSTAL AND A MICRO-PIXEL AVALANCHE PHOTODIODE Ahmadov G.S. a,b,c, Ahmadov F.I. b,c, Kopatch Yu.N. a, Telezhnikov S.A. a, Nuriyev S.M. a,b,
A Measurement of Monoenergetic Neutrons from 9 Be(p,n) 9 B
Journal of the Korean Physical Society, Vol. 32, No. 4, April 1998, pp. 462 467 A Measurement of Monoenergetic Neutrons from 9 Be(p,n) 9 B J. H. Kim, H. Bhang, J. H. Ha, J. C. Kim, M. J. Kim, Y. D. Kim
THE AMS RICH COUNTER
THE AMS RICH COUNTER G. BOUDOUL ISN Grenoble ISN-GRENOBLE 1 The AMS RICH collaboration: Bologna, Grenoble, Lisbon, Madrid, Maryland, Mexico 2 The AMS collaboration UNAM S.C.C. TING (MIT), PI 3 AMS Scientific
Image Quality and Adaptive Imaging
Image Quality and Adaptive Imaging Matthew A. Kupinski Associate Professor College of Optical Sciences University of Arizona Tucson, Arizona November 7, 2012 Introduction Imaging equation The need for
Neutron Induced Nuclear Counter Effect in Hamamatsu Silicon APDs and PIN Diodes
Neutron Induced Nuclear Counter Effect in Hamamatsu Silicon APDs and PIN Diodes Rihua Mao, Liyuan Zhang, Ren-yuan Zhu California Institute of Technology Introduction Because of its immunity to magnetic
3. Which of the following statements is (are) TRUE about detector crystals in Anger cameras?
BioE 1330 - Exam 2 11/13/2018 Answer Sheet - Correct answer is A for all questions 1. Unlike CT, in nuclear medicine A. Bremsstrahlung is not used to produce high-energy photons. B. signal can be increased
Equalisation of the PMT response to charge particles for the Lucid detector of the ATLAS experiment
Equalisation of the PMT response to charge particles for the Lucid detector of the ATLAS experiment Camilla Vittori Department of Physics, University of Bologna, Italy Summer Student Program 2014 Supervisor
What is Albira and How Does the System Work and Why is it Differentiated Technology? Page 1
What is Albira and How Does the System Work and Why is it Differentiated Technology? Page 1 Why Albira? Tri-modality: PET, SPECT, CT Modular and state-of-the-art electronics 6 configurations Novel, Proprietary
David B. Cassidy. Department of Physics and Astronomy, University of California, Riverside, USA. Varenna, July 09
Experimental production of many- positron systems: L2, techniques David B. Cassidy Department of Physics and Astronomy, University of California, Riverside, USA cassidy@physics.ucr.edu Varenna, July 09
Time of Flight measurements with MCP-PMT
International Symposium on the Development of Detectors, 2006/4 at SLAC Time of Flight measurements with MCP-PMT - Very high resolution TOF counter - Lifetime of MCP-PMTs T.Ohshima, K.Inami, N.Kishimoto,
A novel method to calibrate DOI function of a PET detector with a dual-ended-scintillator readout
A novel method to calibrate DOI function of a PET detector with a dual-ended-scintillator readout Yiping Shao a Department of Imaging Physics, University of Texas M.D. Anderson Cancer Center, 55 Holcombe
Timing resolution measurement of a 3 Lanthanum Bromide detector
Timing resolution measurement of a 3 Lanthanum Bromide detector L. Galli, M. De Gerone, S. Dussoni, D. Nicolò, A.Papa, F. Tenchini, G. Signorelli INFN Pisa, INFN Genova, PSI Villigen 1 th Pisa Meeting
Polarization Correlation in the Gamma- Gamma Decay of Positronium
Polarization Correlation in the Gamma- Gamma Decay of Positronium Bin LI Department of Physics & Astronomy, University of Pittsburgh, PA 56, U.S.A April 5, Introduction Positronium is an unstable bound
Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory
Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory Title Labr3:Ce scintillators for gamma ray spectroscopy Permalink https://escholarship.org/uc/item/38f0c7zv Authors Shah, K.S.
