ADDITIONAL ATTACHMENT

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1 ADDITIONAL ATTACHMENT Index Annexure No. I II III IV V VI VII Name of Annexure Copy of NOC and CCA letter of existing project List of products List of raw materials Details of production and manufacturing processes Details of hazardous waste generation during operation Emissions from combustion of fossil fuels from stationary or mobile sources Layout Plan

2 COPY OF NOC AND CCA LETTER OF EXISTING PROJECT ANNEXURE-I

3 ANNEXURE-I (CONT )

4 ANNEXURE-I (CONT )

5 ANNEXURE-I (CONT )

6 ANNEXURE-I (CONT )

7 ANNEXURE-I (CONT )

8 ANNEXURE-I (CONT )

9 ANNEXURE-I (CONT )

10 List of Products: Annexure-II No. Name of Products Quantity (MT/Month) Existing Proposed Total 1. Diclofenac Sodium IP/BP A. 2:6 Dichloro DIphenyl N-Acetyl Chloride B. 1-(2;6-Dichloro Phenyl) 1; 3 Dihydro Indole 2 one Diclofenac Potassium Diclofenac Diethyl Ammonium Chlorzoxazone Fenbendazole Oxfendazole Triclobendazole Febantel Closantel Base Gabapentine Ondensetronticl Dehydrate Total By Products 1 Hydrochloric Acid Aluminum Chloride Solution Dil. Acetic Acid Liquor Ammonia 0 6 6

11 List of Raw Materials: Annexure-III No Raw Material Type of Storage Mode of Transport 1. 2,6 Dichloro Phenol Drum By Road 2. Potassium Carbonate Bags By Road 3. Methyl Mono Chloro Acetate Drum By Road 4. Toluene MS Tank By Road 5. Aniline Oil MS Tank By Road 6. Sodium Metal (Sodium Methoxide) Drum By Road 7. Methanol MS Tank By Road 8. Chloro Acetyl Chloride Drum By Road 9. Aluminum Chloride Bag By Road 10. Caustic Flakes Bags By Road 11. Carbon Bags By Road 12. Catalyst Bags By Road 13. Caustic Potash Bags By Road 14. Diclofenac Sodium Bags By Road 15. Acetic Acid SS Tank By Road 16. Diclofenac Acid Drum By Road 17. Diethyl Amine Drum By Road chloro 2-amino phenol Bags By Road 19. T. Urea Bags By Road 20. Hydrochloric acid HDPE TANK By Road 21. Carbon Bags By Road Nitro, 2 Chloro Aniline Bags By Road 23. Thiophenol Drum By Road 24. Hydrazine Hydride Drum By Road 25. Methyl Chloro Formate Drum By Road 26. Hydrogen Cyanamide Drum By Road 27. Acetone SS Tank By Road 28. Fenbendazole Drum By Road 29. Hydrogen Peroxide Drum By Road 30. Dimethyl Sulfoxide Drum By Road 31. Sodium Hydroxide Bags By Road 32. 4,5 Dichloro-2-Nitro Phenyl Acetamide Bags By Road 33. Dimethyl Formamide Drum By Road 34. 2,3 Dichlorophenol Bags By Road 35. Potassium Carbonate Bags By Road 36. Raney Nickel MS Tank By Road 37. Carbon Disulfide Drum By Road 38. Potassium Hydroxide Bags By Road

12 ANNEXURE-III No Raw Material Type of Storage Mode of Transport 39. Hydrous Bags By Road Nitro-5-(Phenylthio) Aniline Bags By Road 41. Methoxy Acetyl Chloride Drum By Road 42. Methylene Dichloride Drum By Road 43. Hydrogen Gas cylinders By Road 44. Xylene Drum By Road 45. Decyl Bromide Drum By Road 46. Thiourea Drum By Road 47. Sodium Carbonate Bags By Road 48. Sodium Dithionite Bags By Road decyl Bromide Drum By Road 50. 1,3-cyclohexadione Drum By Road 51. Phenyl hydrazine Drum By Road 52. Zinc chloride Bags By Road 53. Dimethyl sulfate Drum By Road 54. Para formaldehyde Drum By Road 55. Ammonia soln Drum By Road Methylimidazole Bags By Road 57. 1,1-Cyclohexane diacetic acid mono amide Bags By Road 58. Tri ethylamine Drum By Road 59. 3:5 DiIodosalicylic Acid Drum By Road 60. Closantel Amine Bags By Road 61. Phosphorus Trichloride Drum By Road

