Michele Mari. Post-Doc Researcher (Assegnista di Ricerca) - Università degli Studi di Urbino Carlo Bo.

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1 Michele Mari Post-Doc Researcher (Assegnista di Ricerca) Date and place of birth 01/08/1986, Urbino (Italy) Sex Male Nationality Italian Address (office) Piazza Rinascimento 6, Urbino, Italy Telephone (office/lab) / 28 Current position and research interests Oct 2014 Now Post-Doc Researcher (Assegnista di Ricerca) - Catalytic functionalization of indoles and sustainable synthesis of chiral indole-based alkaloids Synthesis of biologically active indole-containing molecules, total synthesis of natural products (mainly Indole-containig alkaloids), design and synthesis of novel Melatonin receptors ligands, new methods for the synthesis of bis-indoles and catalytic indole reactivity, dehydroalanine reactivity and applications, protein and peptide chemistry, synthesis, analysis and biological activity of Avenanthramides. Sep 2017 Now President of the Board of Directors and Founder of GLUOS S.r.l. P.Iva e C.F , Spin Off Company of University of Urbino Carlo Bo and Innovative Start Up based on the Synthesis of Organic Molecules for Medical Devices, Cosmethics, Nutraceutical and Pharmaceutical Products. Education Ph.D. Medicinal Chemistry Professional Qualification Pharmacist Master s Degree Medicinal Chemistry and Technology Dec Strategic Indole functionalization for the synthesis of Tryptophan-containing alkaloids and biologically active Tryptamines Advisor Prof. Gilberto Spadoni Nov 2011 Qualification to practice in Italy Oct 2011 (110/110 cum Laude) Total Synthesis of (-)-Indolactam V Advisor Prof. Giovanni Piersanti Visiting periods Jun 2013 Feb 2014 Visiting Ph.D. Student - ETH Zurich in the group of Prof. Jeffrey W. Bode Total Chemical Synthesis of Proteins with KAHA Ligation Teaching activity Mar 2016 May 2018 Pharmaceutical and Food Analysis III (Laboratory Assistant) Master s Degree in Medicinal Chemistry and Technology, LM-13 School of Pharmacy, Curriculum Vitae Michele Mari 1

2 Awards and Fellowships Nov 2011 Nov 2014 Dec 2005 Apr 2011 Merit fellowship covering the entire duration of the Ph.D. course (MIUR) Merit fellowship covering the tuitions/materials for the entire duration of the master s degree course (ERSU Urbino) Publications Numbers 18 peer-reviewed articles, h-index: 8, 118 citations (Scopus, 11 th of Sept. 2018) 15 articles published in Q1 quartile, 11 articles published with IF > 4 Referee Activity Tetrahedron Letters (IF: 2.125), Journal of Heterocyclic Chemistry (1.141). List of peer-reviewed publications 18. Bartoccini, F.; Mari, M.; Retini, M.; Bartolucci, S.; Piersanti, G. Organocatalytic Aza-Friedel Crafts/Lactonization Domino Reaction of Naphthols and Phenols with 2- Acetamidoacrylate to Naphtho- and Benzofuranones Bearing a Quaternary Center at the C3 Position J. Org. Chem. 2018, Just Accepted. IF: (Q1 CHEMISTRY, ORGANIC) 17. Ciccolini, C.; Mari, M.; Lucarini, S.; Mantellini, F.; Piersanti, G.; Favi, G. Polycyclic Indolines by Acid-Mediated Intramolecular Dearomative Strategy: Reversing Indole Reactivity in the Pictet Spengler-Type Reaction Adv. Synth. Catal. 2018, Accepted Article. IF: (Q1 CHEMISTRY, ORGANIC) Selected as Very Important Publication (VIP) by the Journal 16. Spadoni, G.; Bedini, A.; Furiassi, L.; Mari, M.; Mor, M.; Scalvini, L.; Lodola, A.; Lucini, V.; Dugnani, S.; Scaglione, F.; Piomelli, D.; Jung, K.-M.; Supuran, C.; Lucarini, L.; Durante, M.; Masini, E.; Rivara, S. Novel dual-acting melatonergic ligands and fatty acid amide hydrolase (FAAH) inhibitors with ocular hypotensive effect J. Med. Chem. 2018, ASAP. IF: (Q1 CHEMISTRY, MEDICINAL) 15. Di Gregorio, G.; Mari, M.; Bartolucci, S.; Bartoccini, F.; Piersanti, G. Divergent reactions of oxindoles with amino alcohols via the borrowing hydrogen process: oxindole ring opening vs. C3 alkylation Org. Chem. Front. 2018, 5, IF: (Q1 CHEMISTRY, ORGANIC) 14. Rivara, S.; Scalvini, L.; Lodola, A.; Mor, M.; Caignard, D.; Delagrange, P.; Lucini, V.; Scaglione, F.; Furiassi, L.; Mari, M.; Lucarini, S.; Bedini, A.; Spadoni, G. Tetrahydroquinoline ring as a versatile bioisostere of tetralin for the preparation of melatonin receptor ligands J. Med. Chem. 2018, 61, IF: (Q1 CHEMISTRY, MEDICINAL) 13. Scarpa, E. S.; Mari, M.; Antonini, E.; Palma, F.; Ninfali, P. Natural and synthetic avenanthramides: a comparative study of their antioxidant, anti-proliferative and anti- inflammatory effects Food Funct. 2018, 9, IF: (Q1 FOOD SCIENCE AND TECHNOLOGY) 12. Salucci, S.; Burattini, S.; Buontempo, F.; Orsini, E.; Furiassi, L.; Mari, M.; Lucarini, S.; Martelli, A. M.; Falcieri, E. Marine bisindole alkaloid: a potential apoptotic inducer in cancer cells Eur. J. Histochem. 2018, 62:2881, IF: (Q3 CELL BIOLOGY) 11. Scarpa, E. S.; Antonini, E.; Palma, F.; Mari, M.; Ninfali, P. Antiproliferative activity of vitexin- -2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms Eur. J. Nutr. 2018, 57, IF: (Q1 NUTRITION & DIETETICS) 10. Di Gregorio, G.; Mari, M.; Bartoccini, F.; Piersanti, G. Iron-Catalyzed Direct C3-Benzylation of Indoles with Benzyl Alcohols Curriculum Vitae Michele Mari 2

