OPTIMIZEFILTRATION. S o lv e n t R e s e r v o i r. I n - l i n e F i l t r a t i o n. I n - L i n e F i l t r a t i o n P r o c e s s

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1 OPTIMIZEFILTRATION HPLC FFiltration i l t r Fi l t r a t i o n i s a n e c e s s a r y c o m p o n e n t i n a n y H P LC s y s t e m. K e e p i n g p a r t i c u l a t e s o u t o f t h e f l o w p a t h p r e v e n t s p r e m a t u r e w e a r o n v i t a l c o m p o n e n t s, w e a r t h a t c o u l d l e a d t o c o s t l y r e p l a c e m e n t o r r e p a i r s. A n h o l i s t i c a p p r o a c h t o f i l t r a t i o n, a d d r e s s i n g p o t e n t i a l p a r t i c u l a t e s t h r o u g h o u t t h e s o l v e n t f l o w p a t h, l e a d s t o a c o n s i s t e n t l y a n d e f f i c i e n t l y o p e r a t i n g c h r o m a t o g r a p h. I d e a l l y, t h e r e a r e t h r e e c r i t i c a l a r e a s w h e r e f i l t r a t i o n i s n e c e s s a r y. S o lv e n t R e s e r v o i r W h i l e t h e a v a i l a b i l i t y o f H P LC - g r a d e s o l v e n t s d i m i n i s h e s t h e n e e d f o r p r e - f i l t e r i n g s o l v e n t s, i t i s s t i l l i m p e r a t i v e t h a t a f i l t r a t i o n d e v i c e b e i n s t a l l e d i n t h e r e s e r v o i r f i l t e r. P l a c i n g a f i l t e r i n t h e r e s e r v o i r i s a n e c o n o m i c a l w a y t o f i l t e r p a r t i c l e s t h a t m a y r e s u l t f r o m b u f f e r s a l t p r e c i p i t a t i o n, i m p r o p e r l y c l e a n e d g l a s s w a r e, o r m i c r o b i a l c o n t a m i n a t i o n ; a l l o f w h i c h a r e n o t r e m e d i e d b y t h e u s e o f H P LC - g r a d e s o l v e n t s. I n - l i n e F i l t r a t i o n T h e g r e a t f r i c t i o n a l f o r c e s g e n e r a t e d a t t h e p i s t o n s e a l i n t e r f a c e i n e v i t a b l y l e a d t o p a r t i c u l a t e s h e d d i n g. P l a c e m e n t o f a f i l t e r i n g e l e m e n t b e t w e e n t h e p u m p a n d i n j e c t o r / a u t o s a m p l e r r e m o v e s t h e s e p a r t i c u l a t e s, p r e v e n t i n g t h e m f r o m a f f e c t i n g d o w n s t r e a m c o m p o n e n t s, c i r c u m v e n t i n g c o s t l y d o w n t i m e a n d / o r r e p a i r s. I n - L i n e F i l t r a t i o n P r o c e s s In-Line Filter Guard Column or Pre-Column Filter Column Detector Solvent Reservoir Autosampler 17 P r e - C o l u m n F i l t r a t i o n I n c o m p a t i b i l i t i e s b e t w e e n s a m p l e m a t r i x a n d m o b i l e p h a s e, s e p t a c o r i n g f r o m t h e s a m p l e n e e d l e, a n d s h e d d i n g f r o m m o v i n g p a r t s i n t h e i n j e c t o r : t h e s e a l l c o n t r i b u t e t o p a r t i c u l a t e s i n t h e r e g i o n p o s t - i n j e c t o r. U s e o f a l o w - i m p a c t, p r e - c o l u m n f i l t e r r e m o v e s t h e s e p a r t i c u l a t e s f r o m t h e f l o w p a t h, s a v i n g y o u r a n a l y t i c a l c o l u m n a n d d e t e c t o r f r o m d e l e t e r i o u s e f f e c t s. w w w. o p t i m i z e t e c h. c o m

