Functional Nanoparticles for biosensor, biocatalytic system (e.g., biofuel), and drug delivery

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1 Functional Nanoparticles for biosensor, biocatalytic system (e.g., biofuel), and drug delivery Ilsoon Lee Brown Bag Seminar/ MSU September 23, 2008, 1

2 Research Interest Nanotechnology, Bioenergy, Alternative Energy, Biomimetic Interface, Polymers, Particle & Film, Self-assembly, Softlithography, Patterning, Nanom ixing & Nanodispersion, Functional Nanomaterials Nanotechnology can be a useful tool to improve the existing technologies (e.g., renewable energy, medicine, and sensors & devices) Fabrication of functional nanoparticles for biosensor, biocatalytic system (e.g., biofuel), and drug delivery 2

3 Funding ( ) [1] NSF - CMMI, SGER: Nanoparticle Incorporated Transferable Wrinkle Free Films, (Role: PI). [2] URC, Novel Nano-Biocarriers For Continuous Saccharification Of Biomass, (Role: PI). [3] Technova Corp., Biomimetic Adhesives Using Micro- and Nano-structure Arrays, (Role: PI), [4] NSF - CBET NER: Novel and Effective Fabrication of Anisotropic Functional Nanoparticles and Their Uses in Biosensors, (Role: PI), [5] Primix Corp., Enhancement of Nanomixing and Nanodispersion Using High Shear Force Nanomixer, (Role: PI), [6] IRGP, Nanofabrication of Functional Biomimetic Interfaces: Polyelectrolyte Multilayer Approaches, (Role: PI), - 12/15/04 6/15/06, [7] CFMR, Functional and (nano)structured Thin Films Based on Polyelectrolyte Multilayers, (Role: PI), [8] AFOSR, Experimental Equipment for (nano)powder Processing, (Role: Co-PI), [9] MEDC, Functional and Nanostructured Biomimetic Interfaces, (Role: Co- PI), [10] SPG, Nanotechnology in the Health and Life Sciences, (Role: Co-PI). 3

4 Achievement ( ) Publication: 28 peer reviewed journal papers (34 during Career, Avg. Journal Impact Factor 5) - Mostly as the corresponding author ex), Adv. Mater, JACS, Nano Lett, Chem Mater, Langmuir Patent: 8 US or World Patents were Filed - 16 MSU invention disclosures (5 as the primary inventor, all final non-provisional) 4

5 Students Production PhD outputs (3); MS (1); Postdoc (1); Current PhD students (3+α): (1) Troy Hendricks, CHE PHD completed, spring 2008, (Oak Ridge National Laboratory, Postdoc) (2) Neeraj Kohli, CHE PHD completed 2007, (Merrimack Pharm. Research Scientist) (3) Srivatsan Kidambi, CHE PHD completed 2007, (Harvard University- Postdoc) (4) Devesh Srivastava, MSE PHD, Final Defense 9/30/2008 (Intel Research Scientist) (5) Jin Soo Ahn, MSE MS completed, (U of Florida PhD) (6) Jue Lu, Postdoc. January 2006 July 07 (7) Sumit Mehrotra, MSE PHD candidate, 2010 (expected) (8) Shaowen Ji, CHE PHD candidate, 2011 (expected) (9) α (1~ 2) New PhD Students, Advisor Selection Process 5

6 Example Student Outputs - Troy Hendricks Troy Hendricks publication: [1] Hendricks, T. R.; Lu, J. Drzal, L. T.; Lee, I., Intact Pattern Transfer of Conductive Exfoliated G raphite Nanoplatelet Nanocomposite Films to Polyelectrolyte Multilayer Platforms, Advanced Materials 20, , (2008). (ISI IF = 7.9) [2] Hendricks, T. R.; Lee, I. "Wrinkle-Free Nanomechanical Film: Control and Prevention of Polym er Film Buckling," Nano Letters, 7 (2), , (2007). [Featured in more than 50 news includ ing Discovery Channel, Chemistry World, MRS bulletin, Times on line, Medical News Today, an d Science News Daily] (ISI IF =10.0) [3] Hendricks, T. R.; Dams, E. E.; Wensing, S. T.; Lee, I. "Effects of Catalyst Introduction Methods Using PAMAM Dendrimers on Selective Electroless Nickel Deposition on Polyelectrolyte Multila yers," Langmuir 23, , (2007). (ISI IF =3.9) [4] Ahn, J. S.; Hendricks, T. R.; Lee, I. "Control of Specular and Diffuse Reflection of Light Using Particle Self-Assembly at the Polymer and Metal Interface," Advanced Functional Materials 1 7, , (2007). (ISI IF =6.8) [5] Srivastava, D.; Hendricks, T. R.; Lee, I. "Step-edge Like Template Fabrication of Polyelectrolyt e Supported Nickel Nanowires," Nanotechnology 18, , (2007). (ISI IF =3.0) [6] Hendricks, T. R.; Lee, I. "A Versatile Approach to Selective and Inexpensive Copper Patterns Using Polyelectrolyte Multilayer Coatings," Thin Solid Films 515, , (2006). (ISI IF = 1.7) [7] Lee, I.; Ahn, J. S.; Hendricks, T. R.; Rubner, M. F.; Hammond, P. T. "Patterned and Controlled Polyelectrolyte Fractal Growth and Aggregations," Langmuir 20, (2004). (ISI IF =3. 9) Three Patent applications / A few awards including Entrepreneurial Facul ty Fellowship, / Several oral presentations at the national meetings. (Oak Ridge National Laboratory, Postdoc) 6

7 1. Nano-injection Molding Process a) [Srivastava, D.; Lee, I. Advanced Materials 18, , (2006)] b) National Science Foundation (CBET) NER: Novel and Effective Fabrication of Anisotropic Functional Nanoparticles and Their Uses in Biosensors, (Role: PI) c) Patent Pending!! Shape as well as size can be very important since nanostructured particles can interact with light or biological molecules in a b c fundamentally different ways. d e f 7

8 2. Nanomechanical Wrinkle-Free Films Figure 1. Overall scheme of the proposed work. Transferable wrinkle free film is to be developed and tested on a pre wrinkled or folded artificial skin where transparent (invisible) and permeable wrinkle preventing film remains on the pre wrinkled or folded artificial skin like invisible patch or cosmetic cream. Detailed procedure is illustrated in Figure 4. Figure 2. Nanoparticle incorporation in polymer film in a specific way may prevent wrinkling in polymer films that would otherwise wrinkle. a) [Hendricks, T. R.; Lee, I. Nano Letters 7 (2), , (2007)] b) National Science Foundation (CMMI), SGER: Nanoparticle Incorporated Transferable Wrinkle Free Films, (Role: PI) c) Patent Pending!!! d) Industrial attraction: P&G and Cosmetic companies 8

9 Publicity (2007) Nanoparticles Join War on Wrinkles For more details, please visit: More than 70 news articles World wide!!! 9

10 9/8 Spot Lights 3. Functional Carbon Nanomaterials (Graphene / xgnp TM ) [Lu; Do; Drzal; Worden; Lee, ACS Nano, 2008] DOI: /nn800244k Functional xgnp via Top down approach!! Novel process Graphite Size controlled functional xgnp Functional Carbon Nanomaterials for Biosensor / Biocatalytic Reactor System (e.g., biofuel) Energy Conversion 10

11 Covers In Journals and Book Adv. Mater. 2002, First Book in Layer-by-layer December 2003 Macromol. Rapid Commun. 2004,