In vivo analysis of Trk receptor signalling in the mouse nervous system Postigo, Juan Antonio
|
|
- Amie Ryan
- 5 years ago
- Views:
Transcription
1 University of Groningen In vivo analysis of Trk receptor signalling in the mouse nervous system Postigo, Juan Antonio IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2001 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Postigo, J. A. (2001). In vivo analysis of Trk receptor signalling in the mouse nervous system Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:
2 REFERENCE LIST -Abercrombie, M. (1946). Estimation of nuclear populations from microtome sections. Anat. Rec. 94, Airaksinen, M. S., Koltzenburg, M., Lewin, G. R., Masu, Y., Helbig, C., Wolf, E., Brem, G., Toyka, K. V., Thoenen, H., and Meyer, M. (1996). Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16, Alcantara, S., Frisen, J., del Rio, J. A., Soriano, E., Barbacid, M., and Silos-Santiago, I. (1997). TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomyinduced cell death. J Neurosci 17, Alsina, B., Vu, T., and Cohen-Cory, S. (2001). Visualizing synapse formation in arborizing optic axons in vivo: dynamics and modulation by BDNF. Nat Neurosci 4, Altar, C. A. (1999). Neurotrophins and depression. Trends Pharmacol Sci 20, _ Aoki, C., Wu, K., Elste, A., Len, G., Lin, S., McAuliffe, G., and Black, I. B. (2000). Localization of brainderived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex. J Neurosci Res 59, Araki, T., Yamada, M., Ohnishi, H., Sano, S., Uetsuki, T., and Hatanaka, H. (2000). Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons. J Neurochem 74, Arenas, E., and Persson, H. (1994). Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo. Nature 367, Atwal, J. K., Massie, B., Miller, F. D., and Kaplan, D. R. (2000). The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron 27, Barbacid, M. (1994). The Trk family of neurotrophin receptors. J Neurobiol 25, Baxter, R. M., Secrist, J. P., Vaillancourt, R. R., and Kazlauskas, A. (1998). Full activation of the plateletderived growth factor beta-receptor kinase involves multiple events. J Biol Chem 273, Belliveau, D. J., Krivko, I., Kohn, J., Lachance, C., Pozniak, C., Rusakov, D., Kaplan, D., and Miller, F. D. (1997). NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis. J Cell Biol 136, Benedetti, M., Levi, A., and Chao, M. V. (1993). Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc Natl Acad Sci U S A 90, Berg, M. M., Sternberg, D. W., Hempstead, B. L., and Chao, M. V. (1991). The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF- induced tyrosine phosphorylation. Proc Natl Acad Sci U S A 88, Berglund, A. M., and Ryugo, D. K. (1986). A monoclonal antibody labels type II neurons of the spiral ganglion. Brain Res 383, Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V., and Rosenthal, A. (1991). Neurotrophin-5: a novel neurotrophic factor that activates trk and trkb. Neuron 7, Bianchi, L. M., Conover, J. C., Fritzsch, B., DeChiara, T., Lindsay, R. M., and Yancopoulos, G. D. (1996). Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice. Development 122, Bibel, M., and Barde, Y. A. (2000). Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14, Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., and Greenberg, M. E. (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, Brady, R., Zaidi, S. I., Mayer, C., and Katz, D. M. (1999). BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons. J Neurosci 19, Butte, M. J., Hwang, P. K., Mobley, W. C., and Fletterick, R. J. (1998). Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry 37, Carroll, P., Lewin, G. R., Koltzenburg, M., Toyka, K. V., and Thoenen, H. (1998). A role for BDNF in mechanosensation. Nat Neurosci 1,
3 -Clary, D. O., and Reichardt, L. F. (1994). An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. Proc Natl Acad Sci U S A 91, Cohen, S., and Levi-Montalcini, R. (1956). A nerve growth stimulating factor, isolated from snake venom. Proc. Natl. Acad. Sci. 42, Cohen-Cory, S., and Fraser, S. E. (1995). Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo. Nature 378, Conover, J. C., Erickson, J. T., Katz, D. M., Bianchi, L. M., Poueymirou, W. T., McClain, J., Pan, L., Helgren, M., Ip, N. Y., Boland, P., and et al. (1995). Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature 375, Cordon-Cardo, C., Tapley, P., Jing, S. Q., Nanduri, V., O'Rourke, E., Lamballe, F., Kovary, K., Klein, R., Jones, K. R., Reichardt, L. F., and et al. (1991). The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 66, Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, Crowley, C., Spencer, S. D., Nishimura, M. C., Chen, K. S., Pitts-Meek, S., Armanini, M. P., Ling, L. H., MacMahon, S. B., Shelton, D. L., Levinson, A. D., and et al. (1994). Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76, Datta, S. R., Brunet, A., and Greenberg, M. E. (1999). Cellular survival: a play in three Akts. Genes Dev 13, Davies, A. M. (1996). The neurotrophic hypothesis: where does it stand? Philos Trans R Soc Lond B Biol Sci 351, Davies, A. M. (1997). Neurotrophin switching: where does it stand? Curr Opin Neurobiol 7, Davies, A. M., Minichiello, L., and Klein, R. (1995). Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons. Embo J 14, Dobrowsky, R. T., Jenkins, G. M., and Hannun, Y. A. (1995). Neurotrophins induce sphingomyelin hydrolysis. Modulation by co- expression of p75ntr with Trk receptors. J Biol Chem 270, Drake, C. T., Milner, T. A., and Patterson, S. L. (1999). Ultrastructural localization of full-length trkb immunoreactivity in rat hippocampus suggests multiple roles in modulating activity- dependent synaptic plasticity. J Neurosci 19, Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. (1997). Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, Eide, F. F., Vining, E. R., Eide, B. L., Zang, K., Wang, X. Y., and Reichardt, L. F. (1996). Naturally occurring truncated trkb receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J Neurosci 16, Enokido, Y., Wyatt, S., and Davies, A. M. (1999). Developmental changes in the response of trigeminal neurons to neurotrophins: influence of birthdate and the ganglion environment. Development 126, Erickson, J. T., Conover, J. C., Borday, V., Champagnat, J., Barbacid, M., Yancopoulos, G., and Katz, D. M. (1996). Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. J Neurosci 16, Ernfors, P., Merlio, J.P. and Persson, H. (1992). Cells expressing mrna for neurotrophins and their receptors during embryonic rat developent. Eur. J. Neurosci. 4, Ernfors, P., Lee, K. F., and Jaenisch, R. (1994). Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368, Ernfors, P., Lee, K. F., Kucera, J., and Jaenisch, R. (1994). Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77, Ernfors, P., Van De Water, T., Loring, J., and Jaenisch, R. (1995). Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14,
4 -Fan, G., Egles, C., Sun, Y., Minichiello, L., Renger, J. J., Klein, R., Liu, G., and Jaenisch, R. (2000). Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities. Nat Neurosci 3, Farinas, I., Jones, K. R., Backus, C., Wang, X. Y., and Reichardt, L. F. (1994). Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369, Farinas, I., Jones, K. R., Tessarollo, L., Vigers, A. J., Huang, E., Kirstein, M., de Caprona, D. C., Coppola, V., Backus, C., Reichardt, L. F., and Fritzsch, B. (2001). Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci 21, Farinas, I., Wilkinson, G. A., Backus, C., Reichardt, L. F., and Patapoutian, A. (1998). Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron 21, Fritzsch, B., Barbacid, M., and Silos-Santiago, I. (1998). The combined effects of trkb and trkc mutations on the innervation of the inner ear. Int J Dev Neurosci 16, Fritzsch, B., Farinas, I., and Reichardt, L. F. (1997). Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion. J Neurosci 17, Fritzsch, B., and Nichols, D. H. (1993). DiI reveals a prenatal arrival of efferents at the differentiating otocyst of mice. Hear Res 65, Fritzsch, B., Pirvola, U., and Ylikoski, J. (1999). Making and breaking the innervation of the ear: neurotrophic support during ear development and its clinical implications. Cell Tissue Res 295, Fritzsch, B., Silos-Santiago, I., Bianchi, L. M., and Farinas, I. (1997). The role of neurotrophic factors in regulating the development of inner ear innervation. Trends Neurosci 20, Funakoshi, H., Frisen, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V. M., and Persson, H. (1993). Differential expression of mrnas for neurotrophins and their receptors after axotomy of the sciatic nerve. J Cell Biol 123, Gage, F. H. (2000). Mammalian neural stem cells. Science 287, Garner, A. S., Menegay, H. J., Boeshore, K. L., Xie, X. Y., Voci, J. M., Johnson, J. E., and Large, T. H. (1996). Expression of TrkB receptor isoforms in the developing avian visual system. J Neurosci 16, Ghosh, A., and Greenberg, M. E. (1995). Distinct roles for bfgf and NT-3 in the regulation of cortical neurogenesis. Neuron 15, Glass, D. J., Nye, S. H., Hantzopoulos, P., Macchi, M. J., Squinto, S. P., Goldfarb, M., and Yancopoulos, G. D. (1991). TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Cell 66, Gu, H., Zou, Y. R., and Rajewsky, K. (1993). Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, Guiton, M., Gunn-Moore, F. J., Glass, D. J., Geis, D. R., Yancopoulos, G. D., and Tavare, J. M. (1995). Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling. J Biol Chem 270, Hallbook, F. (1999). Evolution of the vertebrate neurotrophin and Trk receptor gene families. Curr Opin Neurobiol 9, Hallbook, F., Ibanez, C. F., and Persson, H. (1991). Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6, Hamburger, V. (1934). The effects of wing bud extirpation on the development of the central nervous system in chick embryos. J. Exp. Zool. 68, Hamburger, V. (1992). History of the discovery of neuronal death in embryos. J Neurobiol 23, Hamburger, V. (1993). The history of the discovery of the nerve growth factor. J Neurobiol 24, Hamburger, V. a. L.-M., R. (1949). Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. J Exp. Zool. 111, Heldin, C. H. (1995). Dimerization of cell surface receptors in signal transduction. Cell 80, Henderson, C. E. (1996). Role of neurotrophic factors in neuronal development. Curr Opin Neurobiol 6,
5 -Henderson, C. E., Camu, W., Mettling, C., Gouin, A., Poulsen, K., Karihaloo, M., Rullamas, J., Evans, T., McMahon, S. B., Armanini, M. P., and et al. (1993). Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363, Hetman, M., Kanning, K., Cavanaugh, J. E., and Xia, Z. (1999). Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem 274, Heumann, R. (1994). Neurotrophin signalling. Curr Opin Neurobiol 4, Hofer, M. M., and Barde, Y. A. (1988). Brain-derived neurotrophic factor prevents neuronal death in vivo. Nature 331, Hohn, A., Leibrock, J., Bailey, K., and Barde, Y. A. (1990). Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344, Holgado-Madruga, M., Moscatello, D. K., Emlet, D. R., Dieterich, R., and Wong, A. J. (1997). Grb2- associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc Natl Acad Sci U S A 94, Holtzman, D. M., Li, Y., Parada, L. F., Kinsman, S., Chen, C. K., Valletta, J. S., Zhou, J., Long, J. B., and Mobley, W. C. (1992). p140trk mrna marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron 9, Houenou, L. J., Li, L., Lo, A. C., Yan, Q., and Oppenheim, R. W. (1994). Naturally occurring and axotomyinduced motoneuron death and its prevention by neurotrophic agents: a comparison between chick and mouse. Prog Brain Res 102, Huang, E. J., and Reichardt, L. F. (2001). Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24, Huang, E. J., Wilkinson, G. A., Farinas, I., Backus, C., Zang, K., Wong, S. L., and Reichardt, L. F. (1999). Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development 126, Hubbard, S. R. (2001). Theme and variations: juxtamembrane regulation of receptor protein kinases. Mol Cell 8, Jacobson, M. D., Weil, M., and Raff, M. C. (1997). Programmed cell death in animal development. Cell 88, Jing, S., Tapley, P., and Barbacid, M. (1992). Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron 9, Johnson, D., Lanahan, A., Buck, C. R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., and Chao, M. (1986). Expression and structure of the human NGF receptor. Cell 47, Jones, K. R., Farinas, I., Backus, C., and Reichardt, L. F. (1994). Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76, Jones, L. L., Oudega, M., Bunge, M. B., and Tuszynski, M. H. (2001). Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. J Physiol 533, Jungbluth, S., Koentges, G., and Lumsden, A. (1997). Coordination of early neural tube development by BDNF/trkB. Development 124, Kafitz, K. W., Rose, C. R., Thoenen, H., and Konnerth, A. (1999). Neurotrophin-evoked rapid excitation through TrkB receptors. Nature 401, Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., and Parada, L. F. (1991). The trk protooncogene product: a signal transducing receptor for nerve growth factor. Science 252, Kaplan, D. R., Martin-Zanca, D., and Parada, L. F. (1991). Tyrosine phosphorylation and tyrosine kinase activity of the trk proto- oncogene product induced by NGF. Nature 350, Kaplan, D. R., and Miller, F. D. (2000). Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10, Kaplan, D. R., and Miller, F. D. (1997). Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol 9, Klein, R., Jing, S. Q., Nanduri, V., O'Rourke, E., and Barbacid, M. (1991). The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65,
6 -Klein, R., Lamballe, F., Bryant, S., and Barbacid, M. (1992). The trkb tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 8, Klein, R., Parada, L. F., Coulier, F., and Barbacid, M. (1989). trkb, a novel tyrosine protein kinase receptor expressed during mouse neural development. Embo J 8, Klein, R., Silos-Santiago, I., Smeyne, R. J., Lira, S. A., Brambilla, R., Bryant, S., Zhang, L., Snider, W. D., and Barbacid, M. (1994). Disruption of the neurotrophin-3 receptor gene trkc eliminates la muscle afferents and results in abnormal movements. Nature 368, Klein, R., Smeyne, R. J., Wurst, W., Long, L. K., Auerbach, B. A., Joyner, A. L., and Barbacid, M. (1993). Targeted disruption of the trkb neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75, Knipper, M., Kopschall, I., Rohbock, K., Kopke, A. K., Bonk, I., Zimmermann, U., and Zenner, H. (1997). Transient expression of NMDA receptors during rearrangement of AMPA- receptor-expressing fibers in the developing inner ear. Cell Tissue Res 287, Kohara, K., Kitamura, A., Morishima, M., and Tsumoto, T. (2001). Activity-dependent transfer of brainderived neurotrophic factor to postsynaptic neurons. Science 291, Koliatsos, V. E., Cayouette, M. H., Berkemeier, L. R., Clatterbuck, R. E., Price, D. L., and Rosenthal, A. (1994). Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons. Proc Natl Acad Sci U S A 91, Koliatsos, V. E., Clatterbuck, R. E., Winslow, J. W., Cayouette, M. H., and Price, D. L. (1993). Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron 10, Koltzenburg, M., Stucky, C. L., and Lewin, G. R. (1997). Receptive properties of mouse sensory neurons innervating hairy skin. J Neurophysiol 78, Kou, S. Y., Chiu, A. Y., and Patterson, P. H. (1995). Differential regulation of motor neuron survival and choline acetyltransferase expression following axotomy. J Neurobiol 27, Kruijer, W., Cooper, J. A., Hunter, T., and Verma, I. M. (1984). Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature 312, Lamballe, F., Klein, R., and Barbacid, M. (1991). trkc, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66, Lamballe, F., Smeyne, R. J., and Barbacid, M. (1994). Developmental expression of trkc, the neurotrophin-3 receptor, in the mammalian nervous system. J Neurosci 14, Lamballe, F., Tapley, P., and Barbacid, M. (1993). trkc encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. Embo J 12, Lee, F. S., Kim, A. H., Khursigara, G., and Chao, M. V. (2001). The uniqueness of being a neurotrophin receptor. Curr Opin Neurobiol 11, Lee, K. F., Davies, A. M., and Jaenisch, R. (1994). p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. Development 120, Lee, R., Kermani, P., Teng, K. K., and Hempstead, B. L. (2001). Regulation of cell survival by secreted proneurotrophins. Science 294, Levi-Montalcini, R., Meyer, H., and Hamburger, V. (1954). In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo. Cancer Res. 14, Levi-Montalcini, R. (1987). The nerve growth factor 35 years later. Science 237, Levi-Montalcini, R. (1966). The nerve growth factor: its mode of action on sensory and sympathetic nerve cells. Harvey Lect 60, Levi-Montalcini, R. a. B. B. (1960). Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve growth protein. Proc. Natl. Acad. Sci. 46, Levi-Montalcini, R. a. C., S. (1960). Effects of the extract of mouse submaxillary glands on the sympathetic system. Annals N.Y. Acad. Sci. 85, Levi-Montalcini, R. a. H., V. (1951). Selective growth-stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp. Zool. 116, Lewin, G. R., and Barde, Y. A. (1996). Physiology of the neurotrophins. Annu Rev Neurosci 19,
