COPD Phenotyping: Hyperpolarized Helium-3 Magnetic Resonance Functional Imaging
|
|
|
- Sharlene Goodwin
- 6 years ago
- Views:
Transcription
1 COPD Phenotyping: Hyperpolarized Helium-3 Magnetic Resonance Functional Imaging M Kirby, HO Coxson, DG McCormack and G Parraga Imaging Research Laboratories, Robarts Research Institute; Departments of Medical Biophysics, Medical Imaging, Medicine, Western University, London, Canada; Department of Radiology, James Hogg Research Centre, University of British Columbia, Vancouver, Canada
2 Acknowledgements and Disclosures Collaborators Jim Lewis MD Aaron Fenster PhD FCCPM Nigel Paterson MD Robin McFadden MD Giles Santyr PhD Roya Etemad-Rezai MD Geoff Maksym PhD (Halifax) Param Nair MD (Hamilton) Jim Martin MD (Montreal) Research Team Amir Owrangi MEng Sarah Svenningsen BMSc Daniel Buchanan MSc Nikhil Kanhere BE Damien Pike BSc Christiane Burton BSc Lindsay Mathew PhD Steven Costella MEng Andrew Wheatley BSc Shayna McKay BSc Sandra Halko CCRC, RPT Trevor Szekeres RTMR
3 What is a COPD Phenotype? Han et. al. AJRCCM (2010): A single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes
4 Hyperpolarized 3 He and 129 Xe MRI 3 He MRI MRI 129 Xe MRI
5 He MRI Phenotypes: Static Ventilation Healthy Young Parraga et. al Ex-Smoker Fain et. al Stage II COPD Parraga et. al Alpha-1 Antitrypsin Van Beek et. al Surrogate measure of airways disease
6 He MRI Phenotypes: Diffusion-Weighted Healthy Elderly Parraga et al. Inv Radiol. (2007) COPD Mathew et al. Acad Radiol. (2008) Surrogate measure of alveolar size/emphsema
7 He MRI Phenotypes: Diffusion-Weighted Quantified ADC distribution: 1) Absolute difference 2) Gradient (in ADC / cm) Surrogate measure of regional gas trapping
8 He MRI Phenotypes: Dynamic Ventilation 0.0s 1.3s 5.8s 10.3s 14.8s 19.3s Marshall et. al. Thorax (2012) Surrogate of indirect or collateral ventilation
9 He MRI: COPD Phenotypes Baseline Disease progression 1 2 yr Follow-up 1. Kirby et. al. Radiology (2010)
10 w22jcdkx 3 He MRI: COPD Phenotypes Pre-AB Disease progression 1 Response to airway bypass (AB) interventions 2 Post-AB 1. Kirby et. al. Radiology (2010) 2. Mathew et. al. Can Respir J. (2012)
11 w22jcdkx 3 He MRI: COPD Phenotypes Pre-Salbutamol Disease progression 1 Response to airway bypass (AB) interventions 2 Post-Salbutamol Response to therapy 3 1. Kirby et. al. Radiology (2010) 2. Mathew et. al. Can Respir J. (2012) 2. Kirby et. al. Radiology (2011)
12 He MRI: COPD Phenotypes Pre-Salbutamol Post-salbutamol p = 0.02 Posterior ADC significantly reduced post-salbutamol (p = 0.02) 3 He MRI measures reductions in regional gas trapping post-salbutamol Kirby et al. JAP (2012)
13 He MRI: COPD Phenotypes FEV 1 = 41% pred VDP = 16% FEV 1 = 47% pred VDP = 29% FEV 1 = 45% pred VDP = 20% FEV 1 = 54% pred VDP = 14% Exacerbation Kirby et. al. JMRI (Under review)
14 He MRI: COPD Phenotypes Kirby et. al. JMRI (Under review)
15 He MRI: COPD Phenotypes FEV 1 = 41% pred VDP = 16% FEV 1 = 47% pred VDP = 29% FEV 1 = 45% pred VDP = 20% FEV 1 = 54% pred VDP = 14% Exacerbation Kirby et. al. JMRI (Under review)
16 He MRI: COPD Phenotypes 3 He MRI measures worsening prior to and improvements following exacerbation before FEV 1 Kirby et. al. JMRI (Under review)
17 He MRI: COPD Phenotypes Evidence for adult lung growth: - 33-year-old woman underwent a right-sided pneumonectomy - acinar microstructure multiple b-value 3 He MRI Radial Dimension: 1.0 Alveolar Depth: Butler et al. NEJM (2012)
