Curriculum Vitae. Personal information. About Me. Work Experience

Transcription

1 Curriculum Vitae Personal information First name / Surname Address Michele Mari Via delle querce n.19, 61049, Urbania (PU), ITALY Telephones Laboratory: Mobile: Office: michele.mari@uniurb.it Personal: vikingdeath@hotmail.com Nationality Italian Date of birth 01 August 1986 Gender Male About Me I am an Organic / Medicinal Chemistry Postdoctoral Fellow currently working in the field of Synthesis of biologically active indole-containing molecules. In particular Total Synthesis of Natural Products, mainly Indole-containig alkaloids such as Indolactam V, Clavicipitic Acid, Aurantioclavine and Lysergic Acid, new methods for the synthesis of Bis-indoles and catalytic Indole Reactivity, Dehydroalanine Reactivity and Applications, Protein and Peptide Chemistry. Work Experience Dates Occupation or position held Main activities and responsibilities Name and address of employer Type of business or sector 11/2014 Present Postdoctoral Fellow Catalytic functionalization of indoles and sustainable synthesis of chiral indole-based alkaloids. Design, synthesis, optimization and characterization of biologically active compounds. Universita degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, Urbino (PU), Italy Department of Biomolecular Sciences, Section of Bio-Organic and Pharmaceutical Chemistry (supervisor: Prof. Giovanni Piersanti) Page 1/5 - Curriculum vitae of Michele Mari

2 Education Title of qualification awarded Dates 11/ /2014 Project Principal subjects/occupational skills covered Name and type of organisation providing education and training PhD in Medicinal Chemistry Synthesis of Indole-containing biologically active molecules, total synthesis of several indolecontaining alkaloids and analogues with biological activity, synthesis of Bis-Indoles. Proteins and Peptides Chemistry. -Synthesis, purification and characterization of biologically active compounds -Total synthesis of natural products -Solid phase peptide synthesis, peptide purification and peptide ligations for the synthesis of proteins -Supervisor for master s degree students Università degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, Urbino (PU), Italy ETH Zurich, HCI Building, Vladimir-Prelog-Weg 3, CH-8093, Zurich, Switzerland (Visiting PhD Student from 06/2013 to 02/2014 in Prof. Jeffrey W. Bode Group) Title of qualification awarded Name and type of organisation providing education and training Awards / Fellowships Dates 12/ /2011 First Class Honors Master s Degree (110/110 cum laude) in Medicinal Chemistry and Technology Achieved the qualification to practice as pharmacist in Italy Università degli Studi di Urbino Carlo Bo, Piazza Rinascimento 6, Urbino (PU), Italy Dates 11/ /2014 Fellowship Organisation Issuing the Fellowship Merit fellowship covering the entire duration of the Ph.D. course (3 years) Ministero dell Istruzione, dell Università e della Ricerca (MIUR), Rome, Italy Dates 12/ /2011 Fellowship Organisation Issuing the Fellowship Merit fellowship covering the tuitions/materials for the entire duration of the master s degree course ERSU Urbino, Via V. Veneto 43-45, Urbino (PU), Italy Page 2/5 - Curriculum vitae of Michele Mari

3 Personal skills and competences Mother tongue Italian Other language Understanding Speaking Writing Listening Reading Spoken interaction Spoken production English Very Good Excellent Very Good Very Good Very Good Social skills and competences Organisational skills and competences Technical skills and competences Computer skills and competences Driving licence Interests Due to my academic experience, I have developed good communication skills, stress tolerance and the ability to work both in a team and autonomously. I've also developed effectiveness in public presentations. Good organizational skills, attention to details and ability to meet deadlines. Experience with: - Compound synthesis: mainly classical synthesis (in solution) and microwave synthesis - Solid Phase Peptide Synthesis (manual and automatical using peptide synthesizers) - Compound purification: chromatography, extraction, distillation and crystallization - Compound characterization: TLC, HPLC, LC-MS, GC-MS, IR, NMR, polarimetry, MALDI- TOF. - Use of the most common databases, such as SciFinder, Scopus and Web of Science. Experience with Computer Software: Microsoft Office Word, Excel, Powerpoint, Outlook; Cambridgesoft ChemDraw; Chemical databases (SciFinder, Uniprot); software for the elaboration of chromatograms / spectra (Mestrenova). Italian Driving License (Car) I am mainly interested in: - Music (I ve been studying vocal techniques and singing for 5 years, leading a band, many concerts and studio experiences) - Sports (soccer, basketball, tennis) - Photography - Travelling Page 3/5 - Curriculum vitae of Michele Mari

