RS-fMRI analysis in healthy subjects confirms gender based differences

Transcription

1 RS-fMRI analysis in healthy subjects confirms gender based differences Alberto A. Vergani PhD student in Computer Science and Computational Mathematics University of Insubria Department of Theoretical and Applied Science, Varese, Italy Co-authors of the work: E. Binaghi, S. Strocchi and G. Gonella

2 RS-fMRI analysis in healthy subjects confirms gender based differences

3 RS-fMRI analysis in healthy subjects confirms gender based differences RS = Resting State fmri = functiona Magnetic Resonance Imaging

4 RS-fMRI analysis in healthy subjects confirms gender based differences RS = Resting State fmri = functiona Magnetic Resonance Imaging

5 RS-fMRI analysis in healthy subjects confirms gender based differences RS = Resting State fmri = functiona Magnetic Resonance Imaging In vivo and not invasive techinque Measures haemodynamic response to neural activity Intrinsic contrast (BOLD) = Blood Oxigen Level Dependent signal

6 RS-fMRI analysis in healthy subjects confirms gender based differences RS = Resting State fmri = functiona Magnetic Resonance Imaging In vivo and not invasive techinque Measures haemodynamic response to neural activity Intrinsic contrast (BOLD) = Blood Oxigen Level Dependent signal

7 RS-fMRI analysis in healthy subjects confirms gender based differences RS = Resting State

8 RS-fMRI analysis in healthy subjects confirms gender based differences RS = Resting State Functional connectivity research has revealed a number of networks which are consistently found in healthy subjects, different stages of consciousness and across species, and represent specific patterns of synchronous activity (Biswal 2010 and Raichle 2015)

9 Outline Goals, Data and Methods Results (A, B, C) Conclusions, next analysis and their extension Alberto A. Vergani Genova

10 Goals, Data and Methods / goals RS-fMRI data from 1,414 volunteers collected independently at 35 international centers. We demonstrate a universal architecture of positive and negative functional connections, as well as consistent loci of inter-individual variability. Age and sex emerged as significant determinants ( ). (Biswal et al, PNAS, 2010) Alberto A. Vergani (aavergani@uninsubria.it) Genova

11 Goals, Data and Methods / goals RS-fMRI data from 1,414 volunteers collected independently at 35 international centers. We demonstrate a universal architecture of positive and negative functional connections, as well as consistent loci of inter-individual variability. Age and sex emerged as significant determinants ( ). (Biswal et al, PNAS, 2010) Alberto A. Vergani (aavergani@uninsubria.it) Genova

12 Goals, Data and Methods / goals Compute analysis on data collected in a shared RS-fMRI repository, looking how our results match literature. Alberto A. Vergani (aavergani@uninsubria.it) Genova

13 Goals, Data and Methods / data Alberto A. Vergani (aavergani@uninsubria.it) Genova

14 Goals, Data and Methods / data Alberto A. Vergani (aavergani@uninsubria.it) Genova

15 Goals, Data and Methods / data Alberto A. Vergani (aavergani@uninsubria.it) Genova

16 Goals, Data and Methods / data Alberto A. Vergani (aavergani@uninsubria.it) Genova

17 Goals, Data and Methods / methods Alberto A. Vergani (aavergani@uninsubria.it) Genova

18 Goals, Data and Methods / methods Preprocessing / spatial smoothing, temporal filtering, motion correction and standard registration Alberto A. Vergani (aavergani@uninsubria.it) Genova

19 Goals, Data and Methods / methods Preprocessing / spatial smoothing, temporal filtering, motion correction and standard registration Data reduction / extraction of time series based on the ROIs of Harvard-Oxford atlas Alberto A. Vergani (aavergani@uninsubria.it) Genova

20 Goals, Data and Methods / methods Preprocessing / spatial smoothing, temporal filtering, motion correction and standard registration Data reduction / extraction of time series based on the ROIs of Harvard-Oxford atlas Statistics / compute mean and variance of whole brain activation to test difference between gender signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

