Compact Hydrogen Peroxide Sensor for Sterilization Cycle Monitoring
|
|
- Candace McCarthy
- 5 years ago
- Views:
Transcription
1 Physical Sciences Inc. VG Compact Hydrogen Peroxide Sensor for Sterilization Cycle Monitoring January 26, 2015 Krishnan R. Parameswaran, Clinton J. Smith, Kristin L. Galbally-Kinney, William J. Kessler Acknowledgement of Support The project described was supported by Award Number 4R44EB from the National Institute of Biomedical Imaging and Bioengineering. The content is solely the responsibility of the author(s) and does not necessarily represent the official views of the National Institute of Biomedical Imaging and Bioengineering or the National Institutes of Health. 20 New England Business Center Andover, MA 01810
2 Outline VG Background & Motivation H 2 O 2 facilitates sterile processing in pharmaceutical manufacturing Difficult to measure extremely low (part-per billion) concentrations Solution: Photoacoustic Spectroscopy Less (cost, size) is More Sensor Development Results Summary
3 Sterile Processing in Barrier Isolators Pharmaceutical products manufactured in sterile (aseptic) conditions to prevent contamination and maintain quality VG Incomplete sterilization of manufacturing facilities causes pharmaceutical product recalls, leading to financial loss and compromised patient health
4 Vapor Phase Hydrogen Peroxide (VPHP) Sterilization Liquid hydrogen peroxide solution vaporized and sent into isolator to sterilize Sterilant must be removed to very low levels prior to pharmaceutical filling operations Low VPHP concentration measurement is difficult due to water vapor interference VG
5 Typical Sterilization Cycle (from Bioquell) VG
6 New Challenge: Lower VPHP Detection Limit VG New biologic drugs more sensitive to VPHP Must reduce concentration to 10 ppb before manufacturing Current state of the art not able to reach 10 ppb (0.01 ppm) detection limit Goal: Develop (robust) commercial sensor capable of measuring 10 ppb VPHP in presence of 10,000 ppm water vapor PSI Approach: Mid-Infrared Laser-Based Photoacoustic Spectroscopy (MIR PAS)
7 Spectroscopic Modeling VG Goal: Use spectroscopic modeling to determine system parameters suitable for detecting 10 ppb VPHP in 10,000 ppm water vapor HITRAN database used to calculate spectra Parameters / criteria: Laser wavelength Absorption line strength Non-overlapping spectral features Use CH 4 as calibration gas Identified conditions ideally suited to VPHP detection application
8 Quantum Cascade Laser to Probe VPHP Absorption Line VG Robust semiconductor laser Compact High power, hits target wavelength Room temperature operation Compatible with field-deployment/productization
9 VPHP Measurement Method: Photoacoustic Spectroscopy (PAS) As in optical spectroscopy, mid-infrared laser probes fundamental ro-vibrational absorption lines Produces strong absorption High sensitivity Absorbed light creates heat increases pressure Modulating laser beam creates acoustic wave detected by microphone Acoustic detection eliminates expensive optical mirrors and detector Low cost Compact size Long-term measurement stability VG
10 PAS Figures of Merit (to Maximize Sensitivity) PAS signal amplitude is quantity to maximize Microphone converts pressure signal (A n ) to voltage A C ( ) W α : gas absorption coefficient (cm 1 ) W L : light power n n n L PAS signal is linearly proportional to light power and cell constant (C n ) C n ( 1) LFnQ n V cell n Q : resonator quality factor, V : volume : adiabatic ratio F : scaling factor VG Best resonator shape is long and skinny (like a flute or clarinet!)
11 PAS Major Drawback VG Detection of 1 ppmv CH 4 corresponds to ~0.5 ppmv H 2 O 2 Isolate microphone from background noise Reduces trace sensitivity and drifts over time Very precise (small σ) when average signal (μ) is greater than σ e.g. Can measure 1 ppmv H 2 O 2 with <±10 ppbv precision When μ σ, background noise offset interferes Challenging to detect 10 ppbv H 2 O 2
12 Acoustic Modeling to Optimize Resonator Design Optimize cylindrical acoustic resonator design for trace-detection Measure longitudinal standing wave Increase photoacoustic signal Minimize background noise VG A. Miklo s, P. Hess, and Z. Bozo ki, Application of acoustic resonators in photoacoustic trace gas analysis and metrology, Rev. Sci. Instrum., vol. 72, no. 4, p. 1937, 2001.
