STUDY PROGRAM 2017/2018

Transcription

1 University of Pécs Faculty of Pharmacy PHARMACY Major STUDY PROGRAM 2017/2018 Subjects of the 1-2. semesters (obligatory subjects and criterion requirements) 1

2 1 st semester OPA-AM1 General and Inorganic Chemistry 1 3 OPA-B1E Biomathematics 1 - Theory 6 OPA-B1G Biomathematics 1 - Practice 8 OPA-L1E Analytical Chemistry 1 - Theory 10 OPA-L1G Analytical Chemistry 1 - Practice 13 OPG-GPR Pharmaceutical Propedeutics 15 OPO-GL1 Pharmaceutical Biology 1 17 OPO-Z1E Physics-Biophysics 1 - Theory 20 OPO-Z1G Physics-Biophysics 1 - Practice 22 OPR-ESE First Aid 24 OPR-LAT Pharmaceutical Terminology 25 ATT1 Physical Education nd semester OPA-B2E Biomathematics 2 - Theory 28 OPA-B2G Biomathematics 2 - Practice 30 OPA-FZ1 Physical Chemistry 1 32 OPA-L2E Analytical Chemistry 2 - Theory 35 OPA-L2G Analytical Chemistry 2 - Practice 37 OPA-M2E General and Inorganic Chemistry 2 - Theory 40 OPA-M2G General and Inorganic Chemistry 2 - Practice 42 OPO-AI1 Human Anatomy, Histology and Embriology 1 44 OPO-G2B Pharmaceutical Biology 2 46 OPO-Z2E Physics-Biophysics 2 - Theory 49 OPO-Z2G Physics-Biophysics 2 - Practice 51 ATT2 Physical Education 2 53 ATT Physical Education courses

3 OPA-AM1 GENERAL AND INORGANIC CHEMISTRY 1 Course director: 3 credit semester exam Basic subject autumn semester recommended semester: 1 Number of hours/semester: 28 lectures + 0 practices + 14 seminars = total of 42 hours Course headcount limitations (min.-max.): 5 50 Prerequisites: none DR. PÁL PERJÉSI, professor Department of Pharmaceutical Chemistry Topic The course includes selected General Chemistry topics that are essential for pharmacy students to study the Chemistry-related subjects (eg, Pharmaceutical Chemistry, Pharmaceutical Technology) in the higher semesters. Conditions for acceptance of the semester Acknowledgement of the course is in accord with the Code of studies and Examinations. Maximum three absences can be accepted both from lectures and seminars. Two tests will be written during the semester (on the 7th and the 12th weeks) based on the topics of the lectures and the seminars. The result of both tests should be above 60%. One retake chance is allowed for each test. Evaluation of semester performance is based on the results of the written tests. Mid-term exams One retake chance is allowed for each Midterm Test. Making up for missed classes There is no opportunity to make up missed classes (lectures and seminars). Reading material - Obligatory literature Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, Literature developed by the Department Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational material, University of Pécs, Notes - Recommended literature en.wikibooks.org/wiki/general_chemistry Lectures 1 Classification of matter. Atomic structure. Electron configuration and periodicity. The periodic table. Periodic properties. 2 Classification of matter. Atomic structure. Electron configuration and periodicity. The periodic table. Periodic properties. 3 Structure of molecules. Chemical bonding. Chemical bonding theories. Valence bond theory. Hybrid orbitals. Molecular orbital theory. Moleculas geometry. Dr. Molnár Péter 4 Structure of molecules. Chemical bonding. Chemical bonding theories. Valence bond theory. Hybrid orbitals. Molecular orbital theory. Moleculas geometry. Dr. Molnár Péter 5 States of matter. The gaseous state. Gas laws. Intermolecular forces. The liquid state. The solid state. Phase transitions. Phase diagrams. Dr. Molnár Péter 6 States of matter. The gaseous state. Gas laws. Intermolecular forces. The liquid state. The solid state. Phase transitions. Phase diagrams. Dr. Molnár Péter 7 Water and the aqueous solutions. Dissolution of gases, liquids and solids in liquids. Types of electrolytes. Electrolytic dissociation, degree of dissociation, conductivity, and their relationships Dr. Molnár Péter 8 Water and the aqueous solutions. Dissolution of gases, liquids and solids in liquids. Types of electrolytes. Electrolytic dissociation, degree of dissociation, conductivity, and their relationships. Dr. Molnár Péter 9 Chemical kinetics. Reaction rates. The collision theory. Rate laws and reaction mechanisms. Dr. Molnár Péter 3

4 10 Chemical kinetics. Reaction rates. The collision theory. Rate laws and reaction mechanisms. Dr. Molnár Péter 11 Chemical equilibria. LeChatelier s principle. Protolytic reactions I. Ionization of water. The ph scale. Dr. Lóránd Tamás 12 Chemical equilibria. LeChatelier s principle. Protolytic reactions I. Ionization of water. The ph scale. Dr. Lóránd Tamás 13 Protolytic reactions II. Acid-base concepts. Acid-base equilibria. Dr. Lóránd Tamás 14 Protolytic reactions II. Acid-base concepts. Acid-base equilibria. Dr. Lóránd Tamás 15 Buffers. Physiological buffer systems. Acid-base titrations. Dr. Lóránd Tamás 16 Buffers. Physiological buffer systems. Acid-base titrations. Dr. Lóránd Tamás 17 Heterogeneous equilibria. Thermodynamics and equilibrium. 18 Heterogeneous equilibria. Thermodynamics and equilibrium. 19 Colligative properties. Colloids. 20 Colligative properties. Colloids. 21 Thermochemistry. Basic thermodynamics. 22 Thermochemistry. Basic thermodynamics. 23 Electrochemistry I. 24 Electrochemistry I. 25 Electrochemistry II. 26 Electrochemistry II. 27 Complex ions and coordination compounds I. Structure and isomerism. 28 Complex ions and coordination compounds I. Structure and isomerism. Practices Seminars 1 The periodic table. Periodic properties. 2 The gaseous state. Kinetic theory of gases. Thermodynamic parameters, state functions. 3 Basics of thermodynamics. Internal energy and enthalpy. Entropy. 4 Chemical kinetics. Rate of reactions and reaction order. Temperature dependence of the reaction rate. 5 Homogeneous and heterogeneous chemical equilibria. Equilibrium constant. Le Chateleir principle. 6 Free energy change of chemical reactions. Thermodynamic requirements of spontaneous chemical reactions. 7 Conductivity of electrolytes. Strong and weak electrolytes. 8 Acid-base theories. (Arrhenius, Bronsted-Lowry, Lewis, Pearson) 9 Formation and stability of complexes. Theories of complex formation. 10 ph of aqueous solutions I. Hydrolysis of salts. The hydrolysis constant. 11 ph of aqueous solutions II. Buffers. Buffer capacity. 12 Galvanic cells. Electrode potential. Electrodes of first and second kind. 13 Redox potential. Thermodynamic requirements of spontaneous redox reactions. 14 Electrolysis. Decomposition voltage. Polarization. 4

