ADDITIONAL ATTACHMENT

Transcription

1 ADDITINAL ATTACHMENT LIST F PRDUCTS S. No. Name of Products Production Capacity (MT/Month) Existing Proposed Total 1. Sodium Silico Fluoride Alpha Keto Isoleucine Calcium Salt Alpha Keto Leucine Calcium Salt Alpha Keto Phenylalanine Calcium Salt Alpha Keto Valine Calcium Salt Alpha Hydroxy Methionine Calcium Salt Iron Sucrose Phenyl Acetic Acid Diacerein Tolfenamic Acid Diosmin T.P Ferric carboxy Maltose Sucroferric oxyhydroxide Couple Amines Total By-Products 1. Acetic Acid Methyl Iodide DETAILS F MANUFACTURING PRCESSES EXISTING 1. SDIUM SILIC FLURIDE Manufacturing Process Charge Hydro Fluoro Silicic Acid in a rubber lined reactor. Charge soda ash and sodium chloride in to reactor to precipitate Sodium Silico Fluoride. The precipitate is then centrifuged and washed with water to remove hydrochloric acid completely. The filtrate containing about 1% to 3% HCL is collected in the storage tank of ETP.The neutralized and washed precipitate is dried or keeps wet as per requirement. Then the product is packed in HDPE/PP bags. Chemical reaction H 2 SiF 6 + Na 2 Co 3 Na 2 SiF 6 + H 2 + C 2 (144.08) (106) (188.08) (18) (44) H 2 SiF NaCl Na 2 SiF HCl (144.08) (117) (188.08) (73)

2 Process Flow Diagram HFS Acid Sodium Carbonate REACTR Supernatant to ETP Sodium Chloride REACTR CENTRIFUGE Effluent to ETP Water CENTRIFUGE Effluent to ETP TRAY DRYER Product SDIUM SILIC FLURIDE Material Balance Input Qty. utput Qty HFS Acid 4.33 Supernatant to ETP 0.25 Sodium Carbonate 0.08 Effluent to ETP 7.15 Sodium Chloride 0.59 Product 1 Water PRPSED 2. ALPHA KET ISLEUCINE CALCIUM SALT Manufacturing Process Charge Hydantoin, Monoethanol amine and Methyl ethyl ketone in a SS, Heat the reaction mass up to reflux and completely distill out methyl ethyl ketone and reuse for next batch. Cool the reaction mass and charge DM water and sodium Hydroxide. Adjust the ph to 6-7 with hydrochloric acid and charge calcium chloride in to SS reactor. Heat the reaction mass up to reflux. Distill out water and cool the reaction mass. Filter the isolated solid and dry it, mill it and blend. Pack the material in paper drums. Chemical reaction

3 Process Flow Diagram

4 Material Balance Input Qty. utput Qty Hydantoin 1.43 MEK Distillation 2.29 Methyl Ethyl Ketone 2.3 ML to ETP 8.74 Ethanol Amine 0.87 Ditilled water for boiler 8.57 DM water Washing Solvent 0.7 Sodium Hydroxide 1.1 Drying Loss 0.14 Hydrochloric acid 2.07 Product 1 Calcium Chloride 1.13 MeH Washing ALPHA KET LEUCINE CALCIUM SALT Manufacturing Process Charge DM water and sodium hydroxide in the reactor under stirring. Charge Hydantoin, Glycine and Isobutyraldehyde. Heat to reflux, maintain till reaction will be completed. Distil out Isobutyraldehyde completely and reuse for next batch. Cool the reaction mass and charge DM water and sodium Hydroxide. Adjust the ph 6 to 7 with Hydrochloric acid and charge DM water and calcium chloride in SS reactor and heat the reaction mass up to reflux. Distil out water completely and cool the reaction mass. Filter the isolated solid and dry, mill and then blend. Send the filtrate to ETP. Chemical reaction Process Flow Diagram