18 He MRI: COPD Phenotypes Evidence for adult lung growth: - 48-year-old woman underwent a upper rightsided lobectomy - two b-value 3 He MRI
19 He MRI: New COPD Phenotypes COPDGene: GOLD-Unclassified 1 - normal FEV 1 /FVC, low FEV 1 Non-obstructed emphysema normal FEV 1 /FVC, low D LCO Research Questions: Do ex-smokers with normal spirometry and abnormal D LCO (AD) have other clinically meaningful measurements? How does 3 He MRI relate to these disease attributes? 1. Wan et. al. AJRCCM (2011) 2. Reid et. al. Chest (2002) 3. Chin et. al.. Chest (1998) 4. Corsico et. al. Respir Med Extra (2007)
20 He MRI: New COPD Phenotypes Ex-smoker Normal D LCO Static Ventilation ADC Map homogenous gas distribution, normal 3 He ADC Ex-smoker Abnormal D LCO heterogeneous gas distribution, elevated 3 He ADC GOLD Stage I heterogeneous gas distribution, ventilation defects, elevated 3 He ADC Kirby et al. CHEST (Under review)
21 He MRI: New COPD Phenotypes Normal D LCO (ND) (n=19) Abnormal D LCO (AD) (n=19) Stage I COPD (n=15) Significance of Difference (p) ND-AD AD-COPD 6MWT Distance m (±SD) 430 (99) 341 (95) 417 (41) SGRQ Total Score (±SD) 12 (14)* 29 (21) 25 (17) He MRI Measurements ADC cm 2 /s (±SD) 0.27 (0.03) 0.30 (0.03)* 0.36 (0.08) AD subgroup had significantly worse 6MWD and SGRQ compared with ex-smokers with normal ADC and D LCO
22 He MRI: New COPD Phenotypes Regional Gas Trapping r = p =
23 He MRI: New COPD Phenotypes r = p < r = 0.34 p = 0.02
24 He MRI Phenotypes of COPD 3 He MRI static and dynamic ventilation: Disease progression Exacerbations Response to therapy Indirect pathways/collateral ventilation 3 He MRI ADC: Exacerbations Tissue microstructure
25 London Lung Imaging Research Team
MRI of the airways and lungs Including hyperpolarized techniques
MRI of the airways and lungs Including hyperpolarized techniques Pulmonary Medicine Jason C. Woods Radiology Neonatology Disclosure statements: Financial relationships: Dr. Woods is a consultant to and
Department of Radiology. University of Virginia. Wilson Miller SPIN October 7
Medical Imaging of Hyperpolarized Gases Wilson Miller University of Virginia Department of Radiology October 7 SPIN 2008 p Nuclear Magnetic Resonance Net alignment Excitation RF pulse p p p p B p p Magnetization
The National Lung Health Education Program. Spirometric Reference Values for the 6-s FVC Maneuver*
Spirometric Reference Values for the 6-s FVC Maneuver* John L. Hankinson, PhD; Robert O. Crapo, MD, FCCP; and Robert L. Jensen, PhD Study objectives: The guidelines of the National Lung Health Education
RF Instrumentation for Same-Breath Triple Nuclear Lung MR Imaging of 1 H and Hyperpolarized 3 He and
HARDWARE AND INSTRUMENTATION - Note Magnetic Resonance in Medicine 75:1841 1848 (2016) RF Instrumentation for Same-Breath Triple Nuclear Lung MR Imaging of 1 H and Hyperpolarized 3 He and 129 Xe at 1.5T
Vitamin D deficiency, Smoking, and Lung Function in the Normative Aging Study
1 Vitamin D deficiency, Smoking, and Lung Function in the Normative Aging Study Nancy E. Lange MD, MPH, David Sparrow DSc, Pantel Vokonas MD, Augusto A. Litonjua, MD, MPH Online data supplement 2 For all
Simultaneous assessment of both lung morphometry and gas exchange function within a single breath hold by hyperpolarized 129 Xe MRI
Received: 11 November 2016 Revised: 13 March 2017 Accepted: 14 March 2017 DOI: 10.1002/nbm.3730 RESEARCH ARTICLE Simultaneous assessment of both lung morphometry and gas exchange function within a single