5 Exam topics/questions Written test covering the topics of the lectures and the laboratory practices. The result of the written test must be above 60%. The final grade is based on results of the midterm tests and the written test. Maximum contribution of the results of the midterm tests to to the total score of the written test can be 25%. Participation on the first exam is compulsory. Participants Gulyás Gergely (GUGSAAP.PTE), Kulcsár Győző (KUGDAA.T.JPTE) 5

6 OPA-B1E Course director: BIOMATHEMATICS 1 - THEORY 2 credit semester exam Basic subject autumn semester recommended semester: 1 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): Prerequisites: OPA-B1G parallel DR. LÁSZLÓ GRAMA, associate professor Department of Biophysics Topic Introduction into fundamentals and methods of mathematical analysis. Applications in the fields of physics, chemistry and biology. The course focuses on the acquisition of the basic knowledge of mathematics and special courses will introduce the special applications. Topics discussed during the course: Definition, type and discussion of the functions. Derivatives of elementary functions, geometrical interpretation, differentiation rules and applications. Integration. Solving basic integral problems and differential equations. Examples from physics, chemistry and biology. Conditions for acceptance of the semester Maximum of 25 % absence allowed Mid-term exams Making up for missed classes Reading material - Obligatory literature - Literature developed by the Department htp://biofizika.aok.pte.hu - Notes József Belágyi, László Mátyus, Miklós Nyitrai: Mathematics, textbook Péter Hajdu, László Grama: Selected Problems in Mathematics, problems booklet - Recommended literature Lectures 1 Introduction: a biological example. Variables and functions Dr. Grama László 2 Introduction: a biological example. Variables and functions Dr. Grama László 3 Properties of functions: monotonic, periodic, exponential and log functions. Family of standard functions Dr. Grama László 4 Properties of functions: monotonic, periodic, exponential and log functions. Family of standard functions Dr. Grama László 5 Limits and continuity of functions Dr. Grama László 6 Limits and continuity of functions Dr. Grama László 7 Sequences and series. Infinite series, test of convergence Dr. Grama László 8 Sequences and series. Infinite series, test of convergence Dr. Grama László 9 Rate of change and its limit. Derivatives of elementary functions. Rules of differentiation Pirisi Katalin Erzsébet 10 Rate of change and its limit. Derivatives of elementary functions. Rules of differentiation Pirisi Katalin Erzsébet 11 Higher order derivatives. Taylor s expansion of functions Pirisi Katalin Erzsébet 12 Higher order derivatives. Taylor s expansion of functions Pirisi Katalin Erzsébet 6

7 13 Maximum and minimum of functions. Applications for physical problems Pirisi Katalin Erzsébet 14 Maximum and minimum of functions. Applications for physical problems Pirisi Katalin Erzsébet 15 Indefinite integrals: basic integrals. Techniques of integration Dr. Bugyi Beáta 16 Indefinite integrals: basic integrals. Techniques of integration Dr. Bugyi Beáta 17 Integration by parts and substitutions, composite functions Dr. Bugyi Beáta 18 Integration by parts and substitutions, composite functions Dr. Bugyi Beáta 19 Definite integral. Newton-Leibniz s rule. Applications Dr. Bugyi Beáta 20 Definite integral. Newton-Leibniz s rule. Applications Dr. Bugyi Beáta 21 Differential equations. Types of differential equations. Separable differential equations Dr. Bugyi Beáta 22 Differential equations. Types of differential equations. Separable differential equations Dr. Bugyi Beáta 23 Solution of first-order differential equations Dr. Bugyi Beáta 24 Solution of first-order differential equations Dr. Bugyi Beáta 25 Application of differential equations: chemical reactions, enzymatic reactions Dr. Bugyi Beáta 26 Application of differential equations: chemical reactions, enzymatic reactions Dr. Bugyi Beáta 27 Higher order differential equations. Compartment models Dr. Bugyi Beáta 28 Higher order differential equations. Compartment models Dr. Bugyi Beáta Practices Seminars Exam topics/questions The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the result different from failed ). Participants 7