5 (Continuation from previous page...) Material Balance Input Qty. utput Qty water Isobutyraldehyde Distillation 1.76 sodium hydroxide 1.01 ML 7.73 hydantoin 1.18 Ditilled water for boiler 7.06 glycine 0.88 Washing Solvent 0.66 Isobutyraldehyde 1.82 Drying Loss 0.12 Hydrochloric acid 1.53 Product 1 Calcium Chloride 0.91 MeH Washing ALPHA KET PHENYLALANINE CALCIUM SALT Manufacturing Process Charge Glycine, DM water and Acetic anhydride in glass line reactor and stir the mass for 1hr. Filter the isolated solid and transfer the wet material for next stage and the filtrate (40% acetic acid) keep for selling. Charge Dimethyl formamide, stage-i, sodium acetate, acetic anhydride, benzaldehyde in glass line and heat the reaction mass up to reflux. Distil out acetic anhydride and DMF completely under vacuum and add DM water in reaction mass. Cool it and add Hydrochloric acid in the glass line reactor. Heat the reaction mass up to reflux. Separate out the salt to TSDF for land filling. Cool the reaction mass and add calcium chloride, triethylamine and methanol in the glass line reactor and stir at room temperature. Distil out methanol and reuse for next batch. Filter the isolated solid and send the salt to TSDF site for land filling. The isolated solid of Ca salt of Alpha keto phenylalanine is then undergone drying, milling, blending and packing. Chemical reaction

6 Process Flow Diagram Material Balance Input Qty. utput Qty glycine 1.33 ML 7.63 Acetic anhydride 3.33 Drying Loss 0.12 water 1.34 Acetic Acid 4 Benzaldehyde 2.13 Distil out DMF 3.31 Sodium Acetate 0.4 salt 0.4 DMF Fresh 3.34 Recovery of MeoH 1.29 Hydrochloric acid 3.2 Product 1 Methanol 1.33 TEA 0.83 Calcium Chloride

7 5. ALPHA KET VALINE CALCIUM SALT Manufacturing Process Charge Hydantoin, Glycine, Acetone, Sodium hydroxide and DM water in SS, Heat the reaction mass up to reflux and completely distill out acetone and reuse for next batch. Cool the reaction mass and charge DM water and sodium Hydroxide and adjust the ph to 6-7 with hydrochloric acid. Charge DM water and calcium chloride in to SS reactor. Heat the reaction mass up to reflux. Distill out water and cool the reaction mass. Filter the isolated solid and send the filtrate to ETP. Dry the material, mill it and blend. Pack the material in paper drums. Chemical reaction Process Flow Diagram

8 Material Balance Input Qty. utput Qty water Acetone 2.08 hydantoin 1.33 ML glycine 1 Ditilled water for boiler 8 Acetone 2.13 Washing Solvent 0.51 sodium hydroxide 1.29 Drying Loss 0.13 Hydrochloric acid 2.27 Product 1 Calcium Chloride 1.25 MeH Washing ALPHA HYDRXY METHININE CALCIUM SALT Manufacturing Process Charge Methionine acid and methanol in the glass line reactor. Distill out methanol and reuse for next batch. Charge sodium hydroxide and adjust ph between 6.5 to 7.0 and add carbon. Filter through sparkler and add calcium chloride and centrifuge. Charge methanol and heat up to reflux. Filter the isolated solid and dry, mill and blend.pack the material in fiber drums. Chemical reaction Process Flow Diagram

9 Material Balance Input Qty. utput Qty Methionine Acid 1.39 Activated Carbon 0.03 sodium hydroxide 0.31 Hyflow 0.04 Activated Carbon 0.03 ML to ETP 1 Hyflow 0.04 Washing solvent 0.67 Calcium Chloride 0.42 Drying Loss 0.14 Methanol wash 0.69 Product IRN SUCRSE Manufacturing Process Ferric chloride hexahydrate is dissolve in DM water and react with 20% sodium hydroxide solution at C in form of ferric hydroxide. Centrifuge the gelatinous precipitate of ferric hydroxide and collect the wet lumps. Charge DM water, Ferric hydroxide lumps, sucrose and 20% sodium hydroxide solution in the reactor. Heat it up to reflux. Concentrate the reaction mass by distilling of water and chill the residue in form of Iron Sucrose. Dry the wet cake in the dryer, mill then pack. Chemical reaction Process Flow Diagram DM Water Ferric Chloride Sucrose Hydrochloric acid Caustic soda flakes Filtration by Centrifuge ML to ETP DM Water Centrifuge Sucrose

