WILLIAM R. CARROLL, Ph.D. Assistant Professor of Chemistry

Transcription

1 Tennessee Technological University Department of Chemistry 107 Foster Hall Cookeville, TN (931) Professional Preparation CURRICULUM VITAE WILLIAM R. CARROLL, Ph.D. Assistant Professor of Chemistry California Institute of Technology Pasadena, CA Postdoctoral Scholar in Chemistry and Chemical Engineering working for Professor Emeritus John D. Roberts, Co-mentor for Summer Undergraduate Research Fellowship students (SURF). Research projects include a variety of conformational analyses of small molecules by NMR. University of South Carolina Columbia, SC Ph.D. Department of Chemistry, Advisor: Ken Shimizu. Thesis: Model systems for determining the strength of non-covalent interactions. Georgia Institute of Technology Atlanta, GA Bachelor of Science, Chemistry, May, Participated in undergraduate research program with Lawrence A. Bottomley. Honors and Awards Copenhaver Fellowship, June, Joseph W. Bouknight teaching award, August, Paper highlighted in Nature Chemistry Research has been highlighted in C&E News Aug 8, Research Experience California Institute of Technology Dept. of Chemistry Advisor: Prof. Emeritus John D. Roberts Postdoctoral Scholar in Chemistry: Pasadena, CA 1 P a g e

2 Synthesized and studied the conformational preferences of a variety of small molecules by NMR in both conventional isotropic and anisotropic media. Molecules include 15 N labeled amino acid derivatives, deuterated liquid crystals, and substituted cyclohexanes to name a few. Co-mentored 23 students, 21 undergraduates, 2 high school students, 3 independently funded by Amgen, 1 funded by the Caltech MURF (for underrepresented students), and 8 from universities outside of the US. With the aid of one other postdoctoral scholar prepared all necessary materials for 23 summer research projects in the field of conformational analysis by NMR as well as contributing to grant updates and new proposals for undergraduate student s projects. Our group has a focus on undergraduate publications. Our 10 week summer programs have produced 3 published articles and multiple articles in preparation as well as multiple continuing projects for our group. I have also published one article with my previous research group. Written MATLAB code to interpret both scalar and dipolar couplings independently and simultaneously for the determination of the structure of dynamic systems in solution. University of South Carolina Department of Chemistry Columbia, SC Advisor: Ken Shimizu Graduate research assistant: Major contributions: o Established new projects in our lab which has branched into multiple published works. o Developed a new molecular balance system for measuring face-to-face arene-arene interactions. o Adapted this balance scaffold to better understand many geometries and varieties of arene interactions. o Made bio-nanoparticle imprinted surfaces and characterized them with AFM. o Adapted a minimal stochastic model of molecular imprinting to use with Matlab. o Made molecularly imprinted polymers with cyclodextrin as a functional monomer and quantified binding site heterogeneity using batch rebinding. Authored several peer reviewed journal articles reporting the findings of my works. Trained 3 undergraduates and 1 graduate student in basic synthesis, experimental design, and reaction troubleshooting. Lab techniques organic synthesis, NMR, UV/VIS, Basic AFM, and operated titer plate reader. University of South Carolina Department of Chemistry Advisor: Qian Wang Columbia, SC 2 P a g e

3 Cophenhaver fellowship, June 2005 Explored the surface functionalization of bio-nanoparticles for use with Click (1,3-Dipolar Cycloaddition) reactions. Assessed protein functionalization and purity using FPLC and MALDI. Georgia Institute of Technology Atlanta, GA Advisor: Lawrence A. Bottomley Undergraduate research assistant, January 2002 Assisted in the early stages of development of AFM based flow device. Teaching Experience Tennessee Technological University Cookeville, TN Assistant Professor in Chemistry Instructor of record for Organic Chemistry I (CHEM3010) lecture and lab section Fall 2013, The spectroscopic identification of organic compounds lecture and lab sections for both undergraduate (CHEM4320) and graduate (CHEM5320) students Spring 2014, Organic Chemistry I (CHEM3010) lecture Introduction to Research (CHEM4992) Advanced special topics (CHEM6970) Summer 2014, Organic Chemistry (CHEM3010) lecture and lab sections Introduction to research (CHEM 4991) Chemistry Thesis Seminar (CHEM6911) Fall California Institute of Technology Pasadena, CA Postdoctoral Scholar in Chemistry As a co-mentor in the Caltech summer undergraduate research program (SURF) trained undergraduates in planning and execution of research goals. Trained 19 summer researchers in the operation, interpretation, and theory behind NMR University of South Carolina Department of Chemistry Columbia, SC Undergraduate research mentor Trained undergraduates in planning and execution of research goals. Instructed undergraduates in basic organic synthesis and reaction troubleshooting. Teaching assistant Taught 3 sections of organic chemistry I recitation, 2 sections of Organic II recitation, ½ of a semester of Organic I laboratory, and served 2 semesters as the spectroscopy teaching assistant for Organic I and II laboratories. Taught weekly study sessions reviewing lecture material for students. Designed and graded weekly quiz and assisted in grading tests and finals. Operated and maintained IR spectrometer, ran NMR spectrometer, and taught interpretation of results from both to students. 3 P a g e

