Brain Neurosecretory Cytokines. Immune Response and Neuronal Survival

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1 Brain Neurosecretory Cytokines Immune Response and Neuronal Survival

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3 Library ofcongress Cataloging-in-Publication Data Brain neurosecretory cytokines : immune response and neuronal survival / edited by Armen A Galoyan. p. ;cm. Includes bibliographical references and index. ISBN ISBN (ebook) DOI / Neuropeptides--Physiological effect. 2. Cytokines--Physiological effect. 3. Neurohormones--Physiological effect. 4. Neurons. 1. Galoyan, Armen, [DNLM: 1. Cytokines-physiology. 2. Neurosecretion--physiology. 3. Neuroimmunomodulation. QW 568 B ] QP552.N39B '22--dc ISBN Springer Science+Business Media New York Originally published by Kluwer Academic/Plenum Publishers, New York in 2004 Softcover reprint ofthe hardcover Ist edition A C.I.P. record for this book is available from the Library of Congress AII rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Permissions for books published in Europe: permissions@wkap.n/ Permissions for books published in the United States of America: permissions@wkap.com

4 CONTENTS INTRODUCTION. Chapter 1 NEUROSECRETION OF CYTOKINES BY N. PARA VENTRICULARIS AND N. SUPRAOPTICUS OF HYPOTHALAMUS THE ISOLATION OF NEUROSECRETORY GRANULES FROM BOVINE HYPOTHALAMUS AND NEUROHYPOPHYSIS : BIOASSAY METHODS OF CYTOKINE IDENTIFICATION IDENTIFICATION OF INTERLEUKINS 10. AND 1~ IN THE LYSATES OF NEUROSECRETORY GRANULES OF BOVINE NEUROHYPOPHYSIS AND HYPOTHALAMUS IDENTIFICATION OF IL-2 IN THE NEUROSECRETORY GRANULES OF BOVINE NEUROHYPOPHYSIS AND HYPOTHALAMUS IDENTIFICATION OF IL-6 IN THE NEUROSECRETORY GRANULES OF BOVINE NEUROHYPOPHYSIS IDENTIFICATION OF TUMOR NECROSIS FACTOR a. (TNF-o.) IN THE NEUROSECRETORY GRANULES OF BOVINE HYPOTHALAMUS AND NEUROHYPOPHYSIS 9 Chapter 2 DISCOVERY OF NEW NEUROSECRETORY CYTOKINES: PROLINE RICH PEPTIDES PRODUCED BY N. PARAVENTRICULARIS AND N. SUPRAOPTICUS OF HYPOTHALAMUS ISOLATION OF PROLINE-RICH PEPTIDES FROM THE NEUROSECRETORY GRANULES OF BOVINE NEURO HYPOPHYSIS: PRIMARY STRUCTURES, MASS-SPECTRAL CHARACTERISTICS, AND LOCALIZATION IDENTIFICATION OF PRP-l IN THE BRAIN BY IMMUNOHISTOCHEMICAL METHODS USING POLYCLONAL ANTIBODIES v

