HONEYWELL RESEARCH CHEMICALS

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Bertram Owens
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1 October 2016 Karl Fischer titration seminar HONEYWELL RESEARCH CHEMICALS Dr Katarzyna Pokajewicz

Who is Honeywell? 3 $38.6B in sales for 2015 53% Of sales outside U.S. ~1300 sites 70 countries 129.

2 Who is Honeywell? 3 $38.6B in sales for % Of sales outside U.S. ~1300 sites 70 countries employees Morris Plains, NJ headquarter Fortune 100 NYSE: HON Automation and Control Solutions Aerospace Performance Materials and Technologies 2016 by Honeywell International Inc. All rights reserved.

3 Performance materials and technologies 3 Catalysts, adsorbents and chemicals for processing crude oil Refrigerants Electronic materials Intermediates for paint, varnish and glue

4 Performance materials and technologies 4 Substrates for plastics Nylon resins Nylon foils Disinfectants

5 5 Performance materials and technologies Fertilizer Sulf-N ammonium sulphate Polymer films for drug packaging Luminescent dyes Fine chemicals

6 HONEYWELL RESEARCH CHEMICALS

7 New Research Chemicals Business 7 Background Timeline Q Q Q Q Q September 2014 June 2015 October 2015 December 2015 Merck announces that it will acquire Sigma-Aldrich Fall/Winter 2014 Deal is accepted globally by governments & institutions The European Commission rules the acquisition could lead to unfair competition in certain areas. Sigma-Aldrich has to sell part of its portfolio to proceed with the merger. Honeywell announces its intention to buy divested business from Sigma-Aldrich Honeywell acquires selected product lines from Sigma-Aldrich portfolio 2016 by Honeywell International Inc. All rights reserved.

8 Honeywell 8 Transition agreement Till 15th Dec 2016 agreement with Merck Merck's customer service, distribution, logistics 16 Dec Since mid-nov 2016 Honeywell RC starts operating independly 16th Dec 2016 Honeywell RC works completely on it s own Merck Sigma-Aldrich 16 Nov

9 9 Honeywell porfolio Legacy Sigma-Aldrich Brands: Fluka, Chromasolv, Hydranal, TraceSELECT, Fixanal Products: Solvents, inorganics, titration products Mostly produced by Honeywell as subcontractor! Legacy Honeywell Brand: Burdick&Jackson, Riedel de Haën Solvents (general, analytical and biosynthesis grades, anhydrous), inorganics

10 10 Honeywell porfolio After acquisition: Present: Fluka branded products and S-A with suffix -D All Honeywell, Fluka, Riedel de Haën, Burdick&Jackson branded products

11 Our website 11 In preparation functional in November

12 12 Branding General grade reagents Fluka High purity analytical reagents Riedel de Haën High purity solvents Burdick& Jackson High purity solvents for synthesis Sub-brands: - Hydranal - TraceSELECT - Fixanal Sub-brands: - Chromasolv - TraceSELECT Sub-brands: - BioSyn

Honeywell Research Chemicals 13 Portfolio Brands Portfolio Overview SOLVENTS High-purity solvents and reagents for synthesis SOLVENTS High-purity solvents for dedicated applications ANALYTICAL

13 Honeywell Research Chemicals 13 Portfolio Brands Portfolio Overview SOLVENTS High-purity solvents and reagents for synthesis SOLVENTS High-purity solvents for dedicated applications ANALYTICAL REAGENTS Karl Fischer titration, standards, acids, bases, salts, and ph buffers PERFORMANCE GRADE Solvents and inorganics for general laboratory use Product Lines BioSyn - DNA, RNA and peptide synthesis Anhydrous - Moisturesensitive organic synthesis, organometallic, combinatorial chemistry, and related applications Chromasolv - Chromatography techniques including LC-MS, UHPLC, Headspace, and GC Spectroscopy - IR and UV- Vis applications ACS and Pharmacopoeia Grade - Industrial and pharmaceutical applications TraceSELECT Solvents - Trace and low-metal content analysis Analytical Inorganics Standard Solutions - Buffers and concentrated solutions Hydranal - Karl Fischer titration for measuring water content TraceSELECT Inorganics - Trace and low-metal content analysis Solvents - ACS specific use (HPLC), ACS general use, solvents for histology, and reagent grade for chemical synthesis and other industrial applications Inorganics - Chemical synthesis and inorganic chemistry including essential acids and bases, salts, metals and elements, and reagents for chemical reactions Services & Technology Returnable/Re-usable Container Program for BioSyn Solvents and Blends reduces carbon footprint while saving time and money Returnable/Re-usable Container Program reduces carbon footprint while saving time and money Honeywell LabReady for customer-specific blends using proprietary, closed-loop blending technology Special Packaging Technology for guaranteed, free flowing powder in hygroscopic inorganics Dedicated Packaging for Volumetric Solutions Supply in Larger Quantity Scalable to Production Requirements by Honeywell International Inc. All rights reserved.

