Metrology for Molecular Radiotherapy MetroMRT V. Smyth (coordinator) Lena Johansson, Andrew Fenwick, Kelley Ferreira et al.
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1 EMRP Health(II) Metrology for Molecular Radiotherapy MetroMRT V. Smyth (coordinator) Lena Johansson, Andrew Fenwick, Kelley Ferreira et al.
2 Metro-MRT Metrology for Molecular Radiotherapy, WP No Work Package Name Active JRP-Participants (WP leader in bold) WP1 Activity measurements for molecular radiotherapy CEA, ENEA, NPL WP2 Quantitative Imaging for Molecular Radionuclide Therapy NPL, CMI, ENEA, VSL, RMH- ICR, UCL-CI, IFO, SMGH, SAH, ISS WP3 Measurement of absorbed dose from radionuclides ENEA, CMI, NPL, PTB, VSL, RMH-ICR, UCL-CI, IFO, SMGH, SAH WP4 Modelling and uncertainty analysis NPL, CMI, ENEA, RMH-ICR, UCL-CI, MRP-LUND WP5 Creating Impact CMI, All partners WP6 Management and Coordination NPL, All partners
3 The consortium Six leading European NMIs with special expertise and experience in radionuclide activity measurement and ionising radiation dosimetry: NPL (UK, Coordinator), CEA (France), CMI (Czech Republic), ENEA (Italy), PTB (Germany) and VSL (Netherlands) Seven unfunded partners at the forefront of pre-clinical and clinical research into quantitative radionuclide imaging and MRT dosimetry: Christie (UK), RMH-ICR (UK), UCL-CI (UK), Velindre (UK), IFO (Italy), SMGH (Italy), SAH (Italy), ISS (Italy), MRP-LUND (Sweden) Collaborators: NIST (USA) and an increasing number of clinics
4 WP1: Activity measurements for molecular radiotherapy WP1 will investigate TDCR-Čerenkov detection, a new primary measurement method for high energy beta emitters used for MRT. This applies to Y-90 but has also been tested with other high-energy beta emitters such as P-32.
5 New TDCR at NPL a primary method for beta emitters
6 Triple to Double Coincidence Ratio vial A B C F Coincidence and dead-time unit PMT preamplifiers AB CA T F BC D F Time base scalers
7 TDCR with liquid scintillation Free parameter model TDCR method (3 PMTs): D E max Q(E)E Q(E)E 2M 2 3M 3 S (E)(3(1 e ) - 2(1 e ) ) de 0 E max Q(E)E 3M T S(E)(1 e ) 0 3 The free parameter M is derived from the ratio of the experimental counting rate. TDCR R R T D T D de
8 TDCR with Cerenkov counting Free parameter model needs to incorporate direction of Cerenkov light (non-isotropic): Adding the theory (Frank and Tamm, 1937) for direction of Cerenkov light into the equation NPL Simulate (GEANT4) the light distribution CEA or Use the method as a secondary method and calibrate
9 WP2 Quantitative Imaging WP2 will investigate the use of radionuclide imaging devices (SPECT-CT, PET-CT, etc.) for measurement of cumulative activities within critical volumes in patients. Aim: develop a measurement protocol for QI similar to external beam Enable individual dose planning for MRT
10 WP2: Quantitative Imaging Survey of current methodology and choice of radionuclides for this project (Lu-177, I-131 and Y-90) Investigate methods for validation and calibration of quantitative imaging Develop/identify suitable phantoms for audits and traceable calibration transfer Investigate performance of reconstruction and correction parameters Provide advice and guidelines (protocol) for QI
11 WP2: Quantitative Imaging calibration of SPECT cameras with Jaszczak phantom
12 WP2: Quantitative Imaging calibration of SPECT cameras with Jaszczak phantom
13 WP2: Quantitative Imaging Next steps Further calibration measurements with Lu-177 Verification of calibration with athropomorphic phantom (Lu-177) Further studies of influence of correction factors and number of iterations and subsets etc. Monte Carlo simulations Review of draft calibration procedure written by NPL European comparison exercise with phantom calibration
14 Workshop at CEA, Paris May st session: calculation codes and activity measurements X. Mougeot (LNHB): calculation of beta spectra M.N. Amiot (LNHB): simulation of ionization chambers for radionuclide metrology F. Salvat (University of Barcelona): PENELOPE code I. Ivanchenkov (CERN): Geant4 code 2nd session: Quantitative imaging I. Buvat (CERN-Paris 7 and 11 Universities): quantitative Imaging M. Ljungberg (Lund): quantitative imaging (Bremsstrahlung, 90Y) L. Ferrer (Nantes University): clinical applications 3rd session: Dosimetry A. Desbrée (IRSN): personalized dosimetry (90Y microspheres) C. Villagrasa (IRSN): Geant4-DNA code M. Bardiès (INSERM/Toulouse): from codes to clinical applications
15 People PhD Student Johan Gustafsson from Lund University Hospital secondment to NPL working on Uncertainties Dr. Alan Green from UCL started to work at NPL PhD Student Jill Merrett Quantitative Imaging Sheila MacMahon, medical physicist on sabbatical from Vancouver (Canada)
16 MetroMRT web page or Google MetroMRT
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