13 Annexure-IV Manufacturing Processes: 1) Diclofenac Sodium IP/BP: Stage - I: In ss reactor charge Toluene + 2,6 Dichloro Phenol + Potassium Carbonate & reflux for 12hrs & cool to room temperature & add Methyl Mono Chloro Acetate reflux for 5hrs & recover toluene. Ether is reacts with aniline in present of sodium Methoxide forms Dichloro DIphenyl Aniline & Methanol to be recover. Stage - II: In a glass line reactor Dichloro diethyl amine previously drayed reacts with Chloro acetyl chloride toluene as a solvent forms N-Chloro acetyl 2:6 Dichloro DIphenyl amine i.e. one of intermediates to be sale. The HCl gas generated to be scrub in water give Hydrochloric acid i.e. by product. Stage - III: In a glass line reactor N-Chloro deri. Is reacts with Alluminium Chloride at boiling temperature the HCL gas is generated & scrub in water gives Hydrochloric Acid i.e. by product. After completion of reaction the mass is dumped in 1.5 times water then neutch filter it. The ML is alluminium chloride solution it recycle for three times i.e. by product. The product is Indolenone Intermediate & to be sales it. Stage - IV: In a ss reactor in water Indolenone hydrolyzed by caustic solution & gives Crude Diclofenac Sodium filter it. The ML is west water 750ltrs. Stage - V: Final Diclofenac Sodium Crude Diclofenac Sodium is dissolved in DM water, Carbon & charged reflux & filter, cool & centrifuge it. The ML is recycled in stage-iv. The products dry at 80 c to 85 c i.e. Diclofenac Sodium 675kgs. 2) Diclofenac Potassium Stage - I: In ss reactor charge Toluene + 2,6 Dichloro Phenol + Potassium Carbonate & reflux for 12hrs & cool to room temperature & add Methyl Mono Chloro Acetate reflux for 5hrs & recover toluene. Ether is reacts with aniline in present of sodium Methoxide forms Dichloro DIphenyl Aniline & Methanol to be recovered. Stage - II: In a glass line reactor Dichloro diethyl amine previously drayed reacts with Chloro acetyl chloride toluene as a solvent forms N-Chloro acetyl 2:6 Dichloro DIphenyl amine i.e. one of intermediates to be sale. The HCl gas generated to be scrub in water give Hydrochloric acid i.e. by product. Stage - III: In a glass line reactor N-Chloro deri. Is reacts with Alluminium Chloride at boiling temperature the HCL gas is generated & scrub in water gives Hydrochloric Acid i.e. by product. After completion of reaction the mass is dumped in 1.5 times water then neutch filter it. The ML is alluminium chloridesolution it recycles for three times i.e. by product. The product is Indolenone Intermediate & to be sales it. Stage - IV: In a ss reactor in water Indolenone hydrolyzed by Potassium Hydroxide solution & gives Crude Diclofenac Potassium filter it. The ML is west water 750ltrs. STAGE-V Final Diclofenac Potassium, Crude Diclofenac Potassium is dissolved in DM water, charge carbon & reflux & filter, cool & centrifuge it. The ML is recycled in stage-iv. The products dry at 80 c to 85 c i.e. Diclofenac Potassium 600kgs. 3) Diclofenac Diethyl Ammonium Stage - I: In a ss reactor charge water + Diclofenac sodium stirr for half an hour slowly add acetic acid & after completion of addition stirr for a hour & filter it. Dry it. The ML is west water neutral 700lits. Stage - II : In ss reactor charge water 750lits + Diclofenac acid stirr well slowly add diethyl amine stirr for