14 Available next year 1 Synthesis solvents 14 Anhydrous solvents Biosyn DNA/RNA and peptide synthesis reagents designed for scientists and manufacturers performing automated oligonucleotide/peptide synthesis Anhydrous solvents, deblocking, activator, capping and oxidation reagents

solvents For inorganic trace analysis, metal

16 16 High purity solvents ACS and Pharmacopeia grade Spectroscopy solvents for UV-VIS and IR TraceSELECT solvents For inorganic trace analysis, metal speciation analysis by LC-ICP-MS Chromasolv for LC and GC

17 Chromasolv solvents For LC 17 Grade HPLC Gradient Plus LC-MS LC-MS Ultra Purity Medium High High Higher Higher Highest Water Low Lower Lower Lower Lower UV Low Lower Lower Lower Lowest HPLC UV Gradient Low Lower Lower Lowest Fluorescence Low Lower Lower Lower Lowest Metal Testing ppb Level ppb Level Non-Volatile Residue Summary Lower Lower Lowest Lowest Lowest Limited Gradient Gradient Analysis Lowest UV and Gradient Analysis Suitability for LC-MS Suitability for UHPLC-MS

18 Grades for HPLC LC-MS Ultra Chromasolv LC-MS Chromasolv Chromasolv Plus Chromasolv gradient grade Chromasolv

19 Chromasolv solvents For GC 26 Grade Pesticide Residue Analysis GC-Headspace Applications Low boiling solvents for direct GC injection High boiling solvents for Headspace/OVI analysis Organic Purity Very High Very High Trace Metal Testing Non-Volatile Residue/ Microfiltration % 0.2 micron filtered Special Suitability tested for residue analysis, 5 ng/l compared to Lindane GC-Headspace tested for OVIs (organic volatile impurities) acc. to Ph.Eur., USP and ICH Typical solvents Acetone, Hexane, Ethyl acetate DMSO, DMA, DMF, Water

21 3 Titration 21 Hydranal line For water determination by Karl-Fischer method Titration solutions, solvents, water standards, auxiliary reagents Other titration methods Ready to use titrant solutions/buffers: - bottled - VOLPAC (5 or 10L) Concentrates - Fixanal Indicators

(TraceSELECT Ultra) Purified by sub-boiling

22 TraceSELECT reagents for metal trace analysis (AAS and ICP) 22 Digestion reagents (acids, bases, salts) trace analysis (TraceSELECT ) ultratrace analysis (TraceSELECT Ultra) Purified by sub-boiling distillation Packed in high-quality HDPE or fluoropolymer bottles

Free flowing powders Anhydrous salts, acids and bases 23 Innovative, proprietary packaging solution that addresses the common issue of clumping that occurs

Technology eliminates the lengthy process of breaking up solids before use and reduces waste. 2.

23 Free flowing powders Anhydrous salts, acids and bases 23 Innovative, proprietary packaging solution that addresses the common issue of clumping that occurs with many hygroscopic salts and buffers by preventing the absorption of water from the surrounding environment. Features: 1. Technology eliminates the lengthy process of breaking up solids before use and reduces waste. 2. Technology allows users to work safer by eliminating the need to break up solids. 3. Packaging sizes range from 100 g to 12 kg to support customer s needs. 4. We offer the broadest selection of products in a format that prevents moisture absorption.

24 24 Others analytical Standards Adsorbents High purity acids, bases, salts (ACS, Pharmacopeia) Analytical consumables Different analytical reagents: derivatisation, mobile phase additives

26 4 Lab essentials 26 For each and every lab day to day use Reagent grade Purum p.a. Laboratory reagent Industrial application grades Histological grade

27 Industrial fine chemicals 27 Key Markets Served: Sealants & Adhesives Catalysts & Catalytic Precursors Metal Treatment Electroplating Oral Care Pharma Food, Beverage and Nutrition

Fischer titration Center of Excellence for Packaging

28 28 Seelze plant, Germany Production site for lab and fine chemicals Hydranal Production Center of Excellence for Karl Fischer titration Center of Excellence for Packaging Engineering High Volume Production and Packing ISO 9001 Certification

29 Muskegon Plant, Michigan, USA 29 ISO 9001 Certification

Honeywell Research Chemicals 30 Our Strengths Leader in high-purity solvents and Karl Fischer titration Best quality material on the market Competitively priced Exceptional lot-to-lot consistency

30 Honeywell Research Chemicals 30 Our Strengths Leader in high-purity solvents and Karl Fischer titration Best quality material on the market Competitively priced Exceptional lot-to-lot consistency Production and QC in Germany and US Broad offer of different grades Bulk availability Flexibility in custom packaging and blending Highly developed returnable containers program 2016 by Honeywell International Inc. All rights reserved.

31 Honeywell Research Chemicals 31 We aim to become your supplier of high quality lab reagents and chemicals for analytical and chemistry laboratories 2016 by Honeywell International Inc. All rights reserved.

32 Thank You

Flk = Acy + Cy z. Discover the perfect formula Fluka Reagents. Fluka TM Accuracy Consistency AUTHENTIC

Flk = Acy + Cy z. Discover the perfect formula Fluka Reagents. Fluka TM Accuracy Consistency AUTHENTIC Flk = Acy + Cy z Fluka TM Accuracy Consistency QUALITY ASSURED AUTHENTIC BY HONEYWELL Discover the perfect formula Fluka Reagents Honeywell now delivers Fluka premium grade inorganic reagents worldwide