M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER

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1 M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER CLASS : PGDCI SUBJECT :... PAPER : I- Basic of Chemoinformatics funsz'k %& 1- lhkh iz'u Lo;a dh glrfyfi esa gy djuk vfuok;z gsa 2- nksuksa l=h; iz'ui= gy djuk vfuok;z gsaa 3- l=h; dk;z mùkjiqflrdk ds vafre i`"b ij lacaf/kr fo"k; dh laiuu laidz d{kkvksa dh frffk;ksa,oa ijke'kznkrk ds uke,oa in dk vo'; myys[k djsaa 4- vafre frffk mijkar l=h; dk;z mùkjiqflrdkvksa dks eku; ugha djrs gq, ewy;kafdr ugha dh tkosxha 5- l=h; dk;z mùkjiqflrdk,a tek djus dh vafre frffk l=h; dk;z mùkjiqflrdk,a tek djus dh jlhn vo'; izkir dj ysaa vizsy 2010 gsa 7- nks l=h; dk;z izkirkadksa esa ls fdlh,d esa vf/kdre vad dh iwoz izpfyr O;oLFkk ds LFkku ij nksuksa l=h; dk;ksza ds izkirkadksa ds vkslr vad l=kar ijh{kk ifj.kke esa tksm+s tk,axsa lhkh iz'uksa ds vad leku gsaa First Assignment Max Marks - 30 Q.1 Explain in phase the integration and access. Or Discuss pharmacophore appearing. Q.2 Explain how is Medical Chemistry changing? Or Discuss the emergence of a discipline i.e.chemoinformatics. Q.3 Give traditional A& I services, embracing the future and leveraging the past. Or What are chemical information specialists actually do? Q.4 Give application of chemoinformatics with drug industry. Or How you will analyze and exploit the HTS data? Q.5 Explain Bio-Technology, Drug discovery and informatics. Or Explain the educational requirement in respect of chemoinformatics. Second Assignment Max Marks - 30

2 Q.1What are the Chemoinformatic techniques? Or What is docking referring physical the between a macromolecular target & a pharmaceuticals? Q.2 What was the situations in 1973, scientific millstones in predicting chemo informatics. Or Give milestones in the development of molecular modeling. Q.3 Give enzymes of A& C Services. Or Discuss complete generation & launching. Q.4 Explain combinational chemistry and chemoinformatics. Or Discuss rational drug discovery (Bio-Chemo informatics). Q.5 Explain revising gene annotations. Or Give prediction of drug and in vivo effects.

3 M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER CLASS : PGDCI SUBJECT :... PAPER : II- Medical Chemistry, receptor, Ligand interaction funsz'k %& 1- lhkh iz'u Lo;a dh glrfyfi esa gy djuk vfuok;z gsa 2- nksuksa l=h; iz'ui= gy djuk vfuok;z gsaa 3- l=h; dk;z mùkjiqflrdk ds vafre i`"b ij lacaf/kr fo"k; dh laiuu laidz d{kkvksa dh frffk;ksa,oa ijke'kznkrk ds uke,oa in dk vo'; myys[k djsaa 4- vafre frffk mijkar l=h; dk;z mùkjiqflrdkvksa dks eku; ugha djrs gq, ewy;kafdr ugha dh tkosxha 5- l=h; dk;z mùkjiqflrdk,a tek djus dh vafre frffk l=h; dk;z mùkjiqflrdk,a tek djus dh jlhn vo'; izkir dj ysaa vizsy 2010 gsa 7- nks l=h; dk;z izkirkadksa esa ls fdlh,d esa vf/kdre vad dh iwoz izpfyr O;oLFkk ds LFkku ij nksuksa l=h; dk;ksza ds izkirkadksa ds vkslr vad l=kar ijh{kk ifj.kke esa tksm+s tk,axsa lhkh iz'uksa ds vad leku gsaa First Assignment Max Marks - 30 Q.1 Discuss ligand based drug design method. Or Structural based virtual screening. Q.2 Give Pharmaco Kinetics in brief. Or Explain such types of antagonism. Q.3 What are abused drugs & their effects? Or Discuss antiinfective Antibiotic drugs. Q.4 Discuss the prospects in Medical Chemistry. Or What are the new places to look for Biodiversity? Q.5 Explain drug discovery process today. Or Discuss molecular approaches in drug discovery. Second Assignment Max Marks - 30 Q.1 Define ligand & receptor. Or Receptor discovery and characterization. Q.2 Give respiratory system drug therapy. Or What are natural sources of lead compounds? Q.3 Explain various aspects of anti-cancer therapy. Or What are challenges for new century for natural products?

