Codice Fiscale: BRLDNL46A49A744W. Curriculum Vitae Daniela BARLOCCO Born: Bellagio (CO) (Italy) Italian Citizen
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1 Codice Fiscale: BRLDNL46A49A744W Curriculum Vitae Daniela BARLOCCO Born: Bellagio (CO) (Italy) Italian Citizen Qualifications: Degree in Pharmacy - University of Pavia 1969 Degree in Chemistry - University of Pavia Proficiency in English - Cambridge 1988 Experience: Teacher of Sciences at State Middle School Researcher at the University of Milan, Faculty of Pharmacy 1988 (Jan-May) Visiting researcher at University College London (Prof. R. Ganellin) Associate Professor at the University of Modena, Faculty of Pharmacy Associate Professor at the University of Milan - Faculty of Pharmacy - Institute of Medicinal Chemistry 1997 (Jul-Aug) Visiting professor at SmithKline Beecham (Harlow, UK) 1997 Scientific coordinator of a joint project with Abbott Laboratories (Chicago) on novel nicotinic agents 1997-today Scientific responsible of three Socrates programs (Hungary, Greece, and Spain) INTAS evaluator 2000-today Full professor of Medicinal Chemistry at the University of Milan Faculty of Pharmacy Contributor to the Monitor Section of Drug Discovery Today Scientific coordinator of a joint project Italy/Korea (Life Sciences) Scientific coordinator of a Joint project Italy/Hungary (Life Sciences) 2005 Member of the Evaluation Panel for the Faculty of Pharmacy in Helsinki (Finland) Scientific coordinator of a joint project with Recordati s.r.l Scientific tutor for the INGENIO action Scientific coordinator of a joint project with Sanofi-Aventis Member of the Evaluation Panel for the Faculty of Pharmacy in Thessaloniky (Greece) Member of the panel of experts of MIUR, CIVR, European Framework Associate Editor of Future Medicinal Chemistry Regional Editor for Mini-Reviews in Medicinal_Chemistry Member of the Editorial Board of: Current Medicinal Chemistry, Current Medicinal Chemistry- Central Nervous System Agents, Medicinal Chemistry reviews-online, Future Medicinal Chemistry Member of the Doctorate School of Chemical Sciences and Technologies Memberships SCI Societa Chimica Italiana- Divisions: Medicinal Chemistry and Organic Chemistry ACS American Chemical Society- Divisions: Medicinal Chemistry, Organic Chemistry and the History of Chemistry ISHC International Society of Heterocyclic Chemistry SMR Society for Medicines Research
2 Publications: 130 Poster or oral presentations: 110 Patents : 4 Scientific activity, fields of interest: -Chemistry of pyridazines and their potential use as bioactive agents, mainly in the following fields: analgesic, cardiovascular, antiulcer, antitumor. -Chemistry of diazabicycloderivatives and their potential use as analgesics acting through opioid, nicotinic or muscarinic mechanism. -Chemistry of spiroderivatives related to RS-86 as potential new muscarinic agents. -Selective α1-antagonists for the treatment of BPH. -Aldose Reductase inhibitors and their use as potential agents for the treatment of long term diabetic complications. -Species specific thymidylate synthase inhibitors either as potential anticancer or antibacterial agents. -ACAT inhibitors as potential antiatherosclerotic agents and for the treatment of Alzheimer s disease -SSAO inhibitors and their use in diabetes. -STAT inhibitors as potential antitumor agents. Teaching activity: Since 2005 I have been involved in the course of Medicinal Chemistry I for the students of Chemistry and Pharmaceutical Technologies (CTF). 8 CFU until last year. From CFU. In addition, since 2007 I am teaching a course of Medicinal Chemistry in Tirana (Albania) at the Faculty of Pharmacy of Nostra Signora del Buon Consiglio, which recognizes a double degree to its students. 10 CFU Selected publications 1) L. Costantino, D. Barlocco. New perspectives on the development of antiobesity drugs. Future Med. Chem. 2015,7(3), ) S. Dell Orto, D. Masciocchi, S. Villa, F. Meneghetti, G. Celentano, D. Barlocco, D. Colombo, L. Legnani, L. Toma, Y. J. Jeon, B-M Kwon, A. Asai and A. Gelain. Modeling, synthesis and NMR characterization of novel chimera compounds targeting STAT3. Med. Chem. Commun. 2014, 5: ) L. Costantino, D. Barlocco. Ghrelin receptor modulators: a patent review ( ). Expert Opin. Ther. Patents, 2014,24(9), ) D. Masciocchi, A. Gelain, F. Porta, F. Meneghetti, A. Pedretti, G. Celentano, D. Barlocco, L. Legnani, L. Toma, B-M Kwon, A. Asai, S. Villa. Synthesis, structure-activity relationships and stereochemical investigations on new tricyclic pyridazinone derivatives as potential STAT3 inhibitors. Med. Chem. Commun. 2013, 4, ) L. Costantino, D. Barlocco. Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry? Future Med. Chem. 2013,5(1),5-7.
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