4 Additional information Pubblications - Spadoni, G.; Bedini, A.; Lucarini, S.; Mari, M.; Caignard, D.-H.; Boutin, J.; Delagrange, P.; Lucini, V.; Scaglione, F.; Lodola, A.; Zanardi, F.; Pala, D.; Mor, M.; Rivara, S. Highly potent and selective MT2 melatonin receptor full agonists from conformational analysis of 1-benzyl- 2-acylaminomethyl-tetrahydroquinolines. J. Med. Chem. 2015, 58, Bartolucci, S.; Mari, M.; Bedini, A.; Piersanti, G.; Spadoni, G. Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-amino Alcohols as Alkylating Agents. J. Org. Chem. 2015, 80, Mari, M.; Lucarini, S.; Bartoccini, F.; Piersanti, G.; Spadoni, G. Synthesis of 2-Substituted Tryptophans via a C3- to C2-Alkyl Migration. Beilstein J. Org. Chem. 2014, 10, Mari, M.; Tassoni, A.; Lucarini, S.; Fanelli, M.; Piersanti, G.; Spadoni, G. Brønsted Acid Catalyzed Bisindolization of α-amido Acetals: Synthesis and Anti-cancer Activity of Bis(indolyl)ethanamino Derivatives. Eur. J. Org. Chem. 2014, 18, Bartoccini, F.; Casoli, M.; Mari, M.; Piersanti, G. Synthesis of (±)-cis-clavicipitic Acid by a Rh(I)-Catalyzed Intramolecular Imine Reaction. J. Org. Chem. 2014, 79, Lucarini, S.; Mari, M.; Piersanti, G.; Spadoni, G. Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates. RSC Adv. 2013, 3, Mari, M.; Bartoccini, F.; Piersanti G. Synthesis of (-) epi-indolactam V by an intramolecular Buchwald-Hartwig C-N Coupling Cyclization Reaction. J. Org. Chem. 2013, 78, Page 4/5 - Curriculum vitae of Michele Mari

5 Participation in Meetings - European School of Medicinal Chemistry, 35 th Edition (28 June - 3 July 2015, Urbino, ITALY) - XIV Sigma-Aldrich Young Chemists Symposium (27-29 October 2014, Riccione, ITALY); oral presentation entitled: Iridium-Catalyzed Hydrogen Transfer: Direct Synthesis of Tryptamines from Indoles - European School of Medicinal Chemistry, 34 th Edition (29 June - 4 July 2014, Urbino, ITALY); poster and selected oral presentation entitled: Strategic Indole and Tryptophan functionlization for the synthesis of Natural Products and Biologically Active Compounds - XXXIX A. Corbella International Summer School on Organic Synthesis ISOS (15-19 June 2014, Gargnano, ITALY); oral and poster presentation entitled: Synthesis of 2-alkylated tryptophans by Friedel-Crafts alkylation of 3-alkylindoles with Dehydroalanine dervatives - Senn Chemicals 50 th Anniversary Symposium (29 August 2013, Zurich, SWITZERLAND) - XII Sigma-Aldrich Young Chemists Symposium (1-3 October 2012, Riccione, ITALY); oral presentation entitled: Concise Synthesis of Indole Alkaloid (-)-Indolactam V via Intramolecular Buchwald-Hartwig Amination - European School of Medicinal Chemistry, 32 nd Edition (2-7 July 2012, Urbino, ITALY) - Boron Neutron Capture Therapy in Pavia: state of the art and perspectives in the light of CARIPLO research projects (28 May 2012, Pavia, ITALY) Page 5/5 - Curriculum vitae of Michele Mari