4 Q.4 What are the drug discovery process today? Or Give ADME/PK as part of a rational approach drug discovery. Q.5 Explain extended therapeutic utility for ligands with affinities Or How is partition co-efficient in drug defined?

5 M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER CLASS : PGDCI SUBJECT :... PAPER : III- Modern Combinatorial Chemistry funsz'k %& 1- lhkh iz'u Lo;a dh glrfyfi esa gy djuk vfuok;z gsa 2- nksuksa l=h; iz'ui= gy djuk vfuok;z gsaa 3- l=h; dk;z mùkjiqflrdk ds vafre i`"b ij lacaf/kr fo"k; dh laiuu laidz d{kkvksa dh frffk;ksa,oa ijke'kznkrk ds uke,oa in dk vo'; myys[k djsaa 4- vafre frffk mijkar l=h; dk;z mùkjiqflrdkvksa dks eku; ugha djrs gq, ewy;kafdr ugha dh tkosxha 5- l=h; dk;z mùkjiqflrdk,a tek djus dh vafre frffk l=h; dk;z mùkjiqflrdk,a tek djus dh jlhn vo'; izkir dj ysaa vizsy 2010 gsa 7- nks l=h; dk;z izkirkadksa esa ls fdlh,d esa vf/kdre vad dh iwoz izpfyr O;oLFkk ds LFkku ij nksuksa l=h; dk;ksza ds izkirkadksa ds vkslr vad l=kar ijh{kk ifj.kke esa tksm+s tk,axsa lhkh iz'uksa ds vad leku gsaa First Assignment Max Marks - 30 Q.1 What are the synthesis principle of natural amino acids? Or Discuss spot synthesis of amino acids. Q.2 What are OBDC library methods (one bead one compound) (OBDC) library) Or Explain coupling chemistry in pharmeco kinetics. Q.3 What are phase derived intermediates? Or What are the challenges facing UHTH? Q.4 Name the new statistical methods. Or Give in order about the sited of metabolism. Q.5 Explain in short of the following (any two) (a) Liquid phase chemistry (b) Multiple parallel synthesis (c) Regent Efficiency (d) Solid-phase extraction Second Assignment Max Marks - 30 Q.1 Explain parallel synthesis on solid-phase. Or Give in short the identification of the active ligands.

6 Q.2 What are solid-phase supported regents. Or Explain in situ synthesis of peptides. Q.3 What are destructive techniques, give names? Or Explain in short solution & gel phase by MMR. Q.4 What are experimental model for coatings. Or Explain in short design based on natural products. Q.5 Explain in short any two of the following. a) Ladder synthesis c)re-synthesis b) Flourouse Synthesis d)phage display libraries

7 M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER CLASS : PGDCI SUBJECT :... PAPER : IV- Chimoinformatics Data base Design & Their Management funsz'k %& 1- lhkh iz'u Lo;a dh glrfyfi esa gy djuk vfuok;z gsa 2- nksuksa l=h; iz'ui= gy djuk vfuok;z gsaa 3- l=h; dk;z mùkjiqflrdk ds vafre i`"b ij lacaf/kr fo"k; dh laiuu laidz d{kkvksa dh frffk;ksa,oa ijke'kznkrk ds uke,oa in dk vo'; myys[k djsaa 4- vafre frffk mijkar l=h; dk;z mùkjiqflrdkvksa dks eku; ugha djrs gq, ewy;kafdr ugha dh tkosxha 5- l=h; dk;z mùkjiqflrdk,a tek djus dh vafre frffk l=h; dk;z mùkjiqflrdk,a tek djus dh jlhn vo'; izkir dj ysaa vizsy 2010 gsa 7- nks l=h; dk;z izkirkadksa esa ls fdlh,d esa vf/kdre vad dh iwoz izpfyr O;oLFkk ds LFkku ij nksuksa l=h; dk;ksza ds izkirkadksa ds vkslr vad l=kar ijh{kk ifj.kke esa tksm+s tk,axsa lhkh iz'uksa ds vad leku gsaa First Assignment Max Marks - 30 Q.1 Explain database management system. Or Give examples of data used in pharmaceutical industry. Q.2 What are different types of information rules. Or Explain set field properties of database. Q.3 What is customizing access of database? Or Explain fast and flexible chemistry Q.4 Explain SQL strength & weakness. Or What is nested SQL statements? Q.5 Give in short the following (any two) a) Digression on Map-ability. b) Array specifications c) Summary of basic techniques. d) failing database Chimoinformatics. Second Assignment Max Marks - 30 Q.1 What is database? Give its advantages. Or Give various types of database system.

