Designed polymers for purification of flavor oils

Size: px
Start display at page:

Download "Designed polymers for purification of flavor oils"

Transcription

1 Designed polymers for purification of flavor oils IFEAT Conference 2014 Rome, September 23, 2014 Ecevit Yilmaz, PhD Global Product Manager Industrial Resins MIP Technologies AB a subsidiary of Biotage AB 2014 Biotage 1

2 Overview of the presentation» The company» Separation techniques» Chromatography, adsorbents and selective separations» Case study: selective pesticide removal from lemon oil» Summary 2014 Biotage 2

3 About Biotage and MIP Technologies 2014 Biotage 3

4 Where we are Charlotte Uppsala Corporate headquarter Lund Cardiff Tokyo Shanghai Legend Sales office Production and R&D Nearly 300 employees ca 500 M SEK turnover 2014 Biotage 4

5 MIP Technologies Experts in polymeric adsorbents» Founded in 2000, Lund Sweden» Acquired by Biotage AB in 2010» Total of 12 chemists (9 PhD)» R&D team to develop novel adsorbents» Full analytical lab to test and QC» Pilot plant to scale-up and manufacture» Activities:» Polymeric adsorbents» Development of new adsorbents and applications» Problem solving service for customers:» High success rate (~ 75 %) in conducted projects» Worked with many of top 100 companies» ~ 15 years in the business 2014 Biotage 5

6 Overview of the presentation» The company» Separation techniques» Chromatography, Adsorbents and Selective separations» Case study: Selective pesticide removal from lemon oil» Summary 2014 Biotage 6

7 Separations and purifications» Separations/Purifications basically have 2 goals:» 1) to remove unwanted substances» Example: remove toxic or allergenic from complex mixtures» 2) to recover a desired substance» Example: extract a valuable compound from a mixture» Selectivity is the ability to distinguish one molecule from other molecules» Target compound» Other compounds etc» Adsorbent = Polymer = Resin 2014 Biotage 7

8 Separation techniques A few generic examples» Distillation» By volatility» Membranes /Filtration» By permeability 2014 Biotage 8

9 Separation techniques» Liquid/Liquid Extraction» By solubility» Precipitation / Re-crystallisation» By solubility 2014 Biotage 9

10 Overview of the presentation» The company» Separation techniques» Chromatography, Adsorbents and Selective separations» Case study: Selective pesticide removal from lemon oil» Summary 2014 Biotage 10

11 Column Chromatography By reversible surface interactions 10 mm Adsorbent 1 2 Typical adsorbent properties Particle size ~ 100 µm Pore size ~ 100 Å Pore volume ~ 0.5 ml/g Surface area ~ 500 m 2 /g Cross-linking ~ 50 % Ligand density ~ 0.5 mmol/g 2014 Biotage 11

12 Adsorbent surface landscape O Reversed Phase Ionic/Polar Designed Imprinted Affinity Selectivity Non-selective materials (hydrophobic, ionic/polar): wide-spread general use. For difficult separations, selective materials are needed: Affinity, imprinted adsorbents, designed adsorbents... In general: non-selective materials are cheap, selective materials cost more Most affinity materials are fragile (biological molecules as ligands) 2014 Biotage 12

13 Potential of selective adsorbents» Resolution of difficult-to-separate compounds» Selective removal of unwanted contaminants» Targeted recovery or enrichment of valuable compounds» Cumbersome purifications with many or large columns» Replacing distillation or liquid-liquid extraction» Energy consumption, purity, contaminants» Avoiding undesired chemicals e.g. salts, flammable organic solvents or toxic chemicals» Green chemistry 2014 Biotage 13

14 Overview of the presentation» The company» Separation techniques» Chromatography, Adsorbents and Selective separations» Case study: Selective pesticide removal from lemon oil» Summary 2014 Biotage 14

15 Citrus flavor oils Extracted from the peel Important ingredient in» Food industry» Drinks industry» Fragrances» Etc Flavor oils may be contaminated with agricultural residues 2014 Biotage 15

16 Pesticides in lemon oil Toxic: similar to nerve agents (e.g. sarin) Many pesticides have a thiophosphoester moiety Present at ppm levels 2014 Biotage 16

17 Selective pesticide removal» Distillation and other standard unit operations cannot always remove the pesticides well» Pesticides and lemon oil constituents are chemically similar (e.g. vapor pressure)» Heat may influence aroma / taste profile» Standard adsorbents do not exhibit sufficient selectivity Development of a selective adsorbent to remove pesticides without affecting key aroma molecules 2014 Biotage 17

18 How to find the best adsorbent? Screen Material opt. Application Note Method opt. Adsorbent library 2500 candidates Hit Adsorbent Extraction Method 2014 Biotage 18

19 Adsorbent surface chemistries O Acidic/ Anionic OH O B OH OH O S O OH N O S O OH Basic/ Cationic H N N N + Cl- NH 2 N N Neutral/ hydrophilic N O O NH R NH O NH 2 OH Neutral/ hydrophobic N Adsorbents have combinations of chemistries 2014 Biotage 19

20 EA001 EA002 EA003 EA004 EA005 EA006 EA007 EA008 EA009 EA010 EA011 EA012 EA013 EA014 EA015 EA016 EA017 EA018 EA019 EA020 EA021 EA022 EA023 EA024 EA025 EA026 EA027 EA028 EA029 EA030 EA031 EA032 % Bound Outcome of a screening example Using the MIP Tech adsorbent library Phase 2014 Biotage 20