2 ation OPTI-SOLV Reservoir Filter If y o u w a n t t o k e e p p a r t i c u l a t e s o u t o f y o u r s y s t e m, a n d w e a r e s u r e y o u d o, y o u n e e d t o s t a r t a t t h e m o s t b a s i c l e v e l - t h e r e s e r v o i r b o t t l e. O P T I - S O LV R e s e r v o i r F i l t e r s e m p l o y a u n i q u e c o n i c a l d e s i g n i n s i d e t h e f i l t e r h o u s i n g p r e v e n t i n g a i r b u b b l e s f r o m g e t t i n g t r a p p e d a n d d i s t u r b i n g y o u r a n a l y s i s. A s o l i d T e f l o n b o d y k e e p s O P T I - S O LV i n t h e b o t t o m o f t h e b o t t l e w h e r e a b o t t o m - m o u n t e d t i t a n i u m f r i t p r o v i d e s u n r e s t r i c t e d s o l v e n t a c c e s s. A s a l w a y s, O p t i m i z e m a k e s i n s t a l l a t i o n a s s i m p l e a s p o s s i b l e - n o t o o l s o r f i t t i n g s r e q u i r e d. PTFE Body OPTI-SOLV Analy tical Reservoir Filters 5 Packs 1/16 O D T u b i n g µm µm U.S. Patent No. 5,525,303 Titanium Frit 1/ 8 O D T u b i n g 3/16 O D T u b i n g (Waters Style) µm µm µm µm All of the above filters are supplied with 5 feet of PTFE tubing preinstalled R e s e r v o i r F i l t e r s w i t h t u b e s t e m s a r e m a d e w i t h H a s t e l l o y C f o r m a x i m u m c o r r o s i o n r e s i s t a n c e a n d i n e r t n e s s. Reservoir Filters with Tube Stem W e a l s o o f f e r R e s e r v o i r F i l t e r s w i t h t u b e s t e m s, m a d e w i t h H a s t e l l o y C f o r m a x i m u m c o r r o s i o n r e s i s t a n c e a n d i n e r t n e s s. 1/16" I D T u b i n g 1/ 8 " I D T u b i n g (Waters Style) 5 Packs µm µm µm µm OPTIMIZEFILTRATION

3 OPTIMIZEFILTRATION F i l t r OPTI-SOLV In-Line filter OP T I - S O LV I n - L i n e F i l t e r s a r e t h e p e r f e c t c h o i c e f o r r e m o v a l o f p a r t i c u l a t e m a t t e r f r o m t h e f l o w p a t h. I n s t a l l e d b e t w e e n t h e p u m p a n d i n j e c t o r / a u t o s a m p l e r, t h e y p r e v e n t d a m a g e t o d o w n s t r e a m c o m p o n e n t s d a m a g e t h a t c a n c o s t y o u i n b o t h i n s t r u m e n t d o w n t i m e a n d t r o u b l e s h o o t i n g l a b o r. Stainless Steel Wrench-Tight Version " W e h a v e b e e n u s i n g O P T I - S O L V I n - L i n e F i l t e r s f o r s e v e r a l y e a r s i n o u r h i g h - t h r o u g h p u t L C / M S A n a l y s i s o f A D M E s c r e e n i n g s a m p l e s. " P a r t n e r : P f i z e r A D M E T e c h n o l o g y G r o u p New! PEEK "Gorilla Grip" Hand-Tight Version U.S. Patent No. 5,525,303 Order Replacement Filters Below O P T I - S O LV s u n i q u e s w i ve l d e s i g n a l l ows f r i t s to b e changed w i t h o u t re m ov i n g t h e co n n e ct i n g t u b i n g. J u s t p l u m b i t o n ce a n d l e a ve i t. H a n d - t i g hte n t h e PEEK h o l d e r to m a ke a h i g h - p re s s u re s e a l, o r fo r t h o s e w h o p refe r w re n ches, we a l s o h a ve a w re n ch -t i g ht s ta i n l e s s s te e l ve r s i o