8 OPA-B1G Course director: BIOMATHEMATICS 1 - PRACTICE 2 credit midsemester grade Basic subject autumn semester recommended semester: 1 Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): Prerequisites: none DR. LÁSZLÓ GRAMA, associate professor Department of Biophysics Topic Introduction into fundamentals and methods of mathematical analysis. Applications in the fields of physics, chemistry and biology. The course focuses on the acquisition of the basic knowledge of mathematics and special courses will introduce the special applications. Topics discussed during the course: Definition, type and discussion of the functions. Derivatives of elementary functions, geometrical interpretation, differentiation rules and applications. Integration. Solving basic integral problems and differential equations. Examples from physics, chemistry and biology. Conditions for acceptance of the semester Maximum of 25 % absence allowed Mid-term exams Making up for missed classes Reading material - Obligatory literature - Literature developed by the Department - Notes József Belágyi, László Mátyus, Miklós Nyitrai: Mathematics, textbook Péter Hajdu, László Grama: Selected Problems in Mathematics, problems booklet Recommended literature Lectures Practices 1 Introduction: a biological example. Variables and functions 2 Introduction: a biological example. Variables and functions 3 Properties of functions: monotonic, periodic, exponential and log functions. Family of standard functions 4 Properties of functions: monotonic, periodic, exponential and log functions. Family of standard functions 5 Limits and continuity of functions 6 Limits and continuity of functions 7 Sequences and series. Infinite series, test of convergence 8 Sequences and series. Infinite series, test of convergence 9 Rate of change and its limit. Derivatives of elementary functions. Rules of differentiation 10 Rate of change and its limit. Derivatives of elementary functions. Rules of differentiation 11 Higher order derivatives. Taylor s expansion of functions 12 Higher order derivatives. Taylor s expansion of functions 13 Maximum and minimum of functions. Applications for physical problems 14 Maximum and minimum of functions. Applications for physical problems 15 Indefinite integrals: basic integrals. Techniques of integration 16 Indefinite integrals: basic integrals. Techniques of integration 17 Integration by parts and substitutions, composite functions 18 Integration by parts and substitutions, composite functions 19 Definite integral. Newton-Leibniz s rule. Applications 20 Definite integral. Newton-Leibniz s rule. Applications 21 Differential equations. Types of differential equations. Separable differential equations 22 Differential equations. Types of differential equations. Separable differential equations 23 Solution of first-order differential equations 24 Solution of first-order differential equations 25 Application of differential equations: chemical reactions, enzymatic reactions 26 Application of differential equations: chemical reactions, enzymatic reactions 27 Higher order differential equations. Compartment models 28 Higher order differential equations. Compartment models 8

9 Seminars Exam topics/questions Participants Dr. Bugyi Beáta (BUBEAB.T.JPTE), Dr. Grama László (GRLHAAO.PTE), Pirisi Katalin Erzsébet (PIKPACT.PTE) 9

10 OPA-L1E Course director: ANALYTICAL CHEMISTRY 1 - THEORY 2 credit semester exam Basic subject autumn semester recommended semester: 1 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): 5 65 Prerequisites: OPA-L1G parallel DR. IMRE HUBER, associate professor Department of Pharmaceutical Chemistry Topic Within the frame of the theoretical and practical trainings of this subject students will study the analytical approach of chemistry. This approach is crucial for the study of almost all pharmaceutical sciences like pharmaceutical chemistry, pharmaceutical technology etc. Students have to learn and examine the theory and practice of analytical reactions, methods, rules and calculations. Students will learn how to identify an unknown inorganic sample in both simple and complex manner of the analysis. At the end of the semester they should be able to know how to analyze an unknown sample for the most important cations and anions. Students should prove to demonstrate that they know how to use the theoretical knowledge in the pharmaceutical practice while finding out what their unknown sample is. Conditions for acceptance of the semester Maximum of 15 % absence allowed Mid-term exams The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the result different from failed ). The students will have to write two written midtermtests. Both can be repeated one time only. The result must be above 60%, respectively!! Exam topics/questions The semester is closed with a written test. In the case the result will not reach the 60% level, the student fails, she or he has to repeat the exam. In all other cases (above 60%), the student will receive a grade from qualitative inorganic analysis, based on the results of the two written tests and the overall result of the practical work throughout the semester (maximum score: 5 points). Making up for missed classes Reading material - Obligatory literature A. Lásztity, J. Gyimesi: Qualitative Inorganic Analysis - Literature developed by the Department The students will receive lecture notes from the lecturer. - Notes - Recommended literature 1. P.W. West, M.M. Vieck, A.L. LeRosen: Qualitative Analysis and Analytical Chemical Separations 2. H F. Holtzclaw, W. R. Robinson: College Chemistry with Qualitative Analysis Lectures 1 Definition, principles 2 Topic of qualitative inorganic analysis 3 Equilibrium reactions in solution 4 Definition, calculations 5 Classification of chemical reactions 6 Electrode potentials 7 Sensitivity and 8 Specificity of a chemical reaction 10

11 9 Classification of the cations 10 1st group of cations 11 2nd group of cations 12 Separation of the first two groups 13 3rd group of cations I 14 3rd group of cations II 15 3rd group of cations III 16 Separation of the 3rd group 17 4th group of cations 18 5th group of cations 19 Classification of anions 20 1st anion group 21 2nd anion group I 22 2nd anion group I 23 3rd anion group 24 3rd anion group II 25 4th anion group I 26 4th anion group II 27 Final written test 28 Summary Practices Seminars Exam topics/questions 1.) Definition, principles and topic of qualitative inorganic analysis. Quality assurance and control of chemical substances and active pharmaceutical ingredients. Available reactions. Stoichiometry. 2. Equilibrium reactions in solution, definition, calculations. Acid-base theories, calculation of ph, complexes (steric structures and isomerism), precipitate formation, solubility. 3.) Classification of chemical reactions: acid-base, complex-forming, and redox reactions. Electrode potentials. 4.) Sensitivity and specificity of chemical reactions. Dilution limit, limit-concentration. Analytical equipment, methods (macro, micro, semimicro, etc.). Preliminary investigations: sample-taking, homogenization, dissolution, digestion, direct heating, flame-test, etc. 5.) Classification of the cations: 1st group of cations (Ag+, Pb2+, Hg22+, Hg2+, Cu2+, Cd2+, Bi3+). 6.) 2nd group of cations (As3+, As5+, Sb3+, Sb5+, Sn2+, Sn4+. Separation of the first two groups of cations. 7.) 3rd group of cations I. (Co2+, Ni2+, Fe2+, Fe3+, Cr3+, Mn2+, Al3+, Zn2+). 8.) 3rd group of cations II. (Co2+, Ni2+, Fe2+, Fe3+, Cr3+, Mn2+, Al3+, Zn2+). Separation of the 3rd group of cations. 9.) 4th and 5th group of cations (Ca2+, Sr2+, Ba2+; Mg2+, Li+, Na+, K+, NH4+). Separation of the 4th and 5th group. Separation of magnesium ion from the other ions of the 5th group. 10.) Classification of the anions: 1st group of anions (CO32-, HCO3-, SO32-, S2O32-, S2- and Sx2-, SiO32-, OCl-). 11.) 2nd group of anions (IO3-, BrO3-, SO42-, PO43-, B(OH)4-, F-). 11