21 Adsorbent design & optimisation» Material morphology» Pore size» Surface area» Pore volume» Bead size» Rigidity Surface chemistry Interaction design Ligand density Binding site design + - O 2014 Biotage 21

22 Optimised designed adsorbent Pesticide clean-up in one step Citrus oil containing pesticides RENSA 101 column 2014 Biotage 22

23 Selective pesticide removal GC-MS scan Selective extraction of pesticides without extracting vital matrix components 2014 Biotage 23

24 Unaffected color, flavor and aroma The cleaned-up lemon oil passed all sensory tests with no impact on the oil quality 2014 Biotage 24

25 Overview of the presentation» The company» Separation techniques» Chromatography, Adsorbents and Selective separations» Case study: Selective pesticide removal from lemon oil» Summary 2014 Biotage 25

26 Summary» Pressure from regulation will force raw material producers and users to evaluate new technologies» New agricultural residues or other contaminants» New knowledge about problematic natural constituents» Separation techniques have pros and cons» Distillation is versatile & established but energy demanding» Old techniques may be expensive and less efficient» Many techniques do not deliver sufficient selectivity» Choosing the right adsorbent + method may be a challenge» Novel adsorbents could improve or lead to new quality of essential oils and economics of processing 2014 Biotage 26

27 Thank you! Biotage 27

5072 CHEMISTRY (NEW PAPERS WITH SPA) TOPIC 1: EXPERIMENTAL CHEMISTRY 5067 CHEMISTRY (NEW PAPERS WITH PRACTICAL EXAM) TOPIC 1: EXPERIMENTAL CHEMISTRY

5072 CHEMISTRY (NEW PAPERS WITH SPA) TOPIC 1: EXPERIMENTAL CHEMISTRY 5067 CHEMISTRY (NEW PAPERS WITH PRACTICAL EXAM) TOPIC 1: EXPERIMENTAL CHEMISTRY 5072 CHEMISTRY (NEW PAPERS WITH SPA) TOPIC 1: EXPERIMENTAL CHEMISTRY 5067 CHEMISTRY (NEW PAPERS WITH PRACTICAL EXAM) TOPIC 1: EXPERIMENTAL CHEMISTRY SUB-TOPIC 1.2 METHODS OF PURIFICATION AND ANALYSIS LEARNING

More information

Chromatography. What is Chromatography?

Chromatography. What is Chromatography? Chromatography What is Chromatography? Chromatography is a technique for separating mixtures into their components in order to analyze, identify, purify, and/or quantify the mixture or components. Mixture

More information

Protein separation and characterization

Protein separation and characterization Address:800 S Wineville Avenue, Ontario, CA 91761,USA Website:www.aladdin-e.com Email USA: tech@aladdin-e.com Email EU: eutech@aladdin-e.com Email Asia Pacific: cntech@aladdin-e.com Protein separation

More information

The City School. Subject: Chemistry CIE Code: Curriculum Distribution Chart

The City School. Subject: Chemistry CIE Code: Curriculum Distribution Chart The City School Curriculum Distribution Chart Class 9: September 2014 to May 2015 Subject: Chemistry CIE Code: 5070 Syllabus Content (As taken from the CIE 2015 syllabus) Topic Content Week Learning Outcomes

More information

10/18/2006. Biotage A Life Science Technology Company

10/18/2006. Biotage A Life Science Technology Company 10/18/2006 Biotage A Life Science Technology Company About Biotage Headquartered in Uppsala, Sweden Three Centers of Excellence Uppsala, Sweden Research & Development Charlottesville VA, U.S.A. Instrument

More information

Chemistry Instrumental Analysis Lecture 28. Chem 4631

Chemistry Instrumental Analysis Lecture 28. Chem 4631 Chemistry 4631 Instrumental Analysis Lecture 28 High Performance Liquid Chromatography () Instrumentation Normal Phase Chromatography Normal Phase - a polar stationary phase with a less polar mobile phase.

More information

Liquid Chromatography

Liquid Chromatography Liquid Chromatography 1. Introduction and Column Packing Material 2. Retention Mechanisms in Liquid Chromatography 3. Method Development 4. Column Preparation 5. General Instrumental aspects 6. Detectors

More information

Chemical Analysis Problem

Chemical Analysis Problem Chemical Analysis Problem Hair analysis is frequently used for the long-term monitoring of drug and alcohol users. You are working at a forensics laboratory and have been given the task of developing a

More information

IGCSE (9-1) Edexcel - Chemistry

IGCSE (9-1) Edexcel - Chemistry IGCSE (9-1) Edexcel - Chemistry Principles of Chemistry Element, Compounds and Mixtures NOTES 1.8: Understand how to classify a substance as an element, compound or mixture Classifications: S Class Element

More information

HICHROM. Chromatography Columns and Supplies. SAMPLE PREPARATION Solid Phase Extraction - CHROMABOND. Catalogue 9. Hichrom Limited

HICHROM. Chromatography Columns and Supplies. SAMPLE PREPARATION Solid Phase Extraction - CHROMABOND. Catalogue 9. Hichrom Limited HICHROM Chromatography Columns and Supplies SAMPLE PREPARATION Solid Phase Extraction - Catalogue 9 The Markham Centre, Station Road Theale, Reading, Berks, RG7 4PE, UK Tel: +44 (0)8 930 3660 Fax: +44

