腦網路連結分析 A Course of MRI
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1 本週課程內容 腦網路連結 (connectivity & network) 結構性與功能性連結關係 (structural/functional connectivity) 腦網路連結分析 A Course of MRI 盧家鋒助理教授國立陽明大學物理治療暨輔助科技學系 alvin01@ym.edu.tw 複雜網路 : 圖學理論 (graph theory) Brain networks Larger brains have more synapses per neuron. Allometric scaling laws Larger organisms have larger brains. Larger brains have disproportionately more white matter than grey matter. 腦網路連結 Brain connectivity & networks Larger brains are metabolically More expensive. Bullmore et al., Nature Reviews Neuroscience, 1: -9, 01.
2 Human brain networks Wiring costs efficiency Clusters of lattice-like short-distance connections between spatially neighboring nodes Nodes aggregated topologically and anatomically as modules minimize wiring cost Topologically direct interconnections between spatially remote brain regions increase efficiency of information processing Cortical folding and connectivity The Tension-based Theory of Cortical Morphogenesis Tension-based folding Pathways should mainly connect brain regions within cortical gyri rather than across sulci. Denser pathways should exhibit white-matter trajectories that are straighter than those of less-dense pathways. Variations in connectivity should become expressed in variations of gyrification or of the placement of gyri and sulci across the cortical surface. Bullmore et al., Nature Reviews Neuroscience, 1: -9, 01. Bullmore et al., Nature Reviews Neuroscience, 1: -9, 01. DC Van Essen, Nature, 8: 1-18, 199. Structural connectivity Invasive tracer methods (for nonhuman species) Tracing of axonal projections with transneuronal tracers Effective tracers require antemortem injections Non-invasive methods Significant correlations in cortical thickness Diffusion MRI and tractography Cortical thickness correlations The possible biological nature the size, density and arrangement of cells (neurons and glial cells) the mutually trophic influences the contribution of heredity common experience-related plasticity Inter-correlated regions may be a part of functional, neuroanatomically interconnected systems. in macaque N Ramnani, Nature Reviews Neuroscience, : 11-, 00. Lerch et al., Neuroimage, 1: , 00. He et al., Cereb Cortex, 1: 0-19, 00. 8
3 Diffusion MR tractography Nodes: brain regions AAL, CMA, Brodmann Edges: fiber connections DSI, DTI Network = nodes + edges Functional connectivity Statistical dependence (correlations, coherence, ICA, ) Functional MRI Correlations in inter-regional BOLD signal Magnetoencephalogram (MEG) Electroencephalogram (EEG) Hagmann et al., Plos Biology, (): e19, Resting-state networks (RSN) (Biswal, 199, 199) "Our brain is never idle even when we are at rest." Spontaneous fluctuation patterns of cortical regions Without task-specific bias, correlates with task performance Resting-state networks Martijn et al., Europ Neuropsychopharmacology, 0: 19-, Martijn et al., Europ Neuropsychopharmacology, 0: 19-,
4 Default mode network (DMN) Motor networks using group-ica Right wrist flexion Right ankle dorsiflexion Including brain regions Posterior cingulate cortex (PCC) Precuneus Inferior parietal cortex (IPC) Dorsal and ventral areas of the medial prefrontal cortex (MPFC) Medial temporal lobe (MTL) Functions Internally mental processes Deactivation during tasking Harrison et al., PNAS, 10(8): , 008. Greicius et al., Cereb Cortex, 19: -8, Chiou et al., Clin Neurophy., 1: 1-1, Structural vs. functional connectivity The structural fiber connectivity is the basis of the synchronization of neuronal activity between anatomically separated brain regions. 結構性與功能性連結關係 structural/functional connectivity The functional connectivity between RSN regions suggests the existence of direct anatomical pathways between these brain areas to facilitate this high level of ongoing interregional communication during rest. 1 Van den Heuvel. Human Brain Mapping, 0(10): 1-11,
5 Anatomical pathways of DMN Anatomical pathways of RSN The seed ROIs are selected based on the functional DMN. Superior frontal-occipital fasiculus (19/) Superior parietal fasiculus (Lt. 1/, Rt. /) Corpus callosum tracts (/) cingulum tract (/) Van den Heuvel. Human Brain Mapping, 0(10): 1-11, Van den Heuvel. Human Brain Mapping, 0(10): 1-11, Anatomical pathways of RSN bilateral MPFC and posterior precuneus Corpus callosum tracts (1/) Connectivity of thalamocortical system Structural DTI versus resting-state fmri (Lt. 1/, Rt. 10/) ACC-insula Corpus callosum tracts (/) Van den Heuvel. Human Brain Mapping, 0(10): 1-11, Zhang et al., Cereb Cortex, 0: ,
6 Imaging results versus histology Motor/premotor Cortex (VL, VLP) Prefrontal Cortex (MB, VA) Structural Connectivity of insula Temporal cortex (MGN) Parietal/occipital Cortex Somatosensory cortex (anterior pulvinar) (lateral pulvinar) Zhang et al., Cereb Cortex, 0: , Lu et al., 01 OHBM. Evidences from corpus callosotomy Loss of resting interhemispheric functional connectivity <Right> Frontal eye field Lateral parietal <Right> hippocampus somatomotor Brain networks Greater than the sum of its parts: combining structural and functional connectivity. Seed PRE POST V1 Seed PRE POST Johnston et al., J Neruosci, 8(): -8, 008. Olaf Sporns. Ann NY Acad Sci 1:109-1, 011.
7 Phase I (010 - mid-01): Hardware, Analysis method, Platform Phase II (mid-01-01): Data acquisition, Free database 複雜網路 : 圖學理論 Complex networks: Graph theory Complex networks Brain have a small-world architecture. High local clustering Low separation Emergence of shortcuts & hubs high signal-propagation speed, computational power, and synchronizability Watts DJ, Strogatz SH, Nature 9:0-, Local segregation Global integration Complex networks Social network WWW internet Biological system Brain network Network construction Nodes Cortical regions Edges Cortical thickness correlations Fiber connections Functional connectivity 8
8 Graph theory: topological properties Local (each node) 8 Global (average over all nodes) Salvador et al, Philos Trans R Soc Lond B Biol Sci, 0, 9-9, 00 degree (the number of neighbors) e.g. degree of node 9 = strength (the connected fiber number*fa) e.g. strength of node 9 = ( )/ =. clustering coefficient (the connection between neighbors, [0~1]) e.g. clustering coefficient of node 9 = / = 0.8 path length (separation) (the minimal steps for connection) e.g. path length from node 9 to node = steps (9 8 ) 9 Network properties The topological observations can reveal a "hidden" or "highlevel" relations between nodes Network hubs The hub can be defined as the brain regions with high nodal efficiency (larger than mean + std). MSA-C The dominant cerebellar atrophy can cause the alteration of whole-brain effeciency. Network properties correlate with ataxia score in MSA-C. strength degree efficient Lo et al.. J NeuroSci, 0(0):18-188, Lu et al., Movement Disord, 8():-9, 01.
9 Modular structure of brain Functional brain networks develop from a local to distributed organization The modular organization is a possible partition of a network. Modularity, Q Q is high low m : the total number of edges C : the modules of the partition P Module 1 Module Densely connected groups of nodes in a module Sparser connections between modules Newman MEJ. Proceedings of the National Academy of Sciences 10: 8-88, 00. Video S1 Fair et al.. Plos Comput Biology, ():e100081, 009. THE END alvin01@ym.edu.tw
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