13 Simulation Results: Resonator Properties vs. Length VG Intensity Map (A.U.) P= 1 atm R = 2.5 mm T = 45 C Cell constant increase is sub-linear Resonator transmission drops exponentially Leads to reduced background noise Q decreases because surface losses increasingly dominate
14 Noise Transmission vs. Buffer & Resonator Dimensions VG Choose buffer dimensions for minimal noise
15 Curves of Growth (CH 4 ) for Different Resonator Dimensions VG Experimental curves of growth validate theoretical model
16 Allan Deviation (CH 4 ) VG Implies ~3 ppb detection limit after 60 s averaging
17 COG and Experimental Detection Limit w/ Methane VG Microphone Noise: ~100 nv Hz 1/2 Lock-in: t=2 sec. f BW =0.08 Hz Lock-in output (with microphone noise) = 28.2 nv From slope of 7cm curve 1 [nv/ppbv] C [ppb] = 28.2 nv With 2 sec. time constant, microphone noise limited detection limit is: C = 28 ppbv 1 minute averaging brings it down to C 5ppbv Implies 2.5 ppbv H 2 O 2 LOD 30
18 VPHP Experimental Setup to Validate CH 4 Results VG Sigma-Aldrich H 2 O 2 and reagent grade H 2 O Cooled to <10 C to avoid condensation on tubing Flow at < 300 sccm to reduce noise from turbulence Drager in-line for near-simultaneous comparison
19 PAS Comparison to Commercial VPHP Sensor (Drager) PAS vs. Drager VG Compare Drager to Raoult s Law PAS Cell & Drager measurements agree within measurement range, precision of Drager
20 Optimized Resonator H 2 O 2 COG at 760 Torr Has Baseline VG Limit of Detection (LOD) is governed by ambient water vapor concentration For 10,000 ppmv H 2 O, LOD is 0.1 ppmv For 7,000 ppmv H 2 O, LOD is ~ 80 ppbv For dry air/n 2 only LOD would be (based on CH 4 results) 4.5 ppbv
21 Measured Absorption Spectra at Different Pressures Ambient Pressure Reduced Pressure VG Minimum noise with 10,000 ppmv of water present is ~7.3 mv Indicates the LOD is: V 2.2 ppmv 90 ppbv 0.17V Minimum noise with 10,000 ppmv of water present is ~0.5 mv Indicates the LOD is: V 1ppmv 32 ppbv 0.016V
22 PSI VPHP Sensor User Interface Details Fits in 19" rack drawer, including control electronics Touch screen user interface Swagelok gas connections Product release expected mid-2015 VG
23 Summary VG New biologic drugs more sensitive to VPHP than small molecules Must reduce concentration to as little as 10 ppbv before manufacturing Current state of the art spectrometers have ~ 0.1 ppmv detection limit Demonstrated photoacoustic VPHP detection in compact, low-cost platform High dynamic range (> 4 orders of magnitude) Detection limit of ~32 ppbv Easily calibrated with CH 4
24 Questions?
II. WAVELENGTH SELECTION
Ozone detection by DFB QCL absorption technique using Multipass cell S.S. Yenaganti 1, S.S.Kulkarni 2, A.J.Verma 3, N.Sreevalsen 4, V.Rathore 5 1 Department of Electronics and Telecommunications Engineering,
More informationOptical Gain and Multi-Quantum Excitation in Optically Pumped Alkali Atom Rare Gas Mixtures
Physical Sciences Inc. Optical Gain and Multi-Quantum Excitation in Optically Pumped Alkali Atom Rare Gas Mixtures Kristin L. Galbally-Kinney, Wilson T. Rawlins, and Steven J. Davis 20 New England Business
More informationCantilever enhanced tunable diode laser photoacoustic spectroscopy in gas purity measurement case study: acetylene in ethylene
Cantilever enhanced tunable diode laser photoacoustic spectroscopy in gas purity measurement case study: acetylene in ethylene Juho Uotila, Jussi Raittila, Ismo Kauppinen ¹Gasera Ltd., Tykistökatu 4, 20520
More informationPulsed Photoacoustic Spectroscopy of I 2 and NO 2
Int J Thermophys (2012) 33:2055 2061 DOI 10.1007/s10765-012-1323-9 Pulsed Photoacoustic Spectroscopy of I 2 and NO 2 Fahem Yehya Anil K. Chaudhary Received: 30 January 2012 / Accepted: 26 September 2012
More informationHigh Sensitivity Gas Sensor Based on IR Spectroscopy Technology and Application
PHOTONIC SENSORS / Vol. 6, No. 2, 2016: 127 131 High Sensitivity Gas Sensor Based on IR Spectroscopy Technology and Application Hengyi LI Department of Electronic Information Engineering, Jincheng College
