Technology, Techniques and Applications. Ric Allott Business Development Manager

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1 Technology, Techniques and Applications Ric Allott Business Development Manager 1

2 Central Laser Facility ASTRA GEMINI VULCAN ARTEMIS ULTRA OCTOPUS High power, ultrashort pulse dual beams of 15 J, 30 fs pulses Pulse every 20s Ultra high-power laser Up to 1 PW peak power Focused intensity > Wcm -2 fs and as ultrafast spectroscopy high harmonic generation IR to soft x-ray Ultrafast vibrational spectroscopy Imaging, laser tweezers and microscopy High-power, ultra-intense lasers for extreme conditions science & applications Laser applications in the physical and life sciences (materials, chemistry, biology)

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4 Light Sheet Microscopy TIRF-tweezers One-photon confocal FLIM 8-channel single molecule Laser hub 5-colour single molecule 3-colour single molecule 2D super-resolution PALM/STORM Multiphoton Confocal FLIM 3D super-resolution SIM/PALM/STORM (2013/14) 3D super-resolution STED Res ~ 50nm

5 Industrial Applications Pharmaceutical & Health Technique: Fluorophore Localisation Imaging Photobleaching (FLImP) 1. Developing Bench Top Microscopes & Automated Analysis for Cancer Diagnosis and Personalised Medicine. 2. Assisting Companies in Characterisation of New Therapeutic Agents to locate Activation Sites of Proteins. FLImP to identify changes in Epidermal Growth Factor Receptors Drug Design High Throughput of Newly Designed mtorc1 Proteins & Atomic Resolution Structural Characterisation for Applications in Drug Design & Development. Confocal Imaging Protein design FLIM Developing Super-Resolution Cryo-FM Leading the development of a new imaging method offering macromolecular level optical resolution of bio-samples preserved in a near-native state. Imaging single and adjacent clusters of EGFR. Resolving clusters separated by 197 nm.

6 Ultra A National Facility for Time-Resolved Spectroscopy

7 TR M PS - LIFEtime Kerr Gated Raman Spectroscopy Fluorescence Rejected Raman Spectra Time Resolved Multiple Probe Spectroscopy triggers molecular reactions providing insights into molecular structural changes of reactions on ps to ms timescale. picoseconds nanoseconds Example Raman response with and without fluorescence rejection Raman Shift / cm -1 Time Resolved IR Bands of water attached to zeolite O-H bands from silanols and acidic sites A unique molecular fingerprint giving insights into new chemical structures. C-H features due to organic deposits? Kerr-gated No gate Mo-ZSM5 (calcined), 4% Mo 2D-IR Spectroscopy Looks at the vibrational coupling between molecules and probes how the energy flows through a molecule on an ultrafast timescale. microseconds Raman Shift / cm -1

8 Techniques TRIR - Time Resolved InfraRed Absorption Spectroscopy TR M PS - Time Resolved Multiple Probe Spectroscopy 2D-IR & Transient 2D-IR IR-Vis SFG Sum Frequency Generation TR³ - Time Resolved Resonance Raman Kerr Gated Raman Wide Range of Ultrafast Light Sources Flexibility to combine Multiple Beams & Multiple Colours Expert Knowledge & Flexibility in Experimental Design & Sample Set-up Specialised sample cells Temperature control & Temperature ramping up to 100 s of C Gas delivery systems Pressurised experiments up to 15 bar Reflectance & Transmission Assemblies What Samples Can We Study? Dilute Solutions Small & Macro Molecular Films & Conductive Polymers Gases in Waveguides Electrochemical Cells Solids Operando Catalysts & Zeolites Surfaces Photovoltaics Biological - Cells

9 Ultra: Industrial Applications Pharmaceutical & Health 2D-IR detection of changes to protein secondary structure. Real-time studies of conformational fluctuations of proteins. Figure shows temperature-induced 2D-IR difference spectra of human Calmodulin protein in the apo-form. Other Areas: Zeolite Acid Site Battery Materials Photovoltaics Glass Technology Fluid Dynamics Fuel Cells Drug Delivery etc Catalytic Technology: Zeolite Characterisation Raman Shift / cm -1 Bands of water attached to zeolite C-H features due to organic deposits? Kerr-gated No gate Mo-ZSM5 (calcined), 4% Mo Kerr Gated Raman in Operando experiments of Zeolite MTO reactions provides insights into the formation carbon during reaction and how this 0 effects catalyst efficiency. The same system can be used to determine time-resolved fluorescence of zeolites in operando and how the fluorescence evolves during different stages of the zeolite deactivation. O-H bands from silanols and acidic sites Raman Shift / cm ps -6 ps -2 ps 10 ps 20 ps 50 ps 200 ps 750 ps 1.75 ns 3.7 ns Wavelength / nm

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