7 -Li, C. W., Van De Water, T.R. and Ruben, R.J. (1978). The fate mapping of the eleventh and twelfth day mouse otocyst: An in vitro study od the sites of origin of the embryonic inner ear sensory structures. J. Morph. 157, Li, L., Oppenheim, R. W., Lei, M., and Houenou, L. J. (1994). Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J Neurobiol 25, Liebl, D. J., Tessarollo, L., Palko, M. E., and Parada, L. F. (1997). Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci 17, Liepinsh, E., Ilag, L. L., Otting, G., and Ibanez, C. F. (1997). NMR structure of the death domain of the p75 neurotrophin receptor. Embo J 16, Lindvall, O., Kokaia, Z., Bengzon, J., Elmer, E., and Kokaia, M. (1994). Neurotrophins and brain insults. Trends Neurosci 17, Liu, X., Ernfors, P., Wu, H., and Jaenisch, R. (1995). Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 375, Liu, X., and Jaenisch, R. (2000). Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. Dev Dyn 218, Lysakowski, A. (1999). Development of synaptic innervation in the rodent utricle. Ann N Y Acad Sci 871, Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., and Yancopoulos, G. D. (1990). Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247, Marshall, C. J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, Martin-Zanca, D., Barbacid, M., and Parada, L. F. (1990). Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev 4, Martin-Zanca, D., Oskam, R., Mitra, G., Copeland, T., and Barbacid, M. (1989). Molecular and biochemical characterization of the human trk proto- oncogene. Mol Cell Biol 9, McAllister, A. K. (2001). Neurotrophins and neuronal differentiation in the central nervous system. Cell Mol Life Sci 58, McAllister, A. K., Katz, L. C., and Lo, D. C. (1996). Neurotrophin regulation of cortical dendritic growth requires activity. Neuron 17, McAllister, A. K., Katz, L. C., and Lo, D. C. (1999). Neurotrophins and synaptic plasticity. Annu Rev Neurosci 22, McAllister, A. K., Katz, L. C., and Lo, D. C. (1997). Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neuron 18, McAllister, A. K., Lo, D. C., and Katz, L. C. (1995). Neurotrophins regulate dendritic growth in developing visual cortex. Neuron 15, McDonald, N. Q., and Hendrickson, W. A. (1993). A structural superfamily of growth factors containing a cystine knot motif. Cell 73, McDonald, N. Q., Lapatto, R., Murray-Rust, J., Gunning, J., Wlodawer, A., and Blundell, T. L. (1991). New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature 354, Meakin, S. O., MacDonald, J. I., Gryz, E. A., Kubu, C. J., and Verdi, J. M. (1999). The signaling adapter FRS- 2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J Biol Chem 274, Meakin, S. O., Suter, U., Drinkwater, C. C., Welcher, A. A., and Shooter, E. M. (1992). The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc Natl Acad Sci U S A 89, Menn, B., Timsit, S., Calothy, G., and Lamballe, F. (1998). Differential expression of TrkC catalytic and noncatalytic isoforms suggests that they act independently or in association. J Comp Neurol 401, Merlio, J. P., Ernfors, P., Kokaia, Z., Middlemas, D. S., Bengzon, J., Kokaia, M., Smith, M. L., Siesjo, B. K., Hunter, T., Lindvall, O., and et al. (1993). Increased production of the TrkB protein tyrosine kinase receptor after brain insults. Neuron 10,
8 -Middlemas, D. S., Lindberg, R. A., and Hunter, T. (1991). trkb, a neural receptor protein-tyrosine kinase: evidence for a full- length and two truncated receptors. Mol Cell Biol 11, Ming, G., Song, H., Berninger, B., Inagaki, N., Tessier-Lavigne, M., and Poo, M. (1999). Phospholipase C- gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23, Minichiello, L., Casagranda, F., Tatche, R. S., Stucky, C. L., Postigo, A., Lewin, G. R., Davies, A. M., and Klein, R. (1998). Point mutation in trkb causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron 21, Minichiello, L., and Klein, R. (1996). TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons. Genes Dev 10, Minichiello, L., Korte, M., Wolfer, D., Kuhn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H. P., Bonhoeffer, T., and Klein, R. (1999). Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24, Minichiello, L., Piehl, F., Vazquez, E., Schimmang, T., Hokfelt, T., Represa, J., and Klein, R. (1995). Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. Development 121, Mou, K., Hunsberger, C. L., Cleary, J. M., and Davis, R. L. (1997). Synergistic effects of BDNF and NT-3 on postnatal spiral ganglion neurons. J Comp Neurol 386, Ninkina, N., Adu, J., Fischer, A., Pinon, L. G., Buchman, V. L., and Davies, A. M. (1996). Expression and function of TrkB variants in developing sensory neurons. Embo J 15, Obermeier, A., Bradshaw, R. A., Seedorf, K., Choidas, A., Schlessinger, J., and Ullrich, A. (1994). Neuronal differentiation signals are controlled by nerve growth factor receptor/trk binding sites for SHC and PLC gamma. Embo J 13, Obermeier, A., Lammers, R., Wiesmuller, K. H., Jung, G., Schlessinger, J., and Ullrich, A. (1993). Identification of Trk binding sites for SHC and phosphatidylinositol 3'- kinase and formation of a multimeric signaling complex. J Biol Chem 268, O'Connor, R., and Tessier-Lavigne, M. (1999). Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons. Neuron 24, Oppenheim, R. W. (1991). Cell death during development of the nervous system. Annu Rev Neurosci 14, Oppenheim, R. W. (1996). Neurotrophic survival molecules for motoneurons: an embarrassment of riches. Neuron 17, Oppenheim, R. W., Prevette, D., Haverkamp, L. J., Houenou, L., Yin, Q. W., and McManaman, J. (1993). Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo. J Neurobiol 24, Palko, M. E., Coppola, V., and Tessarollo, L. (1999). Evidence for a role of truncated trkc receptor isoforms in mouse development. J Neurosci 19, Paves, H., and Saarma, M. (1997). Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons. Cell Tissue Res 290, Pawson, T., and Scott, J. D. (1997). Signaling through scaffold, anchoring, and adaptor proteins. Science 278, Pirvola, U., Arumae, U., Moshnyakov, M., Palgi, J., Saarma, M., and Ylikoski, J. (1994). Coordinated expression and function of neurotrophins and their receptors in the rat inner ear during target innervation. Hear Res 75, Pirvola, U., Ylikoski, J., Palgi, J., Lehtonen, E., Arumae, U., and Saarma, M. (1992). Brain-derived neurotrophic factor and neurotrophin 3 mrnas in the peripheral target fields of developing inner ear ganglia. Proc Natl Acad Sci U S A 89, Qian, X., Riccio, A., Zhang, Y., and Ginty, D. D. (1998). Identification and characterization of novel substrates of Trk receptors in developing neurons. Neuron 21, Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., and Shooter, E. M. (1987). Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 325,