10 (Continuation from previous page...) Caustic Soda Activated Carbon Hyflow Filtration by Sparkler Hyflow Activated carbon Distil out water MeH 50ºC Centrifuge Tray Dryer Milling Methanol reuse for next batch. Drying Loss Product Sifter Blender IRN SUCRSE Material Balance Input Qty. utput Qty DM Water 1.6 ML to ETP 2.53 Ferric chloride 0.4 Hyflow 0.07 Sucrose 0.8 Activated carbon 0.07 Hydrochloric acid 0.12 Ditilled water for boiler 1.39 Caustic soda flakes 0.23 recovered methanol 3.93 DM Water 0.6 Drying Loss 0.13 Sucrose 1.2 Product 1 Caustic soda flakes 0.04 Activated Carbon 0.07 Hyflow 0.07 MeH

11 8.PHENYL ACETIC ACID Manufacturing Process Charge Sodium salt of phenyl acetic acid solution in the reactor. Cool the liquid and charge hydrochloric acid to the reactor. Centrifuge the isolated solid. Send the ML to ETP Chemical reaction Process Flow Diagram Na salt Phenyl acetic acid Distilled out water for use in utilities Hydrochloric Acid/ Sulphuric Filtration by Centrifuge ML to ETP Tray Dryer Drying Loss ML to ETP Phenyl Acetic Material Balance Input Qty. utput Qty Na salt Phenyl acetic Ditilled water for 2.86 acid boiler 1.72 HCl / H 2 S ML 0.36 Drying Loss 0.3 Product DIACEREIN Manufacturing Process Aloe-emodin is reacted with acetic anhydride at temperature 90 to 94 C in presence of sodium acetate. After reaction completion acetic anhydride is distilled out completely under vacuum from reaction mass, water is added in degassed mass. Isolated product is undergone for centrifuge. Tri acetyl Aloe-emodin (Stage-1) oxidized with Chromium trioxide solution in mixture of Acetic acid and acetic anhydride at 57 to 62 C to get Diacerein Crude (Diacerein stage-2). Reaction mass is centrifuged. Water slurry of wet cake is prepared and centrifuged. Crude material is washed with N,N Dimethylacetamide and then with water.wet cake is dried in tray dryer,mill and then pack.

12 Chemical reaction CH 3 CH 3 H H Acetic anhydride H Sodium acetate anhrdrous CH 3 Aloe-emodin M. Wt.= Tri acetyl Aloe-emodin M. Wt.= Process Flow Diagram Acetic Anhydride Aloe-emodine Sulfuric Acid Acetic Acid Chromium trioxide Acetic Acid reuse Centrifuge Distil out ML Water Slurry wash N,N Dimethylacetamide Distillation residue ML to ETP Water Filtration by Centrifuge ML reused for next batch ML to ETP Drying Drying Loss Milling Sifter Diacerein