21 Goals, Data and Methods / methods Preprocessing / spatial smoothing, temporal filtering, motion correction and standard registration Data reduction / extraction of time series based on the ROIs of Harvard-Oxford atlas Statistics / compute mean and variance of whole brain activation to test difference between gender signal Algebra / compute Euclidean metric of exams to test within gender distance Alberto A. Vergani (aavergani@uninsubria.it) Genova

22 Goals, Data and Methods / methods Preprocessing / spatial smoothing, temporal filtering, motion correction and standard registration Data reduction / extraction of time series based on the ROIs of Harvard-Oxford atlas Statistics / compute mean and variance of whole brain activation to test difference between gender signal Algebra / compute Euclidean metric of exams to test within gender distance Functional Connectivity / compute correlation coefficient to investigate Precuneus relations Alberto A. Vergani (aavergani@uninsubria.it) Genova

23 Goals, Data and Methods / methods Preprocessing / spatial smoothing, temporal filtering, motion correction and standard registration Data reduction / extraction of time series based on the ROIs of Harvard-Oxford atlas Statistics / compute mean and variance of whole brain activation to test difference between gender signal Algebra / compute Euclidean metric of exams to test within gender distance Functional Connectivity / compute correlation coefficient to investigate Precuneus relations Alberto A. Vergani (aavergani@uninsubria.it) Genova

24 Outline Goals, Data and Methods Results (A, B, C) Conclusions, Next analysis and their extension Alberto A. Vergani Genova

25 Result A / significant gender differences in BOLD whole brain signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

26 Result A / significant gender differences in BOLD whole brain signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

27 Result A / significant gender differences in BOLD whole brain signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

28 Result A / significant gender differences in BOLD whole brain signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

29 Result A / significant gender differences in BOLD whole brain signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

30 Result A / significant gender differences in BOLD whole brain signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

31 Result A / significant gender differences in BOLD whole brain signal Alberto A. Vergani (aavergani@uninsubria.it) Genova

32 Result B / greater distance within males than females Alberto A. Vergani (aavergani@uninsubria.it) Genova

33 Result B / greater distance within males than females Alberto A. Vergani (aavergani@uninsubria.it) Genova

34 Result B / greater distance within males than females Alberto A. Vergani (aavergani@uninsubria.it) Genova

35 Result B / greater distance within males than females Alberto A. Vergani (aavergani@uninsubria.it) Genova

36 Result B / greater distance within males than females Alberto A. Vergani (aavergani@uninsubria.it) Genova

37 Result B / greater distance within males than females Alberto A. Vergani (aavergani@uninsubria.it) Genova

38 Result C / functional connectivity of Precuneus in the DMN. Alberto A. Vergani (aavergani@uninsubria.it) Genova

39 Result C / functional connectivity of Precuneus in the DMN. Alberto A. Vergani (aavergani@uninsubria.it) Genova

40 Result C / functional connectivity of Precuneus in the DMN. Alberto A. Vergani (aavergani@uninsubria.it) Genova

41 Result C / functional connectivity of Precuneus in the DMN. FEMALE LEFT PRECUNEUS ROIs LABELS Left Precuneous Cortex Right Precuneous Cortex Left Cingulate Gyrus, posterior division Right Cingulate Gyrus, posterior division FEMALE RIGHT PRECUNEUS ROIs LABELS Right Precuneous Cortex Left Precuneous Cortex Right Cingulate Gyrus, posterior division Left Cingulate Gyrus, posterior division Alberto A. Vergani (aavergani@uninsubria.it) Genova