More informationCompact and low-noise quartz-enhanced photoacoustic sensor for sub-ppm ethylene detection in atmosphere
Compact and low-noise quartz-enhanced photoacoustic sensor for sub-ppm ethylene detection in atmosphere P. Patimisco a,b A. Sampaolo a, M. Giglio a, F. Sgobba a, H. Rossmadl c, V. Mackowiak c, B. Gross
More informationSmall Signal Gain in DPAL Systems
Physical Sciences Inc. VG11-010 Small Signal Gain in DPAL Systems Kristin L. Galbally-Kinney, Daniel L. Maser, William J. Kessler, Wilson T. Rawlins, and Steven J. Davis 20 New England Business Center
More informationDetection of hydrogen peroxide based on long-path absorption spectroscopy using a CW EC-QCL
Invited Paper Detection of hydrogen peroxide based on long-path absorption spectroscopy using a CW EC-QCL 1 N.P.Sanchez, 2 Y.Yu, 2 L.Dong, 1 R.Griffin, 2 F.K.Tittel 1 Rice University, Civil and Environmental
More informationSpectroscopic Applications of Quantum Cascade Lasers
Spectroscopic Applications of Quantum Cascade Lasers F.K. Tittel, A. Kosterev, and R.F. Curl Rice University Houston, USA OUTLINE fkt@rice.edu http://www.ruf.rice.edu/~lasersci/ PQE 2000 Snowbird, UT Motivation
More informationPhysics of capnography
Strona 1 z 7 Physics of capnography Bhavani Shankar Kodali MD There are five Physical methods 1. Infra-red Spectrography 2. Molecular Correlation Spectrography 3. Raman Spectrography 4. Mass Spectrography
More informationMid-Infrared Laser based Trace Gas Sensor Technologies: Recent advances and Applications
Mid-Infrared Laser based Trace Gas Sensor Technologies: Recent advances and Applications Frank K. Tittel 1, Qixen He 1, Weilin Ye 1, Huadan Zheng 1, Marilena Giglio 1,2, Pietro Patimisco 2, Angelo Sampaolo
More informationIsotopic Ratio Measurements of Atmospheric Carbon Dioxide Using a 4.3 µm Pulsed QC Laser
Isotopic Ratio Measurements of Atmospheric Carbon Dioxide Using a 4.3 µm Pulsed QC Laser David D. Nelson, J. Barry McManus, Scott C. Herndon and Mark S. Zahniser Aerodyne Research, Inc., 45 Manning Road,
More informationStandoff Spectroscopy of Surface Adsorbed Chemicals
Article Subscriber access provided by OAK RIDGE NATIONAL LAB Standoff Spectroscopy of Surface Adsorbed Chemicals C. W. Van Neste, L. R. Senesac, and T. Thundat Anal. Chem., 2009, 81 (5), 1952-1956 DOI:
More informationWorkshop on optical gas sensing
Workshop on optical gas sensing 15.01.2015 1 Intensity (a.u.) The QCL frequency comb A laser emitting many wavelengths at the same time. Covering a broad spectral range of tens to a few 100 wavenumbers.
More informationFourier Transform Infrared. Spectrometry
Fourier Transform Infrared. Spectrometry Second Editio n PETER R. GRIFFITH S JAMES A. de HASETH PREFACE x v CHAPTER 1 INTRODUCTION TO VIBRATIONAL SPECTROSCOPY 1 1.1. Introduction 1 1.2. Molecular Vibrations
More informationApplication of Raman Spectroscopy for Noninvasive Detection of Target Compounds. Kyung-Min Lee
Application of Raman Spectroscopy for Noninvasive Detection of Target Compounds Kyung-Min Lee Office of the Texas State Chemist, Texas AgriLife Research January 24, 2012 OTSC Seminar OFFICE OF THE TEXAS
More informationFT-IR-iPAS A tool for industrial multicomponent gas measurement Christian Hirschmann 1,2 *, Jussi Tenhunnen 2, Satu Ojala 1,2 and Riitta Keiski 1
108 FT-IR-iPAS A tool for industrial multicomponent gas measurement Christian Hirschmann 1,2 *, Jussi Tenhunnen 2, Satu Ojala 1,2 and Riitta Keiski 1 1 University of Oulu, Mass and Heat Transfer Process
More informationDetection of trace contamination on metal surfaces using the handheld Agilent 4100 ExoScan FTIR
Detection of trace contamination on metal surfaces using the handheld Agilent 4100 ExoScan FTIR Ensuring ultimate cleanliness for maximum adhesion Application Note Author John Seelenbinder Agilent Technologies,
More informationProcess Analytical Technology Diagnosis, Optimization and Monitoring of Chemical Processes
FRAUNHOFER INSTITUTe FoR Chemical Technology ICT Process Analytical Technology Diagnosis, Optimization and Monitoring of Chemical Processes Process Analytical Technology Diagnosis, Optimization and Monitoring
