International Isotope Society. Central European Division. The Synthesis and Applications of Isotopes and Isotopically Labelled Compounds
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1 2. Circular 13 th Workshop The Synthesis and Applications of Isotopes and Isotopically Labelled Compounds Bad Soden, Germany Ramada Treff Hotel June 16-17, 2005
2 Invitation On behalf of the International Isotope Society,, we are pleased to announce the 13 th Workshop at the Ramada Treff Hotel in Bad Soden, th June, The goal of the organizers is to make this meeting a scientific event of excellence, attractive to both industrial and academic scientists involved in the syntheses and applications of isotopes and isotopically labelled compounds. The official language of the conference will be English. Organisation Committee Jens Atzrodt jens.atzrodt@aventis.com sanofi aventis Volker Derdau volker.derdau@aventis.com sanofi aventis Gunther Jaeger jaeger@biotrend.com BIOTREND Mailing address: sanofi aventis Aventis Pharma Deutschland GmbH BIOTREND Chemikalien GmbH Isotope Chemistry & Metabolite Synthesis Eupener Straße 157 ICMS-Frankfurt Köln/ Germany Industriepark Hoechst, G Frankfurt am Main/ Germany FAX: Conference Site The venue for the workshop will be the Ramada Treff Hotel located in the center of Bad Soden, a spa with 30 mineral springs within walking distance. The hotel Restaurant is renowned for its services and wonderful park view location. The Ramada-Treff Bad Soden features a fitness area, with sauna, solarium and whirlpool. The hotel also has a conference hall which can accommodate 1200 people and 12 additional meeting rooms for up to 100 people.
3 Sponsoring International Isotope Society To keep this internationally renowned workshop on a high scientific level with invited speakers from academia and industry and to enable student participation we would like to ask you to join us in financial support of this meeting. The Organisation Committee likes to thank our Sponsors: Vendor Exhibition Commercial exhibitors will have the opportunity to present their products, services and instrumentations. On Thursday late afternoon a social event is planned for all participants within the exhibition and poster presentation area, snacks and drinks will be served. If you are interested in taking part in the industrial exhibition please contact Jens Atzrodt but not later than 15 th May. Since the remaining space is strongly limited reservations will be made on the first come, first serve basis. Conference Mendelejev Tolstoi Exhibition The following exhibitors have already registered: Institute of Isotopes Co., Ltd Heidolph Instruments Labortechnik Nerviano Medical Sciences S.r. Lablogic Systems RC Tritec AG Raytest Isotopenmessgeräte GmbH Campro Scientific GmbH Zinsser Analytics Special Workshops Those of you interested to contribute to and/or to participate in the special workshop Clinical Studies with Isotopically Labelled Compounds should directly contact the organizer Dietrich Seidel. Dietrich Seidel, Aprather Weg 18a, Wuppertal; Tel.: +49-(0) ; Fax: +49-(0) , dietrich.seidel@bayerhealthcare.com
4 Tentative Scientific Program Thursday, June 16, 2005 Workshop Clinical Studies with Isotopically Labeled Compounds Chairman & Dr. Dietrich Seidel, Bayer Healthcare Germany Organizer 10:00 12:00 Room Tolstoi Welcome & Introduction 1:00 1:10 p.m Dr. Jens Atzrodt / Dr. Volker Derdau (Organisation Commitee) Prof. Dr. Ulrich Pleiss, President IIS/CED e.v. Session I Chairman 1:10-2:00 p.m. Plenary Lecture Prof. Dr. Istvan Marko, Louvain-la-Neuve University, Belgium Novel Orthoesters in Organic Synthesis 2:00 2:20 p.m. Dr. Simon Harwood, Glaxo Smithkline, UK The Synthesis of Stable Labelled Ketamine 2:20 2:40 p.m. Dr. Thomas Moenius, Novartis, Switzerland C-13, C-14, N-15 Labelling of 4-Cyano benzylbromide - a versatile Labelling Intermediate 2:40 3:00 p.m. Coffee Break
5 Session II Chairman 3:00 3:50 p.m. Plenary Lecture Prof. Dr. Jonathan Clayden, Manchester University, UK Synthesis and Stereocontrol with Lithiated Amides 3:50 4:10 p.m. Dr. Rhys Salter, Novartis, Switzerland "Isotopic Labelling of STI571 and its Metabolites in the Development of Glivec" 4:10 4:40 p.m. Global IIS sponsored Lecture Prof. Dr. John Gardiner, Manchester University, UK tbd 5:00 6:00 p.m. International Isotope Society, Business Meeting Session III Poster Session and Exhibition 6:00 7:30 p.m. Poster Session and exhibition Commercial Presentation 6:20 6:40 p.m. Zinsser Analytics presentation, Conference Room Tolstoi Commercial Presentation 6:40 7:00 p.m. Raytest presentation, Conference Room Tolstoi Snacks and drinks will be served in the exhibition area 7:10-7: 40 pm Special Evening Lecture Dr. Dedek, University Dresden, Germany Conference Room Tolstoi Congress Dinner 7:45 p.m. Conference Room Mendelejev