12 12.) 3rd group of anions (Cl-, Br-, I-, CN-, SCN-). 13.) 4th group of anions (NO2-, NO3-, ClO3-, ClO4-, CH3COO-). Complex analysis: cation(s) and anion(s) in the same sample. Practices Participants 12

13 OPA-L1G Course director: ANALYTICAL CHEMISTRY 1 - PRACTICE 3 credit midsemester grade Basic subject autumn semester recommended semester: 1 Number of hours/semester: 0 lectures + 42 practices + 0 seminars = total of 42 hours Course headcount limitations (min.-max.): 5 65 Prerequisites: none DR. IMRE HUBER, associate professor Department of Pharmaceutical Chemistry Topic Within the frame of the theoretical and practical trainings of this subject students will study the analytical approach of chemistry. This approach is crucial for the study of almost all pharmaceutical sciences like pharmaceutical chemistry, pharmaceutical technology etc. Students have to learn and examine the theory and practice of analytical reactions, methods, rules and calculations. Students will learn how to identify an unknown inorganic sample in both simple and complex manner of the analysis. At the end of the semester they should be able to know how to analyze an unknown sample for the most important cations and anions. Students should prove to demonstrate that they know how to use the theoretical knowledge in the pharmaceutical practice while finding out what their unknown sample is. Conditions for acceptance of the semester Maximum of 15 % absence allowed Mid-term exams The topic ends with a practical grade. A student with a failed grade is not allowed to enter the exam! The students are supposed to have at least passmark for both midterm tests and a 70% practical result for a license for entering the exam! The knowledge and practical ability of the students will be measured by unknown tests. That means, that they will be given certain amount (number) of unknown analytical samples to be identified by the usual chemical reactions, possible analytical methods! Every student will have his or her own sample set for individual practical work. The result of this work must be above 70%! Making up for missed classes All missed practicals are to be recovered on the next meeting (next week)! Reading material - Obligatory literature A. Lásztity, J. Gyimesi: Qualitative Inorganic Analysis - Literature developed by the Department The students will receive practical guidance from the given instructor week by week. - Notes Recommended literature Lectures Practices 1 Laboratory regulations, safety, protection against accidents, notebook (keeping and recording), laboratory equipment and working place. 2 Safety instructions 3 Laboratory equipment 4 Investigation of the reactions of silver, lead, 5 Mercury(I) and (II), 6 Copper, cadmium and bismuth cations. 7 Study of arsenic, 8 Antimony and 9 Tin ion couples. 10 Studies about nickel, cobalt, Iron(II) and 11 Iron(III), manganese and 12 Chromium cations. 13 Written midterm test. 14 Aluminium 15 Zinc 16 Simple analysis of the 1st group 17 Simple analysis of the 2nd group 18 Simple analysis of the 3rd group 19 Calcium 20 Strontium 21 Barium 13

14 22 Magnesium, Lithium 23 Sodium, Potassium 24 Ammonium 25 Written test II 26 Simple analysis of the 4th group 27 Simple analysis of the 4th group 28 Carbonate, Hydrocarbonate 29 Sulphite, Thiosulphate 30 Polysulphide, Silicate 31 Hypochloride, Iodate 32 Bromate, Sulfate 33 Phosphates 34 Borate, Fluoride 35 Chloride, Bromide 36 Thiocyanide 37 Iodode, Cyanide 38 Nitrite, Nitrate, Chlorate, Perchlorate, Acetate 39 Written test III 40 Complex 41 Summary 42 Closing Seminars Exam topics/questions 1.) Definition, principles and topic of qualitative inorganic analysis. Quality assurance and control of chemical substances and active pharmaceutical ingredients. Available reactions. Stoichiometry. 2. Equilibrium reactions in solution, definition, calculations. Acid-base theories, calculation of ph, complexes (steric structures and isomerism), precipitate formation, solubility. 3.) Classification of chemical reactions: acid-base, complex-forming, and redox reactions. Electrode potentials. 4.) Sensitivity and specificity of chemical reactions. Dilution limit, limit-concentration. Analytical equipment, methods (macro, micro, semimicro, etc.). Preliminary investigations: sample-taking, homogenization, dissolution, digestion, direct heating, flame-test, etc. 5.) Classification of the cations: 1st group of cations (Ag+, Pb2+, Hg22+, Hg2+, Cu2+, Cd2+, Bi3+). 6.) 2nd group of cations (As3+, As5+, Sb3+, Sb5+, Sn2+, Sn4+. Separation of the first two groups of cations. 7.) 3rd group of cations I. (Co2+, Ni2+, Fe2+, Fe3+, Cr3+, Mn2+, Al3+, Zn2+). 8.) 3rd group of cations II. (Co2+, Ni2+, Fe2+, Fe3+, Cr3+, Mn2+, Al3+, Zn2+). Separation of the 3rd group of cations. 9.) 4th and 5th group of cations (Ca2+, Sr2+, Ba2+; Mg2+, Li+, Na+, K+, NH4+). Separation of the 4th and 5th group. Separation of magnesium ion from the other ions of the 5th group. 10.) Classification of the anions: 1st group of anions (CO32-, HCO3-, SO32-, S2O32-, S2- and Sx2-, SiO32-, OCl-). 11.) 2nd group of anions (IO3-, BrO3-, SO42-, PO43-, B(OH)4-, F-). 12.) 3rd group of anions (Cl-, Br-, I-, CN-, SCN-). 13.) 4th group of anions (NO2-, NO3-, ClO3-, ClO4-, CH3COO-). Complex analysis: cation(s) and anion(s) in the same sample. Practices Participants (HUIRAAO.PTE), Dr. Rozmer Zsuzsanna (ROZQAAP.PTE), Gulyás Gergely (GUGSAAP.PTE) 14

