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1 ddddd(dddd) dddd ddddd: ddd ddddddd d1.2 d(ddd) ddddwww.lulu.com

2 ddddddd Five Willows Guy (2005) Follow Your Blessings (2005) Fragrant Orchids of Hidden Valley (2005) Bodhi Tree (2005) Bai Hua Ru Shi (with Nian Qing) (2005) Sunset Is Still Calling (2006) Mastering Software Project Management (2006) Life Stories (2007) Let New Voices Sing (2007) The Funny Side of Trouble (2008) The Many Colors of Poetry (2008) Life Stories (Chinese) (2008) dddddddddddddddd These books could be downloaded for free at 1

3 Dedication dddd ddddddddddd ddddd ddddddddddddd ddddd dddddddddddddd ddddddddddddd dddddddddddddd ddddddddddddddd 2

4 Figure 1: ddddddd 3

5 dd dd dd dd dd dd dd dddddddddd dd dd ddddddddddddd(ddd)dddddd ddddddd(ddd) ddddddddddd(d dd)dddddddddddddddddddd ddddddddddddd(ddd)dddddd dd dd dd dddd dd dd ddddddddddd 4

6 Contents 1 Plasticity Of The Brain Rewire the Brain through Brain Exercise. 7 2 Ways To Improve Brain Fitness and Prevent Alzheimer s Key Findings From Recent NIA Research Ten Steps To Improve Mind Function Nutrition for the Brain Ways To Exercise The Brain Survey of Tools to Exercise the Brain Other Ideas Warning Signals of Alzheimer s Disease Organization and Programs Symptoms Stage of Alzheimer s Some Tests Brain Aging - Process And Prevention Appendix - New Hopes For Alzheimer s Patients Genetic Factors for Alzheimer s Finding Beta-Amyloid Plaque In Brain An Immune Approach To Remove Beta- Amyloid Plaque In Brain

7 5.4 Other Approaches With Great Potential Study of Nasal Insulin to Fight Forgetfulness - SNIFF Anti-Inflammatory Drugs and AD Benefits of Combined Good Diet and Behavior Enrichment Interaction Between Beta- Amyloid and Tau Protein in Nerve Cells Building Cognitive Reserve Two Stories Woody s Story Dad s Story A Few Things About Dad in Naperville Dad s Last Few Years

8 Chapter 1 Plasticity Of The Brain ddddd dddddddddddddd(synapse), ddddd dddddddddddddddddd d d d d d 1 d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d d(hippocampus)ddddddddddddddd dd dd dddddddddddd 1.1 Rewire the Brain through Brain Exercise ddddd 2 dddddddddddddddd 1 Saving New Brain Cells, by Tracey J. Shors, Scientific American, March 2009, page d d d d d The Brain that Changes Itself, d d dnorman Doidge, M.D., Penguin Books (2007) 7

9 dddddddddddddd dddddd(michael Merzenich) ddddddd d dddddddddddddddddposit Science 3 dscientific Learning 4 ddddddddddddd ddddcochlear ddddddddddddddd dd ddcochlearddddddddddddddddd dd ddddddddd ddddddddddddd(brain map) ddd d dd dddddddddd(use it or lose it) dddddd d d ddddddddd( neurons that fire together wire together )ddddddddddddddddddd dd d dddddddddddddddddd(muddy in, muddy out)dddddddddddddddddd dd dd dd dd dddddddddddddddd1.8 ddddd ddddddddddddd( autism ) dddddd dd ddddddddddddddd

10 dd dd ddbdnf ddd(neurotrophic factor) dddddd dd dd dd dd dd dd d dd ddddddddddddposit Science ddddd d dd 9

11 Chapter 2 Ways To Improve Brain Fitness and Prevent Alzheimer s dddddddddd 2.1 Key Findings From Recent NIA Research d d d d d d d d d d d d d d d d d d d d d d d d d d d d d( d d d dd dd dd dd d d d d d d d d d d d d d d d d d d d d d d d d d d d d d dstatins d d d d d d d d d d d d d d d d d d d d d d d d d d d d d dhomocysteine d d d d d d d d d d d d d d d 10

12 dddddddddddfolic acid ddddb6db12 ddhomocysteine dddddddddddd d d d d d d d d d d d d d d d d d d d d dd ddddddddddddd dddddddddddd d dd dd dd dddddddddd ddddddddddddddddddd d d d d d d d d d d d d d d d d d d d d dd dddddddddddddddddddd d d d d d d d d d d d d d d d d d d d d ddddddddddd 1 d ddddddhomocysteine ddddd ddddd dddddd dddddddddddd 1 ddddddd Can Alzheimer s Disease be Prevented? dd 11