13 Material Balance Input Qty. utput Qty Acetic anhydride 7.15 Acetic acid sellable or reuse 8.09 Aloe-emodine 1 Distillation residue Incineration 0.1 Sulfuric acid ML reuse for next batch 25 Acetic acid 15 Effluent to ETP 15 Chromium Trioxide 1.13 Drying loss 0.1 Water Slurry wash 10 Product 1 N,N Dimethylacetamide 10 Water TLFENAMIC ACID Manufacturing Process Part A Tolfenamic Acid Crude Process Stage-I: Manufacturing of potassium salt of o-chlorobenzoic acid rtho chloro benzoic acid is reacted with potassium hydroxide in presence of methanol gives Potassium salt of ortho chloro benzoic acid. Process Stage-II: Condensation of potassium salt of o-chlorobenzoic acid with 3-Chloro 2- Methyl aniline to form crude Tolfenamic acid. Further methanol is distilled and degassed. Solid mass of potassium salt of ortho chloro benzoic acid reacts with 3-Chloro 2-Methyl Aniline in presence of DMF and calcium carbonate by adding catalyst, further reaction mass is charcolized and filtered. The liquid reaction mass is further precipitated by adding HCl which forms crude Tolfenamic Acid. Wet crude Tolfenamic acid is slurry washed in water and dehydrated in toluene by azeotropic distillation and dried. Part B Tolfenamic Acid Purification of crude Tolfenamic acid The crude Tolfenamic acid is dissolved in Dimethyl Formamide, Charcoalized and filtered. Further material is crystallized by applying chilling. Crystallized material is filtered and dried in vacuum tray dryer to get pure Tolfenamic acid. Chemical reaction Part A: Tolfenamic Acid Crude Process Stage I: Conversion of o-chlorobenzoic acid to the corresponding potassium salt. Process Stage II : Condensation of potassium salt of CBA with CMA to give crude Tolfenamic Acid.

14 Part B: Purification of crude Tolfenamic Acid to give the final active substance Tolfenamic Acid Process Flow Diagram N,N Dimethylformamide rthochlorobenzene 3-Chloro methyl aniline Cat-TNA Hydrochloric Acid Water Residue Water Reuse in utilities Centrifuge Drying ML for Distillation DMF reuse for next batch Drying loss N,N Activated Carbon Hyflow Supercel Sparkler Centrifuge Drying Hyflow & Carbon disposed to TSDF & Incinerator ML for Distillation Drying loss Reuse for next Residue Milling Blending Sifting Tolfenamic Acid

15 Material Balance Input Qty. utput Qty N,N Dimethylformamide 4.31 Water reuse in washing 10 rthochlorobenzene 1.71 salt TSDF 0.69 Potassium Carbonate 0.81 DMF Chloro methyl aniline 0.81 Drying loss 0.75 Cat-TNA 0.02 carbon (inci.) 0.04 Hydrochloric acid 0.4 Distilation residue 0.2 Water 8.5 ML to distillation 7.4 N,N Dimethylformamide 7.5 Drying loss 0.2 Activated Carbon 0.04 Product 1 Hyflow Supercel 0.13 Hyflow 0.13 Water DISMIN Manufacturing Process Hesperidin reacts with iodine in presence of sodium hydroxide and pyridine as a solvent. The reaction is carried out at 98 to 103 C. After reaction completion the reaction mass is cooled. Pyridine is distilled out completely under vacuum. Methanol is charged in the reactor. The reaction mass is heated to reflux to get the uniform mixture. After completion of the reflux, reaction mass is cooled. Solid cake (crude Diosmin) is isolated by centrifugation. The wet cake of crude Diosmin is charged into the solution of sodium Thiosulphate in De-ionised water. The mixture is stirred well to become homogenous. Solution of sodium hydroxide is added to get a clear solution. This solution is filtered over hyflow bed and clear filtrate is collected in reactor. Wash the hyflow bed with de-ionized water and collect the washings along with the filtrate in reactor and water is distilled out. Further mass is filtered through sparkler filter. Cool the filtrate, precipitate out the Diosmin by adding concentrated Sulphuric acid. The reaction mass is stirred well to get optimum precipitation of the product. The resulting solid is isolated by centrifugation. The cake in the centrifuge is washed with purified water.the wet cake is taken in purified water in the reactor. The slurry is heated and stirred well. The solid is isolated by centrifugation. The isolated solid cake in the centrifuge is washed with warm purified water to free of sulphates.the above obtained pure Diosmin is dried in vacuum tray dryer. The product is milled, blended and sifted on a sieve. Chemical reaction H C H3 H H H H H Hesperidi H H C H 3 + I2 + N a H H C H 3 H H H H H Diosmi H H C H 3