More information

COC Biotechnology Program

COC Biotechnology Program COC Biotechnology Program High Performance Liquid Chromatography (HPLC) Version B Chromatography is used by scientists to separate one substance from another in companies such as: food and beverage, pharmaceutical,

More information

Lecture 25: Manufacture of Maleic Anhydride and DDT

Lecture 25: Manufacture of Maleic Anhydride and DDT Lecture 25: Manufacture of Maleic Anhydride and DDT 25.1 Introduction - In this last lecture for the petrochemicals module, we demonstrate the process technology for Maleic anhydride and DDT. - Maleic

More information

Open Column Chromatography, GC, TLC, and HPLC

Open Column Chromatography, GC, TLC, and HPLC Open Column Chromatography, GC, TLC, and HPLC Murphy, B. (2017). Introduction to Chromatography: Lecture 1. Lecture presented at PHAR 423 Lecture in UIC College of Pharmacy, Chicago. USES OF CHROMATOGRAPHY

More information

High Performance Liquid Chromatography

High Performance Liquid Chromatography STANDARDBASE techniques: High Performance Liquid Chromatography Drenthe College, The Netherlands 1. Introduction HPLC. High Performance Liquid Chromatography High Performance Liquid Chromatography (HPLC)

More information

Chemical Processes Part 1: Intro and Chemistry Basics

Chemical Processes Part 1: Intro and Chemistry Basics Chemical Processes Part 1: Intro and Chemistry Basics How are chemistry and chemical engineering different? Chemists Small batches Determine reactions to make new compounds in test tubes Prepare and conduct

More information

Packings for HPLC. Packings for HPLC

Packings for HPLC. Packings for HPLC Summary of packings for HPLC In analytical HPLC, packings with particle sizes of 3 to 10 µm are preferred. For preparative separation tasks, also particles with diameters larger than 10 µm are applied.

More information

What type of samples are common? Time spent on different operations during LC analyses. Number of samples? Aims. Sources of error. Sample preparation

What type of samples are common? Time spent on different operations during LC analyses. Number of samples? Aims. Sources of error. Sample preparation What type of samples are common? Sample preparation 1 2 Number of samples? Time spent on different operations during LC analyses 3 4 Sources of error Aims Sample has to be representative Sample has to

More information

the study of things all around us, its properties, what makes it up and how things can change.

the study of things all around us, its properties, what makes it up and how things can change. Vocabulary Word Definition Chemistry the study of things all around us, its properties, what makes it up and how things can change. Matter Matter is the stuff all around us: your computer, the air you

More information

Chapter 3. Water and the Fitness of the Environment

Chapter 3. Water and the Fitness of the Environment Chapter 3 Water and the Fitness of the Environment 1 Importance of water Overview: The Molecule That Supports All of Life Water is the biological medium here on Earth All living organisms require water

More information

CHROMATOGRAPHY AND MASS SPECTROMETER

CHROMATOGRAPHY AND MASS SPECTROMETER 22 CHROMATOGRAPHY AND MASS SPECTROMETER 22.1 INTRODUCTION We know that the biochemistry or biological chemistry deals with the study of molecules present in organisms. These molecules are called as biomolecules

More information

Universal Indicator turns green. Which method is used to obtain pure solid X from an aqueous solution? A. mixture

Universal Indicator turns green. Which method is used to obtain pure solid X from an aqueous solution? A. mixture 1 The results of some tests on a colourless liquid X are shown. oiling point = 102 Universal Indicator turns green What is X? ethanol hydrochloric acid pure water sodium chloride (salt) solution 2 blue

More information

Nutrition Beverages and Plant Extracts.

Nutrition Beverages and Plant Extracts. Nutrition Beverages and Plant Extracts. Beverages and Plant Extracts The beverages industry is a dynamic, global industry with an increasing demand for high quality products. Fruit juices are generally

More information

Extraction. A useful technique for purification of mixture. Dr. Zerong Wang at UHCL. Separation processes

Extraction. A useful technique for purification of mixture. Dr. Zerong Wang at UHCL. Separation processes Extraction A useful technique for purification of mixture Separation processes Liquid-liquid extraction Adsorption Filtration Solid-liquid extraction (leaching) Elution chromatography Membrane separation

More information

Removal of suspended and dissolved organic solids

Removal of suspended and dissolved organic solids Removal of suspended and dissolved organic solids Types of dissolved solids The dissolved solids are of both organic and inorganic types. A number of methods have been investigated for the removal of inorganic

More information

CEE 697z Organic Compounds in Water and Wastewater

CEE 697z Organic Compounds in Water and Wastewater Print version CEE 697z Organic Compounds in Water and Wastewater NOM Characterization Ran Zhao Lecture #6 Dave Reckhow - Organics In W & WW Outline Introduction of NOM Water treatment processes for NOM

More information

Chapter 3 Membrane Processes for Water Production

Chapter 3 Membrane Processes for Water Production Chapter 3 Membrane Processes for Water Production Application of Membrane Processes in Water Environment Fusion Tech Hydrology Molecular biology Surface Chem Nano particles Biofilm CFD Catalyst Space station

More information

Edexcel GCSE Chemistry. Topic 2: States of matter and mixtures. Methods of separating and purifying substances. Notes.