15 OPG-GPR Course director: PHARMACEUTICAL PROPEDEUTICS DR. SZILÁRD PÁL, assistant professor Institute of Pharmaceutical Technology and Biopharmacy 1 credit midsemester grade Pharm. theoretical module and practical skills subject autumn semester recommended semester: 1 Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours Course headcount limitations (min.-max.): 1 80 Prerequisites: none Topic This course is an introduction to the discipline of pharmaceutics (propedeutics), within pharmacist s hierarchy, their relationship with other healthcare workers and current specialties are also introduced. Students get a review on fundamentals and basic terms of pharmaceutics. Design and manufacture of medicine, and proper use of dosage forms is also demonstrated. Conditions for acceptance of the semester - students must fulfil requirements determined by the Code of Studies and Examinations - attendance of the lectures according to the Code of Studies and Examinations Mid-term exams Students have to write three assessments during the semester. The third assessments is from the whole semester s lectures. Students have to reach 60,1 % in this case. In case of confirmed absence from the assessment, re-take chance is sossible for the student. Missing the retake results 0 % assessment. Making up for missed classes Students must fulfil requirements determined by the Code of Studies and Examinations. Students have to bring a medical certificate. Topic of missed lectures has to be made up for in the form of a short written report (approx. 1 page, font size: 12) Reading material - Obligatory literature - Literature developed by the Department - Notes - Recommended literature Official pharmacopoeias (Ph. Hg. VIII., Ph. Eur.) Formulae Normales VII. (FoNo VII.) Pharmindex Compendium Lectures 1 Pharmacist s hierarchy in the healthcare Dr. Pál Szilárd 2 Characteristics of the pharmaceutical education, its structure, disciplines, career opportunities Dr. Pál Szilárd 3 Origin of pharmacy, present and future Dr. Pál Szilárd 4 Pharmacy as a healthcare institution Dr. Pál Szilárd 5 Role of the pharmaceutical industry and wholesalers, drug control Dr. Pál Szilárd 6 Mid-term written assessment Dr. Pál Szilárd 7 Relationship between the healthcare workers (physicians, medical staff, pharmacists, nurses) Dr. Pál Szilárd 8 Equipment in the pharmacy, appliances for the manufacture of medicines Dr. Pál Szilárd 9 Equipment and methods for pharmaceutical measurement, concept of the pharmaceutical accuracy; preparation Dr. Pál Szilárd 10 Mid-term written assessment Dr. Pál Szilárd 11 Basics of preparation processes liquid Dr. Pál Szilárd 15

16 12 Basics of preparation processes semi-solid and solids Dr. Pál Szilárd 13 Pharmaceutical literature, pharmacopoeias, Formulae Normales in Hungary Dr. Pál Szilárd 14 End-year assessment Dr. Pál Szilárd Practices Seminars Exam topics/questions Students will receive the topic lists in the Institute and/or on the website. Participants Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE) 16

17 OPO-GL1 PHARMACEUTICAL BIOLOGY 1 Course director: DR. KATALIN SIPOS, associate professor Department of Pharmaceutical Biology 4 credit semester exam Med.-biol. theoretical module and practical skills subject autumn semester recommended semester: 1 Number of hours/semester: 42 lectures + 1 practices + 13 seminars = total of 56 hours Course headcount limitations (min.-max.): Prerequisites: none Topic The 2-semester Biology course provides the essential fundamental molecular biological knowledge for the pharmaceutical students. In the first semester students will study the structure and main functions of the living eukaryotic cells. We will discuss briefly the structural features of prokaryotes as well as viruses. The majority of the topics will deal with the information storage and utilization of the cells, and the regulation of these processes. Conditions for acceptance of the semester Maximum of 25 % absence allowed Mid-term exams There are two mid-term exams the results of which is included in the semester exam. Making up for missed classes According to personal agreement Reading material - Obligatory literature - Literature developed by the Department The materials of the lectures and seminars will appear on Neptune. - Notes - Recommended literature Cooper GM: The Cell: A Molecular Approach, 2nd edition, PubMed Elliott WH, Elliott DC: Biochemistry and Molecular Biology, 3rd edition Thompson & Thompson: Genetics in Medicine Crai NL: Molecular Biology, Principles of Genome Function, OUP 2010 Young ID: Medical Genetics Lectures 1 Introduction. Dr. Sipos Katalin 2 Building blocks of the cell. Dr. Sipos Katalin 3 Genom and gene expression. Varga Edit 4 Tools and techniques in molecular biology I. Poór Viktor Soma 5 Tools and techniques in molecular biology II. Poór Viktor Soma 6 Cellular differentiation. Poór Viktor Soma 7 Stem cells. Poór Viktor Soma 8 The nucleus and the cellular membranes. Dudás Réka 9 Structure of DNA. Dr. Pandur Edina 10 Chromosomes and genomes. Dr. Pandur Edina 11 Mitochondrium: structure and function. Mitochondrial DNA. Dudás Réka 17

18 12 Cytoplasmic organelles: endoplasmic reticulum, Golgi apparatus, lysosomes. Dr. Pandur Edina 13 Replication I. Poór Viktor Soma 14 Replication II. Poór Viktor Soma 15 Repair mechanisms. Poór Viktor Soma 16 Transcription in prokaryotic cells. Dr. Sipos Katalin 17 Eukaryotic transcription: mrna. Dr. Sipos Katalin 18 Eukaryotic transcription: trna, rrna. Dr. Sipos Katalin 19 Regulation of transcription. Dr. Sipos Katalin 20 Transcription factors. Dr. Pandur Edina 21 The genetic code. Varga Edit 22 Structure and functions of ribosomes. trna Dr. Pandur Edina 23 Steps of translation. Dr. Pandur Edina 24 Protein analysing methods I. Nagy Laura 25 Protein analysing methods II. Nagy Laura 26 Gene regulation: prokaryotes. Poór Viktor Soma 27 Regulation of gene expression in eukaryotes I. Nagy Laura 28 Regulation of gene expression in eukaryotes II. Nagy Laura 29 Posttranslational modifications. Poór Viktor Soma 30 Degradation of proteins. Poór Viktor Soma 31 Intracellular trafficing of proteins: nucleus, mitochondrion. Dr. Sipos Katalin 32 Intracellular trafficing of proteins: ER. Dr. Sipos Katalin 33 Intracellular trafficing of proteins: Golgi, lysosomes. Dr. Sipos Katalin 34 Antibiotics. Nagy Laura 35 Cell cycle I Dr. Sipos Katalin 36 Cell cycle II Dr. Sipos Katalin 37 Mitosis I Dr. Pandur Edina 38 Mitosis II Dr. Pandur Edina 39 Meiosis I Poór Viktor Soma 40 Meiosis Poór Viktor Soma 18