n. T h e u s e r- f r i e n d l y d e s i g n i s we l l s u i te d fo r a n u m b e r of a p p l i ca t i o n s, s u ch a s h i g h te m p e ra t u re e nv i ro n m e nt s, w h e re q u i ck changes a re i m p e ra t i ve. OPTI-SOLV In-Line Solvent Filter Holders In-Line Solvent PEEK Hand-Tight Holder In-Line Solvent Stainless Steel Wrench-Tight Holder T w o - P i e c e P E E K o r S t a i n l e s s S t e e l H o l d e r s 19 Replacement Filters (Frits) µm, 0.062" Dia Replacement Filters, 10 Pk µm, 0.062" Dia Replacement Filters, 10 Pk µm, 0.125" Dia Replacement Filter, 10 Pk µm, 0.125" Dia Replacement Filters, 10 Pk µm, 0.187" Dia Replacement Filters, 10 Pk µm, 0.187" Dia Replacement Filters, 10 Pk µm, 0.187" Dia Replacement Filters, 10 Pk S S Inser t N u t & Ferru l e Fil ter Element Po r t Tubing w w w. o p t i m i z e t e c h. c o m

4 ation OPTI-LYNX in-line filter Ne e d m o r e r o o m t o c h a n g e y o u r i n - l i n e f i l t e r? W i t h H P LC s y s t e m s g e t t i n g s m a l l e r a n d m o r e c o m p a c t, t h e a r e a s t o w o r k w i t h a r e a l s o d e c r e a s i n g i n s i z e. T h i s o f t e n m a k e s g e t t i n g a t t h o s e c o m p o n e n t s t h a t n e e d f r e q u e n t c h a n g i n g q u i t e a t a s k - e s p e c i a l l y i f y o u n e e d w r e n c h e s! R e v o l u t i o n a r y q u i c k c o n n e c t d e s i g n i s i d e a l f o r h i g h t e m p e r a t u r e G P C a n d p o s i t r o n e m i t t i n g r a d i o n u c l i d e f i l t r a t i o n - n o t j u s t H P LC. T h e O P T I - LY N X I n - L i n e F i l t e r S y s t e m f e a t u r e s O p t i m i z e T e c h n o l o g i e s ' p r o p r i e t a r y O P T I - LY N X h a r d w a r e, a l l o w i n g f i l t e r c h a n g e s t o b e d o n e i n a q u i c k q u a r t e r - t u r n. O P T I - LY N X I n - L i n e F i l t e r s o f f e r u n m a t c h e d v e r s a t i l i t y w i t h a c h o i c e o f e i g h t d i f f e r e n t f i l t e r i n s e r t p o r o s i t y / d i a m e t e r c o m b i n a t i o n s f o r e v e r y p o s s i b l e f i l t e r i n g n e e d. T h e O P T I - LY N X I n - L i n e F i l t e r K i t c o m e s w i t h a l l t h e h a r d w a r e y o u n e e d t o u p g r a d e y o u r c u r r e n t s y s t e m t o O P T I - LY N X u s i n g y o u r e x i s t i n g H P LC t u b i n g. OPTI-LYNX In-Line Filter Kit AA Includes: Bayonet connector, holder cap, holder tube, fittings. (Order filters separately from chart below.) U.S. Patent No. 5,525,303 OPTI-LYNX Filter Inserts 10 Packs R e c o m m e n d e d f o r Pr e- Column use R e c o m m e n d e d f o r I n - l i n e u s e CD CD Low Volume Filter Insert, 0.5 µm/0.062 diameter CE CE Low Volume Filter Insert, 2.0 µm/0.062 diameter CF CF Medium Capacity Filter Insert, 0.5 µm/0.125 diameter CG CG Medium Capacity Filter Insert, 2.0 µm/0.125 diameter 10 Packs CH CH High Capacity Filter Insert, 0.5 µm/0.187" diameter CI CI High Capacity Filter Insert, 2.0 µm/0.187 diameter CJ CJ* Semi-Prep Filter Insert, 2.0 µm/0.250 diameter CL CL* Semi-Prep Filter Insert, 10.0 µm/0.250 diameter *OPTI-LYNX Semi-Prep Filter Inserts are rated for use at pressures of up to 4,000 psi (other OPTI-LYNX products are rated to 6,000 psi unless otherwise stated). OPTI-LYNX Filter Inserts are rated at temperatures up to 175º C. OPTIMIZEFILTRATION