8 Q.2 Explain database design examples. Or Give in short chemoinformatics database. Q.3 Describe in short the different normal forms. Or How will you setup a data base? Q.4 What is referential integrity, How you will use it? Q.5 Explain in short the followings (any two) a) Data definition communications. b) SQL's DML statements. c) Internet data structure. d) Any case study database design.

9 M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER CLASS : PGDCI SUBJECT :... PAPER : V- Chemical Information Sources funsz'k %& 1- lhkh iz'u Lo;a dh glrfyfi esa gy djuk vfuok;z gsa 2- nksuksa l=h; iz'ui= gy djuk vfuok;z gsaa 3- l=h; dk;z mùkjiqflrdk ds vafre i`"b ij lacaf/kr fo"k; dh laiuu laidz d{kkvksa dh frffk;ksa,oa ijke'kznkrk ds uke,oa in dk vo'; myys[k djsaa 4- vafre frffk mijkar l=h; dk;z mùkjiqflrdkvksa dks eku; ugha djrs gq, ewy;kafdr ugha dh tkosxha 5- l=h; dk;z mùkjiqflrdk,a tek djus dh vafre frffk l=h; dk;z mùkjiqflrdk,a tek djus dh jlhn vo'; izkir dj ysaa vizsy 2010 gsa 7- nks l=h; dk;z izkirkadksa esa ls fdlh,d esa vf/kdre vad dh iwoz izpfyr O;oLFkk ds LFkku ij nksuksa l=h; dk;ksza ds izkirkadksa ds vkslr vad l=kar ijh{kk ifj.kke esa tksm+s tk,axsa lhkh iz'uksa ds vad leku gsaa First Assignment Max Marks - 30 Q.1 Explain the future of the scientific internet. Or How you will distinguish scholarly journals from other periodicals. Q.2 What are the advantages of computer searching? Or Explain chemical safely & toxicology information. Q.3 Explain environmentally friendly analytical chemistry. Or Discuss the CIS: Chemical information system. Q.4 Discuss in short biographical information. Or Explain in short about access to patents. Q.5 What are the various sources by which you can get a detailed knowledge of a chemical world. Or What is trn news reader; How does it works? Second Assignment Max Marks - 30 Q.1 Discuss the importance of various types of publications. Or What is the purpose of searching chemical abstracts on line.

10 Q.2 What do you understand by primary literature, discuss any one of them? Or What are patents, their search & trade mark depository library? Q.3 What is visual molecular dynamics (VMD)? Or Give types of complex-readable sources. Q.4 How analytical chemistry is useful for obtaining informations? Or How the name reactions complications are solved? Q.1 What is the criteria of primary secondary and tertiary literature. Or What do you know about physical properties of organic solvent for database.

