Kurt Breitenkamp, Ph.D.

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1 Senior Managing Scientist Polymer Science & Materials Chemistry 149 Commonwealth Drive Menlo Park, CA (650) tel Professional Profile Trained as a polymer scientist and organic chemist, Dr. Breitenkamp provides a wide range of chemistry, polymer science, and surface science expertise applicable to medical devices, consumer electronics, and intersecting products including wearable electronics, point of care diagnostics, and other integrated devices. His extensive polymer chemistry and polymer materials characterization knowledge has supported product development at all stages including design, materials selection, and performance validation. Using a variety of analytical chemistry techniques, he also specializes in the compositional identification of contaminants, having specific experience with extractable and leachable compounds to assess polymer biocompatibility. Dr. Breitenkamp also has hands-on experience preparing and testing materials for biological applications including: biocompatible and biodegradable polymers, polymer therapeutic and diagnostic agents, polymer nanoparticles, bioconjugation, tissue engineering, hydrogels, 3D bioprinting, and in vitro and in vivo testing of polymer materials. In the area of environmental technology, he has experience preparing and modifying polymer membranes for water purification, conductive polymers, and organic photovoltaic device fabrication. He also has extensive coatings formulation and testing experience including emulsion polymer synthesis, latex film formation, and anti-fouling coatings. Prior to joining Exponent, Dr. Breitenkamp co-founded and served as Chief Technology Officer of Intezyne Technologies, a biotechnology company focused on the development of advanced, polymer nanoparticles for targeted drug delivery. As Intezyne's CTO, Dr. Breitenkamp invented novel synthetic strategies to produce functional poly(ethylene glycol) (PEG) and amphiphilic block copolymers. He also led four preclinical development programs including polymer micelle-encapsulated iron oxide nanoparticles (MRI contrast agent), small molecule drugs (targeted chemotherapy), amyloid-beta peptides (Alzheimer's vaccine), and DNA/RNA therapeutics (gene therapy). After his tenure at Intezyne, Dr. Breitenkamp joined The Scripps Research Institute where he initiated efforts to develop new classes of conductive polymers and hybrid polymer-virus nanoparticles. In his previous consulting practice, he gained practical product development experience working with clients in the medical device, drug delivery, and cleantech space. A prolific innovator, Dr. Breitenkamp is listed as an inventor on 21 patent families that include 26 issued US patents. Academic Credentials & Professional Honors Ph.D., Polymer Science and Engineering, University of Massachusetts, Amherst, 2009 M.S., Polymer Science and Engineering, University of Massachusetts, Amherst, 2002 B.S., Polymer Science, University of Southern Mississippi, /17 Page 1

2 Arthur K. Doolittle Award from the Polymer Materials Science and Engineering (PMSE) Division of the American Chemical Society, 2006 Professional Affiliations Startup Leadership Program: Global Chief Operating Officer, Program (2012-present) San Diego Chapter - Founding Fellow (2011), Co-program leader (2012) American Chemical Society Polymer Chemistry Division Polymer Materials Science and Engineering Division Patents U.S. Patent Application Number : Immunotherapy for Treatment of Amyloid-related Disorders Using Encapulated Beta-Amyloid Peptides (Cao, C, Lin, X, Breitenkamp K, Skaff, H, Sill K). U.S. Patent Number 8,299,663: Compositions Comprising Polymeric Micelles for Drug Delivery (Sill K, Skaff H, Breitenkamp K, Breitenkamp R). U.S. Patent Application Number , PCT Patent Application Number PCT/US2009/042283: Synthesis of Hybrid Block Copolymers from Difluoroacetate Salts (Breitenkamp K, Sill K). U.S. Patent Number 8,980,326, 7,799,339, PCT Patent Application Number PCT/US2008/062033: Hybrid Block Copolymer Micelles with Mixed Stereochemistry for Encapsulation of Hydrophobic Agents (Sill K, Skaff H, Breitenkamp K). U.S. Patent Application Number , PCT Patent Application Number PCT/US2008/062113: Modification of Biological Targeting Groups for the Treatment of Cancer (Breitenkamp K, Rios-Doria J, Breitenkamp R, Sill K, Skaff H). U.S. Patent Number 8,263,663: Azide Functionalized Peptide Targeting Groups (Sill K, Skaff H, Breitenkamp K, Breitenkamp R). U.S. Patent Number 8,258,190, PCT Patent Application Number PCT/US2008/062038: Encapsulated Contrast Agents (Skaff H, Sill K, Breitenkamp K). U.S. Patent Number 7,618,944: PCT Patent Application Number PCT/US2008/055557: Encapsulated Beta-amyloid Peptides (Breitenkamp K, Sill K, Skaff H, Breitenkamp R). U.S. Patent Number 8,066,824, PCT Patent Application Number PCT/US2007/073020: Covalent Modification of Metal Surfaces (Breitenkamp K, Breitenkamp R, Sill K, Skaff H). U.S. Patent Application Number , PCT Patent Application Number PCT/US2011/021411: Plasma Modification of Metal Surfaces (Sill K, Skaff H, Breitenkamp K). U.S. Patent Number 8,212,083, PCT Patent Application Number PCT/US2007/010358: Heterofunctional Poly(ethylene glycol) Containing Acid-Labile Amino Protecting Groups and Uses Thereof (Breitenkamp K, Sill K, Skaff H). U.S. Patent Numbers 8,609,857, 8,207,353, 7,893,277, 7,560,588, PCT Patent Application Number 08/17 Page 2