Edexcel GCSE Chemistry. Topic 2: States of matter and mixtures. Methods of separating and purifying substances. Notes. Edexcel GCSE Chemistry Topic 2: States of matter and mixtures Methods of separating and purifying substances Notes 2.5 Explain the difference between the use of pure in chemistry compared with its everyday

More information

HPLC Column Material - Bulk Ware

HPLC Column Material - Bulk Ware HPLC Column Material - Bulk Ware Constantly growing demands on separation efficiency and availability of solid phase material for packing HPLC columns and column packing stations have motivated us to provide

More information

Moisture holding capacity 61 to 69 % Shipping Weight Specific gravity 1.06 to 1.08 Particle size

Moisture holding capacity 61 to 69 % Shipping Weight Specific gravity 1.06 to 1.08 Particle size Product Data Sheet AMBERLITE XAD7HP Industrial Grade Polymeric Adsorbent Introduction AMBERLITE XAD7HP is a polymeric adsorbent, supplied as white insoluble beads. It is a non ionic aliphatic acrylic polymer

More information

DOUBLE DISPLACEMENT REACTIONS. Double your pleasure, double your fun

DOUBLE DISPLACEMENT REACTIONS. Double your pleasure, double your fun DOUBLE DISPLACEMENT REACTIONS Double your pleasure, double your fun Industrial processes produce unwanted by-products. Dissolved toxic metal ions-copper, mercury, and cadmium-are common leftovers in the

More information

Your Partner for Specialty Chemical Innovation & Technology

Your Partner for Specialty Chemical Innovation & Technology CORPORATE OVERVIEW Your Partner for Specialty Chemical Innovation & Technology CORPORATE OVERVIEW OUR COMPANY GROWTH MPD Chemicals is a US-based manufacturer of custom and specialty chemicals with over

More information

Microorganisms. Dissolved inorganics. Native vs. Introduced; Oligotrophic vs. Eutrophic Millions to billions per ml or g Complex consortia

Microorganisms. Dissolved inorganics. Native vs. Introduced; Oligotrophic vs. Eutrophic Millions to billions per ml or g Complex consortia 1 Microorganisms Native vs. Introduced; Oligotrophic vs. Eutrophic Millions to billions per ml or g Complex consortia Species makeup: f(t, O 2, ph, nutrients, etc.) Indicators & pathogens Dissolved inorganics

More information

Chromatography. writing in color

Chromatography. writing in color Chromatography writing in color Outlines of Lecture Chromatographic analysis» Principles and theory.» Definition.» Mechanism.» Types of chromatography.» Uses of Chromatography. In 1906 Mikhail Tswett used

More information

Distillation. Presented by : Nabanita Deka

Distillation. Presented by : Nabanita Deka Distillation OPTIMIZATION FOR MAXIMISATION Presented by : Nabanita Deka LPG department OIL INDIA LIMITED DATED-04.03.2011 Basics of mass transfer Mass transfer : Transfer of material from one homogeneous

More information

Food Additives and Fragrance Materials (Flammable) Group Standard HSR002576

Food Additives and Fragrance Materials (Flammable) Group Standard HSR002576 Food Additives and Fragrance Materials (Flammable) Group Standard 2017 - HSR002576 GROUP STANDARD UNDER THE HAZARDOUS SUBSTANCES AND NEW ORGANISMS ACT 1996 Food Additives and Fragrance Materials (Flammable)

More information

IGCSE(A*-G) Edexcel - Chemistry

IGCSE(A*-G) Edexcel - Chemistry IGCSE(A*-G) Edexcel - Chemistry Principles of Chemistry Atoms NOTES 1.8 Describe and explain experiments to investigate the small size of particles and their movement including: Dilution of coloured solutions

More information

Sample Prep Options for GC users

Sample Prep Options for GC users Sample Prep Options for GC users Tina Chambers Technical Specialist Sample Preparation tina.chambers@agilent.com 949-842-0493 Why Bother? Removal of interferences which would otherwise affect detection

More information

Chromatography & instrumentation in Organic Chemistry

Chromatography & instrumentation in Organic Chemistry Chromatography & instrumentation in Organic Chemistry What is Chromatography? Chromatography is a technique for separating mixtures into their components in order to analyze, identify, purify, and/or quantify

More information

Introduction to Chromatography

Introduction to Chromatography Introduction to Chromatography Dr. Sana Mustafa Assistant Professor Department of Chemistry, Federal Urdu University of Arts, Science & Technology, Karachi. What is Chromatography? Derived from the Greek

More information

HPLC Winter Webinars Part 2: Sample Preparation for HPLC

HPLC Winter Webinars Part 2: Sample Preparation for HPLC HPLC Winter Webinars Part 2: Sample Preparation for HPLC Jon Bardsley, Application Chemist Thermo Fisher Scientific, Runcorn/UK The world leader in serving science What am I Going to Talk About? What do

More information

Story of success FEB 2018

Story of success FEB 2018 Story of success FEB 2018 AGEN DA ABOUT US PRODUCTION & CAPACITY PARTNERSHIP IN PORTUGAL Establishment What do we do The secret The story of Bifix M A S T E R B A T C H E S & A D D I T I V E S FOUNDATION

More information

Pharmacognosy Lab. Senna s Advantages : Used for patients who aren t responsive for milder laxatives Senna s Disadvantages :

Pharmacognosy Lab. Senna s Advantages : Used for patients who aren t responsive for milder laxatives Senna s Disadvantages : Pharmacognosy Lab Lab1,2,3 Comparative determination of glycosides in Senna using different methods of extraction ( Soxhlet, Maceration, & Ultrasonic bath ) Senna s Advantages : I. Used as Stimulant Laxative

More information

Pure Chromatography Consumables Pure flexibility. Pure specialization. Pure convenience.

