(1) : Laboratoire de Physique Corpusculaire, Campus des Cézeaux, Clermont-Ferrand
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1 Intercomparison on the Usage of Computational Codes in Radiation Dosimetry P1 : Brachytherapy : 192 Ir γ-ray source. Calculation of angular anisotropy and dose distribution in water Lucie Berger (1), Lydia Maigne (1), Vincent Breton (1), Denise Donnarieix (1+2) (1) : Laboratoire de Physique Corpusculaire, Campus des Cézeaux, Clermont-Ferrand (2) : Unité de physique médicale, département de radiothérapie-curiethérapie du Centre anticancereux Jean Perrin de Clermont-Ferrand July
2 Goals PCSV team at Laboratoire de Physique Corpusculaire of Clermont-Ferrand : an interface between corpuscular physic and life sciences What is the Monte Carlo simulation Platform GATE? Problem P1 : Characteristics of the simulations Geometry Physical processes Energy cuts Calculations Results July
3 Develop a software interface between corpuscular physic and the life sciences Deployment of grid for bio-informatics The DataGrid project Reduce time computing Parallelization of Monte Carlo simulations optimize performances of detectors and traitements Improve images quality Data management of genomic experiences Study of the dosimetry of medical care GEANT4 Monte Carlo simulations in nuclear medicine, radiotherapy-brachytherapy July
4 PCSV team : a pluridisciplinary research V. Breton (Research associate) Centre Jean Perrin Département de radiothérapie-curiethérapie INSERM U494 (Paris) SPECT simulation Radiotherapy-brachytherapy D. Donnarieix (PhD medical physicist) L. Maigne (PhD student) Grid computing DataGrid Y. Legré OpenGATE collaboration : development of a Monte Carlo simulation Platform for nuclear medicine Nuclear medicine D. Lazaro (PhD student) Centre Jean Perrin Service de médecine nucléaire IASA Athènes GATE validation on an experimental gamma camera July
5 Geant4 Application for Tomographic Emission GATE a Monte-Carlo simulation platform for nuclear medicine based on GEANT July
6 The Monte Carlo simulation platform GATE GATE : Geant4 Application for Tomographic Emission Based on Geant4 C++ object oriented langage Reliable cross sections Framework: interface GATE development modeling of detectors, sources, patient movement (detector, patient) time-dependent processes (radioactive decay, movement management, biological kinetics) Ease of use Command scripts to define all the parameters of the simulation (geometry construction, specification of physical processes, sources) User interface C++ classes Gate Framework Geant July
7 The simulation for the problem P1 GATE allows complete flexible description of the real geometry 192 Ir Core 0.9 mm 0.65 mm 4.5 mm 3.6 mm Woven Steel Cable 192 Ir energy spectrum : 33 γ emissions from 61,49 kev to 1378,30 kev The output file Root generated contains deposited energies in water The calculation of angular anisotropy factors and relative deposit dose is done using a C++ program Root July
8 Calculation of angular anisotropy factors The simulated source is positionned in a 30 cm water sphere (sensitive detector) 10 millions photons are generated isotropically following a 4 4π solid angle Anisotropy factors were calculated at 19 polar angles θ, at distances r = 1.0, 2.0, 3.0, 4.0 and 5.0 cm Energy cuts for photons 1 kev Range cuts for electrons 1 mm (~347 kev in water) Comparison to other Monte Carlo simulations of HDR sources : microselectron-hdr source with MCPT code GammaMed HDR Plus source with Geant3 code July
9 1. Angular Anisotropy factors calculation system r = 1.0, 2.0cm, R = 4mm, H = 2mm r = 3.0, 4.0cm, R = 8mm and H = 4mm r = 5.0cm, R = 8mm and H = 8mm July
10 Results for a 1 kev energy cut for photons and 1,0 mm cut for electrons July
11 Anisotropy factors with GATE Relative deviation in % between GATE and Geant3 Angle (deg) , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , GEANT3 : «The absolute dose rate data for points 1cm away from the source were grouped as curved (z constant and y varaible) and these curves were fitted to a function given by the product of the geometry factor for linear sources G(y,z) and a fourth degree polynomy in y with adjustable parameters.» Angle (deg) ,069 7,128 5,562 4,629 2,522 1,336 1,265 0,829 0,000 0,146 2,418 3,181 3,092 4,834 7,253 6,538 2, ,721 0,710 0,639 0,529 0,886 2,378 1, July ,291 4,254 0,174 0,933 0,686 0,526 0,083 0,289 0,000 1, r (cm) ,079 3,486 2,446 2,799 1,892 1,673 1,061 0,960 0,000 0,595 1,074 1,749 1,691 1,657 2,738 4,084 0, ,400 1,755 4,014 2,457 0,979 0,229 0,899 0,972 0,000 0,045 0,205 0,037 0,712 2,603 1,412 1,513 3, ,772 3,251 1,499 1,182 1,673 0,652 0,472 0,781 0,000 0,323 0,234 0,220 0,474 1,856 0,751 1,057 0,
12 2. Dose distribution Generation of 18.7 millions photons isotropically following a 4π solid angle Determination of the dose distribution from 4.8 to 4.8 cm each 0.2 cm on the X-axis, at 1 cm away from the source Energy cuts for photons : 1 kev and 10 kev Range cuts for electrons : 1 mm and 0,01 mm July
13 Dose distribution calculation system July
14 Results July
15 Thank you July
16 Anisotropy function for r= 1.0 cm July
17 Anisotropy function for r= 2.0 cm July
18 Anisotropy function for r= 3.0 cm July
19 Anisotropy function for r= 4.0 cm July
20 Anisotropy function for r= 5.0 cm July
21 Dose distribution measurement system July
22 Dose Distribution for a fixed source July
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