3 PCT/US2007/010462: Poly(ethylene glycol) Containing Chemically Disparate End Groups (Breitenkamp K, Sill K, Skaff H). U.S. Patent Numbers 8,779,008, 8,426,477, 8,263,665, 7,638,558, PCT Patent Application Number PCT/US2006/012382: Polymeric Micelles for Drug Delivery (Breitenkamp K, Sill K, Skaff H, Breitenkamp R). U.S. Patent Application Numbers , , PCT Patent Application Number PCT/US2006/004160: Synthesis of Homopolymers and Block Copolymers (Breitenkamp K, Sill K). U.S. Patent Numbers 8,268,936, 7,601,796, PCT Patent Application Number PCT/US2006/000144: Synthesis of Hybrid Block Copolymers and Uses Thereof (Breitenkamp K, Sill K). U.S. Patent Number 7,612,153, PCT Patent Application Number PCT/US2005/038187: Heterobifunctional Poly(ethylene glycol) and Uses Thereof (Breitenkamp K, Sill K, Skaff H). U.S. Patent Number 7,897,797: Cyclooctene Monomers (Emrick TS, Breitenkamp K). U.S. Patent Number 8,163,814: Process of forming crosslinked copolymer film, crosslinked copolymer film formed thereby, and water purification membrane (Emrick TS, Breitenkamp K, Revanur R, Freeman BD, McCloskey B). U.S. Patent Number 7,750,103: Cyclooctene Monomers and Polymers, Water Purification Articles, Methods Utilizing Substituted Cyclooctene Polymers, Crosslinked Copolymer and its Preparation (Emrick TS, Breitenkamp K, Revanur R, Freeman BD, McCloskey B). U.S. Patent Number 7,332,609, PCT Patent Application Number PCT/US2005/037972: Polyethylene Glycol-substituted Pyridine Ligands and Related Water-Soluble Catalysts (Emrick TS, Breitenkamp K). U.S. Patent Numbers 7,989,544, 7,851,543, 7,598,313, PCT Patent Application Number PCT/US2004/028668: Amphiphilic Polymer Capsules and Interfacial Assembly of Capsules (Emrick TS, Breitenkamp K). Publications Hovlid ML, Lau JL, Breitenkamp K, Higginson CJ, Laufer B, Manchester, M, Finn MG. Encapsidated atom-transfer radical polymerization in Qβ virus-like nanoparticles. ACS Nano 2014; 8: Kislukhin AA, Hong VP, Breitenkamp K, Finn MG. Relative performance of alkynes in copper-catalyzed azide-alkyne cycloaddition. Bioconjugate Chemistry 2013; 24: Wen A, Ryan M, Yang A, Breitenkamp K, Pokorski J, Steinmetz N. Photodynamic activity of viral nanoparticles conjugated with C60. Chemical Communications 2012; 48: Cui X, Breitenkamp K, Lotz M, D'Lima D. Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances bioprinted human neocartilage formation. Biotechnology and Bioengineering 2012; 109: Cui X, Breitenkamp K, Finn MG, Lotz M, D'Lima D. Direct human cartilage repair using 3D bioprinting technology. Tissue Engineering Part A 2012; 18: Schwartz E, Breitenkamp K, Fokin VV. Synthesis and postpolymerization functionalization of poly(5-iodo- 1,2,3-triazole)s. Macromolecules 2011; 44: Pokorski J, Breitenkamp K, Liepold LO, Qazi S, Finn MG. Functional virus-based polymer-protein 08/17 Page 3