Pure Chromatography Consumables Pure flexibility. Pure specialization. Pure convenience. Pure Chromatography Consumables Pure flexibility. Pure specialization. Pure convenience. Pure Consumables More focus on your application The Pure consumable portfolio offers an unrivaled range of products

More information

CHROMATOGRAPHY. The term "chromatography" is derived from the original use of this method for separating yellow and green plant pigments.

CHROMATOGRAPHY. The term chromatography is derived from the original use of this method for separating yellow and green plant pigments. CHROMATOGRAPHY The term "chromatography" is derived from the original use of this method for separating yellow and green plant pigments. THEORY OF CHROMATOGRAPHY: Separation of two sample components in

More information

The Biological Importance of Water

The Biological Importance of Water The Biological Importance of Water Why is water important? Major component of all living systems and our planet. Occupies most of a cells volume. Has major properties that living systems require. Water

More information

Chromatography. Chromatography is a combination of two words; * Chromo Meaning color * Graphy representation of something on paper (writing)

Chromatography. Chromatography is a combination of two words; * Chromo Meaning color * Graphy representation of something on paper (writing) Chromatography Chromatography is a combination of two words; * Chromo Meaning color * Graphy representation of something on paper (writing) Invention of Chromatography Mikhail Tswett invented chromatography

More information

THE ROLE OF CHEMICAL SYNTHESIS IN SUPPORT OF THE SUBSTITUTION PRINCIPLE Ferdinando Fiorino Elisa Perissutti

THE ROLE OF CHEMICAL SYNTHESIS IN SUPPORT OF THE SUBSTITUTION PRINCIPLE Ferdinando Fiorino Elisa Perissutti Unit of Medicinal Chemistry LIFE-EDESIA workshop Milan, Dicember 10 th 2014 THE ROLE OF CHEMICAL SYNTHESIS IN SUPPORT OF THE SUBSTITUTION PRINCIPLE Ferdinando Fiorino Elisa Perissutti Università degli

More information

Water - HW. PSI Chemistry

Water - HW. PSI Chemistry Water - HW PSI Chemistry Name 1) In a single molecule of water, the two hydrogen atoms are bonded to a single oxygen atom by A) hydrogen bonds. B) nonpolar covalent bonds. C) polar covalent bonds. D) ionic

More information

Automated Sample Preparation. Andrew Duggan, PhD Aman Sharma Shimadzu Scientific Australia

Automated Sample Preparation. Andrew Duggan, PhD Aman Sharma Shimadzu Scientific Australia Automated Sample Preparation Andrew Duggan, PhD Aman Sharma Shimadzu Scientific Australia Complete Workflow Solution Extrahera Analyte Extraction Solvent Evaporation Turbovap Analyte analysis LC/MS & GC/MS

More information

General Separation Techniques

General Separation Techniques ecture 2. Basic Separation Concepts (1) [Ch. 1] General Separation Techniques - Separation by phase creation - Separation by phase addition - Separation by barrier - Separation by solid agent - Separation

More information

Introduction to Work in Laboratory

Introduction to Work in Laboratory INSTITUTE OF MEDICAL BIOCHEMISTRY AND LABORATORY MEDICINE Introduction to Work in Measuring volumes, filtration, centrifugation, solubility, separation Practical in Medical Biochemistry General Medicine

More information

SPE. Simply Efficient! Watchers bond Solid Phase Extraction by ISU. Ver

SPE. Simply Efficient! Watchers bond Solid Phase Extraction by ISU. Ver SPE Simply Efficient! Watchers bond Solid Phase Extraction by ISU Ver. 05-11 Solid Phase Extraction Basic principles of Solid Phase Extraction Solid phase extraction (SPE) is a powerful method for sample

More information

Chromatographic Methods of Analysis Section - 4 : Ion Exchange Chrom. Prof. Tarek A. Fayed

Chromatographic Methods of Analysis Section - 4 : Ion Exchange Chrom. Prof. Tarek A. Fayed Chromatographic Methods of Analysis Section - 4 : Ion Exchange Chrom. Prof. Tarek A. Fayed Ion Exchange Chromatography (IEC) In this type of chromatography, the solid stationary phase )organic resin) is

More information

The Solubility is the Solution

The Solubility is the Solution The Solubility is the Solution The Company BellandTechnology AG is a polymer technology company, originally founded in Switzerland 1983. BellandTechnology developed a proprietary selectively soluble polymer

More information

Matter Properties and Changes

Matter Properties and Changes Matter Properties and Changes What is matter? anything that takes up space (volume) and has mass everything around you is made up of matter matter has 3 main states: solid, liquid, and gas Physical Property

More information

Methods of purification

Methods of purification Methods of purification Question Paper 1 Level IGSE Subject hemistry (0620/0971) Exam oard ambridge International Examinations (IE) Topic Experimental techniques Sub-Topic Methods of purification ooklet

More information

Solutions. Experiment 11. Various Types of Solutions. Solution: A homogenous mixture consisting of ions or molecules

Solutions. Experiment 11. Various Types of Solutions. Solution: A homogenous mixture consisting of ions or molecules Solutions Solution: A homogenous mixture consisting of ions or molecules -Assignment: Ch 15 Questions & Problems : 5, (15b,d), (17a, c), 19, 21, 23, 27, (33b,c), 39, (43c,d),45b, 47, (49b,d), (55a,b),

More information

Analytical Technologies in Biotechnology Prof. Dr. Ashwani K. Sharma Department of Biotechnology Indian Institute of Technology, Roorkee