19 41 Transport through biological membranes Dr. Sipos Katalin 42 Consultation. Dr. Sipos Katalin Practices 1 Preparation of biological buffers (TE, loading, PAGE, DNA isolation solutions). Seminars 1 Macromolecules as building blocks of living cells. 2 Separation techniques. 3 Detection in molecular biology. 4 Cytoskeleton. 5 Bases of PCR. 6 Sequencing methods. 7 Transcription: summary. 8 Viruses. 9 Human Genome Project. 10 Molecular biological methods in Pharmaceutical research. 11 Intracellular targeting: summary. 12 Mechanisms of antibiotics. 13 Signal transduction: summary. Exam topics/questions There are no given exam questions. The topics of the exam will be the materials of lectures and seminars. Participants Dr. Pandur Edina (PAEFAA.T.JPTE), Dr. Sipos Katalin (SIKMAAO.PTE), Dudás Réka (DURGAAT.PTE), Nagy Laura (NALPACT.PTE), Poór Viktor Soma (POVFAB.T.JPTE), Varga Edit (VAEQABT.PTE) 19

20 OPO-Z1E Course director: PHYSICS-BIOPHYSICS 1 - THEORY DR. ANDRÁS SZILÁRD LUKÁCS, associate professor Department of Biophysics 2 credit semester exam Med.-biol. theoretical module and practical skills subject autumn semester recommended semester: 1 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): Prerequisites: OPO-Z1G parallel Topic The course addresses the physical basis of the structure and function of biological systems. The main topics include atomic and nuclear physics, thermodynamics, transport processes, molecular and supramolecular systems, bioelectric phenomena, and biological motion. Conditions for acceptance of the semester Maximum of 25 % absence allowed Mid-term exams During the semester the student will have to write two tests on the 6th and 13th week, Based on the results those students who achieved grade 4 or 5 can keep the obtained grade as an exam grade. In order to be eligible for the exam the students have to achieve a satisfacatory grade. Making up for missed classes Missed practices can be made up during make-up opportunities provided by the department. During each make-up lab, only one missed practice can be executed. Reading material - Obligatory literature - Literature developed by the Department Handouts and other online materials can be found on the departmental website ( - Notes - Recommended literature Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, 2009 Lectures 1 Introduction Dr. Lukács András Szilárd 2 Gas laws Dr. Lukács András Szilárd 3 Kinetic theory of gases Leipoldne Víg Andrea Teréz 4 Work: internal energy of a gas, definition of work and heat. Leipoldne Víg Andrea Teréz 5 Specific heat: relationship between heat and specific heat. The basics of calorimetry Leipoldne Víg Andrea Teréz 6 Enthalpy: definition of enthalpy, enthalpy at constant pressure. Leipoldne Víg Andrea Teréz 7 Entropy: classical approach of entropy.statistical approach of entropy Dr. Lukács András Szilárd 8 2nd law of thermodynamics Dr. Lukács András Szilárd 9 Gibbs free energy Dr. Lukács András Szilárd 10 Energetics of metabolism: the pathways of metabolism,connection to free energy Dr. Bódis Emőke 11 Protein structure, thermodynamics of folding Dr. Lukács András Szilárd 12 Cytoskeletal proteins Huberné Barkó Szilvia 20

21 13 Motor proteins Huberné Barkó Szilvia 14 Fluid flow Huber Tamás 15 Diffusion, osmosis Huber Tamás 16 Membrane structure Ujfalusi Zoltán 17 Membrane transport Ujfalusi Zoltán 18 Oscillatory motion Ujfalusi Zoltán 19 Waves: types and properties of waves. Interference, diffraction, standing waves Ujfalusi Zoltán 20 Electromagnetic waves Ujfalusi Zoltán 21 X-ray: generation and types of X-rays Leipoldne Víg Andrea Teréz 22 X-ray diffraction Leipoldne Víg Andrea Teréz 23 Biophysics of vision Dr. Kengyel András Miklós 24 Biophysics of hearing Dr. Kengyel András Miklós 25 Introduction to atomic physics Dr. Szabó-Meleg Edina 26 Atomic models Dr. Szabó-Meleg Edina 27 Photoelectric effect, Frank-Herz experiment Dr. Szabó-Meleg Edina 28 Introduction to quantum mechanics Dr. Lukács András Szilárd Practices Seminars Exam topics/questions The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the result different from failed ). Participants 21

22 OPO-Z1G Course director: PHYSICS-BIOPHYSICS 1 - PRACTICE DR. ANDRÁS SZILÁRD LUKÁCS, associate professor Department of Biophysics 2 credit midsemester grade Med.-biol. theoretical module and practical skills subject autumn semester recommended semester: 1 Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): Prerequisites: none Topic The aim of the course to help to deepen the knowledge gained from the Physics-Biophysics 1 theory. Conditions for acceptance of the semester Maximum of 25 % absence allowed Mid-term exams The students will have a test during the semester and they should have a satisfacatory result in order to be eligible for the exam. The grade of the test is the final grade of the course. Making up for missed classes The students can be absent for three times. There are three make-up labs at the end of the semester. Reading material - Obligatory literature Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, Literature developed by the Department Online materials on departmental website ( - Notes Biophysics Laboratory Manual, Pécs University Press, Pécs - Recommended literature P.W. Atkins and Loretta Jones: Chemical Principles Lectures Practices 1 Introduction. Laboratory safety rules 2 Introduction. Laboratory safety rules 3 Direct current measurements 4 Direct current measurements 5 Alternative current measurements 6 Alternative current measurements 7 Electric conductivity. Refractometry 8 Electric conductivity. Refractometry 9 Spectroscopy and spectrophotometry 10 Spectroscopy and spectrophotometry 11 Polarimetry 12 Polarimetry 13 Viscosity of fluids 14 Viscosity of fluids 15 Surface tension 16 Surface tension 17 Adsorption and swelling 18 Adsorption and swelling 19 Centrifugation 20 Centrifugation 21 Electrophoresis 22 Electrophoresis 23 Make-up lab, seminar 24 Make-up lab, seminar 22

