Lecture Topic B

Transcription

1 Lecture Topic B

2 Surface Engineering Au, Cu, Ag Al2O3 HS-R (OH)3-P-O-R SiO2 X3Si-O-R Tailored Surface Chemistry

3 Micro-contact printing Polymer stamp (PDMS) Siliconmicrostructure or PMMA resist

4 Micro-contact printing Polymer stamp (PDMS) Ink

5 Micro-contact printing Polymer stamp (PDMS) Ink

6 Surface Engineering Surface Polymerized Polypeptides

7 Poly-γ-benzylglutamate Orientational Change of α-helix by solvent Resulting change in layer thickness

8 Poly-γ-benzylglutamate Orientational Change of α-helix by solvent Resulting change in layer thickness

9

10 Surface Engineering Surface Patterning

11 Surface patterning Microcontact Printing (Whitesides) 1 µm Electron Beam Lithography of Self-Assembled Monolayers (Craighead) 1 nm Dip-Pen Lithography of Self-Assembled Monolayers (C.A. Mirkin)

12 Micro-contact printing of solutions M. Wang, H.-G. Braun, T. Kratzmüller, E. Meyer, Adv. Mater. 13, 1312 (2000)

13 Micro-contact printing of solutions M. Wang, H.-G. Braun, T. Kratzmüller, E. Meyer, Adv. Mater. 13, 1312 (2000)

14 Micro- and nanotechnology as multidisciplinary fields Physics Fundamentals for structuring technologies Optical tweezers Dip pen lithography

15 Affecting Physicochemical and Physical Properties of Surfaces by Surface Patterning

16 Wetting on patterned surfaces Non-wettable wettable T > Tdew Peltierelement T < Tdew Peltierelement

17 Wetting

18 Liquid morphologies on striped surfaces Theoretical description: R. Lipowsky, Structured surfaces and morphological wetting transitions, Interface Science 9, (2001)

19 Liquid morphologies on patterned surfaces

20 Dewetting

21 Water assisted dewetting H.-G. Braun, E. Meyer, Thin Solid Films 345, 222 (1999)

22 Film rupture during dewetting on homogeneous surfaces

23 Film formation by controlled dewetting on micropatterned surfaces E. Meyer, H.-G. Braun, Macromol. Mater. Eng. 276/277, 44 (2000)

24 Mesophases of amphiphilic molecules A. Mueller, D. O Brien, Chem. Rev. 2002, 102, 727

25 Lipid bilayers and their transitions A. Mueller, D. O Brien, Chem. Rev. 2002, 102, 727

26 Topochemical Polymerisation of polydiacetylenes G. Wegner

27 Polymerisable diacetylenes in vesicles / liposomes / layers H.Y. Shim, S.H. Lee, D.J. Ahn, K.-D. Ahn, J.M. Kim, Mat. Sci. Eng. C 24, 2004, 157

28 H.Y. Shim, S.H. Lee, D.J. Ahn, K.-D. Ahn, J.M. Kim, Mat. Sci. Eng. C 24, 2004, 157

29 Stress induced transformations of polydiacetylene molecules ( AFM, SNOM) R.W. Carpick, J.Phys.Cond. Matter 16, 2004, R679

30 Planar conformation of polyconjugated polymer backbone in blue polydiacetylenes R.W. Carpick, J.Phys.Cond. Matter 16, 2004, R679

31 Change in colour due to interaction of polyacrylic acid with blue ( B) vesicles J.M. Kim et. Al., Adv. Mat. 15, 2003, 1118

32 Polydiacetylenes as molecular stress sensors R. Jelinek, JACS 123, 2001, 417

33 Formation of vesicle networks by electroporation, tether formation and extrusion O. Orwar, Langmuir 99, 2002, 11573

34 Formation of vesicle networks O. Orwar, Langmuir 99, 2002, 11573

35 Formation of multi component vesicle networks O. Orwar, Langmuir 99, 2002, 11573

36 Formation of multi component vesicle networks O. Orwar, Langmuir 99, 2002, 11573

37 3-d Liposome networks attached to SU-8 Resist O. Orwar, Langmuir 20, 2004, 5637

38 Formation of vesicle networks O. Orwar, Langmuir 99, 2002, 11573

39 Knots in nanofluidic vesicle networks O. Orwar, PNAS 101, 2004, 7949

40 Brochard-Wyart, Langmuir 19, 2003, 575

41 Brochard-Wyart, Langmuir 19, 2003, 575

42 Seifert et. Al. PRL, 2004,

43 Maeda, BBA 1564, 2002, 165

44 O. Orwar, Anal. Chem. 75, 2003, 2529

45 Formation of vesicle networks on microstructured surfaces O. Orwar, Langmuir 100, 2003, 3904

46 Generating flow between vesicle networks by changing their shape M. Karlsson, O. Orwar, Annual Reviews Physical Chemistry 55, 2004, 613