Measuring the invisible using Quantitative Magnetic Resonance Imaging
Measuring the invisible using Quantitative Magnetic Resonance Imaging Paul Tofts Emeritus Professor University of Sussex, Brighton, UK Formerly Chair in Imaging Physics, Brighton and Sussex Medical School,
Translational Imaging of Pulmonary Gas-Exchange Using. Suryanarayanan Sivaram Kaushik. Department of Biomedical Engineering Duke University
Translational Imaging of Pulmonary Gas-Exchange Using Hyperpolarized 129 Xe Magnetic Resonance Imaging by Suryanarayanan Sivaram Kaushik Department of Biomedical Engineering Duke University Date: Approved:
Supplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Lange P, Celli B, Agustí A, et al. Lung-function trajectories
How accurately can the parameters from a model of anisotropic. be estimated? Bayesian view
Journal of Magnetic Resonance 184 (27) 62 71 www.elsevier.com/locate/jmr How accurately can the parameters from a model of anisotropic 3 He gas diffusion in lung acinar airways be estimated? Bayesian view
Efficacy of the FEV 1 /FEV 6 ratio compared to the FEV 1 /FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over
Brazilian Journal of Medical and Biological Research (2007) 40: 1615-1621 Airway obstruction diagnosis ISSN 0100-879X 1615 Efficacy of the FEV 1 /FEV 6 ratio compared to the FEV 1 /FVC ratio for the diagnosis
Sensitivity Enhancement and Fast NMR BCMB 8190
Sensitivity Enhancement and Fast NMR BCMB 8190 References T. Maly, G.T. Debelouchina, V.S. Bajaj, K-N. Hu, C-G. Joo, M.L. Mak Jurkauskas, J.R. Sirigiri, P.C.A. van der Wel, J. Herzfeld, R.J. Temkin, and
Impedance Imaging of the Thorax: Why it s difficult, and what we are doing about it?
Impedance Imaging of the Thorax: Why it s difficult, and what we are doing about it? Biomedical Engineering Research Centre (BIRC) Western Univerity, London, ON, 6 May 2015 Andy Adler Professor & Canada
International Journal of Scientific & Engineering Research, Volume 5, Issue 4, April ISSN
International Journal of Scientific & Engineering Research, Volume 5, Issue 4, April2014 1474 Pulmonary Function Test in Normal Healthy School Children Kundan Mittal, Tanu Satija, Jyoti Yadav, K B Gupta,
Bayesian variable selection for identifying subgroups in cost-effectiveness analysis
Bayesian variable selection for identifying subgroups in cost-effectiveness analysis Elías Moreno 1 Francisco Javier Girón 2 Francisco José Vázquez Polo 3 Miguel Negrín 3 1 University of Granada, Spain
Analysis of Sigmoidal Equations To Describe the Pulmonary Pressure- Volume Curve in Acute Respiratory Distress Syndrome
54 The Open Critical Care Medicine Journal, 2008, 1, 54-62 Open Access Analysis of Sigmoidal Equations To Describe the Pulmonary Pressure- Volume Curve in Acute Respiratory Distress Syndrome Sandra Orfao
By choosing to view this document, you agree to all provisions of the copyright laws protecting it.
c 2010 IEEE. Reprinted, with permission, from L. Sørensen, S. B. Shaker, M. de Bruijne, Quantitative analysis of pulmonary emphysema using local binary patterns, IEEE Transactions on Medical Imaging, 2010.
Application of diffusion MRI to cancer, heart and brain connectome imaging
Colloquium @ Department of Physics, NTU Application of diffusion MRI to cancer, heart and brain connectome imaging March 11, 2014 Wen-Yih Isaac Tseng MD, PhD Advanced Biomedical MRI Lab Center for Optoelectronic
QUALITY ASSURANCE OF MAGNETIC RESONANCE IMAGING FOR ADAPTIVE RADIOTHERAPY: PRELIMINARY INVESTIGATIONS TREVOR THANG 1 Supervisors: Dr.