13 2.2 Ten Steps To Improve Mind Function ddddddd 2 dddddddddddddd dddd dd dddddddddd dd ddddddddddddddddd dd dd dddddddddd ddddddddd, dddddddddddd dd dddd(caffeine) dddddddd ddddddddddd dddddddddddddd dd dd 2 ddhttp:// dddleonard J. Hansen 12

14 ddddddddddddddddd dddddddddddddd dddddddddd 2.3 Nutrition for the Brain ddddddddddd 3 dddddddddd dd dddddddddddddddd dddd- ddddddddddddomega-3 d ddddddddddc de dddddddddd dddddd 1d d d d d d d d d d d d d d d d d d d(avocado)dddd(flax seed) dd 2d d d d d d d d d d d d d d d d d d d d d dd 3d d d d d d d d d d d d(complex carbohydrates)d d d d d d d d d d d d d dd 4ddddddddd(seaweed)ddd(blueberry)dd ddddddddd d d d d d d d d d d d d d d d d d d d d d(dddddc, de, folic acid d)ddddd 3 pillar 1.htm 13

15 coenzyme Q10 alpha lipoic acid ginkgo biloba ddddd phosphatidylserine DHA - omega-3 ddd acetl-l-carnitine 14

16 Chapter 3 Ways To Exercise The Brain dddddd 3.1 Survey of Tools to Exercise the Brain dddddddddd Brain Fitness positscience.com MindFit - mindfit.com Sudoku game - sudoku.com, websudoku.com Brain bashers - brainbashers.com 3.2 Other Ideas dddd 15

17 dd ddddddd(dr. Tamaino 1 ) dddd dddddddddddd ddddd- ddddddddddddddd dddddddddddddddd 1 See Measure of the Heart, by Mary Ellen Geist, page

18 Chapter 4 Warning Signals of Alzheimer s Disease dddddddd 4.1 Organization and Programs ddddddddd( - d d d d d d d d d d d d d d d( ) ddddddddd( 4.2 Symptoms ddddd( Alzheimer s Disease)ddddddd dd d d(stroke) dddddddddddddd 17

19 dd d d dd 1 dddddddddddddddddddd dd dddhttp:// dddd 1.ddddddddddddd dd dd,dddddddd,dddddddddddd d,dddddddd,dddddddd,ddddd dddddddddddddddddd,ddddd ddd 2.dddddddddddd ddddddddddd,dddddddddddd dd,dddddddddddddddddddd ddddddddddddddddd,dddddd dddddd,dddddddddddd 3.dddddddddd ddddddddddddddddd,dddddd dd ddddd,dddddddddddd,ddddd dddddd 4.dddddddddd dd dd ddddddddd,dddddddd,ddddd ddddddd 5.ddddd 1 ddddhttp:// 18

20 dd dd dddd,ddddddddddddddddddd dddddddd,ddddddddd 6.ddddddddd dddddddddddddd,ddddddddd ddd,ddddddddd,dddddddddd d d,ddddddddddd 7.dddddd ddddddddddddddddddd,dddd dd dddddddddd,dddddddddd,dd ddddddd 8.dddddddddd dd d d,ddddddddddddd,ddddd,ddd ddd 9. ddddddd,dddddddddddddddd dddddddddddddd,ddddddddd dddddddd 10.dddddddddddddddddddd ddddddddd,ddddddddddddd dddddddddddddd,ddddddddd dd 19

21 dddddddddd 2 ddddddddddd d dd dd dd dd dd 4.3 Stage of Alzheimer s dd dd 3 d dddddddd d d d d d d d d d d d d d d d d d d d d dd dddddddddddddddddddd ddddddddddddddddd dddddddd dddddddddddd dddddddddddddddd dddddddddddd 2 Preventing Alzheimer s by William R. Shankle, M.D., Daniel G. Amen, M.D., Perigee Books (2004) 3 ddddhttp:// 20

22 ddddddddddd dddddddddd dddddddddd dddddddddddddd ddddddddd75 ddd7 dd(68d61d d) ddddddd ddddddddd ddddddddddddddddddd dddddddddddd ddddddddddddddddddd ddddd ddddddddddddddd40 d4d20 d2d dddddddddddddddd ddddddddddddddd ddddddddddddddddd 21

23 dddddddddddddddddddd dd dddd ddddddd ddddddd- ddddddddd dddddddddddd dddddddddddd(dd)dddddd dd dddddddddddd d d d d d d d d d d d d d d d d d d d d dddddddddddd ddddddddddddd ddddddddddddddd dddddddddddddddddddd ddddddddddddddddddd 4.4 Some Tests ddddd 4 dddddddddddddddd dddddddddd 4 The Better Brain Book by David Perlmutter. M.D. and Carol Colman, Penguin Group (2004) 22

