John D. Knight 114 Oakdale Dr. Summerville, SC (843)

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1 John D. Knight 114 Oakdale Dr. Summerville, SC (843) Education Duke University Durham, NC Ph.D. Department of Chemistry, July Thesis: The Anti Selective Aldol Addition of Ketones to Aldehydes Mediated by N-Amino Cyclic Carbamate Chiral Auxiliaries and Its Use in the Asymmetric Total Synthesis of (+)- and (-)-Mefloquine Hydrochloride. College of Charleston Charleston, SC Bachelor of Science, Chemistry, Magna Cum Laude, May Minor in Meteorology. Graduate of Honors College. Participated in research under Dr. Charles F. Beam resulting in publications and presentations from Teaching The Citadel Charleston, SC Experience Visiting Assistant Professor Fall Present Taught first semester Organic Chemistry lecture (CHEM 207) as well taught and coordinated the corresponding laboratory sections (CHEM 217). Courses taught: CHEM 207 and 217 Trident Technical College North Charleston, SC Laboratory Instructor Spring I 2017 Taught Organic Chemistry laboratory sections in the Department of Physical Science at Trident Technical College. Duties included giving pre-laboratory lectures, grading, and overseeing students conducting laboratory experiments. Courses taught: CHM-211L William Peace University Raleigh, NC Visiting Lecturer Spring 2016 Taught second semester General Chemistry and Organic Chemistry courses in the Spring semester in the Department of Biology, Chemistry, Environmental Studies, and Physics. Also in charge of preparing and teaching the laboratories associated with each course. Courses taught: CHE-112, 112L, 212, 212L Meredith College Raleigh, NC Adjunct Instructor Fall 2015 Taught a first semester General Chemistry lecture course (45-50 undergraduate students) in the Department of Chemistry, Physics, and Geoscience. Additionally, taught an undergraduate laboratory section related to the same course. Courses taught: CHE-111 & CHE-141

2 University of North Carolina Chapel Hill, NC Postdoctoral Researcher Fall 2014 Spring 2015 Supervised four undergraduate students in academic research focused on the asymmetric total synthesis of natural products. Responsibilities included training the students in synthetic lab techniques, the handling of chemical reagents, training in the use of necessary instrumentation such as NMR, mass spectrometry, and IR, the monitoring of progress on individual projects, the discussion of results and synthetic planning, and the critiquing and guiding of each student through the process of writing a final written report on their research. Each student made significant progress and, and one student successfully completed her total synthesis. Students final reports available upon request. Christina Lai (UNC 15): Total Synthesis of the Bicyclic Polyketide Lactone Polyrhacitide A ( ) Ashley Harris (UNC 15): Total Synthesis of the Bicyclic Polyketide Lactone Polyrhacitide A (2013) Glynis L. Coyne (UNC 16): Asymmetric Total Synthesis of an Analogue of (-)-Pironetin ( ) - synthesized Nathan S. Suskovic (UNC 15): Asymmetric Total Synthesis of (+)-Anphanamol ( ) Duke University Durham, NC Analytical Chemistry; Laboratory Teaching Assistant Laboratory course focused on analytical lab techniques. Responsibilities included the setting up of the atomic absorption/emission (AA/AE) and cyclic voltammetry/coulometry experiments and instructing individual students on using the instrumentation and conducting said experiments. Each student was graded objectively based on results from setting up the experiment. (Spring 2008, Fall 2008, Fall 2009, Fall 2011) Advanced Synthetic Techniques; Teaching Assistant Laboratory course focused on advanced synthetic and other laboratory techniques. Responsibilities included the instruction, supervision, and training of students in advanced lab techniques and chemical characterization, and grading of written reports. (Spring 2009) Organic Chemistry; Recitation Teaching Assistant Recitation teaching assistant position for second semester organic chemistry lecture course. Responsibilities included conducting recitation sections for students, helping write problem sets and exams for the professor teaching the course, and supervising the grading and regarding of course exams. (Spring 2010) Organic Chemistry I & II; Laboratory Teaching Assistant Basic organic chemistry laboratory courses. Responsibilities included developing pre-laboratory lectures, instructing and supervising students in organic chemistry laboratory techniques and experiments, the checking of laboratory notebooks, the grading of student lab reports, and the grading of

