Self-Evaluation Across Adolescence: A Longitudinal fmri Study. Dani Cosme

Transcription

1 Self-Evaluation Across Adolescence: A Longitudinal fmri Study Dani Cosme

2 Background Adolescence is a formative period for the development of identity and self-concept (Pfeifer & Peake, 2012) Self-referential processing is associated with activity in cortical midline structures (Northoff et al., 2006) Unclear how self-referential processing and the underlying neural networks that support it develop over time 2

3 Developmental Trajectories Linear Increase Early Adolescent Specific Adolescent Emergent 3

4 Study Design 6 year longitudinal fmri study 10 years old 13 years old 16 years old T1 N = females T2 N = females T3 N = females All 3 Ts N = females Included N = females Included participants ages: T1 M = 10.1, SD = 0.35 T2 M = 13.0, SD = 0.32 T3 M = 16.3, SD =

5 Task Design Self-evaluation paradigm 2 x 2 within subjects factorial block design Stimuli presented auditorily SOCIAL ACADEMIC SELF I am popular I make many spelling mistakes HARRY POTTER Harry gets left out at school Harry reads very quickly Rest (21 s) Self (75 s) Rest (21 s) Harry (75 s) Rest (21 s) Self (75 s) Rest (21 s) Harry (75 s) Rest (21 s) 5

6 Data Acquisition & Analysis Siemens 3T Allegra scanner at UCLA Preprocessed & analyzed using SPM 6 Brain extraction, realignment, coregistration, reorientation, normalization to age-appropriate templates, smoothing Participants with excessive motion and/or unsatisfactory preprocessing were excluded Only participants with complete data were included in the analysis Flexible factorial model was used at the RX level Time (T1, T2, T3) x Target (self, other) x Domain (social, academic)

7 Self > Other z = -18 Main effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) right lateral OFC BA 47 t = 3.73, k = t left VS BA 25 t = 4.18, k = 146 right VS BA 25 t = 4.06, k = 90 x = -4 racc / vmpfc (BA 24 / 32 / 10) t = 5.35, k = 888 y = 10 7

8 Self > Other 8

9 Early Adolescent Specific Trends Quadratic effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) t 4 2 x = 2 racc BA 24 / 32 t = 4.31, k = 133 dacc BA 24 t = 3.07, k = 92 Precuneus BA 7 t = 3.70, k = 288 9

10 Early Adolescent Specific Trends Quadratic effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) t 4 2 x = 2 racc BA 24 / 32 t = 4.31, k = 133 dacc BA 24 t = 3.07, k = 92 Precuneus BA 7 t = 3.70, k =

11 Adolescent Emergent Trends Asymptotic effects using ventromedial ROI mask p <.005, k = 37 (AlphaSim corrected FDR p <.05) 3.5 t 1.5 x = 4 racc / mofc BA 24 / 32 / 12 t = 3.72, k = 307 vmpfc BA 10 t = 3.54, k = 65 11

12 Adolescent Emergent Trends Asymptotic effects using ventromedial ROI mask p <.005, k = 37 (AlphaSim corrected FDR p <.05) 3.5 t 1.5 x = 4 racc / mofc BA 24 / 32 / 12 t = 3.72, k = 307 vmpfc BA 10 t = 3.54, k = 65 12

13 Summary 13

14 Future Directions Do these trajectories continue into late adolescence? What are the possible explanations for these developmental trajectories? Deeper processing and integration at T2? Greater variability at T1/T3? Does this represent a shift from subcortical to cortical processing over time? How does pubertal status relate to these trajectories? How do these functional trajectories relate to structural trajectories? What roles do subregions of racc / vmpfc play in supporting self-evaluation? 14

15 15 Friday Poster Session, #P-1-103

16 Thank you! University of Oregon Jennifer Pfeifer Jordan Livingston John Flournoy Will Moore 16 University of California Los Angeles Mirella Dapretto John Mazziotta Matthew Lieberman Carrie Masten

17 17 Additional Slides

18 Self > Other Main effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) racc, vmpfc 18

19 Self > Other Main effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) left VS right VS 19

20 Self > Other Main effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) right lateral OFC 20

21 Self > Other Simple Effects T1 T2 T3 left VS t = 4.19, k = 65 y =? racc, vmpfc x = 0 racc, vmpfc x = 0 *p <.005, k = 65 t = 6.73, k = 710 t = 5.89, k = 378 dacc t = 5.79, k = 101 MCC p <.005, k = t = 7.38, k = 466 Precuneus t = 3.97, k = 103 left VS t = 4.47, k = 206

22 Self > Other x=2 racc precuneus BA 7 t = 3.70, k = 288 x = -10 BA 24 / 32 t = 4.31, k = 133 dacc BA 24 t = 3.07, k = 92 left lat. precuneus t BA 7 t = 3.70, k = 119 Quadratic effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05)

23 Other > Self Main effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) x = -2 x = 2 right PCC (BA 31 / 23) t = 4.33, k = 188 dmpfc (BA 6 / 8) t = 4.16, k = 216 precuneus (BA 7) t = 3.57, k = 100 x = 52 mofc (BA 11) t = 4.41, k = 118 angular gyrus (BA 39) t = 4.23, k = t left anterior temporal cortex (BA 20) t = 4.69, k = 155

24 Other > Self Quadratic effects at the whole-brain level p <.005, k = 76 (AlphaSim corrected FDR p <.05) z = -8 x = 32 left FFG (BA 19/37) t = 4.04, k = 148 right FFG (BA 19/37) t = 4.17, k = 229 right anterior insula (BA 13) t = 3.69, k = t

25 Intraclass Correlations Main Effects % Variation racc 18.9 Left VS 9.1 Right VS 4.2 Right lofc 26.9 Quadratic Effects % Variation racc 23.9 dacc 12.5 Precuneus 47.6 Left PCC 27.2 Asymptotic Effects % Variation racc / mofc 16.1 vmpfc