TCD-IISc Symposium in Chemistry & Chemical Biology

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1 TCD-IISc Symposium in Chemistry & Chemical Biology Monday 24 th June - Wednesday 26 th June 2013 Tercentenary Hall, Trinity Biomedical Sciences Institute

Clive Williams, Dean of the Faculty of Engineering, Mathematics & Science and Professor of Chemical Biology.

Clive Williams, TCD Thorfinnur Gunnlaugsson, Professor of Chemistry.

development of novel luminescent sensors, self-assemblies and materials and their potential use in medical applications.

Research interest in macromolecular X-ray crystallography, membrane lipids and proteins, membrane mimetics, robotics,

Research interest in Protein Folding and Biomolecular NMR Spectroscopy: Probing the attainment of natively- or

2 Clive Williams, Dean of the Faculty of Engineering, Mathematics & Science and Professor of Chemical Biology. Research interests in cancer drug discovery and relevant biomechanical mechanisms. Clive Williams, TCD Thorfinnur Gunnlaugsson, Professor of Chemistry. Research areas include supramolecular organic and inorganic chemistry and medicinal chemistry where the emphasis is on the development of novel luminescent sensors, self-assemblies and materials and their potential use in medical applications. Thorfinnur Gunnlaugsson, TCD Martin Caffrey, Professor of Membrane Structural & Functional Biology. Research interest in macromolecular X-ray crystallography, membrane lipids and proteins, membrane mimetics, robotics, structure-function relationships. Martin Caffrey, TCD Ken Mok, Assistant Professor in Biochemistry. Research interest in Protein Folding and Biomolecular NMR Spectroscopy: Probing the attainment of natively- or alternativelyfolded three-dimensional molecular structures. Ken Mok, TCD Isabel Rozas, Professor in Chemistry. Research interest in the design, synthesis and biophysical and biochemical study of new dual action agents targeting DNA as intercalators and minor-groove binders with potential as more selective anticancer drugs. Isabel Rozas, TCD

TCD Stephen Connon, Professor of Synthetic Chemistry.

methodology and the design of new anti-cancer and anti-bacterial agents.

Research interest in the liquid-phase processing and atom-by-atom characterisation by aberration

3 Andrew Bowie, Professor in Immunology. Research interest in viral immune evasion Andrew Bowie, TCD Ed Lavelle, Assistant Professor in Immunology. Research interest in mechanisms of action of vaccine adjuvants and delivery systems Ed Lavelle, TCD Stephen Connon, Professor of Synthetic Chemistry. Research interests include organocatalysis, the discovery and development of novel synthetic methodology and the design of new anti-cancer and anti-bacterial agents. Stephen Connon, TCD Valeria Nicolosi, ERC Research Professor. Research interest in the liquid-phase processing and atom-by-atom characterisation by aberration - corrected electron microscopy of low-dimensional nanomaterials. Valeria Nicolosi, TCD Yurii Gun ko, Professor in Chemistry. Research interest in the synthesis and chemical functionalization of inorganic nanomaterials (quantum dots, magnetic and metal nanoparticles) for biomedical applications, photovoltaics and catalysis Yurii Gun'ko, TCD

Robert Baker, Assistant Professor in Chemistry.

chemistry. Robert Baker, TCD Paula Colavita, Assistant Professor in Chemistry.

chemistry and charge transfer at disordered carbons and oxide surfaces, for biomaterials, environmental and energy

Research interests in coordination chemistry approaches towards supramolecular materials for sustainable energy

Wolfgang Schmitt, TCD Eoin Scanlan, Assistant Professor in Chemistry.

4 Robert Baker, Assistant Professor in Chemistry. Research interest in fundamental and applied actinide chemistry, with a focus on coordination and organometallic uranium chemistry. Robert Baker, TCD Paula Colavita, Assistant Professor in Chemistry. Her work focuses on achieving control of interfacial chemical and photochemical reactions, with emphasis on radical chemistry and charge transfer at disordered carbons and oxide surfaces, for biomaterials, environmental and energy conversion applications. Paula Colavita, TCD Wolfgang Schmitt, Associate Professor in Chemistry. Research interests in coordination chemistry approaches towards supramolecular materials for sustainable energy applications or materials with advanced magnetic and electronic attributes. Wolfgang Schmitt, TCD Eoin Scanlan, Assistant Professor in Chemistry. Chemistry. Research interests include the design and development of novel Glycotherapeutics. The development of new synthetic methodology for the synthesis of glycosidase inhibitors, oligosaccharides and glycoconjugates Eoin Scanlan, TCD Luke O Neill, Professor of Biochemistry. The major focus of his research is to provide a molecular understanding of innate immunity and inflammation Luke O'Neill, TCD

Hanudatta S. Atreya, Associate Professor of Chemistry.

Hanudatta S. Atreya, IISc Uptal Tatu, IISc Uptal Tatu, Professor of Biochemistry.