6 Friday, June 18, 2005 Session IV Chairman: 8:30 9:20 a.m. Plenary lecture Prof. Dr. Mathias Beller, Ifok Rostock, Germany Homogeneous Catalysis A Powerful Tool for the Synthesis of Pharmaceuticals 9:20 9:40 a.m. Jan Kozempel, Charles University, Prague, Czech Republic Preparation of ortho-radiohalogenated Phenylazides and Triazenes, versatile Building Blocks for Indirect Labelling 9:40 10:00 a.m. Dr. Conrad Raab, Merck Sharp & Dohme, United States 10:00-10:20 a.m. Coffee Break MRL's Approach to Labelled Compound Synthesis Session V Chairman: 10:20 10:50 a.m. Invited Lecture Prof. Dr. Kristiina Wähälä, Helsinki University, Finnland Controlled Polydeuteration of Estrogenic Compounds 10:50 11:10 a.m. Dr. Andreas Roßmann, Isolab GmbH, Germany " Fundamental Facts and some Applications of Stable Isotope Analysis in Food Control 11:10 11:30 a.m. Dr. Detlef Stöckigt, Symrise GmbH & Co. KG, Germany "Authentication of Natural Products" 11:30 11:45 a.m. Dr. Karl Schmeer, Bayer CropScience, Germany 11:45 11:50 a.m. Short Break Enhanced Sensitivity of 14 C-Detection in Combination with micro-hplc
7 Session VI Chairman: 11:50 12:10 a.m. Dr. John Herbert, Sanofi aventis, UK Catalyst Stability in Iridium-mediated Isotope Exchange 12:10 12:40 a.m. Dr. Cor Janssen, Johnson & Johnson, Belgium 12:40 1:30 p.m. Lunch Pd/C catalyzed Hydrogenolytic H/T Exchange in Solvents. Effects on Solvent and Product in a Bromine-Tritium Exchange Reaction. Session VII Chairman: 1:30 2:00 p.m. Prof. Dr. Hans-Christian Riekhof, Private University of Applied Sciences Göttingen, Germany "Development of a Departmental Strategy in R&D" 2:00 2:20 p.m. Prof. Dr. Jürgen Kiefer, Gießen University, Germany "Radiation Risk - New Insights and Developments". Session VIII Chairman: 2:20 2:40 p.m. Peter Mäding, Research Centre Rossendorf, Germany A New Module-assisted Synthesis of the Versatile, Bifunctional Labelling Agent [ 18 F]SFB: From Radiochemistry to Applications 2:40 3:00 p.m. Dr. Steffen Fischer, Institute of Interdisciplinary Isotope Research Leipzig, Germany Synthesis of 18 F Labelled Bicyclic Analogues of Vesamicol as Potential VAChT Imaging Agents
8 3:00 3:45 p.m. Invited Lecture Prof. Dr. Friedrich Hammerschmidt, University Vienna, Austria First direct chemical synthesis of chiral methanol (CHDTOH) of 98% ee and its use to determine the stereochemistry of the methyl transfer in the biosynthesis of fosfomycin. Closing Remarks 3:45 p.m. Dr. Jens Atzrodt / Dr. Volker Derdau (Organisation Commitee) Travel Information By airplane: Best way to travel from Frankfurt airport to Bad Soden is by taxi (duration min) or by the S-Bahn (S8 or S9) via Frankfurt central station (HBf). From Frankfurt/Hahn you can go to Frankfurt central station (HBf) by bus (20 Euro, 2h). By train: By car: From Frankfurt central station (HBf) you can use the S-Bahn S3 to go to Bad Soden (30 min). The conference site is in walking distance (see map) to the station, just at the other side of the Kurpark in the Paul-Reiss street. From the highway A66 (exit Höchst) drive onto the B8 (direction North/Bad Soden). Next exit right (direction Bad Soden). Drive straight on until you see the Ramada Treff Hotel at your right side.
9 Registration International Isotope Society Registration fees covers attendance to the scientific program and entrance to the exhibition area, coffee breaks and lunches during the congress sessions as well as the traditional Congress Dinner on Thursday evening. Closing date for registration is 15 th May Registrations will be confirmed upon receipt of payment only. I will be attending the European IIS Meeting Full registration 150 University persons 75 Registration Fee Registration* Deadline: 15 th May, 2005 Hotel accommodation has to be paid directly to the hotel, 45 rooms are reserved in the Ramada Treff Hotel I request hotel accommodation Accommodation from: June June June 2005 Registration Information Last Name: Organisation Single Room (100 /per night) Double Room First Name: Address Title: Fax: Phone Advice is available on local accommodation and other details: Gunther Jaeger BIOTREND Chemikalien GmbH Postfach D Köln Tel: Fax: jaeger@biotrend.com Payment The registration fee for the meeting includes 5,- membership fee (CED) and should be forwarded directly to: IIS-CED e.v., c/o BIOTREND, Bank Account: Postbank Köln, Account-No , branch code Cheques to be made in Euro and should be send to Gunther Jaeger.
10 Registration for Exhibition The vendor exhibition and poster session will take place in salons Stolze (7,50 x 6,50 m) and von Bethmann (8,50 x 9,00 m). In the whole exhibition area a height of 3 m is provided. Prices for booths (standard size: two square meter) are effective for the duration of the congress. Closing date for payment is 15 th May Registrations will be confirmed upon receipt of payment only. For special needs and requirements or if you need additional floor space please contact Jens Atzrodt. Exhibition Fee* Exhibition registration for standard booth + conference booklet 300 Additional conference booklet + data CD 50 Company/ Organization: Address: Company Information Web Address Contact person Position Contact information Phone Fax Products/services to be presented at your booth Payment The registration fee should be forwarded directly to: IIS-CED e.v., c/o BIOTREND, Bank Account: Postbank Köln, Account-No , branch code Cheques to be made in Euro and should be send to Gunther Jaeger.
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