Krishna Kattel, Ph.D.

Transcription

1 Postdoctoral Research Associate Department of Pharmaceutical Sciences University of Nebraska Medical Center Omaha, NE Tel: (Office) (H.P.) . krishna.kattel@unmc.edu kattel.krishna@gmail.com EDUCATION Krishna Kattel, Ph.D Ph. D. Nano Material Chemistry, Kyungpook National University, Daegu, Republic of Korea (Supervisor: Prof. Gang Ho Lee) 2002 M. Sc. Inorganic Chemistry, Tribhuvan University, Kathmandu, Nepal 2000 B.Sc. Science (Chemistry and Biology), Tribhuvan University, Bharatpur, Nepal RESEARCH AND PROFESSIONAL EXPERIENCE Present Postdoctoral Research Associate, Department of Pharmaceutical Sciences, University of Nebraska Medical Center (UNMC), Omaha, NE, USA (Supervisor: Prof. Ram I. Mahato) Postdoctoral research associate, Institute of Integrated Cell Material Sciences (icems), Kyoto University, Kyoto, Japan (Supervisor: Prof. Franklin Kim) TEACHING EXPERIENCE Lecturer, Head/Department of Chemistry, St. Mary s College, Kathmandu, Nepal Asst. Lecturer, Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu, Nepal Lecturer, Department of Chemistry, Capital College and Research Center (CCRC), Kathmandu, Nepal HONORS AND AWARDS KNU Honor Scholarship (KHS), Ministry of Education, Republic of Korea, June PUBLICATIONS 1. Kattel, K.; Park, J. Y.; Xu, W.; Bony, B. A.; Heo, W. C.; Tegafaw, T.; Kim, C. R.; Ahmad, M. W.; Jin, S.; Baeck, J. S.; Chang, Y, Kim, T. J.; Bae, J. E.; Chae, K. S.; Jeong, J. Y.; Lee, G. H. Surface Coated Eu(OH)3 Nanorods: A Facile Synthesis, Characterization, MR Relaxivities and In Vitro Cytotoxicity. Journal of Nanoscience and Nanotechnology 2013, 13,

2 2. Xu, W.; Park, J. Y.; Kattel, K.; Ahmad, M.W.; Bony, B. A.; Heo, W. C.; Jin, S.; Park, J. W.; Chang, Y.; Kim, T. J.; Park, J. A.; Do, J. Y.; Chae, K. S.; Lee, G. H. Fluorescein - Polyethyleneimine Coated Gadolinium Oxide Nanoparticles as T1 Magnetic Resonance Imaging (MRI)-Cell Labeling (CL) Dual Agents. RSC Advances 2012, 2, Xu, W.; Park, J. Y.; Kattel, K.; Bony, B. A.; Heo, W. C.; Jin, S.; Park, J. W.; Chang, Y.; Do, J. Y.; Chae, K. S.; Kim, T. J.; Park, J. A.; Kwak, Y. W.; Lee, G. H. A T1, T2 Magnetic Resonance Imaging (MRI)-Fluorescent Imaging (FI) By Using Ultrasmall Mixed Gadolinium-Europium Oxide Nanoparticles. New Journal of Chemistry 2012, 36, Xu, W. ; Kattel, K. ; Park, J. Y. ; Chang, Y.; Kim, T. J.; Lee, G. H. Paramagnetic Nanoparticle T1 and T2 MRI Contrast Agents. Phys. Chem. Chem. Phys 2012, 14, [ authors have equal contribution]. 5. Kattel, K.; Park, J. Y.; Xu, W.; Kim, H. G.; Lee, E. J.; Bony, B. A.; Heo, W. C.; Jin, S.; Baeck, J. S.; Chang, Y., Kim, T. J.; Bae, J. E.; Chae, K. S.; Lee, G. H. Paramagnetic Dysprosium Oxide Nanoparticles and Dysprosium Hydroxide Nanorods as new T2 MRI contrast agent. Biomaterials 2012, 33, Kattel, K.; Park, J. Y.; Xu, W.; Kim, H. G.; Lee, E. J.; Bony, B. A.; Heo, W. C.; Chang, Y., Kim, T. J.; Do, J. Y.; Chae, K. S.; Kwak, Y. W.; Lee, G. H. Water Soluble Ultrasmall Eu2O3 Nanoparticles as a Fluorescent Imaging Agent: In Vitro and In Vivo Studies. Colloids and Interfaces A: Physiochemical and Engineering Aspects 2012, 394, Kattel, K.; Park, J. Y.; Xu, W.; Kim, H. G.; Lee, E. J.; Bony, B. A.; Heo, W. C.; Lee, J. J.; Jin, S.; Baeck, J. S.; Chang, Y., Kim, T. J.; Bae, J. E.; Chae, K. S.; Lee, G. H. A Facile Synthesis, In Vitro and In Vivo MR Studies of D-glucuronic Acid Coated Ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho and Er) Nanoparticles as a New potential MRI Contrast Agent. ACS Applied Materials and Interfaces, 2011, 3, Park, J. Y.; Kattel, K.; Xu, W.; Kim, H. G.; Lee, E. J.; Chang, Y., Kim T. J.; Lee, G. H. Longitudinal Water Proton Relaxivities of Gd(OH)3 Nanoparticles, Gd(OH)3 Nanoparticles, and Gd2O3 Nanoparticles: Dependence on Particle Diameter, Composition and Morphology Journal of Korean Physical Society, 2011, 59, Baek, M. J.; Park, J. Y.; Xu, W.; Kattel, K; Kim, H. G.; Lee, E. J.; Patel, A. K.; Lee, J. J.; Chang, Y.; Kim, T. J.; Bae, J. E.; Chae, K. S.; Lee, G. H. Water Soluble MnO Nanocolloid for a Molecular T1 MR Imaging: A Facile One Pot Synthesis, In vivo T1 MR Images, and Account for Relaxivities. ACS Applied Materials and Interfaces, 2010, 2, Choi, E. S.; Park, J. Y.; Kattel, K.; Xu, W.; Lee, G. H.; Baek, M. J.; Kim, J. H.; Chang, Y.; Kim, T. J. Longitudinal Water proton Relaxivity of 3d and 4f Transitional Metal Oxide Nanoparticles. Journal of Korean Physical Society, 2010, 56, Choi, E. S.; Park, J. Y.; Baek, M. J.; Xu, W.; Kattel, K.; Kim, J. H.; Lee, J. J.; Chang, Y.; Kim, T. J.; Bae, J. E.; Chae, K. S.; Suh, K. J.; Lee, G. H. Water Soluble Ultra- Small Manganese Oxide Surface Doped Gadolinium Oxide (Gd2O3@MnO) Nanoparticles for MRI Contrast Agent. Europian Journal of Inorganic Chemistry, 2010,