3 J. Org. Chem. 2017, 82, IF: (Q1 CHEMISTRY, ORGANIC) 9. Bartolucci, S.; Bartoccini, F.; Mari, M.; Piersanti, G. A simple, modular synthesis of C4- substituted tryptophan derivatives Org. Biomol. Chem. 2016, 14, IF: (Q1 CHEMISTRY, ORGANIC) 8. Bartolucci, S.; Mari, M.; Di Gregorio, G.; Piersanti, G. Observations concerning the synthesis of tryptamine homologues and branched tryptamine derivatives via the borrowing hydrogen process: synthesis of psilocin, bufotenin, and serotonin Tetrahedron 2016, 72, IF: (Q2 CHEMISTRY, ORGANIC) 7. Spadoni, G.; Bedini, A.; Lucarini, S.; Mari, M.; Caignard, D.-H.; Boutin, J.; Delagrange, P.; Lucini, V.; Scaglione, F.; Lodola, A.; Zanardi, F.; Pala, D.; Mor, M.; Rivara, S. Highly potent and selective MT 2 melatonin receptor full agonists from conformational analysis of 1-benzyl- 2- acylaminomethyl-tetrahydroquinolines J. Med. Chem. 2015, 58, IF: (Q1 CHEMISTRY, MEDICINAL) 6. Bartolucci, S.; Mari, M.; Bedini, A.; Piersanti, G.; Spadoni, G. Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected β-amino Alcohols as Alkylating Agents J. Org. Chem. 2015, 80, IF: (Q1 CHEMISTRY, ORGANIC) 5. Mari, M.; Lucarini, S.; Bartoccini, F.; Piersanti, G.; Spadoni, G. Synthesis of 2-Substituted Tryptophans via a C3- to C2-Alkyl Migration Beilstein J. Org. Chem. 2014, 10, IF: (Q2 CHEMISTRY, ORGANIC) 4. Mari, M.; Tassoni, A.; Lucarini, S.; Fanelli, M.; Piersanti, G.; Spadoni, G. Brønsted Acid Catalyzed Bisindolization of α-amido Acetals: Synthesis and Anti-cancer Activity of Bis(indolyl)ethanamino Derivatives Eur. J. Org. Chem. 2014, 18, IF: (Q1 CHEMISTRY, ORGANIC) 3. Bartoccini, F.; Casoli, M.; Mari, M.; Piersanti, G. Synthesis of (±)-cis-clavicipitic Acid by a Rh(I)-Catalyzed Intramolecular Imine Reaction J. Org. Chem. 2014, 79, IF: (Q1 CHEMISTRY, ORGANIC) 2. Lucarini, S.; Mari, M.; Piersanti, G.; Spadoni, G. Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indol-acrylates RSC Adv. 2013, 3, IF: (Q1 CHEMISTRY, MULTIDISCIPLINARY) 1. Mari, M.; Bartoccini, F.; Piersanti G. Synthesis of (-) epi-indolactam V by an intramolecular Buchwald-Hartwig C-N Coupling Cyclization Reaction J. Org. Chem. 2013, 78, IF: (Q1 CHEMISTRY, ORGANIC) Submitted publications awaiting for approval 2. Bedini, A.; Fraternale, A.; Crinelli, R.; Mari, M.; Bartolucci, S.; Chiarantini, L.; Spadoni, G. Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids 1. Ninfali, P.; Mari, M.; Meli M. A.; Antonini, E. Oat-based functional cookies enriched with avenanthramides to control cellular inflammation Conferences Contributions 7 contributions presented by M. Mari 4 oral presentations Organization 2. European School of Medicinal Chemistry, ESMEC th Advanced Course of Medicinal Chemistry and Seminar for Ph.D. students International conference (~120 participants) Member of the Organizing Committee Curriculum Vitae Michele Mari 3