3 lecture exams. Laboratory reports were graded based on a course-wide grading rubric. (Summer 2 nd Session 2008, Summer 1 st and 2 nd Session 2009, Summer 1 st and 2 nd Session 2010, and Summer 2 nd Session 2012) General Chemistry; Laboratory Teaching Assistant Summer general chemistry course taught with an emphasis on preparing students to take organic chemistry. Students conducted organic chemistry reactions while3 gaining experiences relevant for a general chemistry laboratory course. Teaching assistant responsibilities included assisting in prelaboratory lectures, instructing and supervising students in laboratory techniques and handling of chemical reagents, the introduction of characterization techniques (NMR, IR, GC-MS) to students, laboratory notebook checking, and the critical assessment of student posters at the end of the summer session. (Summer 2012) Advanced General Chemistry; Laboratory Teaching Assistant Laboratory course for students who obtained Advanced Placement credit in general chemistry with an emphasis on biological chemistry. Responsibilities included developing pre-laboratory lectures, instructing and supervising students in laboratory techniques and experiments, the checking of laboratory notebooks, the grading of student lab reports, and the grading of lecture exams based on a course-wide rubric. (Fall 2007) Research University of North Carolina Chapel Hill, NC Experience Advisor: Michael T. Crimmins September 2012 August 2015 Postdoctoral research on the total synthesis of marine natural products, such as Brianthein A, utilizing the dianionic Ireland-Claisen rearrangement. Extended the use of the dianionic Ireland-Claisen rearrangement to more structurally diverse and complex substrates. Duke University Durham, NC Advisor: Don M. Coltart August 2007 July 2012 Explored the inherent anti selectivity of the aldol addition of chiral N-amino cyclic carbamate (ACC) hydrazones with aldehydes. This work led to development of the asymmetric total synthesis of the anti-malarial drug mefloquine hydrochloride utilizing an asymmetric Darzens reaction of an ACC hydrazone. Both enantiomers of the drug were prepared separately for biological testing. College of Charleston Charleston, SC Advisor: Charles F. Beam May 2005 August 2007 Synthesized numerous heteroaromatic compounds using strong base techniques. Syntheses involved the formation of di- or trianion derivatives of ketones, hydrazones, or oximes and their subsequent condensation with carbonyl compounds followed by cyclization.

4 Awards Pelham Wilder Fellowship July 2012 Duke Chemistry Department Fellowship awarded based on nomination by teaching faculty and vote by departmental faculty. Recognizes excellence in teaching by graduate students. Award: $250 personal bonus, $250 research award. Outstanding Undergraduate Chemistry Major April 2007 based on the nomination and vote of faculty. Recognizes outstanding accomplishments by a specific undergraduate chemistry major in a given year. Chemistry Departmental Honors April 2007 based based on Chemistry major GPA. Major Field Test Award April 2007 based on performance on the Chemistry Major Field Test exam. The Hypercube Scholar Award April 2007 based on the nomination and vote of faculty Recognizes an undergraduate student who has utilized computer-based molecular modeling during the student s research career. Award: Personal copy of Hyperchem modeling software. Outstanding Undergraduate Research Award April 2007 Awarded by the Charleston chapter of Sigma Xi for best oral presentation in chemistry at the South Carolina Academy of Science conference in Columbia, SC. Awarded by panel of judges at the conference. Presentation title: Strong- Base Synthesis of Symmetrical Triketones. Award: $250 personal award, recognition at banquet meeting of local Sigma Chi chapter. Outstanding Undergraduate Research Award April 2007 Awarded by the Charleston chapter of Sigma Xi for best oral presentation in chemistry at the South Carolina Academy of Science conference in Columbia, SC. Presentation title: Synthesis of Heterocyclic Compounds Using New Methodology with Dianions of β-diketones. Award: $250 personal award, recognition at banquet meeting of local Sigma Chi chapter. South Carolina Palmetto Fellows Scholarship College fellowship from the State of South Carolina based on academic performance in high school and SAT score. Amount: $6,700 to $7,500 per academic year