23 25 Make-up lab, seminar 26 Make-up lab, seminar 27 Make-up lab, seminar 28 Make-up lab, seminar Seminars Exam topics/questions Participants Dr. Lukács András Szilárd (LUATAA0.PTE), Dr. Szabó-Meleg Edina (MEEDAA.T.JPTE), Huber Tamás (HUTEAB.T.JPTE), Szatmári Dávid (SZDHAAT.PTE), Ujfalusi Zoltán (UJZDAA.T.JPTE), Ujfalusi-Pozsonyi Kinga (POKAAA.T.JPTE) 23

24 OPR-ESE Course director: FIRST AID 0 credit signature Criterion requirement subject autumn semester recommended semester: 1 Number of hours/semester: 0 lectures + 6 practices + 8 seminars = total of 14 hours Course headcount limitations (min.-max.): Prerequisites: none DR. LAJOS BOGÁR, professor Department of Operational Medicine Topic To learn how to give the temporary help to an injured or a sick person before professional medical treatment can be provided. To get familiar with the timely assistance, comprising of simple medical and life saving techniques. Conditions for acceptance of the semester Signature Mid-term exams - Making up for missed classes It is possible to make up for missed classes by appointment. Reading material - Obligatory literature - Literature developed by the Department - Notes - Recommended literature Göbl Gábor: Oxyológia, Medicina Könyvkiadó, Budapest, Bogár Lajos: Érzéstelenítés - Esetfantáziák vészhelyzetekről medikusoknak és fiatal orvosoknak, Medicina Könyvkiadó, Budapest, Bogár Lajos: Intenzív - Egy pályakezdés esetfantáziái, Akadémiai Kiadó, Budapest, Lectures Practices 1 Patient examination 2 Recovery position and rescue technics 3 BLS 4 BLS AED 5 First aid in trauma 6 Comatose patient Seminars 1 First aid in general, emergency care systems 2 CPR 3 Chest and abdominal pain 4 First aid in trauma cases 5 Burns, frostbites, electrical shock 6 Poisoning 7 Stroke, head and spinal trauma 8 Convulsion, diabetes, allergy, fever Exam topics/questions Participants Dr. Bátai István (BAIMABO.PTE), Dr. Bogár Lajos (BOLGAAO.PTE), Dr. Csontos Csaba (CSCSAAP.PTE), Dr. Kiss Tamás (KITFAAO.PTE), Dr. Molnár Tihamér (MOTTAA0.PTE), Dr. Nagy Bálint János (NABGAAO.PTE), Dr. Nagy Judit (NAJFAAO.PTE), Dr. Szabó Zoltán (SZZFABP.PTE) 24

25 OPR-LAT Course director: PHARMACEUTICAL TERMINOLOGY 0 credit signature Criterion requirement subject autumn semester recommended semester: 1 Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): 3 50 Prerequisites: OPG-GPR parallel GABRIELLA HÁBEL, language teacher Department of Languages for Specific Purposes Topic This course will enable students to acquire the basic vocabulary of pharmaceutical Latin so that they can use it creatively in their future profession. Students will become acquainted with the - elements and formulae of prescribing, - main categories of common medicines in Latin and English, - routes of drug administration (absorption, inhalation, intramuscular...) - basic terminology alluding to drug preparations (liquid, semisolid, solid), - most frequently used abbreviations in prescriptions etc. Conditions for acceptance of the semester Two midterm tests Mid-term exams Making up for missed classes If appropriate, making up the midterm test is possible. Reading material - Obligatory literature - Literature developed by the Department - Notes - Recommended literature University Script Materials available on Neptun Lectures Practices 1 Introduction to pharmaceutical terminology. Significance of pharmaceutical terminology in practice. Greek and Latin word parts pertaining to drugs. 2 Introduction to pharmaceutical terminology. Significance of pharmaceutical terminology in practice. Greek and Latin word parts pertaining to drugs. 3 Routes of drug-administration (absorption, inhalation, oral, intravenous). 4 Routes of drug-administration (absorption, inhalation, oral, intravenous). 5 Drug preparations (liquid, semisolid). 6 Drug preparations (liquid, semisolid). 7 Terminology of the digestive system. Main categories of medicines and their actions concerning the gastrointestinal tract. 8 Terminology of the digestive system. Main categories of medicines and their actions concerning the gastrointestinal tract. 9 Vitamins. Classification. Terminology. 10 Vitamins. Classification. Terminology. 11 Terminology of the heart and circulation. Main categories of medicines and their actions concerning the cardiovascular system. 12 Terminology of the heart and circulation. Main categories of medicines and their actions concerning the cardiovascular system. 13 Test I. 14 Test I. 15 Terminology of the respiratory system. Main categories of medicines and their actions. 16 Terminology of the respiratory system. Main categories of medicines and their actions. 17 About asthma in a nut shell. Anti-inflammatory drugs and bronchodilators. Terminology (inhalers, nebulizers, pills). 18 About asthma in a nut shell. Anti-inflammatory drugs and bronchodilators. Terminology (inhalers, nebulizers, pills). 19 Therapeutic uses of herbal medicines. Parts of plants (nomina drogarum) 20 Therapeutic uses of herbal medicines. Parts of plants (nomina drogarum) 21 Introduction to prescriptions. Abbreviations used in prescriptions. 22 Introduction to prescriptions. Abbreviations used in prescriptions. 25

