YOUR INSTRUCTOR WILL SHOW YOU EXAMPLES OF PORTFOLIOS COMPLETED BY PREVIOUS STUDENTS.

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Darcy Ball
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1 Chem 305 Name Partner Section (Circle) M Tu W Th F Date MOLECULAR PORTFOLIO This assignment* allows you to apply concepts and knowledge learned in class to the interpretation of the structure of an assigned drug molecule. As we learn concepts in lecture, you will be asked to complete specific portions of the project. You will work with one other student on this project. You may work with your lab partner or another student in class. You and your partner(s) will turn in one portfolio and will receive the same score. YOUR INSTRUCTOR WILL SHOW YOU EXAMPLES OF PORTFOLIOS COMPLETED BY PREVIOUS STUDENTS. Most of the information needed to complete your portfolio is provided in lecture and in your text. Specific information about your assigned drug (structure, chemical formula, etc.) can be obtained from several sources including: We used this website during our internet workshop. It is a good resource for finding out general information about your assigned drug. Merck Index: an encylopedia of chemicals, drugs, and biologicals This book is the standard reference for chemical and physical properties of organic compounds. You can find this book in the reference area of all three Los Rios libraries, public libraries, and local medical libraries (Sutter Resource Library at 2800 L St., Rm 600 ( ), UCD Medical Library at th St.) When using this book, look for your drug in the index. The index will give a number for the compound (not a page number). Also, when interpreting the skeletal structures, C 6 H 5, is a phenyl ring ( ). Physician s Desk Reference This book gives much of the same information as the drug circulars provided by the pharmaceutical manufacturers. It also describes some of the chemical properties of drugs. Drug pamphlets from your pharmacist Scoring Section Your Score Possible Points General Description and Names Line-bond/Skeletal Structure Expanded Structural Formula Molecular Geometry Molar Mass Hydrogen Bonding with Water Polarity and Solubility Predictions Solution Calculations Appearance of Portfolio * Portions of this assignment are from H. Kerby at Madison Technical College in Madison, WI 10-1

2 General Description Directions: Use suggested resources such as the Physician s Desk Reference, Merck Index, and internet sites such as and to learn about your drug. Type or neatly print the drug brand name, the generic name (if it differs from the drug name), and the chemical name. Chemical names are usually long and hyphenated terms that sometimes contain numbers. Ask your instructor for help if you are unsure about the names. Brand Name Generic Name Chemical Name At home, type or neatly print a set of paragraphs or bullets about your drug. Include information on: a) what the drug is used for (indications), b) when you should not take the drug (contra-indications), c) what the drug does in the body, d) any significant interactions with other drugs, and e) anything you think is interesting about your drug. Include any significant contraindications and/or drug interactions. Use a second sheet if necessary. Do not include more than 2 pages. Be sure to define your terms. For example, if a drug is a vasoconstrictor you should explain what that means. PLEASE NOTE THAT PLAGARISM IS NOT PERMITTED: THIS MEANS THAT YOU MUST WRITE ABOUT YOUR DRUG IN YOUR OWN WORDS; CUTTING AND PASTING IS NOT ACCEPTABLE. I WILL BE CHECKING ASSIGNMENTS USING TURNITIN.COM, AND YOU SHOULD TOO!!! 10-2

3 Line-bond/skeletal Structure and Lone-Pairs Directions: Draw the line-bond/skeletal structure for your assigned molecule. Portions of your molecule may be represented as a condensed structural formula (-CH 3, - OH, etc.). Include any lone pairs on the appropriate atoms. 10-3

4 Expanded Structural Formula Directions: Draw the expanded structural formula of your assigned molecule (showing all atoms and all covalent bonds) in the space below. Include any lone pairs. 10-4

5 VSEPRT Molecular Geometry Predictions Directions: Show the expanded structure of your drug below. If your structure contains atoms other than C or H, check these other atoms and add lone pairs of electrons to each until the octet rule is satisfied for that atom. Use VSEPR theory to predict the molecular geometry around each central atom. Use a color-coded key (include a key for your colors) to indicate the geometry around each central atom. 10-5

6 Molecular Formula and Molar Mass Calculations Directions: Write the molecular formula of your molecule. Calculate the molar mass of your drug to the hundredth s place using the molar masses from the periodic table in your text. The mass given in the Merck Index may differ from this by a few hundredths. Clearly show the setup for your molar mass calculation below. 10-6

7 Hydrogen Bonding with Water Directions: Show the structure of your molecule below. Illustrate all ways that your molecule could form hydrogen bonds with water, either as a hydrogen donor or as a target (receiver) of hydrogen bonds from water. Do this by drawing bent water molecules as necessary and representing hydrogen bonds between water and the drug using dashed RED lines (---). Be sure that it is exactly clear which atoms on each molecule are involved in the hydrogen bonds. If your drug molecule is not capable of forming hydrogen bonds with water, fully explain why not below. 10-7

8 Polarity and Solubility Predictions Directions: Show your molecule below. Circle or highlight all polar portions of the molecule. Make a reasonable prediction about whether your molecule will be soluble in water or not and explain your reasoning. If your molecule seems to be borderline in polarity, making it difficult to predict solubility, explain your reasoning and the difficulty involved. Find a source (Merck Index, PDR, etc.) that discusses the water-solubility of your drug. Compare your predictions with the information you find on the water-solubility of your drug and comment on any discrepancies. 10-8

9 Solution Calculations Directions: Clearly show the setups for your calculations. 1. You wish to prepare 50.0 ml of 2.30 x 10 2 M solution of your drug. Describe how to prepare this solution from the pure drug and deionized water. Analytical balances and volumetric flasks are available to you. (Assume that your drug dissolves in water, at least to the extent necessary for this problem.) Use complete sentences in your description of the solution preparation process. Show any required calculations you would need to make. 2. Calculate how many milligrams of the drug are contained in 2.0 ml of a 3.0 % (wt/vol) solution of your drug. 10-9

10 Summary of Collaboration and Shared Effort Use this part of the portfolio to describe your contribution to the portfolio and your efforts in the collaborative nature of this assignment. Please type or print neatly. Each partner should fill out this information independently. You will turn this sheet in separately from the rest of your portfolio. If there is a significant inequity in the amount of effort of each participant, this will be reflected in the grades received

Lab: Model Building with Covalent Compounds - Introduction

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