5 OPTIMIZEFILTRATION F i l t r OPTI-SOLV EXP Pre-Column Filter Op t i m i z e T e c h n o l o g i e s i s p r o u d t o i n t r o d u c e t h e O P T I - S O LV E X P H a n d T i g h t P r e - C o l u m n F i l t e r f o r e x t r e m e h i g h p r e s s u r e a p p l i c a t i o n s. O P T I - S O LV E X P H a n d T i g h t P r e - C o l u m n F i l t e r i s i d e a l f o r p r o t e c t i n g c o l u m n s w i t h s m a l l p a r t i c l e s i z e m a t e r i a l e m p l o y i n g u l t r a h i g h p r e s s u r e t e c h n i q u e s. S u c h t e c h n i q u e s a n a l y z e s a m p l e s i n t h e m o s t d e m a n d i n g a p p l i c a t i o n s, w h i c h c a n d e c r e a s e t h e l i f e o f t h e s e e x p e n s i v e c o l u m n s. E X P P r e - C o l u m n F i l t e r s h e l p e x t e n d t h a t l i f e a n d p r o t e c t y o u r c o l u m n i n v e s t m e n t, w i t h o u t s a c r i f i c i n g p e r f o r m a n c e. E x t r e m e H i g h P r e s s u r e i s a l s o r e f e r r e d t o a s U P LC, U H P LC ( U l t r a H i g h P r e s s u r e C h r o m a t o g r a p h y ), X t r e m e LC, o r X - LC. A d va n t a g e s o f U s i n g O P T I - S O LV E X P P r e - C o l u m n F i l t e r S y s t e m Approved for Use at 20,000 psi Tested to 30,000 psi Patented Auto Adjusting ZDV Column Connection Hand Tight Filter Replacement - NO TOOLS! Low Volume, Low Dispersion Cartridges E X P P r e - C o l u m n F i l t e r c o n f i g u r a t i o n New! Holder Cap Uni-Directional Cartridge Insert Holder Body OPTI-SOLV EXP Pre- Column Filter Holder OPTI-SOLV EXP Pre-Column Filter Holder Includes Holder Cap and Body Cartridges ordered separately - see table below. OPTI-SOLV EXP Pre- Column Replacement Filter Cartridges µm, OPTI-SOLV EXP Filter Cartridge, 5 Pack µm, OPTI-SOLV EXP Filter Cartridge, 5 Pack µm, OPTI-SOLV EXP Filter Cartridge, 10 Pack µm, OPTI-SOLV EXP Filter Cartridge, 10 Pack 21 w w w. o p t i m i z e t e c h. c o m

6 ation OPTI-SOLV Mini Filter Th e O P T I - S O LV M i n i F i l t e r p r o v i d e s l o w - i m p a c t f i l t e r i n g i n a p a c k a g e n o l a r g e r t h a n a f i n g e r t i g h t f i t t i n g. U s e t h e m t o p r o l o n g t h e l i f e o f y o u r a n a l y t i c a l c o l u m n, o r b e f o r e y o u r m a s s s p e c t r o m e t e r a s a l a s t l i n e o f d e f e n s e a g a i n s t d e b r i s. T h e O P T I - S O LV M i n i F i l t e r ' s d e s i g n a u t o m a t i c a l l y a d j u s t s t o f i t a l l b r a n d s o f c o l u m n s. P e r f e c t z e r o - d e a d - v o l u m e c o n n e c t i o n s a r e o b t a i n e d e v e r y t i m e w i t h o u r p a t e n t e d a u t o m a t i c t u b e s t o p d e p t h a d j u s t m e n t. U n i q u e d e p t h - f i l t e r i n g e l e m e n t s a l l o w f o r g r e a t e r c a p a c i t y w i t h n o b a n d s p r