4 Urbino, July 1-5, 2018 List of conference contributions CONTRIBUTIONS PRESENTED BY M.M. 1. European School of Medicinal Chemistry, ESMEC th Advanced Course of Medicinal Chemistry and Seminar for Ph.D. students International conference (~120 participants) Member of the Organizing Committee Urbino, July 2-6, G. Di Gregorio, M. Mari, S. Bartolucci, F. Bartoccini, G. Piersanti Divergent borrowing hydrogen reactions of oxindoles with amino alcohols: C3 alkylation vs. oxindole ring opening Tetrahedron Symposium 19th Edition Poster Riva del Garda (Italy), 26-29/06/ M. Mari, G. Lattanzi, G. Piersanti, G. Spadoni C-H Borylation followed by Cross-coupling or other tranformations for Melatonin modification: Straightforward preparation of 2- and 7-substituted Melatonin derivatives Oxford Synthesis Summer Conference Poster Oxford (UK), 11-12/08/ M. Mari, G. Lattanzi, G. Piersanti, G. Spadoni Modification of Melatonin by C-H Borylation followed by Cross-coupling or other tranformations: straighforward preparation of 2- and 7-substituted Melatonin derivatives European Workshop on Drug Synthesis (EWDSy) - 6 th Edition Poster Certosa di Pontignano (Italy), 15-19/06/ M. Mari, S. Bartolucci, G. Piersanti, G. Spadoni Iridium-Catalyzed Hydrogen Transfer: Direct Synthesis of Tryptamines from Indoles Sigma-Aldrich Young Chemists Symposium XIV Edition Oral Presentation Riccione (Italy) 27-29/10/ M. Mari Strategic Indole and Tryptophan functionlization for the synthesis of Natural Products and Biologically Active Compounds European School of Medicinal Chemistry - 34 th Edition Selected Oral Presentation and Poster Urbino (Italy) 29/06-4/07/ M. Mari, F. Bartoccini, S. Lucarini, G. Piersanti, G. Spadoni Synthesis of 2-alkylated tryptophans by Friedel-Crafts alkylation of 3-alkylindoles with Dehydroalanine dervatives A. Corbella International Summer School on Organic Synthesis ISOS XXXIX Edition Selected Oral Presentation and Poster Gargnano (Italy) 15-19/06/ M. Mari, F. Bartoccini, G. Piersanti Concise Synthesis of Indole Alkaloid (-)-Indolactam V via Intramolecular Buchwald-Hartwig Amination Sigma-Aldrich Young Chemists Symposium XII Edition Oral Presentation Riccione (Italy) 1-3/10/2012 Participantion in other conferences - European School of Medicinal Chemistry, 38 th Edition (1-5 July 2018, Urbino, Italy) - European School of Medicinal Chemistry, 37 th Edition (2-6 July 2017, Urbino, Italy) - European School of Medicinal Chemistry, 36 th Edition (26 June - 1 July 2016, Urbino, Italy) - European School of Medicinal Chemistry, 35 th Edition (28 June - 3 July 2015, Urbino, Italy) Curriculum Vitae Michele Mari 4

5 - Senn Chemicals 50 th Anniversary Symposium (29 August 2013, Zurich, Switzerland) - European School of Medicinal Chemistry, 32 nd Edition (2-7 July 2012, Urbino, Italy) - Boron Neutron Capture Therapy in Pavia: state of the art and perspectives in the light of CARIPLO research projects (28 May 2012, Pavia, Italy) Other informations Languages Membership Social Skills Organizational Skills Technical Skills Informatics Driving licence Interests Italian: Mother Tongue English: excellent understanding and speaking, very good writing ability Italian Chemical Society (SCI), Division of Medicinal Chemistry Due to my Academic and Spin Off/Start Up experience, I have developed good communication skills, stress tolerance and the ability to work both in a team and autonomously. I've also developed effectiveness in public presentations Good organizational skills, attention to details and ability to meet deadlines Compound synthesis: mainly classical synthesis (in solution) and microwave synthesis Solid Phase Peptide Synthesis (manual and automatical using peptide synthesizers) Compound purification: chromatography, extraction, distillation and crystallization Compound characterization: TLC, HPLC, LC-MS, GC-MS, IR, NMR, polarimetry, MALDI-TOF Software: Microsoft Office Word, Excel, Powerpoint, Outlook; Cambridgesoft ChemDraw; Chemical databases (SciFinder, Scopus, Web of Science, Google Scholar, Uniprot); software for the elaboration of chromatograms / spectra (Mestrenova), use of the Wordpress platform for website building, Social Media Managing (Facebook, Twitter). Graphic skills: Photoshop, imovie Italian Driving Licence B, own car Music (I ve been studying vocal techniques and singing for 5 years, leading a band, many concerts and studio experiences) Sports (soccer, basketball, tennis) Nature (Qualification for harvesting wild mushrooms in Marche region) Entrepreneurship (Startupper and Founder of a University Spin off Company, Founder of the Urbino Contamination Community, with the aim of spreading the entrepreneurship vision in the University and in the City of Urbino) Photography Travelling Curriculum Vitae Michele Mari 5