9 -Ramón y Cajal, S. ( ). Histologie du Système Nerveux de l Homme et des Vertébrés, Volume I et II. (Madrid: Consejo Superior de Investigaciones Cientificas). -Riccio, A., Ahn, S., Davenport, C. M., Blendy, J. A., and Ginty, D. D. (1999). Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286, Riddle, D. R., Lo, D. C., and Katz, L. C. (1995). NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation. Nature 378, Robinson, R. C., Radziejewski, C., Spraggon, G., Greenwald, J., Kostura, M. R., Burtnick, L. D., Stuart, D. I., Choe, S., and Jones, E. Y. (1999). The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk- binding site. Protein Sci 8, Robinson, R. C., Radziejewski, C., Stuart, D. I., and Jones, E. Y. (1995). Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. Biochemistry 34, Rodriguez-Tebar, A., Dechant, G., and Barde, Y. A. (1991). Neurotrophins: structural relatedness and receptor interactions. Philos Trans R Soc Lond B Biol Sci 331, Rodriguez-Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A., and Downward, J. (1997). Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89, Rusch, A., Lysakowski, A., and Eatock, R. A. (1998). Postnatal development of type I and type II hair cells in the mouse utricle: acquisition of voltage-gated conductances and differentiated morphology. J Neurosci 18, Ryden, M., and Ibanez, C. F. (1996). Binding of neurotrophin-3 to p75lngfr, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkc. J Biol Chem 271, Saffell, J. L., Williams, E. J., Mason, I. J., Walsh, F. S., and Doherty, P. (1997). Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18, Saragovi, H. U., and Gehring, K. (2000). Development of pharmacological agents for targeting neurotrophins and their receptors. Trends Pharmacol Sci 21, _ _ Schechter, A. L., and Bothwell, M. A. (1981). Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association. Cell 24, Schecterson, L. C., and Bothwell, M. (1994). Neurotrophin and neurotrophin receptor mrna expression in developing inner ear. Hear Res 73, Schimmang, T., Minichiello, L., Vazquez, E., San Jose, I., Giraldez, F., Klein, R., and Represa, J. (1995). Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets. Development 121, Schlessinger, J. (2000). Cell signaling by receptor tyrosine kinases. Cell 103, Schneider, R., and Schweiger, M. (1991). A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkb tyrosine kinase receptors. Oncogene 6, Schwartz, P. M., Borghesani, P. R., Levy, R. L., Pomeroy, S. L., and Segal, R. A. (1997). Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning. Neuron 19, Schwenk, F., Baron, U., and Rajewsky, K. (1995). A cre-transgenic mouse strain for the ubiquitous deletion of loxp- flanked gene segments including deletion in germ cells. Nucleic Acids Res 23, Segal, R. A., and Greenberg, M. E. (1996). Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 19, Segal, R. A., Pomeroy, S. L., and Stiles, C. D. (1995). Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci 15, Seidah, N. G., Benjannet, S., Pareek, S., Chretien, M., and Murphy, R. A. (1996). Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. FEBS Lett 379, Shieh, P. B., and Ghosh, A. (1997). Neurotrophins: new roles for a seasoned cast. Curr Biol 7, R Silos-Santiago, I., Fagan, A. M., Garber, M., Fritzsch, B., and Barbacid, M. (1997). Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors. Eur J Neurosci 9,
10 -Smeyne, R. J., Klein, R., Schnapp, A., Long, L. K., Bryant, S., Lewin, A., Lira, S. A., and Barbacid, M. (1994). Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368, Snider, W. D. (1994). Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77, Soderling, T. R. (2000). CaM-kinases: modulators of synaptic plasticity. Curr Opin Neurobiol 10, Sofroniew, M. V., Howe, C. L., and Mobley, W. C. (2001). Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 24, Song, H. J., and Poo, M. M. (1999). Signal transduction underlying growth cone guidance by diffusible factors. Curr Opin Neurobiol 9, Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Reid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., and et al. (1991). The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkb tyrosine kinase receptor. Cell 65, Spoendlin, H., and Schrott, A. (1988). The spiral ganglion and the innervation of the human organ of Corti. Acta Otolaryngol 105, Squinto, S. P., Stitt, T. N., Aldrich, T. H., Davis, S., Bianco, S. M., Radziejewski, C., Glass, D. J., Masiakowski, P., Furth, M. E., Valenzuela, D. M., and et al. (1991). trkb encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 65, Stephens, R. M., Loeb, D. M., Copeland, T. D., Pawson, T., Greene, L. A., and Kaplan, D. R. (1994). Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12, Strohmaier, C., Carter, B. D., Urfer, R., Barde, Y. A., and Dechant, G. (1996). A splice variant of the neurotrophin receptor trkb with increased specificity for brain-derived neurotrophic factor. Embo J 15, abs.html. -Stucky, C. L., DeChiara, T., Lindsay, R. M., Yancopoulos, G. D., and Koltzenburg, M. (1998). Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors. J Neurosci 18, Stucky, C. L., and Lewin, G. R. (1998). Neurotrophin-3 and neurotrophin-4 are sequentially required for the survival of D-hair receptors. Forum of European Neuroscience 10, Suter, U., Heymach, J. V., Jr., and Shooter, E. M. (1991). Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. Embo J 10, Sutter, A., Riopelle, R. J., Harris-Warrick, R. M., and Shooter, E. M. (1979). Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem 254, Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., and Parada, L. F. (1993). trkc, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development 118, Tessier-Lavigne, M., and Goodman, C. S. (1996). The molecular biology of axon guidance. Science 274, Tsoulfas, P., Soppet, D., Escandon, E., Tessarollo, L., Mendoza-Ramirez, J. L., Rosenthal, A., Nikolics, K., and Parada, L. F. (1993). The rat trkc locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Neuron 10, Tsoulfas, P., Stephens, R. M., Kaplan, D. R., and Parada, L. F. (1996). TrkC isoforms with inserts in the kinase domain show impaired signaling responses. J Biol Chem 271, Tucker, K. L., Meyer, M., and Barde, Y. A. (2001). Neurotrophins are required for nerve growth during development. Nat Neurosci 4, Urfer, R., Tsoulfas, P., O'Connell, L., Hongo, J. A., Zhao, W., and Presta, L. G. (1998). High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors. J Biol Chem 273, Urfer, R., Tsoulfas, P., O'Connell, L., Shelton, D. L., Parada, L. F., and Presta, L. G. (1995). An immunoglobulin-like domain determines the specificity of neurotrophin receptors. Embo J 14,
11 -Vaillant, A. R., Mazzoni, I., Tudan, C., Boudreau, M., Kaplan, D. R., and Miller, F. D. (1999). Depolarization and neurotrophins converge on the phosphatidylinositol 3- kinase-akt pathway to synergistically regulate neuronal survival. J Cell Biol 146, Valenzuela, D. M., Maisonpierre, P. C., Glass, D. J., Rojas, E., Nunez, L., Kong, Y., Gies, D. R., Stitt, T. N., Ip, N. Y., and Yancopoulos, G. D. (1993). Alternative forms of rat TrkC with different functional capabilities. Neuron 10, Vejsada, R., Sagot, Y., and Kato, A. C. (1994). BDNF-mediated rescue of axotomized motor neurones decreases with increasing dose. Neuroreport 5, Vejsada, R., Sagot, Y., and Kato, A. C. (1995). Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo. Eur J Neurosci 7, Vetter, M. L., Martin-Zanca, D., Parada, L. F., Bishop, J. M., and Kaplan, D. R. (1991). Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene. Proc Natl Acad Sci U S A 88, Wiechers, B., Gestwa, G., Mack, A., Carroll, P., Zenner, H. P., and Knipper, M. (1999). A changing pattern of brain-derived neurotrophic factor expression correlates with the rearrangement of fibers during cochlear development of rats and mice. J Neurosci 19, Wiesmann, C., Ultsch, M. H., Bass, S. H., and de Vos, A. M. (1999). Crystal structure of nerve growth factor in complex with the ligand- binding domain of the TrkA receptor. Nature 401, Williams, R. W., and Herrup, K. (1988). The control of neuron number. Annu Rev Neurosci 11, Wybenga-Groot, L. E., Baskin, B., Ong, S. H., Tong, J., Pawson, T., and Sicheri, F. (2001). Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell 106, Xie, Y., and Longo, F. M. (2000). Neurotrophin small-molecule mimetics. Prog Brain Res 128, Xing, J., Ginty, D. D., and Greenberg, M. E. (1996). Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273, Xing, J., Kornhauser, J. M., Xia, Z., Thiele, E. A., and Greenberg, M. E. (1998). Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol 18, Xu, B., Zang, K., Ruff, N. L., Zhang, Y. A., McConnell, S. K., Stryker, M. P., and Reichardt, L. F. (2000). Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron 26, Yamashita, H., Avraham, S., Jiang, S., Dikic, I., and Avraham, H. (1999). The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. J Biol Chem 274, Yan, Q., Elliott, J., and Snider, W. D. (1992). Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature 360, Yano, H., Cong, F., Birge, R. B., Goff, S. P., and Chao, M. V. (2000). Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. J Neurosci Res 59, Yao, R., and Cooper, G. M. (1995). Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, Yardley, R. W., Bowes, G., Wilkinson, M., Cannata, J. P., Maloney, J. E., Ritchie, B. C., and Walker, A. M. (1983). Increased arterial pressure variability after arterial baroreceptor denervation in fetal lambs. Circ Res 52, York, R. D., Yao, H., Dillon, T., Ellig, C. L., Eckert, S. P., McCleskey, E. W., and Stork, P. J. (1998). Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392, Yu, H., Fukami, K., Itoh, T., and Takenawa, T. (1998). Phosphorylation of phospholipase Cgamma1 on tyrosine residue 783 by platelet-derived growth factor regulates reorganization of the cytoskeleton. Exp Cell Res 243, Zhou, H., Glass, D. J., Yancopoulos, G. D., and Sanes, J. R. (1999). Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations. J Cell Biol 146,
Selective Regulation of trkc Expression by NT3 in the Developing Peripheral Nervous System
The Journal of Neuroscience, August 1, 1999, 19(15):6559 6570 Selective Regulation of trkc Expression by NT3 in the Developing Peripheral Nervous System Sean Wyatt, Gayle Middleton, Epaminondas Doxakis,
More informationCell Death & Trophic Factors II. Steven McLoon Department of Neuroscience University of Minnesota
Cell Death & Trophic Factors II Steven McLoon Department of Neuroscience University of Minnesota 1 Remember? Neurotrophins are cell survival factors that neurons get from their target cells! There is a
More informationTrophic Factors. Trophic Factors. History 2. History Growth Factors. Giles Plant
217 - Growth Factors Giles Plant Role in: Growth and Trophic Factors Soluble/diffusible factors - polypeptides Proliferation Differentiation (ie Cancer) Survival (degenerative diseases) Innervation Maintenance
More informationMuscle sensory neurons require neurotrophin-3 from peripheral tissues
Development 121, 1341-1350 (1995) Printed in Great Britain The Company of Biologists Limited 1995 1341 Muscle sensory neurons require neurotrophin-3 from peripheral tissues during the period of normal
More informationIntroduction Principles of Signaling and Organization p. 3 Signaling in Simple Neuronal Circuits p. 4 Organization of the Retina p.
Introduction Principles of Signaling and Organization p. 3 Signaling in Simple Neuronal Circuits p. 4 Organization of the Retina p. 5 Signaling in Nerve Cells p. 9 Cellular and Molecular Biology of Neurons
More informationFormation of the Cortex
Formation of the Cortex Neuronal Birthdating with 3 H-thymidine 3H-thymidine is incorporated into the DNA during the S-phase (replication of DNA). It marks all mitotic cells Quantitative technique. (you
More informationTHE PROBLEMS OF DEVELOPMENT. Cell differentiation. Cell determination
We emphasize these points from Kandel in Bi/CNS 150 Bi/CNS/NB 150: Neuroscience Read Lecture Lecture Friday, October 2, 2015 Development 1: pp 5-10 Introduction Brains evolved All higher animals have brains
More informationNeurotrophins and Their Receptors in Rat Peripheral Trigeminal System during Maxillary Nerve Growth
Neurotrophins and Their Receptors in Rat Peripheral Trigeminal System during Maxillary Nerve Growth Urmas Annn/ie,*~ Ulla Pirvola,* Jaan Palgi,* Tlila-Riikka Kiema,* Kaia Palm,*~ Maxim Moshnyakov,* Jukka
More informationBcl-2 Accelerates the Maturation of Early Sensory Neurons
The Journal of Neuroscience, May 1, 1998, 18(9):3344 3350 Bcl-2 Accelerates the Maturation of Early Sensory Neurons Gayle Middleton, Luzia G. P. Piñón, Sean Wyatt, and Alun M. Davies School of Biological
More informationA Role for TrkA during Maturation of Striatal and Basal Forebrain Cholinergic Neurons In Vivo
The Journal of Neuroscience, October 15, 1997, 17(20):7644 7654 A Role for TrkA during Maturation of Striatal and Basal Forebrain Cholinergic Neurons In Vivo Anne M. Fagan, 1 Melinda Garber, 2 Mariano
More informationCharacterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia: Direct NT-3 Activation of TrkB Neurons In Vivo
Neuron, Vol. 21, 325 334, August, 1998, Copyright 1998 by Cell Press Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia: Direct NT-3 Activation of TrkB Neurons In
More informationBio 3411, Fall 2006, Lecture 19-Cell Death.
Types of Cell Death Questions : Apoptosis (Programmed Cell Death) : Cell-Autonomous Stereotypic Rapid Clean (dead cells eaten) Necrosis : Not Self-Initiated Not Stereotypic Can Be Slow Messy (injury can
More informationReading. Lecture VI. Making Connections 9/17/12. Bio 3411 Lecture VI. Making Connections. Bio 3411 Monday September 17, 2012
Lecture VI. Making Connections Bio 3411 Monday September 17, 2012!! 1! Reading NEUROSCIENCE: 5 th ed, pp!507?536! 4 th ed, pp 577-609 Bentley, D., & Caudy, M. (1983). Nature, 304(5921), 62-65. Dickson,
More informationConclusions. The experimental studies presented in this thesis provide the first molecular insights
C h a p t e r 5 Conclusions 5.1 Summary The experimental studies presented in this thesis provide the first molecular insights into the cellular processes of assembly, and aggregation of neural crest and
More informationThe Neurotrophin Receptor p75 Binds Neurotrophin-3 on Sympathetic Neurons with High Affinity and Specificity
The Journal of Neuroscience, July 15, 1997, 17(14):5281 5287 The Neurotrophin Receptor p75 Binds Neurotrophin-3 on Sympathetic Neurons with High Affinity and Specificity Georg Dechant, 1 Pantelis Tsoulfas,
More informationAxon Guidance. Multiple decision points along a growing axon s trajectory Different types of axon guidance cues:
Axon Guidance Multiple decision points along a growing axon s trajectory Different types of axon guidance cues: Contact mediated - requires direct contact by growth cone Long range - growth cone responds
More informationPacinian Corpuscle Development Involves Multiple Trk Signaling Pathways
DEVELOPMENTAL DYNAMICS 231:551 563, 2004 RESEARCH ARTICLE Pacinian Corpuscle Development Involves Multiple Trk Signaling Pathways J. Šedý, 1,5 V. Szeder, 1,2 J.M. Walro, 3 Z.G. Ren, 2 O. Naňka, 1 L. Tessarollo,
More informationDOWNLOAD OR READ : THE NEURONAL CYTOSKELETON MOTOR PROTEINS AND ORGANELLE TRAFFICKING IN THE AXON PDF EBOOK EPUB MOBI
DOWNLOAD OR READ : THE NEURONAL CYTOSKELETON MOTOR PROTEINS AND ORGANELLE TRAFFICKING IN THE AXON PDF EBOOK EPUB MOBI Page 1 Page 2 the neuronal cytoskeleton motor proteins and organelle trafficking in
More informationNeurotrophin-3 Promotes the Differentiation of Muscle Spindle Afferents in the Absence of Peripheral Targets
The Journal of Neuroscience, June 1, 1997, 17(11):4262 4274 Neurotrophin-3 Promotes the Differentiation of Muscle Spindle Afferents in the Absence of Peripheral Targets Robert A. Oakley, 1 Frances B. Lefcort,
More informationCellular Neurobiology BIPN 140 Fall 2016 Problem Set #8
Cellular Neurobiology BIPN 140 Fall 2016 Problem Set #8 1. Inductive signaling is a hallmark of vertebrate and mammalian development. In early neural development, there are multiple signaling pathways
More informationPROPRIOCEPTIVE AFFERENTS SURVIVE IN THE MASSETER MUSCLE OF trkc KNOCKOUT MICE
Proprioceptive afferents survive in the masseter muscle of trkc knockout mice Neuroscience Vol. 95, No. 1, pp. 209 216, 2000 209 Copyright 1999 IBRO. Published by Elsevier Science Ltd Pergamon Printed
More informationMassive loss of neurons in embryos occurs during normal development (!)