11 M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER CLASS : PGDCI SUBJECT :... PAPER : VII- Data Sequencing mining & Visualization funsz'k %& 1- lhkh iz'u Lo;a dh glrfyfi esa gy djuk vfuok;z gsa 2- nksuksa l=h; iz'ui= gy djuk vfuok;z gsaa 3- l=h; dk;z mùkjiqflrdk ds vafre i`"b ij lacaf/kr fo"k; dh laiuu laidz d{kkvksa dh frffk;ksa,oa ijke'kznkrk ds uke,oa in dk vo'; myys[k djsaa 4- vafre frffk mijkar l=h; dk;z mùkjiqflrdkvksa dks eku; ugha djrs gq, ewy;kafdr ugha dh tkosxha 5- l=h; dk;z mùkjiqflrdk,a tek djus dh vafre frffk l=h; dk;z mùkjiqflrdk,a tek djus dh jlhn vo'; izkir dj ysaa vizsy 2010 gsa 7- nks l=h; dk;z izkirkadksa esa ls fdlh,d esa vf/kdre vad dh iwoz izpfyr O;oLFkk ds LFkku ij nksuksa l=h; dk;ksza ds izkirkadksa ds vkslr vad l=kar ijh{kk ifj.kke esa tksm+s tk,axsa lhkh iz'uksa ds vad leku gsaa First Assignment Max Marks - 30 Q.1 What is data mining? Give suitable diagram and example? Or How will you select data mining products categories? Q.2 How data mining help in Biological data analysis? Or What is machine leaving? Q.3 Why is visualize a data mining model? OR What is CHILD, explain in short. Q.4 What are analytical technologies used in data mining? Or How is the space for clustering and nearest neighbor defined? Q.5 How can you compare different mining models using data visualization? Or Discuss the data mining software developments? Second Assignment Max Marks - 30 Q.1 Discuss predictive data mining and classification with terminology. Or Explain data mining process with examples. Q.2 How data mining works? Or Describe data mining architecture.

12 Q.3 What is Ontology understanding module? Or What are the characteristics of data? Q.4 What is decision tree for prediction? Or Write in short on data warehouse design for drug discovery. Q.5 What is difference between characterizing and near to neighbor prediction. Or Give current state of data mining software applications.

13 M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER CLASS : PGDCI SUBJECT :... PAPER : VIII- Drug Design and Discovery funsz'k %& 1- lhkh iz'u Lo;a dh glrfyfi esa gy djuk vfuok;z gsa 2- nksuksa l=h; iz'ui= gy djuk vfuok;z gsaa 3- l=h; dk;z mùkjiqflrdk ds vafre i`"b ij lacaf/kr fo"k; dh laiuu laidz d{kkvksa dh frffk;ksa,oa ijke'kznkrk ds uke,oa in dk vo'; myys[k djsaa 4- vafre frffk mijkar l=h; dk;z mùkjiqflrdkvksa dks eku; ugha djrs gq, ewy;kafdr ugha dh tkosxha 5- l=h; dk;z mùkjiqflrdk,a tek djus dh vafre frffk l=h; dk;z mùkjiqflrdk,a tek djus dh jlhn vo'; izkir dj ysaa vizsy 2010 gsa 7- nks l=h; dk;z izkirkadksa esa ls fdlh,d esa vf/kdre vad dh iwoz izpfyr O;oLFkk ds LFkku ij nksuksa l=h; dk;ksza ds izkirkadksa ds vkslr vad l=kar ijh{kk ifj.kke esa tksm+s tk,axsa lhkh iz'uksa ds vad leku gsaa First Assignment Max Marks - 30 Q.1 Describe database system for protein-ligand structures. Or Explain the evolution plays a role in deciphering protein functions. Q.2 What are the steps involved in docking? Or Discuss the role of computers in molecular modeling. Q.3 Explain phase-i & Phase-II metabolism of drugs. Or Discuss, How do hard drugs solve the problem of toxicity. Q.4 What are the physico-chemical texture that effect rate of absorption. Or Explain difference between genetics and pharmecogenetics. Q.5 How does virtual screening help drug design? Or What are rapid reversible inhibitors? Second Assignment Max Marks - 30 Q.1 Describe here a protein structure deciphers its function. Or What is the role of combination chemistry in drug design. Q.2 Distinguish between quantum mechanics and molecular mechanics. Or Write a note on enzyme induction & inhibition. P.T.O.

14 From Pre Page Q.3 What are soft drugs & how they function? Or Describe the role of solvent in ligand binding. Q.4 Explain the short coming of Lipinski's rule. Or What is proteomics and give its difference from genomics. Q.5 Define the term- (a) Pharmecophores (b) EST (C) SNP Or Write short note on Michaelis- menten equation.

M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER

M P BHOJ (OPEN) UNIVERSITY, BHOPAL ASSIGNMENT QUESTION PAPER Paper - I - Quantum Mechanics Q.1 Explain Erhenfest theorem. (5) Q.2 Explain Fermi Golden rule. (5) Q.3 Discuss Wein - gorden equation & drive equation. (5) Q.4 Write a short note on Exchange degeneracy