Technical University of Denmark
Technical University of Denmark Page 1 of 10 pages Written test, 12 December 2012 Course name: Introduction to medical imaging Course no. 31540 Aids allowed: None. Pocket calculator not allowed "Weighting":
Measurement of the n_tof beam profile in the second experimental area (EAR2) using a silicon detector
Measurement of the n_tof beam profile in the second experimental area (EAR) using a silicon detector Fidan Suljik Supervisors: Dr. Massimo Barbagallo & Dr. Federica Mingrone September 8, 7 Abstract A new
ANAIS: Status and prospects
LSC Laboratorio Subterráneo de Canfranc ANAIS: Status and prospects Miguel Ángel Oliván on behalf of the ANAIS team Universidad de Zaragoza Laboratorio Subterráneo de Canfranc RICAP 2014 Roma International
Bases of radioisotope diagnostic methods
Medical, pharmaceutical applications of radioisotopes Bases of radioisotope diagnostic methods Dr. István Voszka Basis of application: radioisotopes have identical behavior in the organism to corresponding
Development of High-Z Semiconductor Detectors and Their Applications to X-ray/gamma-ray Astronomy
Development of High-Z Semiconductor Detectors and Their Applications to X-ray/gamma-ray Astronomy Taka Tanaka (SLAC/KIPAC) 9/19/2007 SLAC Advanced Instrumentation Seminar Outline Introduction CdTe Diode
Chapter 2 PET Imaging Basics
Chapter 2 PET Imaging Basics Timothy G. Turkington PET Radiotracers Positron emission tomography (PET) imaging is the injection (or inhalation) of a substance containing a positron emitter, the subsequent
Positron Emission Tomography
Positron Emission Tomography CERN Accelerator School Small Accelerators Zeegse, the Netherlands A.M.J. Paans Nuclear Medicine & Molecular Imaging UMC Groningen Elements of Life PET-nuclide Hydrogen Carbon
arxiv: v1 [physics.ins-det] 3 Dec 2018 Fast Interaction Trigger for the upgrade of the ALICE experiment at CERN: design and performance
![arxiv: v1 [physics.ins-det] 3 Dec 2018 Fast Interaction Trigger for the upgrade of the ALICE experiment at CERN: design and performance](/thumbs/96/128514105.jpg "arxiv: v1 [physics.ins-det] 3 Dec 2018 Fast Interaction Trigger for the upgrade of the ALICE experiment at CERN: design and performance")
arxiv:1812.00594v1 [physics.ins-det] 3 Dec 2018 Fast Interaction Trigger for the upgrade of the ALICE experiment at CERN: design and performance Alla Maevskaya for the ALICE collaboration 1, 1 Institute
Towards Proton Computed Tomography
SCIPP Towards Proton Computed Tomography L. R. Johnson, B. Keeney, G. Ross, H. F.-W. Sadrozinski, A. Seiden, D.C. Williams, L. Zhang Santa Cruz Institute for Particle Physics, UC Santa Cruz, CA 95064 V.
Nuclear Medicine Treatments and Clinical Applications
INAYA MEDICAL COLLEGE (IMC) RAD 243- LECTURE 2 Nuclear Medicine Treatments and Clinical Applications DR. MOHAMMED MOSTAFA EMAM Next Lectures Outlines Introduction to Nuclear Physics Physics of Radioactivity
Calibration of the Modular Neutron Array (MoNA)
Calibration of the Modular Neutron Array (MoNA) Robert Pepin Gonzaga University ~1~ Calibration of the Modular Neutron Array (MoNA): Figure 1 - A rendering of the Modular Neutron Array In recent years