MediNet. NA05-MediNet. Detector Instrumentation for Radiation Therapy ( groups; P. Thirolf / LMU) Nuclear Tools for Ion Beam Therapy

Transcription

1 NA05-MediNet Detector Instrumentation for Radiation Therapy ( groups; P. Thirolf / LMU) R&D on improved detection techniques (particles/photons/ electronics) provide training ground for young researchers: exchange program Nuclear Tools for Ion Beam Therapy ( groups; G. Magrin / MedAustron) Radiation quality in Ion Beam Therapy Biological assessments Monte Carlo GEANT4 simulation coordinate experimental efforts 1

2 MediNet Participants Task 1 sites Task 2 sites 2

3 Contractual Activities - MS5.1: Kickoff-Meeting: LMU Munich, May 18/19, MS5.2: Website: - MS5.3: Midterm Meeting Vinča Institute, Belgrade, March 12-14, 2018 Deliverables: D5.1: Report (Nov. 2016, 31 pages): Specific need and proposed solutions of nuclear tools for medicine D5.2: Report (Nov. 2017, 39 pages): 3 Clarifying and adapting nuclear concepts to the medical field

4 Network Activities MediNet Events : - Workshop on In-Vivo Dosimetry (Munich, May 19/20, 2016) 4 - Discussion Seminar: Legnaro, Jan , 2017 Challenges and prospective of the assessment of radiation quality in ion-beam therapy - IV International GEANT4 School (Oct , 2016, Belgrade) - V International GEANT4 School (Oct , 2017, Catania) - XV Seminar on Software for Nuclear, Subnuclear and Applied Physics, May 27 June 1, Alghero/Italy Outreach Activities: conference contributions - ENLIGHT annual meeting (Utrecht, Sept., 2016): MediNet, the detector-oriented network of ENSAR2 for ion beam therapy - 1 st ESTRO Physics Workshop on Micro- and Nanodosimetry for Radiotherapy (Glasgow Nov. 2017) Experimental microdosimetry in MediNet

5 Network Activities New recent tools for networking: MediNet on 5 #MediNet - advertise events (MediNet meetings and related training opportunities for the benefit of MediNet members and others, complementing the website) - advertise PhD, postdoc and fellowship positions: stay up to date with open positions in MediNet MediNet network will benefit from more applications - promote MediNet activities and collaborations: e.g. publicly show MediNet networking activities (pictures of MediNet meetings, MediNet members giving seminars in other MediNet institutions and pictures of experimental campaigns related to MediNet) - increase the visibility of MediNet members Slack workspace: forum/chat for MediNet members messaging app: allows to chat, upload and share files new members can see the entire chat history: easy catch up for new members informal forum for discussions and questions

6 Science in MediNet Research on: Detector Instrumentation for Radiation Therapy 6

7 Science in MediNet Key issue in particle tumour therapy: - localization of Bragg peak within patient/sample range verification of therapeutic proton (or ion) beam Compton camera p, C Various approaches: - prompt photons (spectroscopy, imaging, timing) - (secondary) charged particles - ultrasound (thermal shock) signals 7

8 Compton Camera for Hadron Therapy Treatment Monitoring IRIS group at IFIC-Valencia (G. Llosá et al.) 3 planes: 2x scattering + absorber: LaBr 3 + SiPM arrays 2 nd generation prototype: new SiPMs + new image reconstruction algorithm => improved performance first beam tests at KVI-CART: 22 Na array of 37 point-like sources of 1 mm diameter separated by 10 mm: central resolution: 1.2 mm FWHM 8

9 LMU: Compton camera for Prompt-Gamma Imaging γ origin Compton arc E γ 1-2 MeV Scatterer/Tracker e - Scatterer: Absorber: R&D status: 9 electron tracking scatter detectors absorber detector γ Absorber S. Aldawood et al., Frontiers in Oncology 5, 270 (2015), S. Aldawood et al., Radiat. Phys. & Chem. (2016), Counts / 8 kev p + H 2 O: 12 C* E γ : MeV 16 O* E γ [kev] 6x DSSSD: - spatial resolution of monolithic scintillator reaches design spec. - characterized at clinical proton beam (OncoRay Dresden) - signal processing/daq upgrade: higher rates (~1Mcps) 50 x 50 mm mm thick 128 strips/side Energy [MeV] PMT LaBr 3 LaBr 3 scintillator: 50x50x30 mm 3. multi-anode PMT (16x16=3x3 mm 2 Spatial res. CAP [mm] (1) (2) (1) P.G. Thirolf et al, EPJ Web of Conf. 117, (2016)

10 Gamma detectors for ion beam therapy monitoring in France CLaRyS = Contrôle en Ligne de l hadronthérapie par Rayonnements Secondaires Online ion beam therapy monitoring by secondary radiation Collaboration of 4 institutions -> IPNL (Lyon), LPSC (Grenoble), CPPM (Marseille), CREATIS (Lyon) Development of two gamma cameras: 1. Multi-slit collimated camera 2. Compton camera 3. beam tagging hodoscope: also being developed for ToF measurements -Double-sided silicon strip det. - tungsten collimator - BGO absorber Polystyrene scintillating fibers + optical fibers + multi-anode PMTs Beam Detector components characterization ongoing: First online hodoscope tests performed Collimated camera online test: Sept Compton camera online test: 2019 PG Collimator 6 Absorber (E,x,y,t a )