5 vi CONTENTS 2.3 DETERMINATION OF PRP-l IN THE THYMUS, LYMPH NODES, AND HEART USING MONOCLONAL ANTIBODIES INTERACTIONS OF PRP-l WITH COAGULATION CASCADE COMPONENTS : A POTENTIAL ROLE FOR PRP-l IN THE METABOLISM OF FACTOR XaiANTITHROMBIN III COMPLEX 31 Chapter 3 INTERACTION OF PRP-l WITH CYTOKlNES, HORMONES, AND NEUROTRANSMITTERS EFFECT OF PRP-l AND LYSATES OF NEUROSECRETORY GRANULES ON THE EXPRESSION OF CYTOKINES IN MACROPHAGES AND ASTROCYTES EFFECT OF PRP-l ON THE EXPRESSION OF INTERLEUKINS AND PROLACTIN IN DIFFERENT ORGANS OF MICE DURING ALUMINUM NEUROTOXICOSIS PRP-I INCREASES THE EXPRESSION AND RELEASE OF HUMAN GROWTH HORMONE IN THE CULTURE OF BALB/c MOUSE FIBROBLASTS 40 Chapter 4 ANTIBACTERIAL AND ANTIVIRAL ACTIVITY OF PRP l AND SOME IMMUNOLOGICAL MECHANISMS OF ITS ACTION EFFECTS OF PRP-l ON THE SURVIVAL OF MICE INFECTED WITH DIFFERENT STRAINS OF GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA AT LETHAL DOSES EFFECTS OF PRP-I ON THE GROWTH OF BACTERIA IN THE INTERNAL ORGANS OF MICE INFECTED WITH S. typhimurium EFFECTS OF PRP-l ON ANTI-MICROBIAL ANTIBODY PRODUCTION IN MICE!NFECTED WITH S. typhimurium AND S. cholerae suis IN LETHAL DOSES EFFECT OF PRP-I ON BACTERICIDAL ACTIVITY OF MACROPHAGES EFFECT OF PRP-l ON THE SECRETION OF INTERLEUKIN-l BY PERITONEAL MACROPHAGES OF MICE INFECTED WITH S. typhimurium IN SUBLETHAL DOSES EFFECT OF PRP-l ON THE ANTIGEN-PRESENTING FUNCTION OF MACROPHAGES IN MICE INFECTED WITH S. typhimurium EFFECT OF PRP-I ON THE ACCUMULATION OF MACROPHAGES IN PERITONEAL CAVITIES OF MICE INFECTED WITH S. typhimurium EFFECT OF PRP-I ON THE VIABILITY OF MACROPHAGES IN MICE INFECTED WITH S. typhimurium 50

6 CONTENTS vii 4.9 EFFECT OF PRP-I ON INTERFERON-y (lfn-y) BIOSYNTHESIS IN HUMAN MONONUCLEAR CELLS AND THE REPLICATION OF ENCEPHALOMYOCARDITIS VIRUS IN CELL CULTURE Chapter 5 PRP REGULATION OF T-LYMPHOCYTE DEVELOPMENT AND MYELOPOIESIS INFLUENCE OF PRP-I ON INTERLEUKIN-2-DEPENDENT FUNCTIONS OF HUMAN LYMPHOCYTES IN CULTURE AND ON THE PROLIFERATION OF JURKAT CELLS REGULATION OF THYMOCYTE DIFFERENTIATION BY PRP- I IN NEONATAL AND FETAL THYMUS PRP-I IS A REGULATOR OFMYELOPOIESIS Chapter 6 NEUROPROTECTIVE (ANTINEURODEGENERATIVE) PROPERTIES OFPRP-l PROTECTIVE EFFECT OF PRP-I AGAINST SNAKE VENOM- INDUCED NEURONAL INJURY PROTECTIVE EFFECT OF PRP-I AGAINST TRAUMA- INDUCED CENTRAL AND PERIPHERAL NEURONAL INJURY MORPHOLOGICAL AND BIOCHEMICAL CHANGES IN BRAIN MICROSTRUCTURE IN CRUSH SYNDROME AND EFFECT OFPRP-I PRP-I PROTECTS BRAIN NEURONS AGAINST ALUMINUM (AI) NEUROTOXICOSIS (ELECTRON MICROSCOPY STUDIES) 118 Chapter 7 EFFECT OF PRP-l ON TUMOR CELLS EFFECT OF PRP-I ON THE MORPHOLOGY AND MITOTIC ACTIVITY OF NEURINOMA OF RAT NODULI GASSER (NRNG) CELLS IN CULTURE (ELECTRON MICROSCOPY STUDIES) CHANGES IN THE ULTRASTRUCTURE OF L 929 TUMOR CELLS UNDER THE ACTION OF PRP-I IN VITRO 133 ChapterS BASIC BIOCHEMICAL MECHANISMS OF PRP-l ACTION IN DIFFERENT PATHOLOGIES EFFECT OF PRP-I ON GFAP BIOSYNTHESIS IN ASTROCYTE CULTURE (IMMUNOCYTOCHEMICAL DATA) EFFECT OF PRP-I ON CASPASE ACTIVITY OF MURINE NEUROBLASTOMA N2A 140

7 viii CONTENTS 8.3 REGULATION OF MEMBRANE PHOSPHOLIPID METABOLISM BY PRP-l IN CARDIOPULMONARY INSUFFICIENCY INFLUENCE OF PRP-l ON CONSEQUENCES OF IONIZING IRRADIATION IN RATS 153 Discussion 155 Summary 163 References 165 List of abbreviations 175 Acknowledgements 178 Index 179