14 ANNEXURE-IV two hours. Cool to room temperature. Filter through centrifuge ML is neutral water 700lits. Dry the product i.e. Diclofenac Diethyl Amine dry weight 525kgs. PRODUCT: Diclofenac Diethyl Amine INTERMEIDATE: Diclofenac Free Acid ETP: West water neutral 1400lits 4) Chlorzoxazone Stage - I: In a glass line reactor charge hydrochloric acid + 4-cap heat to reflux maintain for 4 hours. Then charge catalyst reflux for one hour. Cool to 100 c charge water stirr for half an hour filter & ML west water 800lits. Collect cake i.e. crude chlorzoxazone. Stage - II: In ss reactor charge methanol & crude reflux for one hour. Filter in next ss reactor adjust ph-6. Stirr for one hour & recheck it. Centrifuge it ML is west water for ETP 500lits. Collect cake of semi final product. Stage - III: PURIFICATION In ss reactor charge methanol + semi final cake & charcoal. Heat to reflux for two hrs. Filter is at 80 c collect ML in ss reactor cool it to room temperature centrifuge it. Collect methanol dry the cake. Pulverize & pack it i.e. CHLORZOXAZONE USP. 5) Fenbendazole Stage - I: (A) In a ss reactor charge Methanol & 5Chlorophenylthio- 2 -Nitro Aniline heat to reflux i.e.65 C to 70 C. cool to room temperature filter it. Collect crude Methanol & recover methanol from M.L. residue is approx 5kgs. The product it Nitro Thiophenyl Aniline charge Toluene & Nitrothiophenyl aniline heat to C start addition of Hydrazine Hydrate after completion of Hydrazine Hydrate check reduction completion test if ok cool to room temperature wash with 100lits water collect upper organic layer convert it in Hydro Chloride by adding con. HCl & water. Stage - II (B): In glass line reactor charge water & hydrogen cynamide heat it to 50 C. Then start addition of Methyl Chloro Formate & Caustic Flakes. After completion of addition check Ph neutral. Stirr for one hour. The product is Methyl Carbono hydrogen cynamide 270kgs. (B) Stage III: Coupling (A) + (B) In a glass line reactor charge Acetone + Stage I(A) & Stage II(B) couple the both stages at room temperature stirr for 5 hours below room temperature filter it. Collect cake i.e. crude Fenbendazole west water is approx 200 lits product quantity 150kgs wet. Charge wet cake in ss reactor + methanol 2times heat to reflux for one hour. Cool it filter it. Collect methanol & distilled out. Residue is approx 10kgs dry the wet cake. Product is approx 100kgs. Final FENBENDAZOLE. 6) Oxfendazole In a dry clean glass line reactor charge acetic acid, Dimethyl Sulfoxide & Fenbendazole cool to 5 C & add hydrogen peroxide slowly maintain 3 hours. Check TLC for reaction completion. Filter it & wash with acetone. The collect cake & dry it i.e. OXFENDAZOLE 7) Triclobendazole Stage - I: In glass line reactor charge 80kgs DMF + 100kgs Dinitro phenoxy Acetamide & stirr for a hour. Charge 50kgs Dichloro Phenol & 60kgs Potassium Carbonate. Reflux for 8 hours. Check TLC for completion of reaction. Then charge Methanol 150lits & slowly add caustic lye solution. Maintain temperature 70 C to 75 C for 4 hours. Check TLC for absence of Dichloro nitro phenoxy Acetamide of reaction completed add water 250lits. Stirr for half an hour. Filter it & collect cake & dry it. Dry wet 120kgs

