Laboratory of Radiation Detectors and

Transcription

1 (2 staff, 8 PhD students and post-doc, 6-8 master thesis positions) Topics for Master Thesis: (for both ELN and BIO strudents) Detectors, electronics and instrumentation for X and gamma rays applications in medical imaging, X-ray astronomy, nuclear physics, study of matter and industrial applications Integrated circuits for signal processing of detector signals in scientific and industrial applications Pre-requisites: interest/attitude to experimental activity in laboratory basic background on electronics (in particular, for thesis in integrated circuits design) motivation, curiosity

2 INSERT: INtegrated SPECT/MRI for Enhanced Stratification in Radio-chemo Therapy GA n Kickoff: 01/03/13 Duration: 4 years INSERT members Politecnico di Milano (Italy) Mediso Medical Imaging Systems (Hungary) Fondazione Bruno Kessler (Italy) Nuclearfields International BV (Netherlands) MRI.Tools GmbH (Germany) University College London (UK) Universita Vita-Salute San Raffaele (Italy) Universita Degli Studi di Milano (Italy) Cromed Research and Services ltd. (Hungary) CF Consulting srl. (Italy) Goal: to provide improved personalized radio-chemo therapies for brain tumour (Glioma) patients using a specifically developed multi-modality imaging tool

3 MRI: 3 T MRI (internal bore diameter ~60 cm) Customized RF coil SPECT: Stationary system Multi Slit-Slat collimator 25 independent detection modules (FOV ~ 10x5 cm 2 ) Example of coregistration of nonsimultaneous SPECT (colourscale) MRI (grayscale) acquisitions Detection module Collimator RF Coil

4 Detection module (Anger camera): 1. Monolithic slanted scintillator (CsI:Tl. Area~10x5 cm 2.Thickness 8 mm) 2. Silicon PhotoMultipliers matrix 3. ASIC readout and Data Acquisition System Silicon PhotoMultiplier (SiPM) Single SPAD Ph 1 Ph 2 Ph 3 Expected performance from Monte Carlo simulations: Spatial resolution: between 0.8 and 1 mm Energy resolution: between 11% and 15% (Tc-99m kev)

5 MRI Compatibility MRI compatibility tests The MRI RF signals should to interfere with the detection module The detection module should not produce artifacts on the MRI images with PMT MRI off MRI on detector

6 ASIC architecture ANGUS chip HV V DD Baseline Holder SiPM i signal I BIAS V ref, DAC ΔV in =0 D A C - + Peak detection & triggering v out B0 B0 Current conveyor B3 B3 RC FILTER: τ = 250ns, 2μs, 5μs, 10μs 6 mm 5 mm

7 thesis topics: - detection module: development of clinical detection module and reconstruction (including DOI); - experimentation of the preclinical SPECT in small animal measurements at Ospedale San Raffaele (Milano)

8 Proton therapy the measurement of the proton beam range in the target is very important: real range of proton beams in patients may contain uncertainties of up to mm (uncertainties on tissue composition, density, organ motions, patient positioning, etc). Courtesy IBA

9 CNAO - 29/02/16 - Carlo Fiorini - Politecnico & INFN Shift measurements Experimental validation Nasal cavity bea beam m Planning uncertainty > 5 mm (margin of 3.5% + 2 mm) Measurement uncertainty (1.5σ) 2.0 mm

10 Pixelated LYSO crystals 4 x 4 x 22 mm 3 each 80 Pin connectors Optical Resin SiPMs SiPM board ASIC Board thesis topics: - development of the prototype of detection module; measurements with proton beam - development of a new ultra-fast detector+electronics Assembled View ASICs Exploded View DAQ with LabView code (NI courses) system for temperature stabilization of SiPM gains

11 The GAMMA project (INFN) radionuclide travelling at relativistic velocity Worsened spectrum by Doppler effect The localization of the interaction region of the gamma-ray inside a crystal could in principle reduce or eliminate the Doppler broadening recovering the intrinsic performances of a detector. Timing capability of the detector also needed.