24 Lipid Peroxide dd- Lipid Peroxide ddddd ddddddddddddddddd(ddd dfree radical)dddddddddddddd ddddddc de dd Homocysteine dd- ddhomocysteine dddd ddddddddddbd ApoE4 dddd- dapoe4 ddddddddd dddddd C-Reactive ddddd- dddddddddd ddddddddddc-reactive dddd 4.5 Brain Aging - Process And Prevention dddddddddd 5 dddddddddddddddd d d d dfree radical - d d d d d d d(mitochondria) d d d d d d d d d d ddddc, E, domega-3 6 dd- dddddddddddddddddd dddddddd(aspirin) Unraveling/ htm 7 Preventing Alzheimer s by William R. Shankle, M.D., and Daniel G. Amen, M. D. 23

25 dddd- dddddddddddddddd dddd dddd- dddddddddddddddd 24

26 Chapter 5 Appendix - New Hopes For Alzheimer s Patients dd- ddddddddddd 2009 dhbo ddddddddd, dd dddd dd- ddddd 1 ddddddd, dddddd ddddddddddd. dddddddddd. 5.1 Genetic Factors for Alzheimer s dddddddd 1906 d d d d d d d d d d d d d d d d d d ddddddddddddd. dddddddd ddddddddddd, ddddd- ddddd d(beta-amyloid Plaque). dddddddddddd, dddddddddd, dddddd(neurofibrillary 1 The Alzheimer s Project - Momentum In Science, by John Hoffman and Susan Froemke with Susan K. Golant, by Home Box Office,

27 tangle) d d d d(tau tangle). d d d d d d(tau protein) d d d d d d d d d d d d d d d d- d d(microtubule) - ddddddd. ddddd, dd dddddd, dddddddddd. ddddddddddd. ddddddddd ddddd, ddddddddddd. ddddd dddddddddddddd. dddddddd dddd, ddddddd(early-onset) ddddd. ddddddd21 dddddddd(app - amyloid precursor protein) ddddd. ddddddddd dddddddddddd- ddddddd. ddd ddddd- ddddddddddddddddd dddddddd. dddd, ddddddddddddddddd dddd, dddddddddddd. dddddd ddddddddddddddddd. dddd19 ddapoe dd, ddddd, dapoe-4, ddddd. dd ddd. 5.2 Finding Beta-Amyloid Plaque In Brain dddddddd-dddddd dddddddddddddddd-dddd dd, ddd. dddddddpib ddddb dd d(pittsburgh Compound B) dddddddpet dd dddddddd(positron Emission Tomography), d ddddddddddddd-dddddd, ddd. 26

28 dddddddddddddddddddd, dd dddddddddddd. 5.3 An Immune Approach To Remove Beta-Amyloid Plaque In Brain ddddddddddd-dddddd 2008 d d d d d d d d d d d d d d d d d d d(clinical trails). dddddddd, ddddddd, dddd, dddd. ddddddd-ddddddd dddddddddddddd, dd, dddddd ddddd. ddddddddddddddddd d, dddddddddddd. dddd(dr. Schenk) dddddddddddddddd-ddddddd d. ddd. ddddddddddddd(ddddd) ddddddd. ddddddddd(372 dd), dd dddddddddd, dddddd. dddddd ddddddddddd, ddddddddd-dd ddddd(antibody) ddddd, dddddddd dddddddd. 5.4 Other Approaches With Great Potential ddddddddd 27

29 5.4.1 Study of Nasal Insulin to Fight Forgetfulness - SNIFF dddddddd ddddd(dr. Craft) dddddddddddd dddddddddddddd. dddddddd ddddddd, ddddddd(dddddddd), ddddddddddd-dddd, ddddddd. dddddddddddddd, dddddddd d(nebulizer) ddddddddddddddddd ddd. dddd, ddddddddddd Anti-Inflammatory Drugs and AD ddddddddddd d d d d d d d d d d d d d d d d d, dibuprofen dd. dddd, ddddddddddd dddddddddd. dddddd, ddddd, ddddd Benefits of Combined Good Diet and Behavior Enrichment ddddddddddddddd- ddddd ddd ( You can teach an old dog new tricks. ) dddd(dr. Cotman) dddddddd, ddd ddd, ddddd, ddddddddddddd de, C d, ddddddd, dddddddd, dd dddd, ddddddd. ddddddddddd ddd. ddddd, dddddd. dddd, ddd 28

