Positron Emission Tomography based on Resistive Plate Chambers

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Bathsheba Holland
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Marques, Paulo Fonte LIP and University of Coimbra

1 Positron Emission Tomography based on Resistive Plate Chambers Paulo Crespo, Alberto Blanco, Miguel Couceiro, Nuno C. Ferreira, Luís Lopes, Paulo Martins, Rui Ferreira Marques, Paulo Fonte LIP and University of Coimbra SYMPOSIUM ON APPLIED NUCLEAR PHYSICS AND INNOVATIVE TECHNOLOGIES, June 4, 2013

2 1 resistive plate chambers s Implemetation & 2 : preclinical tomography 3 single-bed whole-body 4 P. Crespo et al. 2 / 26

3 1. resistive plate chambers s What are resistive plate chambers? Initially developed for high energy physics (HEP). Single-gap streamer-mode RPC used by the BABAR experiment: Fonte IEEE TNS 2002 P. Crespo et al. 3 / 26

4 s 1. resistive plate chambers What are resistive plate chambers? Initially developed for high energy physics (HEP). Double-gap used by the L3 and Belle exps.: Fonte IEEE TNS 2002 P. Crespo et al. 4 / 26

5 s 1. resistive plate chambers What are resistive plate chambers? Initially developed for high energy physics (HEP). Multigap RPC first proposed by Cerron Zeballos et al NIMA 1996: Fonte IEEE TNS 2002 P. Crespo et al. 5 / 26

6 s 1. resistive plate chambers Converter plate principle Detecting electromagnetic irradiation (mostly γ-rays): Neves MSc 2008 Blanco et al NIMA 2009 P. Crespo et al. 6 / 26

7 s 1. resistive plate chambers Coincidence time resolution Experimental time resolution obtained between two RPC detectors with 6 gaps each (Gouvêa MSc 2007) P. Crespo et al. 7 / 26

8 2. : preclinical State-of-the-art small-animal PET: Technique experiences worldwide exponential growth supported e.g. by pharmaceutical industry and biomedical, fundamental science. Raytest, Germany Inveon DPET, Siemens Coming soon: arpcpet, LIP, Portugal P. Crespo et al. 8 / 26

2. : preclinical State-of-the-art small-animal PET: Technique experiences worldwide exponential growth supported e.g. by pharmaceutical industry and biomedical, fundamental science.

9 2. : preclinical State-of-the-art small-animal PET: Technique experiences worldwide exponential growth supported e.g. by pharmaceutical industry and biomedical, fundamental science. From Athinoula Martinos Center for Biomedical Imaging FHBG = fluoro-hydroxymetil-butil-guanine. HSV-1 = Herpes simplex virus-1. FDG = fluoro-desoxyglucose. FLT = desoxyfluorothymidine. P. Crespo et al. 9 / 26

10 2. : preclinical : LIP proposes innovative preclinical, small-animal (e.g. Blanco et al. TNS 2006) based on knowledge acquired from its developments within high energy physics projects. P. Crespo et al. 10 / 26

11 2. : pre-clinical Implementation: ongoing experimental surpass the spatial resolution of the state of the art for animal PET Imaging a disk-shaped radioactive source: sub-millimetric resolution achieved Martins et al 2012 IEEE NSS/MIC P. Crespo et al. 11 / 26

needle-like radioactive source: sub-millimetric resolution achieved

12 2. : pre-clinical Implementation: ongoing experimental surpass the spatial resolution of the state of the art for animal PET Imaging a needle-like radioactive source: sub-millimetric resolution achieved Martins et al 2013 IEEE NSS/MIC, submitted P. Crespo et al. 12 / 26

13 2. : pre-clinical Implementation: ongoing experimental surpass the spatial resolution of the state of the art for animal PET Imaging a needle-like radioactive source: sub-millimetric resolution achieved Martins et al 2013 IEEE NSS/MIC, submitted P. Crespo et al. 13 / 26

14 2. : pre-clinical Implementation: ongoing experimental surpass the spatial resolution of the state of the art for animal PET Imaging a needle-like radioactive source: sub-millimetric resolution achieved Martins et al 2013 IEEE NSS/MIC, submitted P. Crespo et al. 14 / 26

3. single-bed whole-body is based on state-of-the-art of PET (positron emission tomography): Technique experiences growing utilization in nuclear medicine, e.g. for diagnostic/screening/staging of oncologic, neurologic, and cardiac disease.