47 Diffusion through nanochannels O. Orwar, Anal. Chem. 75, 2003, 2529

48 The concept of vesicle nanofluidic networks M. Karlsson, O. Orwar, Annual Reviews Physical Chemistry 55, 2004, 613

49 Formation of lipid double layer from vesicles SG Boxer, Biophysical Journal, 2002, 83, 3372

50 Mobile microstructured membranes SG Boxer, Langmuir, 2001, 17, 3400

51 Field induced diffusion of lipids SG Boxer, Accounts Chemical Research, 2002, 35, 149

52 Mobile microstructured membranes SG Boxer, Current Opinion Chemical Biology, 2000, 704

53 Membrane Microfluidics SG Boxer, Langmuir, 2003, 19, 1624

54 Membrane Microfluidics SG Boxer, Langmuir, 2003, 19, 1624

55 Dynamics of nanoobjects Motion in ratchets

56 Dynamics of nanoobjects Motion in ratchets

57 Dynamics of nanoobjects Motion in ratchets Bader et. al.appl. Phys. A 75, (2002)

58 Dynamics of nanoobjects Motion in ratchets Bader et. al.appl. Phys. A 75, (2002)

59 Dynamics of nanoobjects Motion in ratchets Bader et. al.appl. Phys. A 75, (2002)

60 Dynamics of nanoobjects Motion in ratchets Gorre-Talini, Spatz, Silberzan Chaos, Vol. 8, No. 3, 1998

61 Dielectric force patterning Fudouzi, Journal of Nanoparticle Research 3: , 2001.

62 Dielectric force patterning Fudouzi, Journal of Nanoparticle Research 3: , 2001.

63 Optical tweezers

64 Optical multitweezers

65 Optical tweezers for multiple particle manipulation

66 Flow behaviour on different scales Turbulent flow Flow on a very large scale

67 Flow behaviour on different scales Laminar flow Small scale

68 Physical effects of small volumes From turbulent to laminar flow Re = vs L / ν = Inertia forces / Viscous forces Re : Reynolds number L vs : mean fluid velocity [m s-1 ] ν : width of channel (pipe) [m] : kinematic fluid viscosity [m2 s-1] Typical Reynolds numbers (Relaminar < < Returbulent) Spermatozoa ~ 1 x 10-2 Blood flow in brain ~ 1 x 102 Blood flow in aorta ~ 1 x 103 Microchannels <1 Person swimming ~ 4 x 106

69 Physical effects of small volumes Parabolic flow profile Laminar and turbulent flow

70 Physical effects of small volumes From turbulent to laminar flow Aqueous solution c0, c1 L 100 nm < L < 100 µm Stationary flow boundary between flowing miscible liquids (water) Concentration gradient c0, c1 causes Mixing through diffusion across the boundary

71 Physical effects of small volumes Increase in specific surface area with decreasing volume R V = 4/3 π R3 S = 4 π R2 Sspecific = S/V = 3 / R Surface interactions and forces become dominating in small dimensions

72 Geometrical features of microfluidic systems

73 Flow induced generation of microemulsion droplets

74 Flow induced generation of microemulsion droplets

75 Rayleigh instability of cylindrical shaped liquid structures

76 Flow induced generation of microemulsion droplets Monodisperse Emulsion Generation via Drop Break Off in a Coflowing Stream P. B. Umbanhowar, V. Prasad, D. A. Weitz Langmuir 16, 347 (2000)

77 Flow induced encapsulation of cells Selective Encapsulation of Single Cells and Subcellular Organelles into Picoliter- and Femtoliter-Volume Droplets Mingyan He, J. Scott Edgar, Gavin D. M. Jeffries, Robert M. Lorenz, J. Patrick Shelby, and Daniel T. Chiu Anal. Chem. 2005, 77,

78 Flow induced generation of complex microphases Monodisperse Double Emulsions Generated from a Microcapillary Device S. Utada, E. Lorenceau, D. R. Link, P. D. Kaplan,H. A. Stone, A. Weitz Science 308, 537 (2005)

79 Flow induced generation of complex microphases Monodisperse Double Emulsions Generated from a Microcapillary Device S. Utada, E. Lorenceau, D. R. Link, P. D. Kaplan,H. A. Stone, A. Weitz Science 308, 537 (2005)

80 Flow induced generation of complex microphases Monodisperse Double Emulsions Generated from a Microcapillary Device S. Utada, E. Lorenceau, D. R. Link, P. D. Kaplan,H. A. Stone, A. Weitz Science 308, 537 (2005)

81 Micro- and nanostructures through self-assembly Guillaume Tresset and Shoji Takeuchi*, Anal. Chem.2005, 77,

82 Cell encapsulatioon in microdroplets Mingyan He, J. Scott Edgar, Gavin D. M. Jeffries, Robert M. Lorenz, J. Patrick Shelby, and Daniel T. Chiu* Anal. Chem.2005, 77,