4 Presentations Zhao, C.; Carroll, W. R.; Parrish, R. M.; Smith, M. D.; Pellechia, P. J.; Sherrill, C. D.; Shimizu, K. D. In Comprehensive study of aliphatic CH-π interactions using molecular balances, American Chemical Society: 2013; pp ORGN-658. Carroll, W. R.; Kenney, M.; Roberts, J. D.; Imidazole-4-propanoic acid as an analog for the serine protease active site: The effects of water on intramolecular hydrogen bonding in acetonitrile American Chemical Society: 2011, p WRM-41. Carroll, W. R.; Shimizu, K. D. Molecular balance for determining the strength of face to face pi-pi interactions Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008, ORGN-573. Carroll, W. R, Kenney, M, Roberts, J. D. 15 N NMR Study of Intramolecular Hydrogen Bonding in Imidazole-4-Propanoic Acid and Its Relevance to the α- Lytic Protease Hydrogen Bonding Network, AAAS annual meeting, Vancouver, Canada,, February 16-20, 2011, poster Zhao, Chen; Carroll, William R.; Pellechia, Perry J.; Smith, Mark D.; Shimizu, Ken D. Torsional molecular balance for measuring CH-π interactions 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 Stephenson, Clifton J.; Carroll, William R.; Yehl, Michael A.; Shimizu, Ken D. Virus imprinting and reuptake in polymer films Polymer Preprints American Chemical Society, Division of Polymer Chemistry 2006, 47, Stephenson, Clifton J.; Carroll, William R.; Yehl, Michael A.; Shimizu, Ken D. Virus imprinting and reuptake in polymer films Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept , 2006, POLY Publications Lai, H. W. H.; Liu, A. T.; Emenike, B. U.; Carroll, W. R.; Roberts, J. D., Conformational Preferences of N,N-Dimethylsuccinamate as a Function of Alkali and Alkaline Earth Metal Salts: Experimental Studies in DMSO and Water As Determined by 1H NMR Spectroscopy. J. Phys. Chem. A 2014, 118, Naveo, E. P.; Emenike, B. U.; Carroll, W. R.; Roberts, J. D. In Solvent effects on amide-amide intramolecular hydrogen bonding as studied by NMR spectroscopy, American Chemical Society: 2013; pp CHED-925. Hwang, J.; Li, P.; Carroll, W. R.; Pellechia, P. J.; Shimizu, K. D., Additivity of substituent effects in aromatic stacking interactions. J. Am. Chem. Soc. 2014, Ahead of Print. Carroll, W. R.; Zhao, C.; Smith, M. D.; Pellechia, P. J.; Shimizu, K. D., A Molecular Balance for Measuring Aliphatic CH-π Interactions, Org. Lett. 2011, 13, P a g e

5 Emenike, B. U.; Carroll, W. R.; Roberts, J. D., Conformational Preferences of cis-1,3-cyclopentanedicarboxylic Acid and Its Salts by 1H NMR Spectroscopy: Energetics of Intramolecular Hydrogen Bonds in DMSO. J. Org. Chem. 2013, 78, Liu, A. T.; Emenike, B. U.; Carroll, W. R.; Roberts, J. D., Conformational Equilibria of N,N-Dimethylsuccinamic Acid and Its Lithium Salt as a Function of Solvent. Org. Lett. 2013, 15, Liu, A. T.; Nag, M.; Carroll, W. R.; Roberts, J. D., Conformational analysis of N,N,N-Trimethyl(3,3-dimethylbutyl)ammonium iodide by NMR spectroscopy: a sterically hindered trans-standard. Magn. Reson. Chem. 2013, 51, Garza, A. J.; Nag, M.; Carroll, W. R.; Goddard, W. A., III; Roberts, J. D., Conformational Preferences of trans-1,2- and cis-1,3-cyclohexanedicarboxylic Acids in Water and Dimethyl Sulfoxide as a Function of the Ionization State As Determined from NMR Spectroscopy and Density Functional Theory Quantum Mechanical Calculations, J. Am. Chem. Soc. 2012, 134, Liu, A. T.; Emenike, B. U.; Carroll, W. R.; Roberts, J. D., Conformational Equilibria of N,N-Dimethylsuccinamic Acid and Its Lithium Salt as a Function of Solvent. Org. Lett. 2013, 15, Emenike, B. U.; Carroll, W. R.; Roberts, J. D., Conformational Preferences of cis-1,3-cyclopentanedicarboxylic Acid and Its Salts by 1H NMR Spectroscopy: Energetics of Intramolecular Hydrogen Bonds in DMSO. J. Org. Chem. 2013, 78 (Copyright (C) 2014 American Chemical Society (ACS). All Rights Reserved.), Carroll, W. R.; Pellechia, P.; Shimizu, K. D., A rigid molecular balance for measuring face-to-face arene-arene interactions. Organic Letters 2008, 10, (16), Wu, X. Y.; Carroll, W. R.; Shimizu, K. D., Stochastic lattice model Simulations of molecularly imprinted polymers. Chemistry of Materials 2008, 20, (13), Chong, Y. S.; Carroll, W. R.; Burns, William G.; Smith, M. D.; Shimizu, K. D., A High-Barrier Molecular Balance for Studying Face-to-Face Arene-Arene Interactions in the Solid State and in Solution. Chemistry - A European Journal 2009, 15, (36), Collaborations Stan Manatt, Jet Propulsion Laboratory retired: NMR coupling constant prediction in small fluorocarbons Synergistic 5 P a g e

6 Taught outreach laboratory in which local middle school and high school students prepared and tested molecularly imprinted polymers. Managed and maintained university dry stills for the department of chemistry P a g e