Supplementary Table 3. Membrane/Signaling/Neural Genes of the DmSP. FBgn CG5265 acetyltransferase amino acid metabolism
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1 Supplementary Table 3 Membrane/Signaling/Neural Genes of the DmSP FlyBase ID Gene Name Molecular function summary Membrane Biological process summary FBgn CG5265 acetyltransferase amino acid metabolism FBgn # activin-beta TGF receptor binding transmembrane receptor FBgn na cation channel adult locomotory behavior FBgn CG7263 oxidoreductase apoptosis FBgn # nompc cytoskeletal protein calcium ion transport FBgn CG13991 peptidase proteolysis/peptidolysis FBgn Porin2 ion channel, porin anion transport FBgn CG31722 voltage-gated ion channel anion transport FBgn # Pkd2 cation channel cation transport; sperm motility FBgn # Lar transmembrane receptor cell surface receptor FBgn CG10396 cytochrome-c oxidase electron transport FBgn # Ca-P60A ATPase calcium ion homeostasis FBgn Adk2 ATP binding ADP biosynthesis FBgn Psa membrane aminopeptidase sugar phosphotransferase FBgn prominin-like unknown intracellular protein transport FBgn CG7514 antiporter alpha-ketoglutarate transport FBgn CG6512 metalloendopeptidase ATP-dependent proteolysis FBgn Cat antioxidant aging; electron transport FBgn Mpcp carrier phosphate metabolism FBgn CoVa cytochrome-c oxidase electron transport
2 FBgn CG6455 unknown unknown FBgn CG17462 transporter DNA replication FBgn CG5527 endothelin-converting enzyme proteolysis/peptidolysis FBgn sesb ADP transport ADP transport FBgn Ant2 ATP:ADP antiporter ADP transport FBgn slam unknown germ cell migration FBgn Vha55 ATP binding ATP biosynthesis Signaling FBgn Pp1-13C amino acid dephosphorylation protein phosphatase type 1 FBgn Galpha49B G-protein signaling pathway signal transducer FBgn CG7115 regulation of cell shape serine/threonine phosphatase FBgn spri intracellular signaling cascade Ras interactor FBgn Rgk1 GTPase signal transduction GTPase FBgn CG9391 intracellular signaling cascade inositol monophosphatase FBgn CG9389 intracellular signaling cascade inositol-1(or 4)-monophosphatase FBgn CG5527 signal transduction endothelin-converting enzyme FBgn # Lar protein tyrosine phosphatase axon guidance; cell adhesion FBgn # gom courtship behavior; learning calcium-mediated signaling FBgn wts G1/S transition serine/threonine kinase FBgn alien cell cycle; development signal transducer FBgn Plkk1 MAPKKK cascade; serine/threonine kinase FBgn heph Notch signaling pathway RNA binding FBgn # activin-beta cell-cell signaling TGF beta receptor binding FBgn CG6180 signal transduction kinase inhibitor
3 FBgn CG33167 G-protein signaling guanyl-nucleotide exchange factor FBgn IMP intracellular signaling cascade inositol-monophosphatase FBgn IMP intracellular signaling cascade inositol-monophosphatase FBgn CG5527 signal transduction zinc ion binding Neural FBgn nompc Ankyrin repeat; cation channel detection of sound FBgn mira asymmetrical protein localization neuroblast cell fate determination FBgn CG33188 receptor binding perception of sound FBgn na Ca2+/Na+ channel adult locomotory behavior FBgn # Lar Cation channel axon guidance FBgn Sod free radical scavenger aging FBgn lola flagellar basal rod protein axon guidance FBgn nemy Ankyrin repeat locomotory behavior FBgn Pkd2 Cation channel larval feeding behavior FBgn # gom Ca2+ binding domain courtship behavior FBgn Pp1-87B serine/threonine phosphatase adult locomotory behavior FBgn ctp axon transport sensory neuron growth FBgn SlgA proline dehydrogenase activity behavioral, locomotor behavior FBgn Act5c sperm individualization expressed in CNS FBgn hts constituent of cytoskeleton expressed in CNS FBgn grn transcription factor activity expressed in CNS FBgn Ets65A transcription factor activity expressed in VNC FBgn DP transcription factor activity expressed in CNS FBgn CG11033 transcription factor activity transmission of nerve impulse
4 FBgn # Ca-P60A calcium-transport expressed in CNS FBgn Glued microtubule motor activity retrograde axon cargo transport FBgn # activin beta growth factor activity dendrite morphogenesis FBgn Galpha49B signal transducer activity perception of taste; visual behavior FBgn sidestep transcriptional repressor activity motor axon guidance # Present in multiple categories
5
Supplemental table S7.
Supplemental table S7. GO terms significantly enriched in significantly up-regulated genes of the microarray. K: number of genes from the input cluster in the given category. F: number of total genes in
GO ID GO term Number of members GO: translation 225 GO: nucleosome 50 GO: calcium ion binding 76 GO: structural
GO ID GO term Number of members GO:0006412 translation 225 GO:0000786 nucleosome 50 GO:0005509 calcium ion binding 76 GO:0003735 structural constituent of ribosome 170 GO:0019861 flagellum 23 GO:0005840
S1 Gene ontology (GO) analysis of the network alignment results
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