He extensively uses mass spectrometry in his research involving molecular chaperones from Amoebiasis, Bebesiosis, Giardiasis, Malaria as well as Trypanosomiasis

Research interests are in the areas of Membrane-biophysics; Gene and drug delivery; Molecular theranostics, Molecular medicine; G- quadruplex ligands; Supramolecular

Santanu Bhattacharya, IISc Dipshikha Chakravortty, IISc Dipshikha Chakravortty, Associate Professor in Chemistry.

5 Hanudatta S. Atreya, Associate Professor of Chemistry. Research interests in the areas of NMR methodology development in solution and solid state, structural biology, metabolomics, nanobiology and cancer biology. Hanudatta S. Atreya, IISc Uptal Tatu, IISc Uptal Tatu, Professor of Biochemistry. Research interests include diagnosis and Hsp90 targeted drug development against neglected diseases of human and animal origin especially equine. He extensively uses mass spectrometry in his research involving molecular chaperones from Amoebiasis, Bebesiosis, Giardiasis, Malaria as well as Trypanosomiasis causing organisms. Santanu Bhattacharya, Professor of Chemistry. Research interests are in the areas of Membrane-biophysics; Gene and drug delivery; Molecular theranostics, Molecular medicine; G- quadruplex ligands; Supramolecular assemblies, Molecular Gels; Ionand bio-sensors and Nanomaterials. Santanu Bhattacharya, IISc Dipshikha Chakravortty, IISc Dipshikha Chakravortty, Associate Professor in Chemistry. Our group works extensively on the various evasion strategies used by pathogenic bacteria to avoid the host defence system. We have worked on the ways by which host-pathogen cross talk determines the fate of infection. This understanding allowed us to develop potential vaccine candidate against Salmonella typhimurium and typhi. We have also developed new drug deivery techniques to treat intracellular pathogens. Aninda Jiban Bhattacharyya, Associate Professor in Chemistry. His broad areas of research are in Materials and Physical Chemistry with specific focus on materials for applications in energy and environment. Aninda Jiban Bhattacharyya, IISc

Srinivasan Sampath, Professor in Chemistry.

electrochemical sensors, energy systems, surface enhanced Raman scattering (SERS) substrates. Srinivasan Sampath, IISc Balaji Jagirdar, IISc Uday Maitra, IISc Balaji Jagirdar, Professor in Chemistry.

synthesis and properties of nanostructured materials; materials for hydrogen storage and generation. Uday Maitra, Professor in Chemistry.

Pakkirisamy Thilagar, Assistant Professor in Chemistry.

6 Srinivasan Sampath, Professor in Chemistry. Research is in the area of interfacial electrochemistry involving exfoliated graphite, transition metal nitrides and carbides, nano(bi)metallic systems and organic thin films on surfaces - Towards electrochemical sensors, energy systems, surface enhanced Raman scattering (SERS) substrates. Srinivasan Sampath, IISc Balaji Jagirdar, IISc Uday Maitra, IISc Balaji Jagirdar, Professor in Chemistry. Research interests in the areas of activation of unreactive chemical bonds in small molecules and their functionalization using organometallic compounds; homogeneous and heterogeneous catalysis; synthesis and properties of nanostructured materials; materials for hydrogen storage and generation. Uday Maitra, Professor in Chemistry. Research is in the areas of Chemistry of bile acids; Functional soft materials; organic-inorganic hybrid soft materials. He is also greatly interested in Chemistry education. Pakkirisamy Thilagar, Assistant Professor in Chemistry. His group is currently involved in the design and synthesis of new molecules/materials containing p-block elements for the potential application in the field of Catalysis (FLP), Molecular Electronics (OLED,OTFT), Chemosensory materials and Boronopeptides (Proteasome Inhibitors). Pakkirisamy Thilagar, IISc Puspendu K Das, Professor in Chemistry. Research interests are in the general areas of dynamics and spectroscopy: specifically ir spectroscopy, nonlinear optics with molecules and materials, nanoparticle interaction with biomaterials and chemical sensors. Puspendu K Das, IISc

Srinivasan Natarajan, Professor in Chemistry.

Designed synthesis, structure, magnetic, catalytic and photocatalytic studies.

Prabhakaran, Assistant Professor in Chemistry.