5 College of Charleston Academic Scholarship College fellowship from the College of Charleston foundation based on academic performance in highs school. Amount: $4,000 per academic year Presentations 1. Asymmetric Total Synthesis of (+)- and (-)-Mefloquine Hydrochloride via N Amino Cyclic Carbamate Hydrazones. Southeastern Regional Meeting of the American Chemical Society in Richmond, VA. October 26 th, (poster) 2. A Lifetime of Lithium Diisopropylamide and Hydrazones. Department of Chemistry, College of Charleston in Charleston, SC. October 13 th, (seminar) 3. Strong-Base Synthesis of Symmetrical Triketones. Annual Meeting of the South Carolina Academy of Science in Columbia, SC. April 20 th, (oral presentation) 4. Preparation of NH-, N-Carbomethoxy- and N-Carboethoxypyrazolyl-orthobenzenesulfonamides from Polylithiated Carboalkoxyhydrazones and Methyl 2- (Aminosulfonyl)benzoate. 58 th Southeast Regional Meeting of the American Chemical Society in Augusta, GA. November 1 st, (oral presentation) 5. Synthesis of Heterocyclic Compounds Using New Methodology with Dianions of β-diketones. Annual Meeting of the South Carolina Academy of Science in Columbia, SC. March 10th, (oral presentation) 6. Preparation of Pyrazole-Carboxylic Acid Esters and N-H Pyrazoles from Dilithiated Carbomethoxyhydrazones and Esters. 231 st ACS National Meeting in Atlanta, GA. March 27 th, (poster presentation) Publications 1. Stereoselective Synthesis of Quaternary Carbons via the Dianionic Ireland- Claisen Rearrangement. M. T. Crimmins, J. D. Knight, P. S. Williams, and Y. Zhang, Organic Letters, 2014, 16(9), Expanding the Scope of the Asymmetric anti-aldol Addition of Chiral N-Amino Cyclic Carbamate Hydrazones. J. D. Knight and D. M. Coltart, Tetrahedron Letters., 2013, 54(40), Asymmetric Anti-aldol Addition of Achiral Ketones via Chiral N-Amino Cyclic Carbamate Hydrazones. J. D. Knight and D. M. Coltart, Chemical Communications, 2013, 49(68),

6 4. Asymmetric Total Synthesis of the Antimalarial Drug (+)-Mefloquine Hydrochloride via Chiral N-Amino Cyclic Carbamate Hydrazones. J. D. Knight, S. J. Sauer, and D. M. Coltart, Organic Letters, 2011, 13(12), (Featured in Synfacts, 2011, 9, 9035). 5. Synthesis and Crystal Structure Determination of 3-Phenyl-2-(2- phenylhyrazino)-4h-1-benzothiopyran-4-one. C. M. Metz, J. D. Knight, S. J. Pastine, W. T. Pennington, and C. F. Beam, Journal of Chemical Crystallography, 2010, 40(6), Synthesis and Crystal Structure Determination of Methyl 2-acetyl-5 -phenyl- 2H-spiro[benzo[d]isothiazole-3,3 -pyrazole]-1,1-dioxide-2 (4 H)-carboxylate and Methyl 2-acetyl-5 -(2-thienyl)-2H-spiro[benzo[d]isothazole-3,3 -pyrazole]- 1,1-dioxide-2 (4 H)-carboxylate. R. Metz, J. D. Knight, A. C. Dawsey, W. T. Pennington, D. G. Van Derveer, J. B. Brown, K. J. Bigham, and C. F. Beam, Journal of Chemical Crystallography, 2010, 40(4), Preparation of 2H-spiro[benzo[d]isothiazole-3,3 -pyrazole]-1,1-dioxide-2 (4 H)-carboxylates from Dilithiated C(α),N-Carboalkoxyhydrazones and Methyl 2-(aminosulfonyl)benzoate. A. C. Dawsey, C. Potter, J. D. Knight, Z. C. Kennedy, E. A. Smith, A. M. Acevedo-Jake, A. J. Puciaty, C. R. Metz, W. T. Pennington, and C. F. Beam, Journal of Heterocyclic Chemistry, 2009, 46(2), Characterization of New and Some Known Organic Compounds: Phenyl Carbazate and its Transformation into Hydrazones. J. D. Knight, D. L. Weddle, J. McLaughlin, A. Straumanis, and C. F. Beam, Chemical Educator, 2009, 14(1), Preparation of 2-[1-Phenyl-1H-pyrazol-5-yl]benzoic Acids from Dilithiated C(α),N-Phenylhydrazones and Methyl Hydrogen Phthalate. A. C. Dawsey, J. D. Knight, and C. F. Beam, Synthetic Communications, 2008, 38(23), New Strong Base Synthesis of Symmetrical 1,5-Diaryl-1,3,5-pentanetriones from Acetone and Benzoate Esters. J. D. Knight, C. R. Metz, W. T. Pennington, D. J. Vanderveer, and C. F. Beam, Synthetic Communications, 2008, 38(14), Preparation of 4,5-Dihydronaphth[2,1-c]isoxazoles from Dilithiated 2- Tetralone Oxime and Select Esters. E. Choi, J. D. Knight, M. D. Malatanos, J. M. Rhett, M. J. Walters, S. P. Dunn, and C. F. Beam, Synthetic Communications, 2008, 38(5), Preparation of 2-(1H-pyrazol-5-yl)benzenesulfonamides from Polylithiated C( ),N-Carbo-tert-butoxyhydrazones and Methyl 2 -(Aminosulfonyl)benzoate. J. D. Knight, J. B. Brown, J. S. Overby, C. F. Beam, and N. D. Camper, Journal Heterocyclic Chemistry, 2008, 45(1),