12 thesis topics: - development and experimentation of the detector based on 2'' and 3'' LaBr 3 scintillator - development of imaging algorithms for Doppler broadening correction - development of an ultra high (10.000) dynamic range ASIC - study and experimentation of timing properties of the detector+electronics

13 SiPMs array Position sensitivity in large scintilllators γ-rays Reconstructed Z of irradiated points along the depth of the scintillator: horizontal axis is the true Z, vertical axis is the reconstructed Z.

14 GOAL: design of a readout ASIC able to cover a high dynamic range ( ) with LaBr 3 +SiPM γ ray scintillator scintillation photons keV gamma ray: SiPm signals SiPM photodetectors MeV gamma ray: SiPm signals max min

15 The SIDDHARTA experiment Strong interaction studies al low energy through precise X-ray spectroscopy measurements of Kaonic atoms transitions Kaonic hydrogen higher Kα Kβ EM value K-p Kα New goal: Measurement of the strong interaction induced shift and width of the 1 s state of kaonic deuterium

16 Upgrade the apparatus with 200 cm 2 of new SDD detectors SDD array DAΦNE (Italy) SDD array J-PARK (Japan) Drawings courtesy of H.Zmeskal (SMI- ÖAW, Vienna) thesis topics: - characterization of the detection modules and SFERA ASIC vs. experiment specifications (resolution, linearity,...); - installation in the experiment, beam tests

17 Goal: Development of a versatile detector based on arrays of Silicon Drift Detectors and low-noise electronics for Synchrotron applications Sample Synchrotron X- ray beam X- ray Fluorescence beam ARDESIA detector I 0 I T

18 Approach for ARDESIA design Assembly of monolithic arrays of four units simple, modular high-rate capability medium/large dead area readout channels monolithic chip of 4 SDDs area single SDD: 25mm 2 readout: 4 channels CUBE max. output rate: 0.5Mcps/ch. (analog) 1-3Mcps/ch. (digital) energy resolution: < 150eV X-ray beam X-ray beam X-ray beam sample sample sample thesis topics: - development of the detection module and of the instrument to be installed at LNF (Frascati) and ESRF (Grenoble), exp. measurements - development and test of the new readout ASIC (TERA)

19 SCARLET: Monolithic pixellated spectroscopy detector SDD array 1 1mm 2 SDD readout ASIC bump bonding thesis topics: - study of a new detector: pixel of the ASIC (pre+shaper+adc, power, area,..); technology (bump-bonding); detector performances evaluation; mask for charge sharing sample 8mm collimator features: 1Mcps/SDD (with 200ns analog shaping) 64 Mcps total counting rate full analog processing (preamp.+filter) in the ASIC pixel E.Res. peak. time ADC integrated in the ASIC (1 for 4 ch.)

20 ASIC architecture

21 Design of integrated circuits: schematics and simulations layout circuits test post-layout

22 and finally. presentation of the thesis diploma delivery and party

23 Preliminary list of available thesis 1) INSERT - detection module: development of clinical detection module e reconstruction (including DOI); - experimentation of the preclinical SPECT in small animal measurements at Ospedale San raffaele 2) ARDESIA - development of the detection module and of the instrument to be installed at LNF and ESRF, measurements - development and test of the new TERA readout ASIC 3) SCARLET - study of a new detector: pixel of the ASIC (pre+shaper+adc, power, area,..); technology (bump-bonding); detector performances evaluation; mask for charge sharing 4) SIDDHARTA - characterization of the detection modules and new SFERA ASIC vs. experiment specifications (resolution, linearity,...); installation in the experiment and beam tests at LNF-INFN in Frascati 5) TRISTAN - development of new multi-element detector and readout ASIC for TRISTAN experiment for neutrinomass measurement and dark matter search

24 6) GAMMARAD - development of the prototype of detection module; measurements with proton beam - development of a new ultra-fast detector+electronics 7) GAMMA - development and experimentation of the detector based on 2'' and 3'' LaBr3 scintillator - development of imaging algorithms for Doppler broadening correction - development of an ultra high (10.000) dynamic range ASIC - study and experimentation of timing properties of the detector+electronics 8) SMART FOUNDRY - development of a new radiation sensor to be installed in a magnet for metal waste analysis in foundries You are very welcome to visit our lab, to talk with master students and PhD students and even to stay one afternoon to see what people is doing..