More informationCommercialization of autonomous sensor systems for quantifying pco 2 and total inorganic carbon
Commercialization of autonomous sensor systems for quantifying pco 2 and total inorganic carbon PI: Michael DeGrandpre, PhD Dept. of Chemistry, University of Montana, Missoula, MT 59812 Phone: (406) 243-4227
More informationNear-Infrared Spectroscopy of Nitride Heterostructures EMILY FINAN ADVISOR: DR. OANA MALIS PURDUE UNIVERSITY REU PROGRAM AUGUST 2, 2012
Near-Infrared Spectroscopy of Nitride Heterostructures EMILY FINAN ADVISOR: DR. OANA MALIS PURDUE UNIVERSITY REU PROGRAM AUGUST 2, 2012 Introduction Experimental Condensed Matter Research Study of large
More informationSignal Processing Evaluated by Allan and Hadamard Variances
Signal Processing Evaluated by Allan and Hadamard Variances J. Skřínský, M. Skřínská, and Zdeněk Zelinger Abstract Laser spectrometry offers high sensitivity and broad dynamic range, permitting monitoring
More informationDetermination of Thermo Physical Parameters of C 60 Using Fourier Transform Infrared Photoacoustic Spectroscopy
Egypt. J. Solids, Vol. (7), No. (), (004) 51 Determination of Thermo Physical Parameters of C 60 Using Fourier Transform Infrared Photoacoustic Spectroscopy S. Abdallah Department of Physics and Mathematics,
More informationModulation cancellation method for laser spectroscopy
Invited Paper Modulation cancellation method for laser spectroscopy V. Spagnolo* a,b, L. Dong, a A. A. Kosterev, a D. Thomazy, a J. H. Doty III, a and F. K. Tittel a a Department of Electrical and Computer
More informationFundamentals of Particle Counting
Fundamentals of Particle Counting 1 Particle Counting: Remains the most significant technique for determining the cleanliness level of a fluid Useful as a tool for qualification and monitoring cleanroom
More informationReal-time ppb CO 2 Impurity Detection by an Advanced FTIR- UVF System
Real-time ppb CO 2 Impurity Detection by an Advanced FTIR- UVF System Presented at the BevTech Conference, Albuquerque, NM 2018 by Charles M. Phillips Ph.D., Max Analytical Technologies Mark Taylor, Vice
More informationOptical Properties of Thin Semiconductor Films
Optical Properties of Thin Semiconductor Films Grolik Benno,KoppJoachim October, 31st 2003 1 Introduction Optical experiments provide a good way of examining the properties of semiconductors. Particulary
More informationIn-Situ FTIR Spectroscopy and Metrology of a Tungsten CVD Process
In-Situ FTIR Spectroscopy and Metrology of a Tungsten CVD Process A. Singhal, L. Henn-Lecordier and J. N. Kidder Jr. University of Maryland, College Park, MD C.A. Gogol, J.F. Kushneir Inficon, Inc. East
More informationModeling the Response of Photoacoustic Gas Sensors
Excerpt from the Proceedings of the COMSOL Conference 29 Boston Modeling the Response of Photoacoustic Gas Sensors Samara L. Firebaugh* 1, Francois Roignant 2, and Eugene A. Terray 3 1 United States Naval
More informationREMOTE SENSING OF ATMOSPHERIC TRACE GASES BY OPTICAL CORRELATION SPECTROSCOPY AND LIDAR
REMOTE SENSING OF ATMOSPHERIC TRACE GASES BY OPTICAL CORRELATION SPECTROSCOPY AND LIDAR by Benjamin Thomas Grégory David, Christophe Anselmo, Alain Miffre, Jean-Pierre Cariou and Patrick Rairoux Institute
More informationFourier transform infrared spectroscopy (FTIR) is a method used to obtain an infrared
Fourier Transform Infrared Spectroscopy: Low Density Polyethylene, High Density Polyethylene, Polypropylene and Polystyrene Eman Mousa Alhajji North Carolina State University Department of Materials Science
More informationSpectroscopy tools for PAT applications in the Pharmaceutical Industry
Spectroscopy tools for PAT applications in the Pharmaceutical Industry Claude Didierjean Sr. Technology and Applications Consultant Real Time Analytics Mettler Toledo AutoChem, Inc. claude.didierjean@mt.com
More informationPramfina-J. Phys., Vol. 30, No. 2, February 1988, pp Printed in India.