7 13. Tris(2-carboxyethyl)phosphine Hydrochloride. J. M. Yost, J. D. Knight, and D. M. Coltart. e-eros Encyclopedia of Reagents for Organic Synthesis, Synthesis of NH-,2H-4,5-Dihydrobenzin[g]azoles and Related Compounds from 1-Tetralone Carbomethoxyhydrazones and Aromatic Esters. J. D. Knight, C. R. Kramp, E. J. Hilton, J. H. Vella, B. J. Grant, L. M., Hajiaghamohseni, M. A. Meierhoefer, S. P. Dunn, M. J. Walters, J. S. Overby, C. R. Metz, W. T. Pennington, D. G. VanDerveer, and C. F. Beam, Industrial Engineering and Chemistry Research, 2007, 46(26), Preparation of 3 -Aryl spiro[1,2-benzisothiazole-3,5 (4 H)-isoxazole]-1,1- dioxides from Dilithiated C(α),O-Oximes and Methyl 2- (Aminosulfonyl)benzoate. B. J. Grant, C. R. Kramp, J. D. Knight, M. A. Meierhoefer, J. H. Vella, C. L. Sober, C. R. Metz, C. F. Beam, W. T. Pennington, D. J. Vanderveer, and N. D. Camper, Journal of Heterocyclic Chemistry, 2007, 44(3), The Preparation of 3,3a,4,5-Tetrahydroarylnaphth[1,2-c]isoxazoles from Dilithiated 1-Tetralone and Select Benzaldehydes. J. H. Vella, N. S. Patel, M. A. Meierhoefer, E. J. Hilton, C. L. Sober, B. J. Grant, C. R. Kramp, J. D. Knight, C. R. Metz, C. F. Beam, W. T. Pennington, D. G. VanDerveer, and N. D. Camper,, Journal of Heterocyclic Chemistry, 2006, 43(2), Skills Organic synthesis, anhydrous and inert atmosphere techniques, purification techniques, diazomethane generation, 1 H, 13 C, and 19 F NMR spectroscopy (Varian and Bruker), two-dimensional NMR spectroscopy, liquid chromatography-mass spectrometry (LC-MS), solvent purification systems, high performance-liquid chromatography (HPLC), gas chromatography (GC), Fourier Transform Infrared spectroscopy (FT-IR), melting temperature, optical rotation/polarimetry, recrystallization, atomic absorption/emission (AA-AE), molecular modeling, MestReNova NMR software, Microsoft Word, Microsoft Excel, Microsoft Powerpoint, Windows and Mac operating systems.

Chemistry Courses -1

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