3 PRESENTATIONS INTERNATIONAL CONFERENCES 1. Krishna Kattel Ultrasmall Metal Oxide Nanoparticles as Advanced Magnetic Resonance Imaging Contrast Agent and Fluorescent Imaging Agent April 19, 2013, Kyoto University, Kyoto, Japan (Oral Session). 2. Krishna Kattel, Ja Young Park, Wenlong Xu, Badrul Bony Alam, Woo Cheol Heo, Tirusew Tegafaw, Gang Ho Lee. Synthesis, Characterization, In Vitro and In Vivo MR Studies of Dy(OH)3 Nanostructures for T2 MRI Contrast Agent. International Society for Magnetic Resonance in Medicine (ISMRM) 20 th Annual Meeting and Exhibition (Abstract no. 4339), May 2012, Melbourne, Australia. 3. Badrul Alam Bony, Ja Young Park, Krishna Kattel, Wenlong Xu, Woo Cheol Heo, Tirusew Tegafaw and Gang Ho Lee. Manganese Oxide Dped Gadolinium Oxide Nanoparticles for both T1 and T2 MRI Contrast Agent International Society for Magnetic Resonance in Medicine (ISMRM) 20 th Annual Meeting and Exhibition (Abstract no. 4081), May 2012, Melbourne, Australia. 4. Woo Cheol Heo, Ja Young Park, Krishna Kattel, Wenlong Xu, Tirusew Tegafaw Mengesha, Badrul Alam Bony and Gang Ho Lee. Synthesis and Characterization of Ultrasmall Gadolinium Oxide Nanoparticles for Advanced T1 MRI Contrast Agent International Society for Magnetic Resonance in Medicine (ISMRM) 20 th Annual Meeting and Exhibition (Abstract no. 4083), May 2012, Melbourne, Australia. 5. Ja Young Park, Krishna Kattel, Wenlong Xu, Badrul Alam Bony, Woo Cheol Heo, Tirusew Tegafaw Mengesha and Gang Ho Lee. Synthesis and Properties of Gadolinium Iodate Nanoparticles as a MRI/CT Contrast Agent International Society for Magnetic Resonance in Medicine (ISMRM) 20 th Annual Meeting and Exhibition (Abstract no. 4086), May 2012, Melbourne, Australia. 6. Wenlong Xu, Krishna Kattel, Ja Young Park, Badrul Alam Bony, Woo Cheol Heo, Tirusew Tegafaw Mengesha and Gang Ho Lee. Single Phase Ultrasmall GdEuO3 Nanoparticles as Dual Imaging Agent: T1 MRI-Fluorescence Imaging Agent International Society for Magnetic Resonance in Medicine (ISMRM) 20 th Annual Meeting and Exhibition (Abstract no. 4079), May 2012, Melbourne, Australia. 7. Krishna Kattel, Wenlong Xu, Badrul Alam Bony, Wasi Ahmad, Tirusew Tegafaw Cho Rong Kim and Gang Ho Lee, Surface coated Eu(OH)3 nanorods: Synthesis, characterization, MR relaxivities and in vitro cytotoxicities. The 10 th International Nanotec Symposium & Exhibition, August 2012, Coex, Seoul, Republic of Korea. 8. Krishna Kattel, Ja Young Park, Wenlong Xu, Eun Jeong Lee, Han Gyeol Kim, Gang Ho Lee, Synthesis and Characterization of D-glucuronic Acid Coated Dy2O3 Nanoparticles for Magnetic Resonance Imaging (MRI) Contrast Agent. International Society for Magnetic Resonance in Medicine (ISMRM) 19 th Annual Meeting and Exhibition (Abstract no. 3704), May 2011, Montreal, Quebec, Canada. 9. Krishna Kattel, Ja Young Park, Wenlong Xu, Bony Badrul Alam, Han Gyeol Kim, Eun Jeong Lee, Woo Cheol Heo, Surface Coated Ultrasmall Dysprosium Oxides Nanoparticles for Magnetic Resonance Imaging (MRI) Contrast Agent. The 9 th 3