Pramfina-J. Phys., Vol. 30, No. 2, February 1988, pp. 135-141. Printed in India. Photoacoustic spectra of some laser dyes R S RAM and OM PRAKASH Division of Standards, National Physical Laboratory, New
More informationState Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Laser Spectroscopy, Shanxi
Ppb-level H S detection for SF decomposition based on a fiber-amplified telecommunication diode laser and a background-gas-induced high-q photoacoustic cell Xukun Yin,, Lei Dong,,,a) Hongpeng Wu,, Weiguang
More informationDesign and Development of a Smartphone Based Visible Spectrophotometer for Analytical Applications
Design and Development of a Smartphone Based Visible Spectrophotometer for Analytical Applications Bedanta Kr. Deka, D. Thakuria, H. Bora and S. Banerjee # Department of Physicis, B. Borooah College, Ulubari,
More informationPutting Near-Infrared Spectroscopy (NIR) in the spotlight. 13. May 2006
Putting Near-Infrared Spectroscopy (NIR) in the spotlight 13. May 2006 0 Outline What is NIR good for? A bit of history and basic theory Applications in Pharmaceutical industry Development Quantitative
More informationREAL TIME MEASUREMENTS OF ACETYLENE IN ETHYLENE MANUFACTURING PROCESS. FIELD TRIALS OF THE TDLAS BASED ANALYZER
REAL TIME MEASUREMENTS OF ACETYLENE IN ETHYLENE MANUFACTURING PROCESS. FIELD TRIALS OF THE TDLAS BASED ANALYZER Airat Amerov, Mike Fuller John Orendorff, John Howse AMETEK Process Instruments, LyondellBasell
More informationChemistry 524--Final Exam--Keiderling May 4, :30 -?? pm SES
Chemistry 524--Final Exam--Keiderling May 4, 2011 3:30 -?? pm -- 4286 SES Please answer all questions in the answer book provided. Calculators, rulers, pens and pencils are permitted. No open books or
More informationChem Homework Set Answers
Chem 310 th 4 Homework Set Answers 1. Cyclohexanone has a strong infrared absorption peak at a wavelength of 5.86 µm. (a) Convert the wavelength to wavenumber.!6!1 8* = 1/8 = (1/5.86 µm)(1 µm/10 m)(1 m/100
More informationUV3000. Accurate, precise, and portable ambient gas point analyzer
UV3000 Accurate, precise, and portable ambient gas point analyzer The Cerex UV3000 is a multifunction analyzer designed to detect part per billion (ppb) to percent level concentrations of multiple gases
More informationStudent Projects for
MINERALS RESOURCES Student Projects for 2016-17 The CSIRO On-line Analysis (OLA) Group offers opportunities for students to undertake applied physics research projects at our Lucas Heights laboratories.
More informationLaser Excitation Dynamics of Argon Metastables Generated in Atmospheric Pressure Flows by Microwave Frequency Microplasma Arrays
Physical Sciences Inc. Laser Excitation Dynamics of Argon Metastables Generated in Atmospheric Pressure Flows by Microwave Frequency Microplasma Arrays W.T. Rawlins, K.L. Galbally-Kinney, S.J. Davis Physical
More informationImproved diode laser spectrometer for ortho/para ratio measurements in water vapor
Improved diode laser spectrometer for ortho/para ratio measurements in water vapor A.I. Nadezhdinskii, D.Yu.Namestnikov, K.P.Pavlova, Ya.Ya. Ponurovskii, D.B. Stavrovskii A. M. Prokhorov General Physics
More informationCharacterisation of vibrational modes of adsorbed species
17.7.5 Characterisation of vibrational modes of adsorbed species Infrared spectroscopy (IR) See Ch.10. Infrared vibrational spectra originate in transitions between discrete vibrational energy levels of
More informationSpectroscopy in Inorganic Chemistry. Vibration and Rotation Spectroscopy
Spectroscopy in Inorganic Chemistry Symmetry requirement for coupling combination bands and Fermi resonance 2 3 V 3 1505 cm -1 (R, IR) E' stretches v 1 888 cm -1 (R) A 1 ' stretch V 2 718 cm -1 (IR) A
More informationHefei
2017 3rd International Conference on Computer Science and Mechanical Automation (CSMA 2017) ISBN: 978-1-60595-506-3 Experimental Study of Broadening Coefficients for the v3 Band of CO by Tunable Diode
More informationNew Developments in Raman Spectroscopic Analysis
New Developments in Raman Spectroscopic Analysis Mike Kayat B&W Tek, Inc 19 Shea Way Newark, DE 19713 United States of America +1 302 368 7824 mikek@bwtek.com 1 Overview Raman spectroscopy is now an established
More informationModel Answer (Paper code: AR-7112) M. Sc. (Physics) IV Semester Paper I: Laser Physics and Spectroscopy
Model Answer (Paper code: AR-7112) M. Sc. (Physics) IV Semester Paper I: Laser Physics and Spectroscopy Section I Q1. Answer (i) (b) (ii) (d) (iii) (c) (iv) (c) (v) (a) (vi) (b) (vii) (b) (viii) (a) (ix)
More information6 Terahertz-Wave Propagation Model
6 Terahertz-Wave Propagation Model 6-1 Atmospheric Propagation Model of Terahertz-Wave Knowledge of atmospheric propagation property of terahertz-wave is very important for terahertz technology and its
More informationFrequency combs for ultrasensitive molecular detection
Frequency combs for ultrasensitive molecular detection Konstantin Vodopyanov CREOL Ind. Affil Symp., CREOL, March 13, 2015 Konstantin Vodopyanov p. 1 What are frequency combs? Theodor W. Hänsch and John
More informationMolExplorer: A New Tool for Computation and Display of Spectra from the HITRAN Database
MolExplorer: A New Tool for Computation and Display of Spectra from the HITRAN Database H. Harde a, J. Pfuhl a, M. Wolff b, H. Groninga b a Helmut Schmidt University Hamburg, b PAS-Tech, Germany I. Motivation
More informationSensor Control Unit Design for a Photoacoustic Indoor Multi-Gas Monitor
Sensor Control Unit Design for a Photoacoustic Indoor Multi-Gas Monitor Aimé Lay-Ekuakille 1, Giuseppe Vendramin 1, Amerigo Trotta 1 Dipartimento d Ingegneria dell Innovazione, University of Salento, Via
More informationFTIR Spectrometer. Basic Theory of Infrared Spectrometer. FTIR Spectrometer. FTIR Accessories
FTIR Spectrometer Basic Theory of Infrared Spectrometer FTIR Spectrometer FTIR Accessories What is Infrared? Infrared radiation lies between the visible and microwave portions of the electromagnetic spectrum.