Types of Cell Death Apoptosis (Programmed Cell Death) : Cell-Autonomous Stereotypic Rapid Clean (dead cells eaten) Necrosis : Not Self-Initiated Not Stereotypic Can Be Slow Messy (injury can spread) Apoptosis
More informationSignaling to the Nucleus by an L-type Calcium Channel- Calmodulin Complex Through the MAP Kinase Pathway
Signaling to the Nucleus by an L-type Calcium Channel- Calmodulin Complex Through the MAP Kinase Pathway Ricardo E. Dolmetsch, Urvi Pajvani, Katherine Fife, James M. Spotts, Michael E. Greenberg Science
More information5- Semaphorin-Plexin-Neuropilin
5- Semaphorin-Plexin-Neuropilin 1 SEMAPHORINS-PLEXINS-NEUROPILINS ligands receptors co-receptors semaphorins and their receptors are known signals for: -axon guidance -cell migration -morphogenesis -immune
More informationSupplemental table S7.
Supplemental table S7. GO terms significantly enriched in significantly up-regulated genes of the microarray. K: number of genes from the input cluster in the given category. F: number of total genes in
More informationAxon guidance I. Paul Garrity March 15, /9.013
Axon guidance I Paul Garrity March 15, 2004 7.68/9.013 Neuronal Wiring: Functional Framework of the Nervous System Stretch reflex circuit Early theories of axonogenesis Schwann: many neurons link to form
More informationThe majority of cells in the nervous system arise during the embryonic and early post
Introduction Introduction The majority of cells in the nervous system arise during the embryonic and early post natal period. These cells are derived from population of neural stem cells first shown by
More informationCell-Cell Communication in Development
Biology 4361 - Developmental Biology Cell-Cell Communication in Development October 2, 2007 Cell-Cell Communication - Topics Induction and competence Paracrine factors inducer molecules Signal transduction
More informationMIT 9.14 Class The growth of the long extensions of neurons and related topics
9.14 - Brain Structure and its Origins Spring 2005 Massachusetts Institute of Technology Instructor: Professor Gerald Schneider A sketch of the central nervous system and its origins G. E. Schneider 2005
More informationNGF - twenty years a-growing
NGF - twenty years a-growing A molecule vital to brain growth It is twenty years since the structure of nerve growth factor (NGF) was determined [ref. 1]. This molecule is more than 'quite interesting'
More informationMCDB 4777/5777 Molecular Neurobiology Lecture 29 Neural Development- In the beginning
MCDB 4777/5777 Molecular Neurobiology Lecture 29 Neural Development- In the beginning Learning Goals for Lecture 29 4.1 Describe the contributions of early developmental events in the embryo to the formation
More informationCOMPUTER SIMULATION OF DIFFERENTIAL KINETICS OF MAPK ACTIVATION UPON EGF RECEPTOR OVEREXPRESSION
COMPUTER SIMULATION OF DIFFERENTIAL KINETICS OF MAPK ACTIVATION UPON EGF RECEPTOR OVEREXPRESSION I. Aksan 1, M. Sen 2, M. K. Araz 3, and M. L. Kurnaz 3 1 School of Biological Sciences, University of Manchester,
More informationPolypeptide growth factors: Structure, function and mechanism of action
Pure & Appl. Chem., Vol. 66, No. 1, pp. 9-14, 1994. Printed in Great Britain. @ 1994 IUPAC Polypeptide growth factors: Structure, function and mechanism of action Ralph A. Bradshaw, Ritsuko Fujii, Hubert
More informationMechanisms of Human Health and Disease. Developmental Biology
Mechanisms of Human Health and Developmental Biology Joe Schultz joe.schultz@nationwidechildrens.org D6 1 Dev Bio: Mysteries How do fertilized eggs become adults? How do adults make more adults? Why and
More informationN 'Gr, the prototype of a family of closely related
NGF-stimulated Retrograde Transport of trka in the Mammalian Nervous System Michael D. Ehlers,* David R. Kaplan, I Donald L. Price,**~ll and Vassilis E. Koliatsos*~ lj Departments of *Neuroscience, ~Pathology,
More informationNeural development its all connected
Neural development its all connected How do you build a complex nervous system? How do you build a complex nervous system? 1. Learn how tissue is instructed to become nervous system. Neural induction 2.