42 Result C / functional connectivity of Precuneus in the DMN. FEMALE LEFT PRECUNEUS ROIs LABELS Left Precuneous Cortex Right Precuneous Cortex Left Cingulate Gyrus, posterior division Right Cingulate Gyrus, posterior division FEMALE RIGHT PRECUNEUS ROIs LABELS Right Precuneous Cortex Left Precuneous Cortex Right Cingulate Gyrus, posterior division Left Cingulate Gyrus, posterior division MALE LEFT PRECUNEUS ROIs LABELS Left Precuneous Cortex Right Precuneous Cortex Left Cingulate Gyrus, posterior division Right Cingulate Gyrus, posterior division MALE RIGHT PRECUNEUS ROIs LABELS Right Precuneous Cortex Left Precuneous Cortex Right Cingulate Gyrus, posterior division Left Cingulate Gyrus, posterior division Alberto A. Vergani (aavergani@uninsubria.it) Genova

43 Outline Goals, Data and Methods Results (A, B, C) Conclusions, Next analysis and their extension Alberto A. Vergani Genova

44 Conclusions, next analysis and their extension Alberto A. Vergani Genova

45 Conclusions, next analysis and their extension A / Dynamics. There are significant differences in the mean and in the variance among males and females functional time series (BOLD signal). B / Patterns. The distance within males is greater than in the females. C / Connectivity. Precuneus has the higher correlations (CC > 0.80) with its controlateral part and with the posterior division of cingulate gyrus. Next analysis / clustering of time series and subcortical analysis Extension / using other datasets belongs to NITRC repository Thank you ;-) Alberto A. Vergani (aavergani@uninsubria.it) Genova

46 Conclusions, next analysis and their extension A / Dynamics. There are significant differences in the mean and in the variance among males and females functional time series (BOLD signal). B / Patterns. The distance within males is greater than in the females. C / Connectivity. Precuneus has the higher correlations (CC > 0.80) with its controlateral part and with the posterior division of cingulate gyrus. Next analysis / clustering of time series and subcortical analysis Extension / using other datasets belongs to NITRC repository Thank you ;-) Alberto A. Vergani (aavergani@uninsubria.it) Genova

47 Conclusions, next analysis and their extension A / Dynamics. There are significant differences in the mean and in the variance among males and females functional time series (BOLD signal). B / Patterns. The distance within males is greater than in the females. C / Connectivity. Precuneus has the higher correlations (CC > 0.80) with its controlateral part and with the posterior division of cingulate gyrus. Next analysis / clustering of time series and subcortical analysis Extension / using other datasets belongs to NITRC repository Thank you ;-) Alberto A. Vergani (aavergani@uninsubria.it) Genova

48 Conclusions, next analysis and their extension A / Dynamics. There are significant differences in the mean and in the variance among males and females functional time series (BOLD signal) B / Patterns. The distance within males is greater than in the females. C / Connectivity. Precuneus has the higher correlations (CC > 0.80) with its controlateral part and with the posterior division of cingulate gyrus. Next analysis / clustering of time series and subcortical analysis Extension / using other datasets belongs to NITRC repository Thank you ;-) Alberto A. Vergani (aavergani@uninsubria.it) Genova

49 Conclusions, next analysis and their extension A / Dynamics. There are significant differences in the mean and in the variance among males and females functional time series (BOLD signal) B / Patterns. The distance within males is greater than in the females. C / Connectivity. Precuneus has the higher correlations (CC > 0.80) with its controlateral part and with the posterior division of cingulate gyrus. Next analysis / clustering of time series and subcortical analysis Extension / using other datasets belongs to NITRC repository Thank you ;-) Alberto A. Vergani (aavergani@uninsubria.it) Genova

50 Conclusions, next analysis and their extension A / Dynamics. There are significant differences in the mean and in the variance among males and females functional time series (BOLD signal) B / Patterns. The distance within males is greater than in the females. C / Connectivity. Precuneus has the higher correlations (CC > 0.80) with its controlateral part and with the posterior division of cingulate gyrus. Next analysis / clustering of time series and subcortical analysis Extension / using other datasets belongs to NITRC repository Thank you ;-) Alberto A. Vergani (aavergani@uninsubria.it) Genova