e a d i n g o r l o s s o f p e r f o r m a n c e. T h e e f f i c i e n t d e s i g n r e q u i r e s n o h o l d e r a n d t h r e a d s i n t o a n y p o r t. D e p t h - f i l t e r d e s i g n d e l i v e r s h i g h e r c a p a c i t y w i t h l o w v o l u m e PEEK body U.S. Patent No. 5,525,303 2 µm SS Frit (Or 0.5 µm) 5 µm SS frit OPTI-SOLV mini Filter Floating tube stem provides ZDV connection into any port OPTI-SOLV Direct Connect Mini Filter, 0.5 µm, 5/Pack OPTI-SOLV Direct Connect Mini Filter, 2.0 µm, 5/Pack OPTI-SOLV Direct Connect Mini Filter, 5.0 µm, 5/Pack OPTIMIZEFILTRATION

7 OPTIMIZEFILTRATION OPTI-SOLV F i Micro l Filter t r Fo r y o u r v o l u m e c r i t i c a l f i l t e r i n g n e e d s, w e n o w o f f e r t h e O P T I - S O L V M i c r o F i l t e r. B a s e d o n t h e s a m e d e s i g n t h a t h a s m a d e t h e M i n i F i l t e r a h u g e s u c c e s s, t h e M i c r o F i l t e r c u t s t h e i n t e r n a l v o l u m e t o l e s s t h a n n L, b u t r e t a i n s t h e M i n i F i l t e r s e a s e o f u s e a n d f u n c t i o n a l i t y. T h e M i c r o F i l t e r i s d e s i g n e d t o b e u s e d i n t o d a y s l o w v o l u m e, h i g h s e n s i t i v i t y c h r o m a t o g r a p h i c a p p l i c a t i o n s a s a l a s t l i n e o f d e f e n s e a g a i n s t d e b r i s. A s w i t h a l l o f O p t i m i z e c o l u m n p r o t e c t i o n p r o d u c t s, t h e O P T I - S O L V M i c r o F i l t e r f e a t u r e s a z e r o - d e a d - v o l u m e c o n n e c t i o n u t i l i z i n g o u r p a t e n t e d f l o a t i n g s t e m t e c h n o l o g y. T h e O P T I - S O LV M i c r o F i l t e r ' s e a s e o f u s e a n d f u n c t i o n a l i t y p e r f o r m e x c e p t i o n a l l y f o r v o l u m e c r i t i c a l a p p l i c a t i o n s. A d va n t a g e s o f t h e O P T I - S O LV M i c r o F i l t e r Designed to filter out particles extending column life Perfect Zero-Dead-Volume connections every time Floating stem automatically adjusts to any depth port Easy to use finger tight - No tools required Rated to 6000 psi New! OPTI-SOLV Micro Filter OPTI-SOLV Micro Filter, 1.0 µm, 5/Pack OPTI-SOLV Micro Filter, 2.0 µm, 5/Pack U.S. Patent No. 5,525, OPTI-SOLV Biocompatible Micro Filter, 0.5 µm, 5/Pack OPTI-SOLV Biocompatible Micro Filter, 10 µm, 5/Pack 23

8 ation OPTI-SOLV Nano Filter Th e O P T I - S O L V N a n o F i l t e r f o l l o w s o u r M i c r o F i l t e r a n d s h a r e s t h e s a m e d e s i g n s p e c i f i c a t i o n s, b u t c u t s t h e i n t e r n a l v o l u m e d o w n e v e n m o r e. W i t h l e s s t h a n 5 0 n l o f i n t e r n a l v o l u m e, t h e O P T I - S O LV N a n o F i l t e r i s i d e a l f o r m a s s s p e c t r o m e t r y t o p r o t e c t y o u r e l e c t r o s p r a y a n d n a n o s p r a y t i p s f r o m c l o g g i n g w i t h d e b r i s. PEEK Body 0.5 µm SS Screen U.S. Patent No. 5,525,303 OPTI-SOLV Nano Filter OPTI-SOLV Biocompatible Nano Filter, 0.5 µm, 5/Pack F l o a t i n g t u b e s t e m p r o v i d e s Z D V c o n n e c t i o n i n t o a n y p o r t f o r b o t h t h e N a n o a n d M i c r o F i l t e r New! OPTIMIZEFILTRATION