More informationBio 127 Section I Introduction to Developmental Biology. Cell Cell Communication in Development. Developmental Activities Coordinated in this Way
Bio 127 Section I Introduction to Developmental Biology Cell Cell Communication in Development Gilbert 9e Chapter 3 It has to be EXTREMELY well coordinated for the single celled fertilized ovum to develop
More informationCell Cell Communication in Development
Biology 4361 Developmental Biology Cell Cell Communication in Development June 25, 2008 Cell Cell Communication Concepts Cells in developing organisms develop in the context of their environment, including
More informationBlockade of Endogenous Neurotrophic Factors Prevents the Androgenic Rescue of Rat Spinal Motoneurons
The Journal of Neuroscience, June 15, 2001, 21(12):4366 4372 Blockade of Endogenous Neurotrophic Factors Prevents the Androgenic Rescue of Rat Spinal Motoneurons Jun Xu, 1 Karen M. Gingras, 1 Lynn Bengston,
More informationThe Role of G-Protein Coupled Estrogen Receptor (GPER) in Early Neurite Development. Kyle Pemberton
The Role of G-Protein Coupled Estrogen Receptor (GPER) in Early Neurite Development Kyle Pemberton Acknowledgement Dr. Xu Lab Members Brittany Mersman Nicki Patel Pallavi Mhaskar Jason Cocjin Committee
More informationPopulations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo
Development 128, 4715-4728 (2001) Printed in Great Britain The Company of Biologists Limited 2001 DEV1729 4715 Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis
More informationNEUROTROPHIC FACTORS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT: FUNCTION & SPECIFICITY
From DEPARTMENT OF MEDICAL BIOCHEMISTRY & BIOPHYSICS Karolinska Institutet, Stockholm, Sweden NEUROTROPHIC FACTORS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT: FUNCTION & SPECIFICITY Anna Stenqvist Castelo-Branco
More informationHierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex
Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex Elke Stein and Marc Tessier-Lavigne* Axonal growth cones that cross the nervous
More informationTrkA Amino Acids Controlling Specificity for Nerve Growth Factor*
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275, No. 11, Issue of March 17, pp. 7870 7877, 2000 2000 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. TrkA Amino Acids
More informationFUNCTIONS AND MECHANISMS OF RETROGRADE NEUROTROPHIN SIGNALLING
FUNCTIONS AND MECHANISMS OF RETROGRADE NEUROTROPHIN SIGNALLING Larry S. Zweifel*, Rejji Kuruvilla and David D. Ginty* Abstract Neuronal connections are established and refined through a series of developmental
More informationSignal Transduction. Dr. Chaidir, Apt
Signal Transduction Dr. Chaidir, Apt Background Complex unicellular organisms existed on Earth for approximately 2.5 billion years before the first multicellular organisms appeared.this long period for
More informationNervous System Organization
The Nervous System Nervous System Organization Receptors respond to stimuli Sensory receptors detect the stimulus Motor effectors respond to stimulus Nervous system divisions Central nervous system Command
More informationREGULATION OF VERTEBRATE NEURON DEATH IN DEVELOPMENT AND NEURODEGENERATION: ROLE OF TRANSCRIPTION LLOYD A. GREENE COLUMBIA UNIVERSITY NEW YORK, NY
REGULATION OF VERTEBRATE NEURON DEATH IN DEVELOPMENT AND NEURODEGENERATION: ROLE OF TRANSCRIPTION LLOYD A. GREENE COLUMBIA UNIVERSITY NEW YORK, NY MASSIVE LOSS OF NEURONS DURING VERTEBRATE DEVELOPMENT
More information10/2/2015. Chapter 4. Determination and Differentiation. Neuroanatomical Diversity
Chapter 4 Determination and Differentiation Neuroanatomical Diversity 1 Neurochemical diversity: another important aspect of neuronal fate Neurotransmitters and their receptors Excitatory Glutamate Acetylcholine
More informationThe neuron as a secretory cell
The neuron as a secretory cell EXOCYTOSIS ENDOCYTOSIS The secretory pathway. Transport and sorting of proteins in the secretory pathway occur as they pass through the Golgi complex before reaching the
More informationDevelopmental Zoology. Ectodermal derivatives (ZOO ) Developmental Stages. Developmental Stages
Developmental Zoology (ZOO 228.1.0) Ectodermal derivatives 1 Developmental Stages Ø Early Development Fertilization Cleavage Gastrulation Neurulation Ø Later Development Organogenesis Larval molts Metamorphosis
More informationNervous System Organization
The Nervous System Chapter 44 Nervous System Organization All animals must be able to respond to environmental stimuli -Sensory receptors = Detect stimulus -Motor effectors = Respond to it -The nervous
More informationCell-Cell Communication in Development
Biology 4361 - Developmental Biology Cell-Cell Communication in Development June 23, 2009 Concepts Cell-Cell Communication Cells develop in the context of their environment, including: - their immediate
More informationPhysiology 2 nd year. Neuroscience Optional Lecture
Academic year 2018/2019 Physiology 2 nd year Semester 1 Curricula Nervous system physiology Blood physiology Acid-base equilibrium Bibliography: Boron & Boulpaep Medical Physiology, 3 rd edition Physiology
More informationAxonal Growth and Fasciculation Linked to Differential Expression of BDNF and NT3 Receptors in Developing Cerebellar Granule Cells
The Journal of Neuroscience, July 1995, 15(7): 4970-4981 Axonal Growth and Fasciculation Linked to Differential Expression of BDNF and NT3 Receptors in Developing Cerebellar Granule Cells Rosalind A. Segal,
More informationNervous Tissue. Neurons Neural communication Nervous Systems
Nervous Tissue Neurons Neural communication Nervous Systems What is the function of nervous tissue? Maintain homeostasis & respond to stimuli Sense & transmit information rapidly, to specific cells and
More informationThe Role of Proneurotrophins in Apoptotic Signaling in Rat. Brain Neurons
The Role of Proneurotrophins in Apoptotic Signaling in Rat Brain Neurons By Wenyu Song A dissertation submitted to the Graduate School-Newark Rutgers, The State University of New Jersey In partial fulfillment
More informationDomain 6: Communication
Domain 6: Communication 6.1: Cell communication processes share common features that reflect a shared evolutionary history. (EK3.D.1) 1. Introduction to Communication Communication requires the generation,
More informationC. elegans L1 cell adhesion molecule functions in axon guidance
C. elegans L1 cell adhesion molecule functions in axon guidance Biorad Lihsia Chen Dept. of Genetics, Cell Biology & Development Developmental Biology Center C. elegans embryogenesis Goldstein lab, UNC-Chapel
More information9/4/2015 INDUCTION CHAPTER 1. Neurons are similar across phyla Thus, many different model systems are used in developmental neurobiology. Fig 1.
INDUCTION CHAPTER 1 Neurons are similar across phyla Thus, many different model systems are used in developmental neurobiology Fig 1.1 1 EVOLUTION OF METAZOAN BRAINS GASTRULATION MAKING THE 3 RD GERM LAYER
More informationThe growth rate of sensory nerve fibres in the mammalian embryo
Development 00, 307-3 (987) Printed in Great Britain The Company of Biologists Limited 987 307 The growth rate of sensory nerve fibres in the mammalian embryo ALUN M. DAVIES Department of Anatomy, Si George's
More informationESSENTIAL LEARNING OUTCOMES:
ESSENTIAL LEARNING OUTCOMES: Upon satisfactory completion of BIO 2331 - Anatomy and Physiology I, the student should be able to perform the following outcomes and supporting objectives: Outcome: A. Critical/Creative
More informationRANK. Alternative names. Discovery. Structure. William J. Boyle* SUMMARY BACKGROUND
RANK William J. Boyle* Department of Cell Biology, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA * corresponding author tel: 805-447-4304, fax: 805-447-1982, e-mail: bboyle@amgen.com
More informationMassachusetts Institute of Technology Harvard Medical School Brigham and Women s Hospital VA Boston Healthcare System 2.79J/3.96J/BE.
Massachusetts Institute of Technology Harvard Medical School Brigham and Women s Hospital VA Boston Healthcare System 2.79J/3.96J/BE.441/HST522J INTEGRINS I.V. Yannas, Ph.D. and M. Spector, Ph.D. Regulator
More informationMEMBRANE POTENTIALS AND ACTION POTENTIALS:
University of Jordan Faculty of Medicine Department of Physiology & Biochemistry Medical students, 2017/2018 +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ Review: Membrane physiology
More informationRole of Organizer Chages in Late Frog Embryos
Ectoderm Germ Layer Frog Fate Map Frog Fate Map Role of Organizer Chages in Late Frog Embryos Organizer forms three distinct regions Notochord formation in chick Beta-catenin localization How does beta-catenin
More informationA Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification
Neuron 49, 379 393, February 2, 2006 ª2006 Elsevier Inc. DOI 10.1016/j.neuron.2006.01.008 A Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification Ina Kramer,
More informationAn Evolutionarily Conserved Transmembrane Protein That Is a Novel Downstream Target of Neurotrophin and Ephrin Receptors
The Journal of Neuroscience, January 1, 2001, 21(1):176 185 An Evolutionarily Conserved Transmembrane Protein That Is a Novel Downstream Target of Neurotrophin and Ephrin Receptors Haeyoung Kong, 1 Jim
More informationAdvanced Higher Biology. Unit 1- Cells and Proteins 2c) Membrane Proteins
Advanced Higher Biology Unit 1- Cells and Proteins 2c) Membrane Proteins Membrane Structure Phospholipid bilayer Transmembrane protein Integral protein Movement of Molecules Across Membranes Phospholipid
More informationNervous Tissue. Neurons Electrochemical Gradient Propagation & Transduction Neurotransmitters Temporal & Spatial Summation
Nervous Tissue Neurons Electrochemical Gradient Propagation & Transduction Neurotransmitters Temporal & Spatial Summation What is the function of nervous tissue? Maintain homeostasis & respond to stimuli
More informationSuppression of p75ntr Does Not Promote Regeneration of Injured Spinal Cord in Mice
542 The Journal of Neuroscience, January 14, 2004 24(2):542 546 Brief Communication Suppression of p75ntr Does Not Promote Regeneration of Injured Spinal Cord in Mice Xing-Yun Song, Jin-hua Zhong, Xin
More informationwith%dr.%van%buskirk%%%
with%dr.%van%buskirk%%% How$to$do$well?$ Before$class:$read$the$corresponding$chapter$ Come$to$class$ready$to$par9cipate$in$Top$Hat$ Don t$miss$an$exam!!!!!!!!!!!!!!!!!!!!!!!!!!$ But$I m$not$good$with$science
More informationLecture 6: Non-Cortical Visual Pathways MCP 9.013/7.68, 03
Lecture 6: Non-Cortical Visual Pathways MCP 9.013/7.68, 03 Roger W. Sperry The problem of central nervous reorganization after nerve regeneration and muscle transposition. R.W. Sperry. Quart. Rev. Biol.