26 23 Reading and explanations of prescriptions. Pharmaceutical terminology in case reports. 24 Reading and explanations of prescriptions. Pharmaceutical terminology in case reports. 25 Summary and repetition. Exercises. 26 Summary and repetition. Exercises. 27 Test II. 28 Test II. Seminars Exam topics/questions - elements and formulae of prescribing - main categories of common medicines in Latin and English - routes of drug administration (absorption, inhalation, intramuscular) - basic terminology alluding to drug preparations (liquid, semisolid, solid) - most frequently used abbreviations in prescriptions Participants Hábel Gabriella (HAGTAAP.PTE) 26

27 ATT1 PHYSICAL EDUCATION 1 Course director: 0 credit signature Criterion requirement subject both semesters semester recommended semester: 1 Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): 2 50 Prerequisites: none The subject can only be registered in case of a PASSED and valid health aptitude test! TAMÁS TÉCZELY, physical education teacher UP MS Sports Facilities Topic This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to deepen the knowledge in the field of healthy lifestyle. Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and how to prevent the body from injuries. Conditions for acceptance of the semester Active participation at least 20 practical lessons provided by the Institute of Human Movement Sciences or regular participation of the trainings of the Medikus Sport Club or PEAC. Mid-term exams - Making up for missed classes We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the end of the teaching weeks with agreement of the PE Teacher. Reading material - Obligatory literature - Literature developed by the Department Not available. - Notes Recommended literature Lectures Practices 1-28 For the list of actual courses please turn to the end of this document Seminars Exam topics/questions Participants Farkas György (FAGMAAO.PTE), Lipcsik Zoltán (LIZIAAT.PTE), Németh Attila Miklós (NEAGAET.PTE), Téczely Tamás (PETLAAT.PTE) 27

28 OPA-B2E Course director: BIOMATHEMATICS 2 - THEORY DR. BEÁTA BUGYI, associate professor Department of Biophysics 2 credit semester exam Basic subject spring semester recommended semester: 2 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): Prerequisites: OPA-B1E completed + OPA-B2G parallel Topic Basic data handling and computer use. Exploring data by graphical and numerical characterisation. Basic concepts of probability and statistical inference. The basic methods for statistical inference most frequently used in medicine. Conditions for acceptance of the semester Maximum of 25 % absence allowed Mid-term exams Two tests during the semester. Making up for missed classes Discussed with the course leader. Reading material - Obligatory literature - Literature developed by the Department - Notes József Belágyi: Medical Biometry, textbook - Recommended literature Lectures 1 Introduction Dr. Hild Gábor 2 Introduction Dr. Hild Gábor 3 The applied methods, Experimental data analysis, Histogram Dr. Hild Gábor 4 The applied methods, Experimental data analysis, Histogram Dr. Hild Gábor 5 The characteristics of population and sample, Elements of standard error calculation, Probability Dr. Hild Gábor 6 The characteristics of population and sample, Elements of standard error calculation, Probability Dr. Hild Gábor 7 Discrete and continuous distributions Dr. Hild Gábor 8 Discrete and continuous distributions Dr. Hild Gábor 9 Statistical hypothesis testing: the sign test Dr. Hild Gábor 10 Statistical hypothesis testing: the sign test Dr. Hild Gábor 11 Statistical hypothesis testing: the u-test Dr. Hild Gábor 12 Statistical hypothesis testing: the u-test Dr. Hild Gábor 13 Analysis of the means with t-test Dr. Hild Gábor 14 Analysis of the means with t-test Dr. Hild Gábor 28

29 15 The chi-squere test and its application Dr. Bugyi Beáta 16 The chi-squere test and its application Dr. Bugyi Beáta 17 Analysis of variance Dr. Bugyi Beáta 18 Analysis of variance Dr. Bugyi Beáta 19 Regression analysis Dr. Bugyi Beáta 20 Regression analysis Dr. Bugyi Beáta 21 Least squares principle Dr. Bugyi Beáta 22 Least squares principle Dr. Bugyi Beáta 23 Correlation analysis. Rank correlation Dr. Bugyi Beáta 24 Correlation analysis. Rank correlation Dr. Bugyi Beáta 25 Survival analysis. The logrank test Dr. Bugyi Beáta 26 Survival analysis. The logrank test Dr. Bugyi Beáta 27 Summary Dr. Bugyi Beáta 28 Summary Dr. Bugyi Beáta Practices Seminars Exam topics/questions The exam consists of problem solving related to the topics of lectures and practices, using tables and making graphs using computers. The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the result different from failed ). Participants 29

30 OPA-B2G Course director: BIOMATHEMATICS 2 - PRACTICE 2 credit midsemester grade Basic subject spring semester recommended semester: 2 Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours Course headcount limitations (min.-max.): Prerequisites: OPA-B1E completed DR. BEÁTA BUGYI, associate professor Department of Biophysics Topic Basic data handling and computer use. Exploring data by graphical and numerical characterisation. Basic concepts of probability and statistical inference. The basic methods for statistical inference most frequently used in medicine. Conditions for acceptance of the semester Maximum of 25 % absence allowed Mid-term exams Two tests during the semester. Making up for missed classes Discussed with the course leader. Reading material - Obligatory literature - Literature developed by the Department biofizika.aok.pte.hu - Notes József Belágyi: Medical Biometry, textbook Recommended literature Lectures Practices 1 Introduction 2 Introduction 3 The applied methods, Experimental data analysis, Histogram 4 The applied methods, Experimental data analysis, Histogram 5 The characteristics of population and sample, Elements of standard error calculation, Probability 6 The characteristics of population and sample, Elements of standard error calculation, Probability 7 Discrete and continuous distributions 8 Discrete and continuous distributions 9 Statistical hypothesis testing: the sign test 10 Statistical hypothesis testing: the sign test 11 Statistical hypothesis testing: the u-test 12 Statistical hypothesis testing: the u-test 13 Analysis of the means with t-test 14 Analysis of the means with t-test 15 The chi-squere test and its application 16 The chi-squere test and its application 17 Analysis of variance 18 Analysis of variance 19 Regression analysis 20 Regression analysis 21 Least squares principle 22 Least squares principle 23 Correlation analysis. Rank correlation 24 Correlation analysis. Rank correlation 25 Survival analysis. The logrank test 26 Survival analysis. The logrank test 27 Summary 28 Summary 30