GO ID GO term Number of members GO: translation 225 GO: nucleosome 50 GO: calcium ion binding 76 GO: structural

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1 GO ID GO term Number of members GO: translation 225 GO: nucleosome 50 GO: calcium ion binding 76 GO: structural constituent of ribosome 170 GO: flagellum 23 GO: ribosome 167 GO: nucleosome assembly 54 GO: protein serine/threonine phosphatase activity 26 GO: cellular component movement 22 GO: cytosolic large ribosomal subunit 16 GO: plasma membrane 26 GO: chromosome organization 50 GO: proton-transporting two-sector ATPase complex 23 GO: cell cycle 16 GO: structural constituent of cytoskeleton 21 GO: calmodulin binding 16 GO: cellular protein metabolic process 12 GO: heme binding 21 GO: protein dephosphorylation 42 GO: pathogenesis 12 GO: ATP synthesis coupled proton transport 14 GO: metallopeptidase activity 11 GO: ribosome biogenesis 24 GO: threonine-type endopeptidase activity 15 GO: proteasome core complex 15 GO: protein tyrosine kinase activity 150 GO: cysteine-type endopeptidase activity 18 GO: nuclease activity 12 GO: cation transport 18 GO: microtubule-based flagellum 17 GO: intracellular 360 GO: phosphatase activity 29 GO: microtubule cytoskeleton organization 11 GO: aminoacyl-trna ligase activity 24 GO: endoplasmic reticulum 12 GO: ATP binding 577 GO: proton transport 21 GO: ATP metabolic process 13 GO: proteolysis 107 GO: microtubule-based process 70 GO: cell adhesion 14 GO: dephosphorylation 27 GO: adenylate cyclase activity 58 GO: GTP binding 107 GO: cyclic nucleotide biosynthetic process 68 GO: phosphorus-oxygen lyase activity 68 GO: ubiquitin-dependent protein catabolic process 61 GO: protein complex 14 GO: protein polymerization 14 GO: protein transport 56 GO: nucleobase, nucleoside, nucleotide and nucleic acid metabolic pro 39 GO: hydrogen ion transmembrane transporter activity 12 GO: catalytic activity 247 GO: cell redox homeostasis 36 GO: metal ion transmembrane transporter activity 11

2 GO: electron carrier activity 50 GO: metalloendopeptidase activity 28 GO: cell surface 26 GO: ATPase activity 64 GO: DNA binding 207 GO: small GTPase mediated signal transduction 40 GO: membrane 261 GO: microtubule 16 GO: transition metal ion binding 18 GO: signal transduction 45 GO: ATP-binding cassette (ABC) transporter complex 11 GO: microtubule motor activity 77 GO: GTPase activity 58 GO: ATP-dependent helicase activity 49 GO: microtubule associated complex 58 GO: nucleocytoplasmic transport 19 GO: nucleoside transmembrane transporter activity 14 GO: cytoskeleton 14 GO: iron ion binding 30 GO: regulation of cell cycle 14 GO: electron transport 35 GO: exonuclease activity 13 GO: hydrolase activity 81 GO: cytoplasm 181 GO: microtubule-based movement 79 GO: cytosol 15 GO: trna aminoacylation for protein translation 23 GO: protein phosphorylation 178 GO: large ribosomal subunit 12 GO: nucleotide-excision repair 11 GO: flavin adenine dinucleotide binding 20 GO: protein kinase activity 180 GO: cysteine-type peptidase activity 13 GO: protein serine/threonine kinase activity 172 GO: translational elongation 21 GO: nucleotide binding 161 GO: endopeptidase activity 24 GO: nucleotidyltransferase activity 12 GO: chromosome 15 GO: nucleic acid binding 265 GO: biosynthetic process 19 GO: ATPase activity, coupled to transmembrane movement of substan 18 GO: mitochondrial inner membrane 23 GO: translation elongation factor activity 14 GO: protein tyrosine/serine/threonine phosphatase activity 16 GO: DNA-directed DNA polymerase activity 14 GO: one-carbon metabolic process 12 GO: DNA replication 30 GO: iron-sulfur cluster binding 18 GO: structural molecule activity 27 GO: protein folding 124 GO: oxidoreductase activity 130 GO: metabolic process 226 GO: cellular_component 1409 GO: metal ion transport 12 GO: protein binding 372

3 GO: translational initiation 24 GO: metal ion binding 33 GO: acyltransferase activity 19 GO: nucleus 350 GO: glycosome 17 GO: mitochondrion 139 GO: unfolded protein binding 84 GO: cytosolic small ribosomal subunit 19 GO: tricarboxylic acid cycle 11 GO: lipid metabolic process 24 GO: DNA metabolic process 17 GO: damaged DNA binding 14 GO: rrna processing 23 GO: nucleoside-triphosphatase activity 107 GO: peptidyl-prolyl cis-trans isomerase activity 28 GO: RNA binding 187 GO: transferase activity 16 GO: N-acetyltransferase activity 15 GO: translation initiation factor activity 27 GO: glycolysis 25 GO: ubiquitin thiolesterase activity 17 GO: helicase activity 75 GO: RNA splicing 16 GO: RNA processing 94 GO: proteasome regulatory particle 16 GO: cytoskeleton organization 14 GO: motor activity 49 GO: integral to membrane 501 GO: biological_process 964 GO: intracellular protein transport 76 GO: membrane raft 14 GO: NAD binding 13 GO: transport 132 GO: ubiquitin-protein ligase activity 23 GO: transporter activity 27 GO: magnesium ion binding 16 GO: ER to Golgi vesicle-mediated transport 14 GO: GPI anchor biosynthetic process 31 GO: zinc ion binding 281 GO: pyridoxal phosphate binding 13 GO: small ribosomal subunit 14 GO: protein metabolic process 12 GO: DNA repair 48 GO: molecular_function 869 GO: purine ribonucleoside salvage 14 GO: nucleoside metabolic process 13 GO: dynein complex 17 GO: binding 267 GO: heat shock protein binding 75 GO: cell growth 13 GO: small conjugating protein ligase activity 16 GO: cellular metabolic process 11 GO: signal transducer activity 11 GO: Rab GTPase activator activity 14 GO: regulation of Rab GTPase activity 14 GO: calcium-dependent cysteine-type endopeptidase activity 17

4 GO: membrane coat 15 GO: UDP-glycosyltransferase activity 24 GO: regulation of protein metabolic process 15 GO: post-translational protein modification 15 GO: trna processing 17 GO: endonuclease activity 11 GO: pseudouridine synthesis 15 GO: pseudouridine synthase activity 15 GO: DNA recombination 15 GO: acid-amino acid ligase activity 12 GO: nucleolus 13 GO: amino acid transport 44 GO: amine transmembrane transporter activity 42 GO: carbohydrate metabolic process 30 GO: ubiquitin cycle 21 GO: transcription regulator activity 14 GO: DNA helicase activity 11 GO: RNA metabolic process 14 GO: methyltransferase activity 30 GO: vesicle-mediated transport 65 GO: protein transporter activity 17 GO: sequence-specific DNA binding transcription factor activity 16 GO: DNA-directed RNA polymerase activity 37 GO: protein modification process 66

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9 Mean (log2) fold change of GO term group in response to heat shock

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