16 Process Flow Diagram Pyridine Hesperidin Sodium De-ionised Water Sodium Thiosulphate Sodium Hydroxide Hyflow Centrifuge Sparkler Iondine Methanol Distill ut Pyridine & Methyl Iodide Hyflow & Salt to TSDF Water Distillation & reuse Sulphuric Acid Purified Water Sparkler Filter Centrifuge Tray Dryer Milling Salt to TSDF ML to ETP Drying Loss Vacuum Tray Sifter Blender Diosmin Material Balance Input Qty. utput Qty Pyridine 6.68 Distil ut Pyridine 5.5 Hesperidin Distil out Methanol 5.15 Sodium hydroxide 0.57 Methyl Iodide 0.43 Iodine 0.49 salt To TSDF 0.5 Methanol 8.89 WaterDistillation 4 De-ionised Water 4 Salt ToTSDF 0.1 Sodium Thiosulphate ML to ETP 9.63 Sodium Hydroxide 0.5 Drying loss 0.05 Hyflow 0.15 Product 1 Sulphuric Acid 0.53 Hyflow 0.15 Purified Water

17 12. 1,2,4 TRIAZL [4,3-A] PYRIDIN-3-NE (T.P.) Manufacturing Process Urea reacted with hydrazine hydrate in presence of water at temperature 105 to 110 C to give semicarbazide. Water is distilled out under vacuum and degas. Methanol is added to dissolve it. Further concentrated Hydrochloric acid is added to precipitate semicarbazide as hydrochloride salt. Semicarbazide hydrochloride reacted with 2- Chloro pyridine in presence of catalyst, using 2- ethoxy ethanol as a solvent to give TP, followed by water crystallization with chilling, centrifugation and dried. Crude TP is purified by water slurry to remove the salts to give pure TP, which is isolated by centrifuging and further wet cake is dried. Chemical reaction H N H 2 N H 2 N C NH 2 + H 2 N NH 2. H 2 NH 2 Urea Hydrazine Hydrate Semicarbazide + H 2 + NH 3 H 2 N H N Methanol Hydrochloric Acid. HCl NH 2 Semicarbazide Hydrochloride C l N + N H H 2 N NH 2 H Cl 2-Chloro-pyridine Semicarbaz ide Hy droc hloride 2- Ethoxy ethanol Cataly st N N N H TP (C rude) N N N H Water slurry N N N H TP (Crude) TP (Pure)

18 Process Flow Diagram Urea Hydrazine Hydrate Methanol Heat Water Hydrochloric Acid Sparkler Salt Chill Centrifuge Methanol reuse ML Water to ETP Drying Drying Loss 2-Ethoxy 100º 2-Chloro Sulfuric Acid Heat Ethoxy Water Cool & Chill Centrifuge ML to ETP Salt Dryer Drying Loss Milling Sifting 1, 2, 4-Triazolo (4, 3-a) Pyridine-3- one Material Balance Input Qty. utput Qty Urea 1.89 ML 2.46 Hydrazine Hydrate 1.97 salt 0.02 Methanol 5 Methanol reuse 4.8 Hydrochloric acid 3.2 ML Ethoxy Ethanol 4.23 Drying loss Chloro Pyridine 1.28 Ethoxy Ethanol 4.2 Sulfuric Acid 0.02 salt 0.05 Water 2 ML 2 drying loss 0.1 product