More informationICP-3000 Inductively Coupled Plasma Optical Emission Spectrometer
Inductively Coupled Plasma Optical Emission Spectrometer Inductively Coupled Plasma Optical Emission Spectrometer Inductively Coupled Plasma Optical Emission Spectrometer is powerful simultaneous full
More informationEfficient Light Scattering in Mid-Infrared Detectors
Efficient Light Scattering in Mid-Infrared Detectors Arvind P. Ravikumar, Deborah Sivco, and Claire Gmachl Department of Electrical Engineering, Princeton University, Princeton NJ 8544 MIRTHE Summer Symposium
More informationGlossary. Analyte - the molecule of interest when performing a quantitative analysis.
Glossary This glossary contains definitions of many important FTIR terms. Many of the terms listed here appeared in italics in the body of the book. Words that appear in italics in the glossary are defined
More informationChemistry 524--Final Exam--Keiderling Dec. 12, pm SES
Chemistry 524--Final Exam--Keiderling Dec. 12, 2002 --4-8 pm -- 238 SES Please answer all questions in the answer book provided. Calculators, rulers, pens and pencils are permitted plus one 8.5 x 11 sheet
More informationRamanStation 400: a Versatile Platform for SERS Analysis
FIELD APPLICATION REPORT Raman Spectroscopy Author: Dean H. Brown PerkinElmer, Inc. Shelton, CT USA RamanStation 400 RamanStation 400: a Versatile Platform for SERS Analysis Introduction Surface Enhanced
More informationLow Temperature Physics Measurement Systems
PAGE 6 & 2008 2007 PRODUCT CATALOG Accelerate your Semiconductor Research & Developments towards Nanoscale Products. Experience your new working horse in the emerging field of semiconductor research for
More informationGas sensing in industry by tunable diode laser spectroscopy (TDLS) Maximilian Lackner
Maximilian Lackner Gas sensing in industry by tunable diode laser spectroscopy (TDLS) Review on state-of-the-art metrology for demanding species concentration, temperature and pressure measurement tasks
More informationInstrumentation and Operation
Instrumentation and Operation 1 STM Instrumentation COMPONENTS sharp metal tip scanning system and control electronics feedback electronics (keeps tunneling current constant) image processing system data
More informationExploring diffraction
Quantum Technology PROGRAMME TEACHER GUIDANCE Exploring diffraction 1 BACKGROUND In this activity we propose some useful ways to develop knowledge and understanding of the theory and practical applications
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 4,000 116,000 120M Open access books available International authors and editors Downloads Our
More informationABB temperature measurement Radiation thermometry. Measurement made easy. Process temperature measurement practice--non-contacting
Whitepaper_ WP_T_Non-Contacting_Temperature_Measurement ABB temperature measurement Radiation thermometry Measurement made easy Process temperature measurement practice--non-contacting By Gary Freeman,
More informationWhole Tablet Measurements Using the Frontier Tablet Autosampler System
a p p l i c a t i o n N O T E Whole Tablet Measurements Using the Frontier Tablet Autosampler System FT-NIR Spectroscopy Introduction Recent advances in NIR technology have changed the ways in which both
More informationUV Hound Series. Dependable High Quality Air Monitoring. Accurate Readings Within Seconds. Portable UVDOAS Multi-gas Analyzers. Multi-Gas Capability
UV Hound Series Portable UVDOAS Multi-gas Analyzers Multi-Gas Capability Dependable High Quality Air Monitoring Individual VOCs PPB Sensitivity Non-Contact Optical Measurement Automated Reporting Configurable
More informationatomic absorption spectroscopy general can be portable and used in-situ preserves sample simpler and less expensive
Chapter 9: End-of-Chapter Solutions 1. The following comparison provides general trends, but both atomic absorption spectroscopy (AAS) and atomic absorption spectroscopy (AES) will have analyte-specific
More informationIRSENS. Méthodes optiques pour l analyse des gaz et des liquides, e.g. détection de cocaïne dans la salive. Nano Tera.