Analytical Technologies in Biotechnology Prof. Dr. Ashwani K. Sharma Department of Biotechnology Indian Institute of Technology, Roorkee Analytical Technologies in Biotechnology Prof. Dr. Ashwani K. Sharma Department of Biotechnology Indian Institute of Technology, Roorkee Module - 3 Chromatographic Method Lecture - 1 Introduction and Basic

More information

SPE Columns. Solid Phase Extraction. SPE Columns

SPE Columns. Solid Phase Extraction. SPE Columns SPE Columns Solid Phase Extraction Solid-phase extraction (SPE) is a separation process by which compounds that are dissolved or suspended in a liquid mixture are separated from other compounds in the

More information

Experiment 1: Thin Layer Chromatography

Experiment 1: Thin Layer Chromatography Experiment 1: Thin Layer Chromatography Part A: understanding R f values Part B: R f values & solvent polarity Part C: R f values & compound functionality Part D: identification of commercial food dye

More information

January 19, 2012, Workshop on Chemical Data Reporting (CDR) Rule Case Studies for Byproduct/Recycling Reporting

January 19, 2012, Workshop on Chemical Data Reporting (CDR) Rule Case Studies for Byproduct/Recycling Reporting January 19, 2012, Workshop on Chemical Data Reporting (CDR) Rule Case Studies for Byproduct/Recycling Reporting Scenario 1 In its operations, ABC Company uses an etchant to strip copper off of a substrate.

More information

SEPARATION TECHNIQUES

SEPARATION TECHNIQUES SEPARATION TECHNIQUES If a substance does not dissolve in a solvent, we say that it is insoluble. For example, sand does not dissolve in water it is insoluble. Filtration is a method for separating an

More information

Chromatography What is it?

Chromatography What is it? Chromatography Most things that are colored are mixtures of different substances of various colors. In a mixture you have several different kinds of chemicals that are all next to each other but not reacting.

More information

Water and the Fitness of the Environment

Water and the Fitness of the Environment Water and the Fitness of the Environment A water molecule can form hydrogen bond with 4 neighbor molecules of water: -polar molecule -cohesive molecule -high surface tension -good solvent -high specific

More information

ERT320 BIOSEPARATION ENGINEERING CHROMATOGRAPHY

ERT320 BIOSEPARATION ENGINEERING CHROMATOGRAPHY ERT320 BIOSEPARATION ENGINEERING CHROMATOGRAPHY CHROMATOGRAPHY Week 9-10 Reading Assignment: Chapter 7. Bioseparations Science & Engineering, Harrison, R; Todd, P; Rudge, S.C and Petrides, D,P CHROMATOGRAPHY

More information

DATES: LAB: Liquid Chromatography Separation of Grape Kool-Aid

DATES: LAB: Liquid Chromatography Separation of Grape Kool-Aid NAME: AP CHEMISTRY DATES: LAB: Liquid Chromatography Separation of Grape Kool-Aid PURPOSE There are a number of analytical techniques used to separate components of a mixture, or solution. They include

More information

Food & Beverage by Eppendorf

Food & Beverage by Eppendorf Food & Beverage by Eppendorf November 27th, 2014 > Eppendorf A summary > Food & Beverage by Eppendorf > Importance of consumables in food analysis > Advantages of automation in food analysis Eppendorf

More information

Chemistry review. Energy levels: The six most abundant elements of life. Types of bonds. Atom:

Chemistry review. Energy levels: The six most abundant elements of life. Types of bonds. Atom: Atom: Chemistry review Energy levels: Energy Levels: move around the nucleus in regions. Different levels have different numbers of electrons. Outermost Energy Level: Atoms are most when they have a outermost

More information

CONTROLLED PRECIPITATION OF ACTIVE PHARMACEUTICAL INGREDIENTS EMPLOYING SUPERCRITICAL FLUIDS: SCALE-UP CONSIDERATIONS

CONTROLLED PRECIPITATION OF ACTIVE PHARMACEUTICAL INGREDIENTS EMPLOYING SUPERCRITICAL FLUIDS: SCALE-UP CONSIDERATIONS CONTROLLED PRECIPITATION OF ACTIVE PHARMACEUTICAL INGREDIENTS EMPLOYING SUPERCRITICAL FLUIDS: SCALE-UP CONSIDERATIONS Albertina Ariën 1 *, Marcus E. Brewster 1, Bruno De Witte 2 1 Johnson & Johnson Pharmaceutical

More information

Separation of Acidic, Basic and Neutral Compounds

Separation of Acidic, Basic and Neutral Compounds Separation of Acidic, Basic and Neutral Compounds Contents Objectives Introduction Background Experimental section H NM Spectra Manuscript prepared by Dr. Almas I. Zayya, Dr. A. Jonathan Singh and Dr.

More information

Coagulant Overview. Tom Coughlin Chemtrade 2015

Coagulant Overview. Tom Coughlin Chemtrade 2015 Coagulant Overview Tom Coughlin Chemtrade 2015 Outline Coagulation Overview Purpose of Coagulation Coagulant types and characteristics Coagulant Options Understanding the role of Coagulation Optimizing

More information

Option D: Medicinal Chemistry

Option D: Medicinal Chemistry Option D: Medicinal Chemistry When synthesizing drugs, they end up as a mixture of many different solvents and need to be separated physical properties will help solubility difference volatility difference

More information

EVOLUTE WCX Columns for Solid Phase Extraction of Quaternary Amines and Strongly Basic Compounds from Aqueous Samples

EVOLUTE WCX Columns for Solid Phase Extraction of Quaternary Amines and Strongly Basic Compounds from Aqueous Samples TN143 EVOLUTE WCX Columns for Solid Phase Extraction of Quaternary Amines and Strongly Basic Compounds from Aqueous Samples This Chemistry Data Sheet provides guidelines for the extraction of quaternary

More information

States of matter. Particles in a gas are widely spread out and can both vibrate and move around freely. They have the most energy of the three states.