4 International Nanotec Symposium &Exhibition, August 2011, Kintex, Seoul. 10. Eun Jeong Lee, Ja Young Park, Wenlong Xu, Krishna Kattel, Han Gyeol Kim and Gang Ho Lee, Water-soluble MnO nanocolloid for a Molecular T1 MR Imaging: A Facile One Pot Synthesis, In vivo T1 MR Images and Account for Relaxivities. International Society for Magnetic Resonance in Medicine (ISMRM) 19 th Annual Meeting and Exhibition (Abstract no. 3705), May 2011, Montreal, Quebec, Canada. NATIONAL CONFERENCES 1. Krishna Kattel, Ja Young Park, Wenlong Xu, Han Gyeol Kim, Eun Jeong Lee, Anil Kumar Kantilal Patel, Gang Ho Lee, Synthesis, Characterization, In Vitro and In Vivo Study of D-glucuronic Acid Coated Dysprosium Oxides Nanoparticles for T2 MRI Contrast Agent. The 108 th Autumn Meeting of the Korean Chemical Society, September 28-30, 2011, Daejeon, Republic of Korea. 2. Krishna Kattel, Ja Young Park, Badrul Alam Bony, Han Gyeol Kim, Eun Jeong Lee, Woo Cheol Heo, Gang Ho Lee, Synthesis and Characterization of Dysprosium Oxides Nanoparticles for Magnetic Resonance Imaging (MRI) Contrast Agent. The 107 th National Meeting of the Korean Chemical Society, April 28-29, 2011, Jeju, Republic of Korea. 3. Woo Cheol Heo, Ja Young Park, Krishna Kattel, Wenlong Xu, Han Gyeol Kim, Eun Jeong Lee, Badrul Alam Bony, Gang Ho Lee, Salt Effect on the Physical Properties of Magnetic Nanoparticles Synthesized at Different NaCl Concenrations The 107 th National Meeting of the Korean Chemical Society, April 28-29, 2011, Jeju, Republic of Korea. 4. Han Gyeol Kim, Jeong Il Park, Ja Young Park, Krishna Kattel, Wenlong Xu, Eun Jeong Lee, Badrul Alam Bony, Woo Cheol Heo, Gang Ho Lee, Dispersion Stability of Aluminium Nanoparticles in Organic Solvent with Polymeric Dispersant The 107 th National Meeting of the Korean Chemical Society, April 28-29, 2011, Jeju, Republic of Korea. 5. Eun Jeong Lee, Wenlong Xu, Krishna Kattel, Ja Young Park, Han Gyeol Kim, Woo Cheol Heo, Badrul Alam Bony, Gang Ho Lee, Synthesis of Water Soluble Gadolinium Iodate Nanoparticles for MRI Contrast Agent The 107 th National Meeting of the Korean Chemical Society, April 28-29, 2011, Jeju, Republic of Korea. 6. Krishna Kattel, Ja Young Park, Wenlong Xu, Myung Ju Baeck, Gang Ho Lee, Synthesis and Characterization of Lanthanide Oxides Nanoparticles. The 105 th National Meeting of the Korean Chemical Society, April 29-30, 2010, Incheon, Republic of Korea. 7. Eun Jeong Lee, Anil Patel, Ja Young Park, Krishna Kattel, Wenlong Xu, Han Gyeol Kim, Gang Ho Lee, Synthesis and Characterization and In Vivo study of Antibody Conjugated Gadolinium Oxides Nanoparticles. The 106 th National Meeting of the Korean Chemical Society, October 14-15, 2010, Daegu, Republic of Korea. 8. Krishna Kattel, Ja Young Park, Wenlong Xu, Han Gyeol Kim, Eun Jeong Lee, Anil Patel, Gang Ho Lee, Synthesis and Characterization of D-glucuronic acid coated Lanthanide Oxides Nanoparticles for Magnetic Resonance Imaging (MRI). The 106 th 4