11 CLaRyS Compton Camera Prototype 11

12 CLaRyS collaboration: TOF- prompt secondary radiation detection idea: use large area polycrystalline diamond as a beam hodoscope first tests: timing resolution < 100 ps for protons and carbon ions first demonstrator : strip detector Large area Diamond Detectors for fast beam tagging applications in particle therapy next steps: - integrated electronic readout - assembly of detector mosaic 1 cm 2 double-sided strip detector 12

13 In-vivo Dosimetry at OncoRay/HZDR (Dresden) Agenda - Proton range verification by means of Prompt Gamma-Ray Timing (PGT) ( t < 1ns) - Proof of Principle clinical application in proton Pencil-Beam-Scanning treatments Methodology - High-throughput spectroscopy with CeBr 3 scintillator + PMT - compact, commercial electronics Problems to be solved - load-leap effects on gain and timing of PMT - Proton bunch monitoring to correct for RF-bunch phase shifts - collecting sufficient statistics per PBS spot (<10 ms) 13 Golnik C et al, Phys Med Biol 59 (2014) Hueso González F et al, Phys Med Biol 60 (2015) Petzoldt J et al., Phys Med Biol 61 (2016) Pausch G et al., IEEE Trans Nucl Sci 63 (2016) Werner T et al., paper presented at PTCOG 56 (2017) WE ARE ON THE WAY TO THE CLINICS!

14 Detectors for Particle Therapy at INFN and U Pisa Range monitoring in particle therapy: - INSIDE in-beam PET system (LFS scintillators + SiPM, 5120 ch.) - clinical tests at CNAO treatment center (Pavia/Italy) Fragmentation studies of radiobiological interest in particle therapy: secondary recoil fragments dose outside tumor - FOOT experiment: FragmentiOn Of Target - development of TOF detector t of TOF detect.: ~ MeV PET images of a patient affected by lacrimal gland carcinoma acquired at CNAO with the INSIDE In-beam PET 14 M.G. Bisogni, A. Del Guerra et al.

15 NA05- MediNet NA 15

16 Task 2 Work Packages Monte Carlo Studies Radiobiology Compatibilities Detectors 16

17 Task 2 Work Packages Clermont INFN Catania Vinca Monte Carlo Studies Radiobiology Compatibilities Detectors 16

18 Task 2 Work Packages Clermont INFN Catania Vinča Monte Carlo Studies AIT U Sevilla SCK CEN Radiobiology Compatibilities Detectors 16

19 Task 2 - Monte Carlo studies New hadronic low-energy models Monte Carlo simulation of the irradiation facilities (LNS-INFN in Catania, TIFPA in Trento) Target fragmentation and contribution to hypoxic tumours; Dose/LET/RBE 3D maps; In-vitro and in-vivo irradiation studies, MC models the preclinical set-up. Biological addressed treatment planning A key factor of this studies is the possibility to introduce inside the GEANT4 environment the real geometry and the material composition of targets. As a consequence, it is possible to perform more precise dosimetric assessments. 17

20 Universidad de Sevilla (Spain) Extension of Geant4-DNA s Upper Energy Limit for Proton EM Transport Participants (Seville): A. D. Domínguez-Muñoz, M. A. Cortés-Giraldo & M. I. Gallardo Collaborators (Geant4-DNA): S. Incerti (CENBG/IN2P3) & Z. Francis (St. Joseph Univ. Beirut) Aim: To cover proton EM transport for the entire energy range of interest in proton therapy Current limit is 100 MeV, which roughly covers the last 7 cm (water) of a clinical proton beam. Our goal is to move this limit up to 250 MeV, or higher, in order to carry out microscopic calculations for any clinical proton beam at any depth. Currently working on modeling ionization process in liquid water: Doubly differential cross sections five occupied water orbitals Dielectric formalism + Relativistic Kinematics Dielectric response function (ε) Energy-loss function (η 2 ). To be validated upon stopping power data 18

21 Task 2 - Radiobiology Vinča Institute of Nuclear Sciences within MediNet Joint activities with INFN LNS concern: 1. Research of cellular DNA damage response induced by ionizing radiation ( 1 H and 12 C), 2. Effects of primary and secondary particles ( 4 He) issued from nuclear fragmentation of carbon ions, 3. Study of plant-derived compounds for their potential therapeutic use as radioprotectors / radio-sensitizers. Joint activities with CNBG, CNRS / IN2P3 / Universite de Bordeaux concern: 1. Contribution to further development of GEANT4-DNA tool regarding early radiation effects, i.e., evaluation of DNA double strand breaks (DSB), 2. Comparison of the number of DNA DSB obtained experimentally by cell irradiations in vitro and by numerical simulations using GEANT4-DNA tool. 19 Vinča Institute of Nuclear sciences, University of Belgrade

22 Instutute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland Task 2 - Detectors Innovative diamond detectors for proton therapy Fig. 1. Exemplary signals by 70 MeV protons at 100 um sccvd diamond, registered by the oscilloscope during measurements. *M. Rydygier, M. Jastrząb, D. Krzempek, T. Nowak, L. Grzanka, P. Bednarczyk, L. Stolarczyk;Radiotherapy proton beam profile measurements using sccvd diamond detectors in a single particle mode; Fig MeV proton beam profiles (grey line) measured with scintilation Lynx detector(1 100%) and Mg Cu P-N TLD detectors at low-intensity regions (<1%). The sccvdd profile (black dots) represents a profile measured with CVD diamond detector. 20 New sccvd diamond detector allowed to determine the profile of proton pencil beam for intensities ranging by 8 orders of magnitude

23 MediNet 21

24 Proton range verification at GFN-UCM PG detector based on FATIMA technology Contrast agents for PET proton range verification Protoacoustic dose reconstruction 22