9 OPTIMIZEFILTRATION OPTI-LYNX F i Pre-Column l tfilters r Pr e - C o l u m n F i l t e r s c a n h e l p e x t e n d t h e l i f e o f y o u r a n a l y t i c a l c o l u m n b y c a t c h i n g p a r t i c u l a t e s t h a t w o u l d o t h e r w i s e c l o g t h e c o l u m n i n l e t f r i t. T h e O P T I - LY N X P r e - C o l u m n F i l t e r S y s t e m b r i n g s u n p a r a l l e l e d v e r s a t i l i t y t o p r e - c o l u m n p r o t e c t i o n, w i t h t h e a d d e d c o n v e n i e n c e o f q u i c k - c o n n e c t o p e r a t i o n. To c h a n g e a n O P T I - LY N X p r e - c o l u m n f i l t e r, s i m p l y g r a b t h e h o l d e r a n d t w i s t - n o t o o l s r e q u i r e d! T h e O P T I - LY N X P r e - C o l u m n F i l t e r S y s t e m c o m e s c o m p l e t e w i t h t h e h a r d w a r e y o u n e e d t o q u i c k - c o n n e c t a n y a n a l y t i c a l c o l u m n w i t h p r e - c o l u m n f i l t r a t i o n. F i l t e r i n s e r t s a r e o r d e r e d s e p a r a t e l y. O P T I - LY N X P r e - C o l u m n F i lt e r c o n f i g u r at i o n Universal Port Adaptor Filter Insert Holder Tube Holder Cap OPTI-LYNX Pre- Column Filter Kit AA Includes: Universal Port Adapter, Holder Cap, Holder Tube, Fitting OPTI-LYNX Filter Inserts are ordered separately - see page w w w. o p t i m i z e t e c h. c o m

10 ation O r d e r i n g F i l t e r I n s e r t s Wi t h O P T I - LY N X, a c c e s s i n g a n d c h a n g i n g t h e f i l t e r i n s e r t t a k e s o n l y a q u a r t e r - t u r n. R e p l a c e f i l t e r s o r c h a n g e f i l t e r d i a m e t e r o r p o r o s i t y i n s e c o n d s, w i t h o u t t o o l s. O P T I - LY N X f i l t e r i n s e r t s a r e a l l t h e s a m e s i z e o n t h e o u t s i d e, a l l o w i n g y o u t o u s e d i f f e r e n t d i a m e t e r s a n d p o r o s i t i e s w i t h t h e s a m e h o l d e r h a r d w a r e. O P T I - LY N X f i l t e r i n s e r t s c o m e i n s e v e r a l c o m b i n a t i o n s o f d i a m e t e r a n d p o r o s i t y, a l l o w i n g y o u t o f i n d y o u r o w n b a l a n c e b e t w e e n f i l t e r i n g c a p a c i t y a n d e x t r a - c o l u m n v o l u m e. OPTI-LYNX Filter Inserts 10 Packs R e c o m m e n d e d f o r P r e - C o l u m n u s e R e c o m m e n d e d f o r I n - l i n e u s e CD CD Low Volume Filter Insert, 0.5 µm/0.062 diameter CE CE Low Volume Filter Insert, 2.0 µm/0.062 diameter CF CF Medium Capacity Filter Insert, 0.5 µm/0.125 diameter CG CG Medium Capacity Filter Insert, 2.0 µm/0.125 diameter 10 Packs CH CH High Capacity Filter Insert, 0.5 µm/0.187" diameter CI CI High Capacity Filter Insert, 2.0 µm/0.187 diameter CJ CJ* Semi-Prep Filter Insert, 2.0 µm/0.250 diameter CL CL* Semi-Prep Filter Insert, 10.0 µm/0.250 diameter *OPTI-LYNX Semi-Prep Filter Inserts are rated for use at pressures of up to 4,000 psi (other OPTI-LYNX products are rated to 6,000 psi unless otherwise stated). OPTIMIZEFILTRATION