19 13. FERRIC CARBXY MALTSE Manufacturing Process Charge ferric chloride in to a reactor containing DM water under constant stirring.charge sodium carbonate solution and adjust the ph between 5.0 and 6.0.Centrifuge the mass and wash with water to remove excess chloride. Collect the wet mass and dissolve it in DM water. Charge maltodextrin and sodium hypochlorite in this mass. Charge Sodium bromide, stir and adjust the ph between to by adding sodium hydroxide solution. Heat the reaction mixture, maintain for four hrs and cool down. Adjust ph of the mixture between 5.5 to 6.5 by dilute HCl. Filter the mass through sparkler filter. Add this solution dropwise to a reactor containing methanol under stirring. Centrifuge the isolated product and wash with methanol. Dry the wet cake, mill and then pack the product HDPE drum. Chemical reaction Ferric chloride Hexahydrate + Sodium carbonate + Purified water (Double Pass Reverse smosis Water) FeCl 3.6H 2 Na 2 C 3 H 2 (M. Wt ) (M.Wt ) (M. Wt. 18) Ferric Hydroxide + Sodium Chloride + Carbon dioxide Fe (H ) 3 NaCl C 2 (M. Wt ) (M.Wt ) (M.Wt 44.00) Fe(H)3 + C 6n H [10n+2] 0 [5n+1] + NaBr + NaCl (Ferric hydroxide) Maltodextrin Sodium Bromide Sodium Hypochlorite [Fex(H)y(H2)z]n [{(C6H105)m(C6H127)l}k Process Flow Diagram

20 Contd.. Material Balance Input Qty. utput Qty DM Water 8.33 ML to ETP Ferric chloride 1.67 Salt TSDF 0.08 Water Reuse for Next Batch 3.23 Sodium Carbonate 1.17 Water wash Distillation residue 0.08 DM Water 0.83 Methanol Maltodextrin 0.62 Drying Loss 0.17 Sodium Hypochlorite 1.47 Product 1 Sodium Bromide 0.01 Sodium Hydroxide 0.08 Hydrochloric Acid 0.05 Methanol 15 Methanol SUCRFERRIC XYHYDRXIDE Manufacturing Process Charge ferric chloride in to reactor containing DM water under constant stirring. Charge sodium carbonate solution and adjust the ph between 5.0 and 6.0.Centrifuge the mass and wash with water to remove excess chloride. Collect the wet mass and dissolve it in DM water. Charge Sucrose and Starch. Charge Acetone to the reactor. Centrifuge the isolated product and ml reuse for next batch. Dry the wet cake, mill and then pack the product HDPE drum. Chemical reaction Contd..

21 Process Flow Diagram

22 Contd.. Material Balance Input Qty. utput Qty DM Water 6.94 ML to ETP Ferric chloride 0.69 Distil ut Water 1.39 Sodium Carbonate 0.69 ml reuse for next batch 1.36 Water 3.47 Drying Loss 0.14 DM Water 1.39 Product 1 Sucrose 0.28 Starch 0.28 Acetone CUPLE AMINE HYDRCHLRIDE Manufacturing Process 2- Chlorophenyl glycinate is taken in methanol thionyl chloride is added at chilled condition in 90to 120 min. Reaction mass is maintained for 30 min at chilled condition. Then heated to 60 to 65 C and maintain temp. 60 to 65 C for 5 hours at room temp. Then product is taken in MDC by extraction at by liq. NH3 basic PH. After MDC extraction organic layer is washed by water followed by NACL treatment. MDC distilled out atmospherically then traces removed by vacuum. ily syrup of 2- Chlorophenyl glycinate is obtained. Tartaric acid solution in methanol is prepared and addition of stage-i plus acetone solution is done up to 40 C. Reaction is maintained for 30 hrs at 32±2 C. After reaction confirmation product is isolated by filtration followed by chilled methanol washing. Wet cake is obtained is dried for 4 hrs at 55 to 60 C. Crude stage II is obtained. Crude StageII is then washed with chilled methanol. 1, 2- Thiopene ethanol is taken in Methylene dichloride and Triethyl amine is charged then socl2 is added slowly at chilled condition. Reaction mass is heated to reflux after reflux of 3hrs. Cooled to 25to 35 C. Water is charged, and then sodium carbonate solution is added to ph 8 to 8.5. After stirring, layer separation and twice water washing. Methylene dichloride is distilled out at atmospherically then degassed under vacuum. Crude stage is obtained. Product Distillation:- Pure stage III is isolated by high vacuum distillation by removing I, II and main fraction of pure stage III.Ester free base of (+) Tartaric salt of stage II is prepared at chilled condition in Methylene dichloride by adding 10% sodium bicarbonate solution. After stirring and layer separation aqueous layer is extracted by Methylene dichloride till product absence in aqueous layer. After water washing and NACL treatment MDC is removed under vacuum up to 35 C. Ester free base is couple with stage-iii in presence of acetonitrile, Na2 Co3 KI (adding lot wise) and TBAB maintaining 96 hrs at reflux. After reaction confirmation cooled to RT and excess Na2 C3, salts removed by filtration followed by acetonitrile washing.