7 Srinivasan Natarajan, Professor in Chemistry. Srinivasan Natarajan Research in the area of Inorganic-Organic Hybrid Framework solids - Designed synthesis, structure, magnetic, catalytic and photocatalytic studies. Li-ion migration in solids (Li-Battery materials) and ceramic pigments. Erode N. Prabhakaran, Assistant Professor in Chemistry. Research in the areas of peptide folding; artificial enzymes; chargetransport along peptides; peptide-based bio-sensors; non-covalent interactions in peptides; peptide conformational dynamics; peptidomimetics. Erode N. Prabhakaran

8 Monday 24 th June: 8.45am: Introduction & Welcome Prof Jane Ohlmeyer, Vice Provost for Global Relations Session 1: Chair - Thorfinnur Gunnlaugsson, Chemistry, Trinity College am: Membrane Protein structure-function Martin Caffrey, Biochemistry, Trinity College am: The Structural Biology of Human Insulin-like Growth Factor System by NMR: Unravelling Potential New Cancer Therapeutics Hanudatta.S. Atreya, NMR Research Centre, IISc am: Tea/Coffee Break (Knowledge Exchange, TBSI) am: Alternatively folded proteins with novel tumoricidal activity Ken Mok, Biochemistry, Trinity College pm: Guanidine derivatives against cancer Isabel Rozas, Chemistry, Trinity College pm: Heat shock protein 90 as a drug target against neglected diseases of human and veterinary origin Uptal Tatu, Biochemistry, IISc pm: Lunch Break

9 Session 2: Chair - Santanu Bhattacharya, Chemistry, IISc pm: Innate immune sensing of DNA Andrew Bowie, Immunology, Trinity College pm: Intracellular life of bacterial pathogens-strategies for survival Dipshikha Chakravortty, Microbiology & Cell Biology, IIsc pm: Tea/Coffee Break (Knowledge Exchange, TBSI) pm: Mode of action of particulate vaccine adjuvants Ed Lavelle, Immunology, Trinity College Session 3: Tuesday 25 th June: Chair - Stephen Connon, Chemistry, Trinity College am: A Few Examples of Confinement Effects in the Context of Electrochemical Processes Aninda Jiban Bhattacharyya, Chemistry, IISc am: Two-dimensional nanomaterials: exploring the flatland atom-byatom Valeria Nicolosi, Chemistry & Physics, Trinity College am: Interfacial Electrochemical Studies Using Modified Surfaces Srinivasan Sampath, Inorganic & Chemistry, IISc

10 am: Tea/Coffee Break (Knowledge Exchange, TBSI) am: Development of multimodal nanoparticles and their biomedical applications Yurii Gun'ko, Chemistry, Trinity College pm: Solvated metal atom dispersion and digestive ripening: duo par excellence for diverse nanostructured materials Balaji Jagirdar, Inorganic & Physical Chemistry, IISc pm Lunch Break pm : Different Facets of Molecular Gels Santanu Bhattacharya, Organic Chemistry IISc pm Lanthanide directed self-assembly formation of supramolecular and nano-structures from organic ligands Thorfinnur Gunnlaugsson, Chemistry, Trinity College pm: Tea/Coffee Break (Knowledge Exchange, TBSI) pm Multi-component, self-assembled, functional soft materials from bile salts Uday Maitra, Organic Chemistry, IISc pm: It s Fun at the Bottom - Adventures in Actinide Chemistry Robert Baker, Chemistry, Trinity College pm Informal Discussions & Reception, Knowledge Exchange, TBSI

11 Wednesday 26 th June: Session 4: Chair - Uday Maitra, Organic Chemistry, IISc am: Organoborane conjugates of Pyrrole Cousins: New Relations and Revelations S. Thilagar, Inorganic & Physical Chemistry, IISc am: Understanding reactions at disordered carbon surfaces: fundamental studies and new applications to biomaterials Paula Colavita, Chemistry, Trinity College am: Interaction of metal nanoparticles with macromolecules Puspendu K. Das, Inorganic & Physical Chemistry, IISc am: Tea/Coffee Break (Knowledge Exchange, TBSI) am: Coordination Chemistry Approaches to Nanoscopic Materials: From Metallo-Supramolecular Cages to High-Surface Area Materials Wolfgang Schmitt, Chemistry, Trinity College pm: Acids, Bases and Frameworks: How are they related? Srinivasan Natarajan, Solid State & Structural Chemistry, IISc pm: Lunch Break

12 Session 5: Chair - Clive Williams, Biochemistry, Trinity College pm: Organocatalysis using cyclic electrophiles and nucleophiles Stephen Connon, Chemistry, Trinity College pm: Accessing what is disallowed by Tailoring Weak Interactions in Peptides Erode N. Prabhakaran, Organic Chemistry, IISc 3: pm: Tea/Coffee Break (Knowledge Exchange, TBSI) 3:40-4:20pm: Strategies for the Synthesis of Glycotherapeutics Eoin Scanlan, Chemistry, Trinity College pm Plenary Lecture New targets in innate immunity to treat inflammatory diseases Luke O'Neill, Biochemistry, Trinity College

CHEMISTRY (CHEM) CHEM 5800 Principles Of Materials Chemistry. Tutorial in selected topics in materials chemistry. S/U grading only.

CHEMISTRY (CHEM) CHEM 5800 Principles Of Materials Chemistry. Tutorial in selected topics in materials chemistry. S/U grading only. Chemistry (CHEM) 1 CHEMISTRY (CHEM) CHEM 5100 Principles of Organic and Inorganic Chemistry Study of coordination compounds with a focus on ligand bonding, electron counting, molecular orbital theory,