Mechanisms and Significance of Cell Volume Regulation

Transcription

1 Mechanisms and Significance of Cell Volume Regulation

2 Contributions to Nephrology Vol. 152 Series Editor Claudio Ronco Vicenza

3 Mechanisms and Significance of Cell Volume Regulation Volume Editor Florian Lang Tübingen 37 figures, 7 in color, and 4 tables, 2006 Basel Freiburg Paris London New York Bangalore Bangkok Singapore Tokyo Sydney

4 Contributions to Nephrology (Founded 1975 by Geoffrey M. Berlyne) Prof. Dr. Florian Lang Physiologisches Institut der Universität Tübingen Gmelinstrasse 5 DE Tübingen (Germany) Library of Congress Cataloging-in-Publication Data Mechanisms and significance of cell volume regulation / volume editor, Florian Lang. p. ; cm. (Contributions to nephrology, ISSN ; v. 152) Includes bibliographical references and indexes. ISBN-13: (hard cover : alk. paper) ISBN-10: (hard cover : alk. paper) 1. Osmoregulation. 2. Cellular control mechanisms. 3. Homeostasis. I. Lang, Florian. II. Series. [DNLM: 1. Cell Size. 2. Ion Channels physiology. 3. Ion Transport physiology. 4. Signal Transduction physiology. W1 CO778UN v / QU 375 M ] QP90.6.M dc Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents and Index Medicus. Disclaimer. The statements, options and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Copyright 2006 by S. Karger AG, P.O. Box, CH 4009 Basel (Switzerland) Printed in Switzerland on acid-free paper by Reinhardt Druck, Basel ISSN ISBN-10: ISBN-13:

5 Contents 1 Cell Volume Regulatory Mechanisms An Introduction Friedrich, B. (Tübingen); Matskevich, I. (Edinburg); Lang, F. (Tübingen) 9 Cell Volume-Sensitive Chloride Channels: Phenotypic Properties and Molecular Identity Okada, Y. (Okazaki) 25 Cell Volume-Regulated Cation Channels Wehner, F. (Dortmund) 54 Sensors and Signal Transduction Pathways in Vertebrate Cell Volume Regulation Hoffmann, E.K.; Pedersen, S.F. (Copenhagen) 105 Activation of Kinases upon Volume Changes: Role in Cellular Homeostasis Alexander, R.T.; Grinstein, S. (Toronto) 125 Tonicity-Dependent Regulation of Osmoprotective Genes in Mammalian Cells Ferraris, J.D.; Burg, M.B. (Bethesda, Md.) 142 Ion Channels and Cell Volume in Regulation of Cell Proliferation and Apoptotic Cell Death Lang, F.; Shumilina, E. (Tübingen); Ritter, M. (Salzburg); Gulbins, E. (Essen).; Vereninov, A. (St. Petersburg); Huber, S.M. (Tübingen) V

6 161 Cell Volume Regulatory Ion Transport in the Regulation of Cell Migration Jakab, M.; Ritter, M. (Salzburg) 181 Cell Volume Regulation in the Renal Papilla Beck, F.-X.; Neuhofer, W. (Munich) 198 Osmosensing and Signaling in the Regulation of Liver Function Schliess, F.; Häussinger, D. (Düsseldorf) 210 Cell Volume and Peptide Hormone Secretion Štrbák, V. (Bratislava) 221 Volume Changes in Neurons: Hyperexcitability and Neuronal Death Pasantes-Morales, H.; Tuz, K. (Mexico) 241 Pathophysiology of Red Cell Volume Browning, J.A.; Ellory, J.C. (Oxford); Gibson, J.S. (Cambridge) 269 Author Index 270 Subject Index Contents VI