15 ANNEXURE-IV Stage - II: In a ss auto clear reactor charge 400lits methanol + stage-i + Raney Nickel pass first Nitrogen Gas & than hydrogen gas rise pressure up to 3kgs & temperature 50 C maintain for 4 hours. Check sample ok. Filter it. Charge ML in another reactor charge potassium hydroxide & carbon sulphide at low temperature. Raise the temperature & reflux for one hour. Check completion of reaction. Distilled out methanol & add water 300lits dil. HCl to Ph 6.5. filter it dry it at C Product Quantity 80kgs. ETP west water 280lits Stage - III: In glass line reactor charge TBZ Thiol + Methanol at room temperature add slowly DMS. Raise temperature 70 C to 75 C & maintain 2-3 hours check reaction completion cool it. Filter it. Wet cake 100kgs. Charge wet cake in glass line reactor + methanol + carbon. Heats to reflux for 2hours cool to room temperature filter it wash with acetone. Dry it. Dry wet 90kgs. 8) Febantel : Stage - I: In glass line reactor charge 2-Nitro-5-(Phenylthio)- aniline, Methoxyacetyl chloride & 200lits Methylene dichloride. Stirr the reaction mass at room temperature. Then start addition of Methoxy acetyl chloride during half an hour. Maintain for 8 hours. Check TLC for reaction completion. Then recover MDC charge water 250lits stirr for 2 hours filter it wash with 25% soda ash solution & dry it. Dry wt 80kgs. Stage - II: In a ss autoclave previously provided nitrogen blanketing charge Methanol 400lits FBT-Amide 80kgs & raney nickel 5.6kgs. Then start processing hydrogen gas. Heat the reaction mass upto C. check the hydrogen pressure constant. Check TLC for completion reaction. Cool to room temperature drain out the material along with washing by methanol. Filter the catalyst. Heat the ML for recovery of methanol & cool to 10 C filter it. Give the suspension wash of cake by Xylene. Then again filter it & recover Xylene from ML 70%. Dry the cake. Dry wet is 56kgs i.e. FBT Amine. Stage - III: In a dry & clean glass line vessel add methanol 160lits+Thiourea 40kgs+1decyl bromide 80kgs. Heat to reflux. Check for reaction completion fro TLC. Distilled out methanol cool to room temperature add MDC 400lits + K2co3soln + Methyl Chloro Formate slowly as the exothermic reaction maintain for 5hrs. Check for completion of reaction. Add water & separate layer. Bottom organic layer heats to reflux & recover MDC 70% in residue add methanol & stirr for one hour & filter it. Collect ML for recovery of methanol 80% dry it. Dry wt 80kgs 9) Closantel Base: Stage - I: In a dry glass line charge toluene 500lits. Add 3:5 Dilodosalicylic acid 325 kgs + Closantel amine 250kgs heat to reflux & then add slowly phosphorus Trichloride. Maintain for 8 hrs check the completion of reaction. Cool to room temperature. Filter it wash with toluene & followed by 550lits water. Collect cake & dry wt is 450kgs Closantel Base. Stage - II: Charge Closantel Base in ss reactor add caustic solution 600lits. Heat to reflux & maintain for 2 hrs. Cool to room temperature check Ph should be alkaline. Filter it wash with 200lits water. Collect cake & dry it. Dry wt 510kgs. 10) Gabapentine Stage - I: Take 350 water and 98.5 NaOH in reactor to got clear solution. And cool -5 to -10 c and charge 1.1 Cyclohaxane di acitic acid monoamide. Cool -5 to -10 c and charge bromine liquid in 1 hour than temp. Rice 35 to 40 c For 3 hours. Charge mdc at 15 c stirrer for 30 min. than charge HCl bring reaction mass PH 2.0 Stirrer for 30 min. than filter the mass. Take crude. Charge methanol and wet cake stirrer 30 min. and filter the reaction mass. Take the stage 1 (84)