States of matter. Particles in a gas are widely spread out and can both vibrate and move around freely. They have the most energy of the three states. States of matter Particles in a solid are closely packed and can vibrate but cannot move around, they have low energies. Particles in a liquid are still closely packed, but can both vibrate and move around

More information

ADSORPTION. Briefly, adsorption is the surface accumulation of material.

ADSORPTION. Briefly, adsorption is the surface accumulation of material. ADSORPTION Briefly, adsorption is the surface accumulation of material. Adsorption is a unit operation in which dissolved constituents are removed from the solvent (water) by transfer to the surfaces of

More information

Chapter 11 Properties of Solutions

Chapter 11 Properties of Solutions Chapter 11 Properties of Solutions Solutions Homogeneous mixtures of two or more substances Composition is uniform throughout the sample No chemical reaction between the components of the mixture Solvents

More information

LATEST TECHNOLOGY IN Safe handling & Recovery OF Solvents in Pharma Industry

LATEST TECHNOLOGY IN Safe handling & Recovery OF Solvents in Pharma Industry LATEST TECHNOLOGY IN Safe handling & Recovery OF Solvents in Pharma Industry TYPICAL SOLVENT USE IN Pharma Industry Usage of solvents in an API process development is for: Diluent to carry out reaction

More information

Principles of Gas- Chromatography (GC)

Principles of Gas- Chromatography (GC) Principles of Gas- Chromatography (GC) Mohammed N. Sabir January 2017 10-Jan-17 1 GC is a chromatographic technique utilizes gas as the mobile phase which is usually an inert gas (Hydrogen, Helium, Nitrogen

More information

Sample Preparation TLC Plates

Sample Preparation TLC Plates TLC PLATES TLC Plates Economical separation method High sample throughput Pilot procedure for HPLC and flash chromatography Versatile range of ready-to-use layers Thin layer chromatography (TLC) is a simple,

More information

LIFE-EDESIA project: overview and Actions B3, B5. Ferdinando Fiorino Francesco Frecentese

LIFE-EDESIA project: overview and Actions B3, B5. Ferdinando Fiorino Francesco Frecentese LIFE-EDESIA project: overview and Actions B3, B5 Ferdinando Fiorino Francesco Frecentese Università degli Studi di Napoli Federico II (UniNA) Department of Pharmacy Unit of Medicinal Chemistry Lab Profile

More information

Product Guide HIGH SILICA ZEOLITE

Product Guide HIGH SILICA ZEOLITE Product Guide HIGH SILICA ZEOLITE OUR HISTORY Union Showa K.K. was founded as a joint venture between Showa Denko K.K. and Union Carbide in 1970. Union Showa K.K. built a new plant in Yokkaichi in Mie

More information

Chapter 2 The Chemistry of Life

Chapter 2 The Chemistry of Life Chapter 2 The Chemistry of Life I. Water Liquid Naturally occurring It expands liquid to solid Covers more than 75% of our surface Most abundant in living organisms most important inorganic compound for

More information

Crystallization Analysis Quality of Water from Water Purification Units Evaluation

Crystallization Analysis Quality of Water from Water Purification Units Evaluation Hagalis AG Kristallanalysen - Qualitätsprüfung Qualitätsberatung - Medizinische Diagnosen Eulogiusstr. 8 88634 Herdwangen-Schönach Hagalis AG * Eulogiusstr. 8 * 88634 ARLIS HISPANIA S.L c/ La Asomada 46

More information

Chromatography. Intro basic terminology types Partition and Adsorption C Ion-Exchange C Gel Filtration (aka Exclusion or Molecular Sieve) C Affinity C

Chromatography. Intro basic terminology types Partition and Adsorption C Ion-Exchange C Gel Filtration (aka Exclusion or Molecular Sieve) C Affinity C Chromatography Intro basic terminology types Partition and Adsorption C Ion-Exchange C Gel Filtration (aka Exclusion or Molecular Sieve) C Affinity C Extremely varied and widely used methodology for separation

More information

ACTIVATED BLEACHING CLAY FOR THE FUTURE. AndrevJ Torok ThomaE D Thomp~on Georgia Kaolin Company Elizabeth, New JerEey

ACTIVATED BLEACHING CLAY FOR THE FUTURE. AndrevJ Torok ThomaE D Thomp~on Georgia Kaolin Company Elizabeth, New JerEey PREPRINT NUMBER 71-H-22 ACTIVATED BLEACHING CLAY FOR THE FUTURE AndrevJ Torok ThomaE D Thomp~on Georgia Kaolin Company Elizabeth, New JerEey ThiE paper is to be preeented at the AIME CENTENNIAL ANNUAL

More information

Lect. 2: Chemical Water Quality

Lect. 2: Chemical Water Quality The Islamic University of Gaza Faculty of Engineering Civil Engineering Department M.Sc. Water Resources Water Quality Management (ENGC 6304) Lect. 2: Chemical Water Quality ١ Chemical water quality parameters