30 ddddddd, ddddddddddddddd. dddd, ddddddddddddddddd Interaction Between Beta-Amyloid and Tau Protein in Nerve Cells dd- ddddddddddddddddd 2006 dddddddddd, dddd(dr. Mucke) dddd-dddddd, dddddddddddd dd, dd,d, dddddd, dddddddddd ddd. ddddddddddd-dddd, dddd ddd, ddddddddddd. dddddddd dddddddddd Building Cognitive Reserve dddddddd dddd(dr. Bennett) dddddddddddd d, ddddddddd. dddddddddddd d, dddddddd. dddddddddd, dd ddddddddddddddd, ddddddd dddddddd. dddddd, ddddddd, ddddddddddd, ddddddddd, dd d. ddddd, dddddd, dddddd. ddd dddddddddddddddddd, dddd d, ddd, dddd, dd, dddddddddd, d ddddddddd. 29

31 Chapter 6 Two Stories dddddd 6.1 Woody s Story ddddd 1 ddd(woody Geist) dddddddddddd d d(g. I. Bill) ddddddddddddddddd dddddd(detroit) E de dddddddddd dd dd ddwarren/conner dddddddddddddd dd dd dd ddd 1 dddd Measure of the Heart, by Mary Ellen Geist,Springboard Press, Mary dddddddddd 30

32 dddddddddd(rosemary) d1948 ddd dd dd ddddddddddddd(mary Ellen) dddd d d d dd d dd dd dd1950 ddddddddddddddddddd dd d dd d dd ddd1994 dddddddddddddddd d dd dd ddddddddddddddaricept dddddd dd dd dd dd ddddddddd dddddddddd(nursing home)ddddddd dd dd dd ddddddddddddd 31

33 dd dd dd dd dd dd dd dd dd dd dd d dd dd dd dd dddddddd(retreat)ddddddddddd d dd dd dd ddd dd dd d dd ddddddddd2005 ddddddddddd78 dd dd dd dd 32

34 dddddddddddd dddddddddd- ddddddddddddd dd dd dd(dr. Tomaino) ddddddddddddddd dd dd ddgrunyons ddddddddddddddddd dd dddddddddddddddddd2005 ddd dd dd dd dd dd dd dd d dd dd dd dd dd dd dd dd dd dd dddd 33

35 ddddddd2007 dddddddddddd dd dd dd d dd dd d dd dd dd dd dd dd d d dd d dd d dddddddddddddddddddd 6.2 Dad s Story ddddd A Few Things About Dad in Naperville dddnaperville ddd(ddddddddd) dddddddddddddnaperville dddd d 34

36 Figure 6.1: dddddddd 35

37 dd d(ddddddd)dddddddddddd. dd dddddddd dnaperville ddddddd dddd dddd dd d dd dd dd dd, dd dd ddddddddddd,ddddddddddd dnaperville, ddddddddddddddddd dd ddddddddddddd dd dd ddddddddddddddd,dddddddd dd dd dd dd dd dd dddddd, dddddd d ddddddddddddddd, dddddd 36

38 dddddddddd,ddddddddddddd d dd dd ddddddddd, ddddddddddddd ddddddddddd dd dd ddd dd dd d dddddd ddddddd ddddddd d dddddddddd dddddddddddd dddddddddd dddddddd? dnaperville dddddddddddddddd dddddddddddddblackwell Forest ddd dd ddd dnaperville dddddddddd(dddddd ddddddddddddddd), ddddd,d dddddddddd. dddddddddddd dddddddddd, dddddddddddd dd dddddddddddd, dddddddddd 37

39 6.2.2 Dad s Last Few Years ddddd( ddddddddd) dd dd dd ddddddd,dddddddd,ddddddd ddddddddd d d dddddddddddddddjames Gear,dd dhelendddddddddddd. ddddddd dd ddddddddddd,dddddddddddd dddddddddddddddddddd d dd dd dddd d d d d d d d d d d d d d d d d d d d d dlongwood Gardendddddddddddddd d d d d d d d d d d d d d d d. dlongwood Gardenddddddddddd dd dd dd 38

40 dd dd dddddddddddddddddddd, dd ddddd. ddddddddddddddddd dd ddddd dd dd dd dd dd ddddddd 39

41 dddd dd dd dd dd dd dd dd dd ddddddddddddddddddd dd dd dd dd ddddddddd dddddddddddddddd dddddddddddd 40

42 41

CONSTRUCTING ARM MEMORY OFFSPRING M MEMORY PARENT. Fig. 1: Von Neumann's self-reproducing automaton

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