23 Base is isolated removing acetonitrile under vacuum up to 45 C Base is dissolved in toluene. Then conc. HCL is added to organic layer at chilled temperature. Reaction mass stirred for 2 hrs at RT. Product is isolated by filtration. Finally, the wet cake is dried at 55 to 60 C for 8 hrs. Chemical reaction Process Flow Diagram Methanol 2-Chlorophenyl glycine Thionyl Chloride REACTR HCL to Scrubber Distil Methanol + Socl2 reuse for next batch Water Liq. Ammonia Methylene Dichloride REACTR Aqueous layer to ETP Sodium Chloride Solution REACTR Aqueous layer to ETP Acetone Stage-I REACTR REACTR Methylene chloride Distilled and reuse. Stage-I

24 Methanol Tartaric acid REACTR Chilled Methanol CENTRIFUGE Methanol + Acetone ML Methanol Stage-II TRAY DRYER REACTR Dry Losses Stage-II Chilled Methanol REACTR Methanol Reused TRAY DRYER Dry Losses Product Water Methylene dichloride 2-Thiophene ethanol Triethyl Amine Thionyl chloride Water Sodium Carbonate REACTR Aqueous layer to ETP Crude Stage-III Water Stage-II Methylene Dichloride Sodium Bicarbonate soln REACTR REACTR REACTR Distilled MDC reused Stage-III I st Cut II nd Cut Residues Product[Stage III] Aqueous layer to ETP Sodium Chloride Soln REACTR Aqueous layer to ETP Acetonitrile Sodium Carbonate Potassium Iodide TBAB Stage III REACTR REACTR Methylene Chloride Distilled Acetonitrile CENTRIFUGE Salts to Discard Toluene REACTR REACTR Acetonitrile Distilled and reuse HCl REACTR

25 CENTRIFUGE Toluene ML DRYER Drying Loss Product MILLING SIFTING CUPLE AMINE HYDRCHLRIDE Material Balance Input Qty. utput Qty Methanol 5.2 HCL to Scrubber Chlorophenyl Distil Methanol + Socl2 and 2.13 glycine reuse for next batch 1 Thionyl Chloride 2.04 aqueous layer to ETP Water 6.51 Methylene chloride Distilled and reuse Liq.Ammonia 1 Methanol + Acetone ML 3.58 Methylene Dichloride 8.8 Dry Losses 0.13 Sodium Chloride Sol 2.54 Methanol ML reuse for next batch 2.13 Acetone 1 Distill MDC & Reuse 1.2 Tartaric acid 0.95 I st Cut Thiophene ethanol 0.81 II nd Cut 0.19 Triethyl Amine 0.97 Residue Thionyl chloride 0.97 Salts to Discard 0.4 Sodium Carbonate 5.26 Acetonitrile Distilled and reuse 1.06 Sodium Bicarbonate soln 14.6 Toluene ML 2.37 Acetonitrile 0.77 Drying Loss 0.02 Potassium Iodide 0.12 Product 1 TBAB 0.03 Toluene 2.4 Hydrochloric Acid