More informationNeuronal Differentiation: Synapse Formation NMJ
Neuronal Differentiation: Synapse Formation NMJ Approaches to study synapse formation Rodent NMJ (cholinergic) Drosophila NMJ (glutamatergic) Rodent CNS synapse (glutamatergic or GABAergic) C. elegans
More informationDendrites - receives information from other neuron cells - input receivers.
The Nerve Tissue Neuron - the nerve cell Dendrites - receives information from other neuron cells - input receivers. Cell body - includes usual parts of the organelles of a cell (nucleus, mitochondria)
More informationNEURONS, SENSE ORGANS, AND NERVOUS SYSTEMS CHAPTER 34
NEURONS, SENSE ORGANS, AND NERVOUS SYSTEMS CHAPTER 34 KEY CONCEPTS 34.1 Nervous Systems Are Composed of Neurons and Glial Cells 34.2 Neurons Generate Electric Signals by Controlling Ion Distributions 34.3
More informationMolecular Cell Biology 5068 In Class Exam 2 November 8, 2016
Molecular Cell Biology 5068 In Class Exam 2 November 8, 2016 Exam Number: Please print your name: Instructions: Please write only on these pages, in the spaces allotted and not on the back. Write your
More informationThe EGF Signaling Pathway! Introduction! Introduction! Chem Lecture 10 Signal Transduction & Sensory Systems Part 3. EGF promotes cell growth
Chem 452 - Lecture 10 Signal Transduction & Sensory Systems Part 3 Question of the Day: Who is the son of Sevenless? Introduction! Signal transduction involves the changing of a cell s metabolism or gene
More informationControl and Integration. Nervous System Organization: Bilateral Symmetric Animals. Nervous System Organization: Radial Symmetric Animals
Control and Integration Neurophysiology Chapters 10-12 Nervous system composed of nervous tissue cells designed to conduct electrical impulses rapid communication to specific cells or groups of cells Endocrine
More informationGeert Geeven. April 14, 2010
iction of Gene Regulatory Interactions NDNS+ Workshop April 14, 2010 Today s talk - Outline Outline Biological Background Construction of Predictors The main aim of my project is to better understand the
More informationCopyright is owned by the Author of the thesis. Permission is given for a copy to be downloaded by an individual for the purpose of research and
Copyright is owned by the Author of the thesis. Permission is given for a copy to be downloaded by an individual for the purpose of research and private study only. The thesis may not be reproduced elsewhere
More informationChem Lecture 10 Signal Transduction
Chem 452 - Lecture 10 Signal Transduction 111202 Here we look at the movement of a signal from the outside of a cell to its inside, where it elicits changes within the cell. These changes are usually mediated
More informationBio Section III Organogenesis. The Neural Crest and Axonal Specification. Student Learning Objectives. Student Learning Objectives
Bio 127 - Section III Organogenesis The Neural Crest and Axonal Specification Gilbert 9e Chapter 10 Student Learning Objectives 1. You should understand that the neural crest is an evolutionary advancement
More informationJCB. Role of PI 3-kinase, Akt and Bcl-2 related proteins in sustaining the survival of neurotrophic factor independent adult sympathetic neurons
JCB Published Online: 27 August, 2001 Supp Info: http://doi.org/10.1083/jcb.200101068 Downloaded from jcb.rupress.org on January 26, 2019 Article Role of PI 3-kinase, Akt and Bcl-2 related proteins in
More informationCitation for published version (APA): Borensztajn, K. S. (2009). Action and Function of coagulation FXa on cellular signaling. s.n.
University of Groningen Action and Function of coagulation FXa on cellular signaling Borensztajn, Keren Sarah IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you
More informationNervous Systems: Neuron Structure and Function
Nervous Systems: Neuron Structure and Function Integration An animal needs to function like a coherent organism, not like a loose collection of cells. Integration = refers to processes such as summation
More informationThe role of ephrins and structured retinal activity in the development of visual map topography
The role of ephrins and structured retinal activity in the development of visual map topography David Feldheim, UC Santa Cruz KITP Brain08 March 21, 2008 Topographic map development in the mouse visual
More informationZool 3200: Cell Biology Exam 5 4/27/15
Name: Trask Zool 3200: Cell Biology Exam 5 4/27/15 Answer each of the following short answer questions in the space provided, giving explanations when asked to do so. Circle the correct answer or answers
More informationNeurons of the paravertebral sympathetic chain represent an
Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons Claude Brodski, Harald Schnürch, and Georg Dechant* Department of Neurobiochemistry, Max Planck Institute of Neurobiology,
More informationEndocytic trafficking of neurotrophins in neural development
Review Endocytic trafficking of neurotrophins in neural development Maria Ascano, Daniel Bodmer * and Rejji Kuruvilla Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA During the
More informationThe effect of neurotrophic factors on spiral ganglion neurons
University of Iowa Iowa Research Online Theses and Dissertations Fall 2012 The effect of neurotrophic factors on spiral ganglion neurons Ramon Gustavo Galindo University of Iowa Copyright 2012 Ramon Galindo
More informationIsoform-Specific Dephosphorylation of Dynamin1 by Calcineurin Couples Neurotrophin Receptor Endocytosis to Axonal Growth
Article Isoform-Specific Dephosphorylation of Dynamin1 by Calcineurin Couples Neurotrophin Receptor Endocytosis to Axonal Growth Daniel Bodmer, 1,2 Maria Ascaño, 1,2 and Rejji Kuruvilla 1, * 1 Department
More informationEmbryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells
J. Anat. (1997) 191, pp. 501 505, with 2 figures Printed in the United Kingdom 501 Review Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells K. R. JESSEN
More informationThe Nervous System. Nervous System Organization. Nerve Tissue. Two parts to the nervous system 11/27/2016
The Nervous System Nervous System Organization Animals must be able to respond to environmental stimuli. Three functions of the nervous system: Sensory input conduction of signals from sensory receptors.
More informationOverview Organization: Central Nervous System (CNS) Peripheral Nervous System (PNS) innervate Divisions: a. Afferent
Overview Organization: Central Nervous System (CNS) Brain and spinal cord receives and processes information. Peripheral Nervous System (PNS) Nerve cells that link CNS with organs throughout the body.
More informationBrunswick School Department: Grades Essential Understandings
Essential Understandings Essential Questions Essential Knowledge Vocabulary Essential Skills The Nervous system controls all voluntary and involuntary actions of the body. Neurons are the main functional
More informationMatrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding
NEURAL REGENERATION RESEARCH April 215,Volume 1,Issue www.nrronline.org INVITED review Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding Christopher M. Madl 1, Sarah
More informationRegulation and signaling. Overview. Control of gene expression. Cells need to regulate the amounts of different proteins they express, depending on
Regulation and signaling Overview Cells need to regulate the amounts of different proteins they express, depending on cell development (skin vs liver cell) cell stage environmental conditions (food, temperature,
More informationNeurons, Synapses, and Signaling
LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson Chapter 48 Neurons, Synapses, and Signaling
More informationNeurite initiation. Neurite formation begins with a bud that sprouts from the cell body. One or several neurites can sprout at a time.
Neurite initiation. Neuronal maturation initiation f-actin polarization and maturation tubulin stage 1: "spherical" neuron stage 2: neurons extend several neurites stage 3: one neurite accelerates its
More information