QUALITY ASSURANCE OF MAGNETIC RESONANCE IMAGING FOR ADAPTIVE RADIOTHERAPY: PRELIMINARY INVESTIGATIONS TREVOR THANG 1 Supervisors: Dr. Eugene Wong 2, Dr. Rob Bartha 1 Department of Medical Biophysics 1,
IMA Preprint Series # 2298
RELATING FIBER CROSSING IN HARDI TO INTELLECTUAL FUNCTION By Iman Aganj, Neda Jahanshad, Christophe Lenglet, Arthur W. Toga, Katie L. McMahon, Greig I. de Zubicaray, Margaret J. Wright, Nicholas G. Martin,
PiNG 2017 PROGRAM. 8:30 8:45 WELCOME and ORIENTATION (Brian Saam) 8:45 9:45 SESSION A: MEOP TUTORIAL (Pierre-Jean Nacher) INVITED ORAL PRESENTATIONS
PiNG 2017 PROGRAM SUNDAY, OCT. 8 th EVENING 18:00 21:00 WELCOME RECEPTION (The Cabin I) MONDAY, OCT. 9 th MORNING 8:30 8:45 WELCOME and ORIENTATION (Brian Saam) 8:45 9:45 SESSION A: MEOP TUTORIAL (Pierre-Jean
Mada, Marius Ovidiu (2009) Application of hyperpolarised Helium-3 in lung functional magnetic resonance imaging. PhD thesis, University of Nottingham.
Mada, Marius Ovidiu (2009) Application of hyperpolarised Helium-3 in lung functional magnetic resonance imaging. PhD thesis, University of Nottingham. Access from the University of Nottingham repository:
The effect of different number of diffusion gradients on SNR of diffusion tensor-derived measurement maps
J. Biomedical Science and Engineering, 009,, 96-101 The effect of different number of diffusion gradients on SNR of diffusion tensor-derived measurement maps Na Zhang 1, Zhen-Sheng Deng 1*, Fang Wang 1,
January NCCTG Protocol No: N0927 Opened: September 3, 2009
January 2011 0915-1 RTOG Protocol No: 0915 Protocol Status: NCCTG Protocol No: N0927 Opened: September 3, 2009 Title: A Randomized Phase II Study Comparing 2 Stereotactic Body Radiation Therapy (SBRT)
A Neurosurgeon s Perspectives of Diffusion Tensor Imaging(DTI) Diffusion Tensor MRI (DTI) Background and Relevant Physics.
A Neurosurgeon s Perspectives of Diffusion Tensor Imaging(DTI) Kalai Arasu Muthusamy, D.Phil(Oxon) Senior Lecturer & Consultant Neurosurgeon. Division of Neurosurgery. University Malaya Medical Centre.
HHS Public Access Author manuscript Inf Process Med Imaging. Author manuscript; available in PMC 2016 January 01.
Generative Method to Discover Genetically Driven Image Biomarkers Nematollah K. Batmanghelich 1, Ardavan Saeedi 1, Michael Cho 2, Raul San Jose Estepar 2, and Polina Golland 1 Nematollah K. Batmanghelich:
PHYSICS OF EXPIRATORY FLOW LIMITATION
CHAPTER 6 PHYSICS OF EXPIRATORY FLOW LIMITATION Jason H. T. Bates Clinical assessment of lung function is most commonly based on a phenomenon known as expiratory flow limitation, 1, in which the magnitude
Spyridon Fortis MD, Edward O Corazalla MSc RPFT, Qi Wang MSc, and Hyun J Kim MD
The Difference Between Slow and Forced Vital Capacity Increases With Increasing Body Mass Index: A Paradoxical Difference in Low and Normal Body Mass Indices Spyridon Fortis MD, Edward O Corazalla MSc
Maximum Voluntary Ventilation in a Population Residing at 2,240 Meters Above Sea Level
Maximum Voluntary Ventilation in a Population Residing at 2,240 Meters Above Sea Level Silvia Cid-Juárez MD MSc, Rogelio Pérez-Padilla MD, Luis Torre-Bouscoulet MD MSc, Paul Enright MD, Laura Gochicoa-Rangel
Magnetic Resonance Spectroscopy: Basic Principles and Selected Applications
Magnetic Resonance Spectroscopy: Basic Principles and Selected Applications Sridar Narayanan, PhD Magnetic Resonance Spectroscopy Unit McConnell Brain Imaging Centre Dept. of Neurology and Neurosurgery
Maximum Voluntary Ventilation in a Population Residing at 2,240 Meters Above Sea Level
Maximum Voluntary Ventilation in a Population Residing at 2,240 Meters Above Sea Level Silvia Cid-Juárez MD MSc, Rogelio Pérez-Padilla MD, Luis Torre-Bouscoulet MD MSc, Paul Enright MD, Laura Gochicoa-Rangel
The Impacts of Wildfire Smoke and the Western Canada BlueSky Wildfire Smoke Forecasting System
The Impacts of Wildfire Smoke and the Western Canada BlueSky Wildfire Smoke Forecasting System Wildland Fire Canada Conference October 2012 Steve Sakiyama, British Columbia Ministry of Environment Steve.Sakiyama@gov.bc.ca
Alternative Approaches to Thoracoscopic Lobectomy: Uniportal, Supxiphoid,
Alternative Approaches to Thoracoscopic Lobectomy: Uniportal, Supxiphoid, Thomas A. D Amico MD Gary Hock Endowed Professor Chief Thoracic Surgery Chief Medical Officer, Duke Cancer Institute Disclosures
REFAAT E. GABR, PHD Fannin Street, MSE R102D, Houston, Texas 77030
NAME: Refaat Elsayed Gabr REFAAT E. GABR, PHD 3-Jul-13 5 pages PRESENT TITLE: ADDRESS: BIRTHDATE: CITIZENSHIP: Assistant Professor of Radiology Department of Diagnostic and Interventional Imaging University
Review. More Review. Things to know about Probability: Let Ω be the sample space for a probability measure P.