IRSENS Méthodes optiques pour l analyse des gaz et des liquides, e.g. détection de cocaïne dans la salive J. Faist, P. Jouy ETH Zurich Nano Tera.ch Info Day 2014 Sensing needs Gases fluids Environment
More informationHo:YLF pumped HBr laser
Ho:YLF pumped HBr laser L R Botha, 1,2,* C Bollig, 1 M J D Esser, 1 R N Campbell 4, C Jacobs 1,3 and D R Preussler 1 1 National Laser Centre, CSIR, Pretoria, South Africa 2 Laser Research Institute, Department
More informationISA QATAR : 90 th Seminar
ANALYTICAL INSTRUMENTATION & MAINTENANCE SYSTEMS (AIMS) ISA QATAR : 90 th Seminar UTILIZATION OF LASERS IN THE FIELD OF GAS ANALYZERS Presenter: ZAHEER JUDDY Electromagnetic Spectrum Electromagnetic Spectrum
More informationPlasmonic sensing of heat transport and phase change near solid-liquid interfaces
Plasmonic sensing of heat transport and phase change near solid-liquid interfaces David G. Cahill and Jonglo Park Department of Materials Science and Engineering University of Illinois at Urbana-Champaign
More informationINTRODUCTION Atomic fluorescence spectroscopy ( AFS ) depends on the measurement of the emission ( fluorescence ) emitted from gasphase analyte atoms
INTRODUCTION Atomic fluorescence spectroscopy ( AFS ) depends on the measurement of the emission ( fluorescence ) emitted from gasphase analyte atoms that have been excited to higher energy levels by absorption
More informationWhite Paper. Overview: NDIR Definition:
Title: NDIR Technology Overview, Compliance, and Comparison to Other Generally Available Gas Measurement Technologies TSN Number: 06 File:\\MII- SRV1\Metron\Bridge_Analyzers\Customer_Service_Documentation\White_Papers\06
More informationComparison of HCD5000 DewPoint Duo to Condumax II
EXECUTIVE SUMMARY This document compares the technology and products of ZEGAZ Instruments (US) to that of Michell Instruments (UK) in the field of hydrocarbon and water dewpoint measurement. INTRODUCTION
More information2101 Atomic Spectroscopy
2101 Atomic Spectroscopy Atomic identification Atomic spectroscopy refers to the absorption and emission of ultraviolet to visible light by atoms and monoatomic ions. It is best used to analyze metals.
More informationChemistry Instrumental Analysis Lecture 15. Chem 4631
Chemistry 4631 Instrumental Analysis Lecture 15 IR Instruments Types of Instrumentation Dispersive Spectrophotometers (gratings) Fourier transform spectrometers (interferometer) Single beam Double beam
More informationVerification of Pharmaceutical Raw Materials Using the Spectrum Two N FT-NIR Spectrometer
APPLICATION NOTE FT-NIR Spectroscopy Authors: Ian Robertson Jerry Sellors PerkinElmer, Inc. Seer Green, UK Verification of Pharmaceutical Raw Materials Using the Spectrum Two N FT-NIR Spectrometer Introduction
More informationPAPER No. 12: ORGANIC SPECTROSCOPY MODULE No. 7: Instrumentation for IR spectroscopy
KNOW MORE Web links https://en.wikipedia.org/wiki/infrared_ http://hiq.lindegas.com/en/analytical_methods/infrared_/non_dispersive_infrared.html http://blamp.sites.truman.edu/files/2012/11/322-ir-and-ftir.pdf
More informationHigh Resolution Optical Spectroscopy
PHYS 3719 High Resolution Optical Spectroscopy Introduction This experiment will allow you to learn a specific optical technique with applications over a wide variety of phenomena. You will use a commercial
More informationBecause light behaves like a wave, we can describe it in one of two ways by its wavelength or by its frequency.
Light We can use different terms to describe light: Color Wavelength Frequency Light is composed of electromagnetic waves that travel through some medium. The properties of the medium determine how light
More informationHiden CATLAB Systems Microreactor for Catalysis Studies & Thermal Analysis
Hiden CATLAB Systems Microreactor for Catalysis Studies & Thermal Analysis vacuum analysis surface science gas analysis plasma diagnostics CATLAB overview The Hiden CATLAB is a catalyst characterisation
More information- IRspectrometer product performance presentation. You can find the press kit as well as high resolution images at
IRsweep AG Auguste-Piccard-Hof 1 IQE, HPT H 4.1 8093 Zürich www.irsweep.com Dr. Andreas Hugi +41 79 778 57 11 andreas.hugi@irsweep.com IRsweep AG, Auguste-Piccard-Hof 1, IQE HPT, CH-8093 Zürich Presse
More informationFourier Transform Infrared Spectrometry
Fourier Transform Infrared Spectrometry \ ' PETER R. GRIFFITHS Department of Chemistry University of California Riverside, California JAMES A. de HASETH Department of Chemistry University of Georgia Athens,
More informationDIODE- AND DIFFERENCE-FREQUENCY LASER STUDIES OF ATMOSPHERIC MOLECULES IN THE NEAR- AND MID-INFRARED: H2O, NH3, and NO2
DIODE- AND DIFFERENCE-FREQUENCY LASER STUDIES OF ATMOSPHERIC MOLECULES IN THE NEAR- AND MID-INFRARED: H2O, NH3, and NO2 Johannes ORPHAL, Pascale CHELIN, Nofal IBRAHIM, and Pierre-Marie FLAUD Laboratoire