26 LIST F RAW MATERIALS SR.N NAME F RAW MATERIAL MTPM EXISTING RAW MATERIALS 1. HFS Acid Sodium Carbonate Sodium Chloride 105 PRPSED RAW MATERIALS 4. Hyflow Supercel Ferric chloride Benzaldehyde Ethanol Amine Isobutyraldehyde Sulfuric acid Chloro Pyridine Chlorophenyl glycine Ethoxy Ethanol Thiophene ethanol Chloro methyl aniline Acetic acid Acetic anhydride Acetone Acetonitrile Activated Carbon Aloe-emodine Calcium Chloride Cat-TNA Caustic soda flakes Chromium Trioxide DMF Fresh Ferric chloride Glycine Hesperidin Hydantoin Hydrazine Hydrate Hydrochloric acid Hyflow Iodine Liq.Ammonia Maltodextrin MeH Methionine Acid Methyl Ethyl Ketone Methylene Dichloride N,N Dimethylacetamide Na salt Phenyl acetic acid rthochlorobenzene Potassium Carbonate Potassium Iodide Pyridine Sodium Hydroxide 0.08 MDE F TRANSPRT By Road By Road

27 SR.N NAME F RAW MATERIAL MTPM 47. Sodium Acetate Sodium Bicarbonate soln Sodium Bromide Sodium Carbonate Sodium Chloride Sol Sodium hydroxide Sodium Hypochlorite Sodium Thiosulphate Starch Sucrose Sulfuric Acid Tartaric acid TBAB TEA Thionyl Chloride Toluene Triethyl Amine Urea 18.9 MDE F TRANSPRT

28 DETAILS F SLID & HAZARDUS WASTE GENERATIN DURING PERATIN S. No. 1. Name of The Waste Discarded Containers/Barrel s/liner Cat. No. Existing Proposed Total MT/Y 5.0 MT/Y or (100 No./M) 2. Process Waste MT/M 3. Used oil Lit/Year 5.12 MT/Y or (100 No./M) 4.76 MT/M 200 Lit/Year 4. ETP Sludge MT/M 8.5 MT/M 10 MT/M 5. Distillation Residue 6. Spent Solvent Spent Carbon Hyflow MT/M 250 MT/Month 0.31 MT/Month 0.97 MT/Month 0.98 MT/M 250 MT/Month 0.31 MT/Month 0.97 MT/Month Method of Storage and Disposal Collection, storage and send to authorized recycler after decontamination. Collection, storage and transport to TSDF site. Collection, storage and reuse as lubricants in the machineries within the premises only or send to authorized reprocessors Collection, storage and transport to TSDF site. Collection, Storage and send for incineration. Collection, Storage, Recovered and reused. Collection, Storage and send for incineration. Collection, storage and transport to TSDF site.

29 EMISSINS FRM CMBUSTIN F FSSIL FUELS FRM STATINARY R MBILE SURCES S. Stack Attached To No. Existing - Nil Fuel Used Stack Height Pollution Control System Final Concentration Proposed Steam Boiler (1000 Kg/Hr) Steam Boiler 1. (600 Kg/Hr) TFH (2 Lac Kcal/Hr) 2. D. G. Set (250 KW + 93 KW) Natural Gas 800 m 3 /Day HSD 20 Lit/Hr 11 meter 9 meter Natural is used as fuel, adequate stack height is provided Adequate stack height is provided SPM 150 mg/nm 3 S ppm N X 50 ppm SPM 150 mg/nm 3 S ppm N X 50 ppm

30 PRCESS EMISSIN S. Stack Attached No. To Existing - Nil Stack Height Pollution Control System Final Concentration Proposed meter Alkali Scrubber followed by Water Scrubber HCl 20 mg/nm 3 WATER CNSUMPTIN No. Purpose WATER CNSUMPTIN (KL/Day) Existing Proposed Total (A) Domestic (B) Industrial 1. Processing Boiler Cooling Washing Scrubbing thers (B) Total Industrial (C) Green Belt Total (A+B+C) WASTE WATER GENERATIN No. Purpose WASTE WATER GENERATIN (KL/DAY) Existing Proposed Total (A) Domestic (B) Industrial 1 Processing Boiler Cooling Washing Scrubbing thers Total (B) (C) Green Belt Total (A+B+C)