More information

WATER, ACIDS, BASES, BUFFERS

WATER, ACIDS, BASES, BUFFERS AP BIOLOGY BIOCHEMISTRY Unit 2 Part 3 ACTIVITY #2 (Chapter 3) NAME DATE PERIOD WATER, ACIDS, BASES, BUFFERS STRUCTURE AND GEOMETRY OF WATER: W Unit 2 Part 3 Biochemistry Activity #2 page 1 of 9 PROPERTIES

More information

SORPTION PROCESS USING POLYAMIDE NANOFIBRES TO REMOVE DYE FROM SIMULATED WASTEWATER. Jakub WIENER, Sihle NTAKA, P. S. NGCOBO, Roman KNÍŽEK

SORPTION PROCESS USING POLYAMIDE NANOFIBRES TO REMOVE DYE FROM SIMULATED WASTEWATER. Jakub WIENER, Sihle NTAKA, P. S. NGCOBO, Roman KNÍŽEK SORPTION PROCESS USING POLYAMIDE NANOFIBRES TO REMOVE DYE FROM SIMULATED WASTEWATER Jakub WIENER, Sihle NTAKA, P. S. NGCOBO, Roman KNÍŽEK Technical University of Liberec, Studentská 2, 461 17 Liberec,

More information

Life s Chemical Basis. Chapter 2

Life s Chemical Basis. Chapter 2 Life s Chemical Basis Chapter 2 Why are we studying chemistry? Chemistry is the foundation of biology Atoms Determine the behavior of elements make up all living things Building blocks of all substances

More information

Experiment Nine Thin Layer Chromatography

Experiment Nine Thin Layer Chromatography Name: Lab Section: 09 Thin Layer Chromatography Experiment Nine Thin Layer Chromatography Introduction Objective Separation of compounds from a mixture is an incredibly important aspect of experimental

More information

Adsorption of Humic acid on Powdered Activated Carbon (PAC)

Adsorption of Humic acid on Powdered Activated Carbon (PAC) Adsorption of Humic acid on Powdered Activated Carbon (PAC) Department of Civil and Environmental Engineering, MSU, East Lansing, MI, 48824, USA Abstract Removal capacity and rate of Humic Acid (HA) onto

More information

SEPARATION BY BARRIER

SEPARATION BY BARRIER SEPARATION BY BARRIER SEPARATION BY BARRIER Phase 1 Feed Barrier Phase 2 Separation by barrier uses a barrier which restricts and/or enhances the movement of certain chemical species with respect to other

More information

Molecularly imprinted polymers

Molecularly imprinted polymers Molecularly imprinted polymers Presentation in Sensors, Arrays, Screening Lennart Niehues, Jan Philip Meyer 1 Overview Introduction Advantages Disadvantages Theory of MIP Requirements for the optimal MIP

More information

What Do You Think? Investigate GOALS. Part A: Precipitation of Calcium

What Do You Think? Investigate GOALS. Part A: Precipitation of Calcium H 2 Woes Activity 6 Water Softening GOALS In this activity you will: Investigate the equilibria behind water softening. Determine which reduces water hardness more, precipitation reactions or ion-exchange

More information

Separation and recovery of mangenese- and cobalt catalysts from wastewater of PTA unit

Separation and recovery of mangenese- and cobalt catalysts from wastewater of PTA unit Trade Science Inc. December 2009 CTAIJ 4(2) 2009 [37-41] from wastewater of PTA unit S.A.A.Sajadi Institute of Water & Energy, Sharif University of Technology, Tehran P.O.Box 11155-8639, (IRAN) E-mail

More information

Finex. Tailor-Made Ion Exchange Resins for Water Treatment Tiia Aromaa, 2012

Finex. Tailor-Made Ion Exchange Resins for Water Treatment Tiia Aromaa, 2012 Finex Tailor-Made Ion Exchange Resins for Water Treatment Tiia Aromaa, tiia.aromaa@finex.fi 2012 Finex in a nutshell Location: History: Kotka, Finland - Resin production at current location in Kotka was

More information

CEE 371 Water and Wastewater Systems

CEE 371 Water and Wastewater Systems Updated: 22 November 2009 CEE 371 Water and Wastewater Systems Print version Lecture #23 Drinking Water Treatment: Ion Exchange, Adsorption & Arsenic Reading: Chapter 7, pp.262-266 David Reckhow CEE 371

More information

1. Ion exchange chromatography

1. Ion exchange chromatography 1. Ion exchange chromatography Ion Exchange Chromatography Most popular method for the separation or purification of charged molecules. In cation exchange chromatography, positively charged molecules are

More information

Chapter 2 Matter and Change p. 38

Chapter 2 Matter and Change p. 38 Chapter 2 Matter and Change p. 38 Describing Matter Properties: 1) Extensive depends on amt of matter in sample - ex s. mass, volume, calories, magnetism 2) Intensive depends on type of matter, not amt.

More information

Isolation & Purification of Proteoglycans (PGs) and Glycosaminoglycans (GAGs) PEG Trainee Lecture July 23, 2012

Isolation & Purification of Proteoglycans (PGs) and Glycosaminoglycans (GAGs) PEG Trainee Lecture July 23, 2012 Isolation & Purification of Proteoglycans (PGs) and Glycosaminoglycans (GAGs) PEG Trainee Lecture July 23, 2012 Most Common Extraction Procedure for PGs 4 M Guanidine-HCl Detergents such as 2% CHAPS or

More information