15 3. single-bed whole-body is based on state-of-the-art of PET (positron emission tomography): Technique experiences growing utilization in nuclear medicine, e.g. for diagnostic/screening/staging of oncologic, neurologic, and cardiac disease. E.g. Palmisano et al. Saudi J Gastroenterol 2011 F, 64 a., symptoms: palpable supracavicular, ganglionic adenopathies, asthenia, anorexia. PET-based diagnostic: adenocarcinoma of the ascendent colon. P. Crespo et al. 15 / 26

16 3. single-bed whole-body : PET technology is extremely costly (millions of e); patient examinations are equally costly (ca e), lengthy in time, morphologically imprecise, often inconclusive when imaging small lesions (detectability, sensitivity, and specificity); and the patient bears a non-negligible amount of radiation dose. P. Crespo et al. 16 / 26

17 3. single-bed whole-body : Prohibitive price of scintillator crystals, and the enormous complexity of a full body system prevent its fabrication. But RPC (resistive plate chamber) technology already provides detectores covering areas of ca. m 2. P. Crespo et al. 17 / 26

18 3. single-bed whole-body : LIP proposed totally innovative, whole-body system by applying to nuclear medicine its knowledge in detectors from high-energy physics (Fonte et al, Portuguese patent). P. Crespo et al. 18 / 26

19 3. single-bed whole-body Implementation (hardware): Project PTDC/SAU-BEB/104630/2008: A novel technology for single-bed whole-body human molecular imaging with higher sensitivity and resolution. Leader: Prof. João José Pedroso de Lima R&D in detectors and electronics P. Crespo et al. 19 / 26

larger than 7 in respect to top tomographs on the market Crespo et

20 3. single-bed whole-body Implementation (software): R&D in Monte Carlo (simulation) Studies suggest increase in system sensitivity larger than 7 in respect to top tomographs on the market Crespo et al TNS 2012, Couceiro et al 2012 IEEE NSS/MIC P. Crespo et al. 20 / 26

21 3. single-bed whole-body Implementation (software): R&D in simulation and reconstruction Z (mm) X (mm) Counts P. Crespo et al. 21 / 26

22 3. single-bed whole-body Implementation (software): R&D in simulation and reconstruction Z (mm) X (mm) Counts Martins et al 2012 IEEE NSS/MIC P. Crespo et al. 22 / 26

23 3. single-bed whole-body Implementation (software): R&D in simulation and reconstruction based on the time-of-flight capabilities of RPC detectors for PET: Martins et al 2012 IEEE NSS/MIC P. Crespo et al. 23 / 26

time-of-flight capabilities of RPC detectors for

24 3. single-bed whole-body Implementation (software): R&D in simulation and reconstruction based on the time-of-flight capabilities of RPC detectors for PET: Martins PhD, in submission P. Crespo et al. 24 / 26

25 (): P. Crespo et al. 25 / 26

26 Thank you for your attention P. Crespo et al. 26 / 26

arxiv: v1 [physics.ins-det] 29 Jun 2011

arxiv: v1 [physics.ins-det] 29 Jun 2011 Performance simulation of a MRPC-based PET Imaging System arxiv:1106.5877v1 [physics.ins-det] 29 Jun 2011 A. Banerjee, S. Chattopadhyay April 16, 2018 Abstract The low cost and high resolution gas-based