More informationRecent Advances and Applications of Semiconductor Laser based Gas Sensor Technology
Recent Advances and Applications of Semiconductor Laser based Gas Sensor Technology F.K. Tittel, Yu. Bakhirkin, A.A. Kosterev M.McCurdy, S.G. So, G. Wysocki & R.F.Curl Rice Quantum Institute, Rice University,
More informationVibrational Spectroscopy of Molecules on Surfaces
Vibrational Spectroscopy of Molecules on Surfaces Edited by John T. Yates, Jr. University of Pittsburgh Pittsburgh, Pennsylvania and Theodore E. Madey National Bureau of Standards Gaithersburg, Maryland
More informationModeling of Trace Gas Sensors
Modeling of Trace Gas Sensors Susan E. Minkoff 1, Noémi Petra 2, John Zweck 1, Anatoliy Kosterev 3, and James Doty 3 1 Department of Mathematical Sciences, University of Texas at Dallas 2 Institute for
More informationAutomated determination of the uniformity of dosage in quinine sulfate tablets using a fiber optics autosampler
Automated determination of the uniformity of dosage in quinine sulfate tablets using a fiber optics autosampler Application Note Author John Sanders. Agilent Technologies, Inc. Mulgrave, Victoria 3170,
More informationThermo Scientific ICP-MS solutions for the semiconductor industry. Maximize wafer yields with ultralow elemental detection in chemicals and materials
Thermo Scientific ICP-MS solutions for the semiconductor industry Maximize wafer yields with ultralow elemental detection in chemicals and materials Trace impurity analysis in chemicals an used in the
More informationDetermination of Flame Dynamics for Unsteady Combustion Systems using Tunable Diode Laser Absorption Spectroscopy. Adam G.
Determination of Flame Dynamics for Unsteady Combustion Systems using Tunable Diode Laser Absorption Spectroscopy Adam G. Hendricks Thesis submitted to the Faculty of the Virginia Polytechnic Institute
More informationINTRODUCTION Strained Silicon Monochromator Magnesium Housing Windows for Monochromator Shutter and Collimator Fission Detector HOPG Monochromator
Design for a Four-Blade Neutron Interferometer INTRODUCTION Strained Silicon Monochromator The neutron beam used for this interferometer is separated from the NIST reactor's main beam using a strained
More informationImagent for fnirs and EROS measurements
TECHNICAL NOTE Imagent for fnirs and EROS measurements 1. Brain imaging using Infrared Photons Brain imaging techniques can be broadly classified in two groups. One group includes the techniques that have
More informationUltra-narrow-band tunable laserline notch filter
Appl Phys B (2009) 95: 597 601 DOI 10.1007/s00340-009-3447-6 Ultra-narrow-band tunable laserline notch filter C. Moser F. Havermeyer Received: 5 December 2008 / Revised version: 2 February 2009 / Published
More informationx Contents Segmented Mirror Telescopes Metal and Lightweight Mirrors Mirror Polishing
Contents 1 Fundamentals of Optical Telescopes... 1 1.1 A Brief History of Optical Telescopes.................... 1 1.2 General Astronomical Requirements..................... 6 1.2.1 Angular Resolution.............................
More informationTHIN FILM DEPOSITION PLASMA PROCESSING VACUUM INSTRUMENTATION JULY 2003
THIN FILM DEPOSITION PLASMA PROCESSING VACUUM INSTRUMENTATION JULY 2003 By monitoring gas species at various locations on a vacuum deposition system, it is possible to highlight process excursions and
More informationFrontiers in quantum cascade laser based analysis of greenhouse gas stable isotopes
Isotope - Ecology Course at the ETHZ 2018 Frontiers in quantum cascade laser based analysis of greenhouse gas stable isotopes Joachim Mohn joachim.mohn@empa.ch Air Pollution / Environmental Technology
More informationModern Techniques in Applied Molecular Spectroscopy
Modern Techniques in Applied Molecular Spectroscopy Edited by FRANCIS M. MIRABELLA Equistar Chemicals, LP A Wiley-Interscience Publication JOHN WILEY & SONS, INC. New York Chichester Weinheim Brisbane
More informationPortable Raman Spectroscopy for the Study of Polymorphs and Monitoring Polymorphic Transitions
Introduction Portable Raman Spectroscopy for the Study of Polymorphs and Monitoring Polymorphic Transitions Philip Zhou and Katherine A. Bakeev, B&W Tek, Inc., Newark, DE Materials can exist in different
More informationAtmospheric Analysis Gases. Sampling and analysis of gaseous compounds
Atmospheric Analysis Gases Sampling and analysis of gaseous compounds Introduction - External environment (ambient air) ; global warming, acid rain, introduction of pollutants, etc - Internal environment
More informationMeasurement Technique and its Application to Trace Components of Atmospheric Gas
F e a t u r e A r t i c l e Feature Article Measurement Technique and its Application to Trace Components of Atmospheric Gas Junji Kato From early on, HORIBA has been developing and adopting various measurement
More information