Prof. Federico Bordi
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1 Prof. Federico Bordi
2 Dept of Physics
3 current research activities in applied physics : a brief outline Federico Bordi federico.bordi@uniroma1.it federico.bordi@roma1.infn.it
4 A long history made short the natural heir of the tradition of the Institute of Physics where P. Blaserna, the first president of the Italian Physical Society, was appointed director in 1872 and in 1926 Enrico Fermi was called to hold the first Chair of Theoretical Physics 5/24/16 Research in applied physics Pagina 101
5 A long history made short the natural heir of the tradition of the Institute of Physics, where P. Blaserna, the first president of the Italian Physical Society, was appointed director in 1872 and in 1926 Enrico Fermi was called to hold the first Chair of Theoretical Physics Today... an intense research activity in all the major areas of Physics: Particle Physics, Physics of Matter, Astrophysics and Cosmology, Theoretical Physics, Biophysics, Geophysics Mathematical and Statistical Physics, and applied Physics : to Cultural Heritage, Medicine, Biotechnology, Material Science and Nanotechnology hos.ng research facili.es of the major Italian research ins.tu.ons, the Na.onal Ins.tute of Nuclear Physics (INFN) and the Consiglio Nazionale delle Ricerche (CNR), appoximately 300 researchers are ac+ve in our department, including the professors at the Sapienza University. 5/24/16 Research in applied physics Pagina 102
![Graphene flakes as poten+al electrodes for Libased ba]eries adsorb much more Lithium ions (Li:C = 1:2) than graphite (Li:C = 1:6)](/docs-images/96/128247870/images/6-1.jpg "Nano-porous graphene, a 3D form of graphene for charge accumula+on LOTUS lab.")
6 Graphene flakes as poten+al electrodes for Libased ba]eries adsorb much more Lithium ions (Li:C = 1:2) than graphite (Li:C = 1:6) Nano-porous graphene, a 3D form of graphene for charge accumula+on LOTUS lab. (interfaces and nanostructures) Maria Grazia BETTI and Carlo MARIANI hvp://server2.phys.uniroma1.it/gr/lotus/index.htm Graphene-based materials for energy and technology Graphene single-sheet as decoupling layer inducing increased magne+c anisotropy of an organometallic molecule (FePc) Nano Letters 14, 4901 (2014) J. Phys. Chem. Letters 6, 1690 (2015)
7 Radio-guided surgery with β-radiation Applied Radiation Physics (ARP) Group Riccardo FACCINI hvp://arpg-serv.ing2.uniroma1.it/arpg-site/ usually long range γ-emi]er are used -> (140keV photon: 8 cm in tissues) Exposure of medical personnel Background from surrounding (healthy ) +ssues 5/24/16 Research in applied physics Pagina 104
8 Applied Radiation Physics (ARP) Group Riccardo FACCINI hvp://arpg-serv.ing2.uniroma1.it/arpg-site/ Radio-guided surgery with β-radiation using short range β-tracer -> (1 MeV photon: 5 mm in tissues) Reduced dose to medical staff Reduced background Smaller administered ac<vity more Compact detectors SCIENTIFIC REPORTS 4, 4401 (2014) 5/24/16 Research in applied physics Pagina 105
9 Applied Radiation Physics (ARP) Group Riccardo FACCINI hvp://arpg-serv.ing2.uniroma1.it/arpg-site/ Radio-guided surgery with β-radiation using short range β-tracer -> (1 MeV photon: 5 mm in tissues) scin.lla.ng crystal + light sensor (SiPM) SCIENTIFIC REPORTS 4, 4401 (2014) 5/24/16 Research in applied physics Pagina 106
10 PhOBiA lab. (Physics of Bio-Assemblies) Federico BORDI and Paolo POSTORINO hvp://server2.phys.uniroma1.it/gr/phobia/index.html Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics a current challenge in early cancer diagnosis is the capability of revealing the presence of few cancer cells on small biological samples
11 PhOBiA lab. (Physics of Bio-Assemblies) Federico BORDI and Paolo POSTORINO hvp://server2.phys.uniroma1.it/gr/phobia/index.html Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics a current challenge in early cancer diagnosis is the capability of revealing the presence of few cancer cells on small biological samples SERS effect based on the localized plasmon resonance in metallic nanostructures increases the intensity of Raman emission of molecules close to the nanopar+cle surface by several orders of magnitude
12 PhOBiA lab. (Physics of Bio-Assemblies) Federico BORDI and Paolo POSTORINO hvp://server2.phys.uniroma1.it/gr/phobia/index.html Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics a current challenge in early cancer diagnosis is the capability of revealing the presence of few cancer cells on small biological samples gold nano-par+cles (AuNp) conjugated with folic acid (FA) are used to SERS-reveal FA receptors that are over-expressed by the rapidly dividing cancer cells (FA is required in DNA synthesis process)
13 PhOBiA lab. (Physics of Bio-Assemblies) Federico BORDI and Paolo POSTORINO hvp://server2.phys.uniroma1.it/gr/phobia/index.html Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics a current challenge in early cancer diagnosis is the capability of revealing the presence of few cancer cells on small biological samples healthy and cancer cells can be dis+nguished by using the (substrate normalized) integrated intensity of the nanovectorspecific SERS band (1580 cm-1), based on the different expression of FOLIC ACID receptors BIOMATERIALS 2016, submived
14 PhOBiA lab. (Physics of Bio-Assemblies) Fabio DOMENICI, Gaio PARADOSSI and Federico BORDI hvp://server2.phys.uniroma1.it/gr/phobia/index.html Complex NANO-particles for theranostics selec+vely targeted thermoresponsive nanogels : a temperature driven shrinking releases the drug cargo (DOXORUBICIN) double shelled (lipid and crosslinked polymer) decafluoropentane (DFP) droplets for enhanced ultrasound contrast Biomacromolecules 16, 1753 (2015) Phys.Chem.Chem.Phys. 18, 8378 (2016)
15 ... and much more NMR diffusion of water for diagnostics NMR lab Silvia CAPUANI hvp://lab-g1.phys.uniroma1.it/ molecular dynamics of proteins Alexander TENENBAUM
16 ... many ac+vi+es Federico BORDI my contacts AM PV G/ i Pla M VA np Bs Bs a) d) c) b)
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