5 National Meeting of the Korean Chemical Society, October 14-15, 2010, Daegu, Republic of Korea. 9. Wenlong Xu, Krishna Kattel, Ja Young Park, Han Gyeol Kim, Eun Jeong Lee, Anil Patel, Gang Ho Lee, Magnetic and Water Proton Relaxivity Properties of Gadolinium Oxide Nanoparticles. The 106 th National Meeting of the Korean Chemical Society, October 14-15, 2010, Daegu, Republic of Korea. ANALYTICAL SKILLSET Inductively coupled plasma spectrophotometer, UV-visible spectrophotometer, Fluorescent spectrometry, FT-IR spectrophotometer, High resolution transmission electron microscopy, (HRTEM), Atomic force microscopy (AFM), Triple quadruple tandem mass spectrometer Confocal laser scanning microscopy, Field emission scanning electron microscopy (FESEM), Fluorescent microscopy Energy-dispersive x-ray spectroscopy, Dynamic light scattering particle size analyzer, Zeta potential analyzer, Thermogravemetric analyzer, High performance liquid chromatography (HPLC), Superconducting quantum interference device- SQUID magnetometer, X-ray diffractometer, MRI scanner. Cell culture, RNA extraction, qrt-pcr, Gel electrophoresis, Western blot, PK/PD modeling and simulations, WinNonlin Pharsight. RESEARCH EXPERTISE Synthesis and Modification of Nanocrystals, Nanosheets, Nanorods and Nanowires Solution-phase synthesis of inorganic nanocrystals, (metal oxides such as 3d and 4f metal oxides), graphene oxide, MoS2 and WS2 nanosheets, metal and metal hydroxide nanorods, gold and silica nanoparticles, modification and functionalization of inorganic nanomaterials. Understanding and Preliminary Interpretation on Bio-imaging Magnetic resonance imaging (MRI) assisted by metal oxide nanocrystals Fluorescent imaging (FI) using europium nanomaterials Drug Delivery Applications of Polymeric Micelles Synthesis of polymers, conjugation of various anticancer drugs, suitable mirna, and targeting agents for in vitro and in vivo therapeutic applications. Bio-distribution and Pharmacokinetics Analytical method development for the quantification of drugs and metabolites, investigating the pharmacokinetics/bio-distribution and PK/PD relationships of novel therapeutics in preclinical model/clinical samples. 5

6 PROFESSIONAL MEMBERSHIP American Association of Pharmaceutical Scientists (AAP) 2014 Korean Chemical Society (KCS) Nepal Chemical Society PERSONAL DETAILS Date of Birth January 14, 1979 Marital Status Married Nationality Nepal REFERENCES Ram I. Mahato, Ph.D. Chair/Professor, Department of Pharmaceutical Sciences University of Nebraska Medical Center, Omaha, NE Phone: Gang Ho Lee, Ph.D Professor, Department of Chemistry College of Natural Sciences Kyungpook National University, Daegu, Republic of Korea Phone: Fax: Franklin Kim, Ph.D. Professor, Institute of Integrated Cell-Material Sciences (icems) World Premier International Research Institute, Kyoto University, Kyoto, Japan Phone: Yongmin Chang, Ph.D. Professor, Department of Molecular Medicine School of Medicine, Kyungpook National University, Daegu, Republic of Korea Phone: Jeffery E. Shield, Ph.D Chair/Robert W. Brightfelt Professor of Engineering Department of Mechanical and Materials Engineering University of Nebraska Lincoln, NE Phone: