Summary of the ICRM Life Sciences Working Group Meeting

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1 Summary of the ICRM Life Sciences Working Group Meeting November 201 National Physical Laboratory, Teddington, UK Jeffery T. Cessna Nuclear Medicine Metrology Meeting, 21 November 2014, NPL, Teddinton, UK

2 International Committee for Radionuclide Metrology (ICRM) The International Committee for Radionuclide Metrology (ICRM) is an association of radionuclide metrology laboratories whose membership is composed of delegates of these laboratories together with other scientists (associate members) actively engaged in the study and applications of radioactivity. It explicitly aims at being an international forum for the dissemination of information on techniques, applications and data in the field of radionuclide metrology. This discipline provides a range of tools for tackling a wide variety of problems in numerous other fields, for both basic research and industrial applications. Radionuclide metrology continues to play an important role in the nuclear industry, supporting activities such as radionuclide production, nuclear medicine, measurement of environmental radioactivity and of radionuclides in food and drinking water, decommissioning of nuclear facilities, nuclear security and emergency preparedness, nuclear physics research, etc.

3 International Committee for Radionuclide Metrology (ICRM) Conceived in 1972, by the organisers of a successful International School on Radionuclide Metrology (Herceg Novi, Yugoslavia, 1972) Complement the work of the Bureau International des Poids et Mesures (BIPM) and the International Atomic Energy Agency International Conference on Radionuclide Metrology and its Application since 1975

5 Working Groups of the ICRM Alpha-Particle Spectrometry: S. Pommé, European Commission, Joint Research Centre (EC-JRC), Institute for Reference Materials and Measurements (IRMM), Geel, Belgium Beta-Particle Spectrometry: X. Mougeot, Laboratoire National Henri Becquerel (LNE-LNHB), CEA-Saclay, Gif-sur-Yvette Cedex, France Gamma-Ray Spectrometry: O. Sima, University of Bucharest, Faculty of Physics, Bucharest-Magurele, Romania Liquid Scintillation Counting: K. Kossert, Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany Low-Level Measurement Techniques: M. Hult, European Commission, Joint Research Center, Institute for Reference Materials and Measurements (EC_JRC-IRMM), Geel, Belgium Life Sciences: J. Cessna, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland, U.S.A. Radionuclide Metrology Techniques: J. Keightley, National Physical Laboratory (NPL), Teddington, Middlesex, UK, M. Unterweger, Physical Measurement Laboratory, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland, U.S.A., C. Bobin, Laboratoire National Henri Becquerel (LNE-LNHB), CEA-Saclay Gif-sur-Yvette Cedex, France, P. De Felice, Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile (ENEA), INMRI, C.R. Casaccia, Roma, Italy

8 Life Sciences Working Group Meeting, November 2014

9 Representatives of NMIs and Others ANSTO, Australia Bayer AS, Norway ENEA, INMRI, Italy IRA-METAS, Switzerland LNHB, France NIST, USA NMIJ, AIST, Japan NPL, UK NRC, Canada PTB, Germany RC POLATOM, Poland SIRTex, Australia SMU, Slovak Republic 25 participants

10 Agenda New Developments Recent Standardizations and Measurements (All) Recent work on the activity metrology of the medical nuclides at NIM China (Liang Juncheng) Activity losses in 10-mL pycnometers (Kelly Ferreira) A thermal separation scheme for Cyclotron produced Tc99m (Raphael Galea) Discussion (All) Comparisons 68 Ge/ 68 Ga Comparison Update (Jeff Cessna) C-11 and F-18 standardisations for linkage with the SIRTI (Andy Fenwick) Discussion of comparison needs (All) Interactions with measurement community Dose calibrator service in Canada (Raphael Galea) The Australian Nuclear Medicine Traceability Program (Freda van Wyngaardt) National Comparison on Y-90 solutions (Karsten Kossert) Discussion (All) Radionuclide calibrators Software to collect dose calibrator linearity data from a decaying source (John Keightley) Th-227 Ion chamber calibration factors which vary with time (Sean Collins) Discussion (All) Activity Measurements of Microspheres Chamber specific height and impurity effects in dose calibrator assays of Y-90 microspheres (Denis Bergeron) Standardization of SIR-Spheres at LNHB (Christophe Bobin) Standardization of SIR-Spheres at NPL (Kelly Ferreira) Activity Measurements of Microspheres Chamber specific height and impurity effects in dose calibrator assays of Y-90 microspheres (Denis Bergeron) Standardization of SIR-Spheres at LNHB (Christophe Bobin) Standardization of SIR-Spheres at NPL (Kelly Ferreira) Quantitative Imaging Quantitative Imaging update NIST (Brian Zimmerman) MetroMRT Update (Andy Fenwick) Discussion (All) Monte Carlo Simulation of Beta emitters in Radionuclide Calibrators Dose calibrator sensitivity for beta emitters and simulation (Frédéric Juget) Discussion of Monte Carlo comparison (Brian Zimmerman) Radium-223 Revisiting the NIST Ra-223 Standardization (Brian Zimmerman) Revisiting the NIST Ra-223 Secondary Standards (Denis Bergeron) Discussion of Ra-223 comparison (John Keightley) Discussion (All) General discussions Discussion of problems and needs in Life Sciences (All) Future actions and meetings of the working group (All) ICRM Life Sciences Working Group, November 2014, NPL

11 LSC-WG LS-WG

12 Proposed 223 Ra international comparison 1-10MBq 223 Ra from a homogeneous master solution Participation among at least 10 NMIs ANSTO, IRA, ENEA, LNHB,NIST, NRC-Canada, NMIJ, NPL, PTB, POLATOM Participants report activities to pilot laboratory NMIs are encouraged to submit results to SIR Results are examined and published Supports international equivalence of activity measurements

14 Action Items Previous Meetings Collection of dose calibrator factors determined by NMIs International comparison of 68 Ge(+ 68 Ga) activity in solution This Meeting Comparison of Monte Carlo simulation of β-emitters in radionuclide calibrators International comparison of 223 Ra activity in solution Collection of method for computer interface with radionuclide calibrators

15 Life Sciences Working Group Meeting, November 2014

Ionizing Radiation Metrology at NMIJ/AIST and ENEA-INMRI

Ionizing Radiation Metrology at NMIJ/AIST and ENEA-INMRI Pierino De Felice and Marco Capogni - ENEA C.R. Casaccia Istituto Nazionale di Metrologia delle Radiazioni Ionizzanti (ENEA-INMRI) Roma ITALY Yoshio