4 nanoparticles by atom transfer radical polymerization. Journal of the American Chemical Society 2011; 133: Steinmetz NF, Hong V, Spoerke ED, Lu P, Breitenkamp K, Finn MG, Manchester M. Buckyballs meet viral nanoparticles: Candidates for biomedicine. Journal of the American Chemical Society 2009; 131: Kratz K, Breitenkamp K, Hule R, Pochan D, Emrick T. PC-polyolefins: Synthesis and assembly behavior in water. Macromolecules 2009; 42: Mark PR, Murthy NS, Weigand S, Breitenkamp K, Kade M, Emrick T. Microphase separated structures in the solid and molten states of double-crystal graft copolymers of polyethylene and poly(ethylene oxide). Polymer 2008; 49: Breitenkamp RB, Ou Z, Breitenkamp K, Muthukumar M, Emrick T. Synthesis and characterization of polyolefin-graft-oligopeptide polyelectrolytes. Macromolecules 2007; 40: Revanur R, McCloskey B, Breitenkamp K, Freeman BD, Emrick T. Reactive amphiphilic graft copolymer coatings applied to poly(vinylidene fluoride) ultrafiltration membranes. Macromolecules 2007; 40: Cardoen G, Breitenkamp K, Emrick T, Coughlin EB. Manifold assembly for the convenient polymerization of ethylene oxide and butadiene. Macromolecules 2006; 39: Breitenkamp K, Emrick T. An Amphiphilic ruthenium benzylidene metathesis catalyst with PEGsubstituted pyridine ligands. Journal of Polymer Science Part A 2005; 43: Skaff H, Lin Y, Tangirala R, Breitenkamp K, Böker A, Russell T, Emrick T. Crosslinked capsules of quantum dots by interfacial assembly and ligand crosslinking. Advanced Materials 2005; 17: Breitenkamp K, Emrick T. Novel polymer capsules from amphiphilic graft copolymers and crossmetathesis. Journal of the American Chemical Society 2003, 125: Breitenkamp K, Simeone J, Jin E, Emrick T. Ring-opening metathesis polymerization of poly(ethylene glycol)-substituted cyclooctene macromonomers. Macromolecules 2002; 35: Book Chapters Breitenkamp K, Junge D, Emrick T. Hollow microcapsules for drug delivery by self-assembly and crosslinking of amphiphilic graft copolymers. In: Polymeric Drug Delivery Volume I - Particulate Drug Carriers. Svenson S (ed), ACS Symposium Series, American Chemical Society, Washington, DC., Vol. 923, pp , Selected Conference Presentations Breitenkamp K. Wearable devices: a new challenge for polymers and adhesives. Oral presentation at the Adhesive and Sealant Council Spring Conference, Nashville, TN, April Breitenkamp K, Chen D, Russell TP, Finn MG. Click functionalization of poly(3-alkylthiophenes) for organic photovoltaic devices. Oral presentation at the American Chemical Society Spring Meeting, San Francisco, CA, Breitenkamp K, Accurso AA, Finn MG. CuI-catalyzed azide-alkyne click chemistry in materials synthesis: Preparation and functionalization of conductive and adhesive polymers. Poster presentation at the 2009 Gordon Conference on Polymers, Mount Holyoke College, MA, June /17 Page 4

5 Breitenkamp K, Emrick T. Polymer capsules prepared by photo-induced crosslinking of aryl azide functionalized amphiphilic graft copolymers at the oil-water interface. ACS Division of Polymeric Materials: Science and Engineering Preprints 2006; 94: Oral presentation at the American Chemical Society Spring Meeting, Atlanta, GA, Breitenkamp K, Parrish B, Breitenkamp R, Emrick T. Self-assembly and crosslinking of amphiphilic graft copolymers Hollow capsules for drug delivery. Poster presentation at the 2004 BEACON symposium on BIONanotechnology: The world of the small in medicine, Hartford, CT, October Breitenkamp K, DeLong C, Kade M, Emrick T. Polyolefin-graft-poly(ethylene glycol) copolymers as new materials for porous and non-porous membrane applications. Poster presentation at the North American Membrane Society (NAMS) Meeting, Honolulu, HI, June Breitenkamp K, Emrick T. Polyolefin-based biomaterials with controlled, pendent functionality including poly(ethylene glycol) and oligopeptides. Poster presentation at the 2003 Gordon Conference on Biomaterials: Biocompatibility/Tissue Engineering, Holderness School, NH, July Breitenkamp K, Junge D, Jin E, Emrick T. Synthesis and polymerization chemistry of PEG- and peptidefunctionalized cyclooctene for biomaterials applications. ACS Division of Polymer Chemistry Preprints 2003; 44: Oral presentation at the American Chemical Society Spring Meeting, New Orleans, LA, Breitenkamp K, Simeone J, Jin E, Emrick T. PEGylated poly(cyclooctene) and polyethylene. ACS Division of Polymer Chemistry Preprints 2002; 43: Poster presentation at the American Chemical Society Fall Meeting in Boston, MA, Peer Reviewer Journal of Polymer Chemistry - Part A 08/17 Page 5