16 ANNEXURE-IV Stage - II: Take acetone water 84 in reactor charge stage - 1 (84) Than charge TEA and bring reaction mass PH 7.2 stirrer 30 min. than filter the reaction mass and take crude Take acetone water 5 add crude stirrer for 1 hours cool 0 to 5 C for hours filter the reaction mass take wet cake and dry at 70 C finish gabapentin 50 11) Ondensetronticl Dehydrate Stage - I: Take water charge 1, 3, Cyclohaxane done in reactor charge phenyl hydrazine in 2 hours. Than temp. Rice 40 C maintain for 3 hours and cool at RT. than filter reaction mass. Wet cake dry. Finish stage I. Stage - II: Charge acetic acid charge zinc chloride heat at 85 C for 1 hour. Than charge stage I maintain 100 C for 3 hours and cool at RT add water than filter the reaction mass. Take crud wet cake charge MeOH stirrer for 1 hours cool & filter stage II dry. Stage - III: Take acetone in reactor charge stage II NaOH and stirrer 30 min. add DMS stirrer for 3 hours cool and filter and dry. Stage - IV: Take DM water in reactor charge stage III charge formaldehyde heat C maintain for 6 hours. Than cool RT & filter wet cake dry. Stage - V: Take DM water in reactor add stage IV cool at 15 C and add Cons. HCL then add limidazole heat at C for 24 hours and cool 5 C neutralise with liquor Ammonia solution filter & wash with chilled water take wet cake charge MeOH add charcoal 2 heat and reflux hot filter mother liquor cool 5 C and stirrer 1 hours and filter dry 65 C stage IV wt methanol recover from mother liquor. Stage - VI: Take DM water charge kg stage - V add MeOH add HCL 70 stirrer for 24 hours at RT than cool 5 C filter dry. The product is ONDANSETRON HCL DIHYDRATE IP / BP.

17 Details of Hazardous Waste Generation during Operation No. Name of the Waste Category No. Existing (MT/M) Proposed (MT/M) Quantity (MT/M) 1 ETP Sludge Used Oil Discarded Containers/Barrels/ plastic Date Expired, discard and off specification medicines no./yeas What so ever to be generated 300 no./yeas 600 no./yeas Fly Ash ANNEXURE-V Method of Storage and Disposal Collection, storage and transport to TSDF site. Collection, storage and reuse as lubricants in the machineries within the premises only or send to authorized re-processors. Collection, storage and send to authorized recycler after decontamination. After giving proper treatment will be disposed at CHWF/TSDF Collection, storage and send to brick manufacturer or send to TSDF site.

18 ANNEXURE-VI Emissions from Combustion of Fossil Fuels from Stationary or Mobile Sources No. Stack Attached to Fuel Used Stack Height APCM Final Concentration Existing Scenario Boiler * 1. (1TPH) Wood Waste/ Agro 30 meter Multi Cyclone waste / 300 kg/day 2. Hot Air Generator 08 meter - 3. D.G Set (Stand By) 100 KVA Proposed Scenario Boiler * (2TPH) Thermic Fluid Heater (2 lac Kcal) D.G Set (Stand By) 250 KVA Diesel 8 Lit/Hr Coal/ Agro waste / 2700 kg/day Coal 1800 kg/day Diesel 20 Lit/Hr 03 meter Acoustic Enclosures 30 meter Multi Cyclone 30 meter Multi Cyclone 09 meter * There will be a common stack for existing and proposed boiler. Emission from Production Process Acoustic Enclosures SPM 150 mg/nm 3 SO ppm NO X 50 ppm SPM 150 mg/nm 3 SO ppm NO X 50 ppm SPM 150 mg/nm 3 SO ppm NO X 50 ppm SPM 150 mg/nm 3 SO ppm NO X 50 ppm SPM 150 mg/nm 3 SO ppm NO X 50 ppm No. Stack Attached to Stack Height APCM Parameter Final Concentration Existing Scenario Water scrubber Reaction vessels meter followed by HCl 20 mg/nm 3 (2 Nos.) Alkali Scrubber There is no additional process emission in proposed scenario

19 Layout Plan of the project site ANNEXURE-VII

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