1 2 Review Data for assessing the sensitivity and specificity of a test are usually of the form disease category test result diseased (+) nondiseased ( ) + A B C D Sensitivity: is the proportion of diseased
Evaluating Interventions on Drug Utilization: Analysis Methods
Evaluating Interventions on Drug Utilization: Analysis Methods Nicole Pratt Quality Use of Medicines and Pharmacy Research Centre University of South Australia For: Colin Dormuth, ScD Associate Professor,
Diffusion Tensor Imaging I: The basics. Jennifer Campbell
Diffusion Tensor Imaging I: The basics Jennifer Campbell Diffusion Tensor Imaging I: The basics Jennifer Campbell Diffusion Imaging MRI: many different sources of contrast T1W T2W PDW Perfusion BOLD DW
Respiratory mechanics in ventilated patients studied with low-frequency forced oscillations. Lorx András MD
Respiratory mechanics in ventilated patients studied with low-frequency forced oscillations PhD thesis Lorx András MD Semmelweis University Doctoral School of Clinical Medicine Supervisor: Dr. Hantos Zoltán
Approaches to sample size calculation for clinical trials in small populations
Approaches to sample size calculation for clinical trials in small populations Frank Miller, Statistiska institutionen, Stockholms universitet Stockholm, 24 februari 2016 Joint work This talk is based
Properties of the nucleus. 8.2 Nuclear Physics. Isotopes. Stable Nuclei. Size of the nucleus. Size of the nucleus
Properties of the nucleus 8. Nuclear Physics Properties of nuclei Binding Energy Radioactive decay Natural radioactivity Consists of protons and neutrons Z = no. of protons (Atomic number) N = no. of neutrons
MRI of the lung using hyperpolarized 3 He at very low magnetic field (3 mt)
MRI of the lung using hyperpolarized 3 He at very low magnetic field (3 mt) C.P. BIDINOSTI()) 1, J. CHOUKEIFE 2, G. TASTEVIN 2, A. VIGNAUD 3, AND P.-J. NACHER 2 1. Department of Physics, Simon Fraser University,
Quantification of the magnetic dust deposition in the magnetopneumographic diagnostic of the human respiratory tract
Quantification of the magnetic dust deposition in the magnetopneumographic diagnostic of the human respiratory tract I. Šimáček, F. Martinická, P. Jurdák Laboratory of Magnetometry, Institute of Measurement
Effect of Bulk Tissue Motion on Quantitative Perfusion and Diffusion Magnetic Resonance Imaging *
MAGNETIC RESONANCE IN MEDICINE 19,261-265 (1991) Effect of Bulk Tissue Motion on Quantitative Perfusion and Diffusion Magnetic Resonance Imaging * THOMAS L. CHENEVERT AND JAMES G. PIPE University of Michigan
Biostatistics 4: Trends and Differences
Biostatistics 4: Trends and Differences Dr. Jessica Ketchum, PhD. email: McKinneyJL@vcu.edu Objectives 1) Know how to see the strength, direction, and linearity of relationships in a scatter plot 2) Interpret
Clinical Research Module: Biostatistics
Clinical Research Module: Biostatistics Lecture 1 Alberto Nettel-Aguirre, PhD, PStat These lecture notes based on others developed by Drs. Peter Faris, Sarah Rose Luz Palacios-Derflingher and myself Who
Bayesian multi-tensor diffusion MRI and tractography
Bayesian multi-tensor diffusion MRI and tractography Diwei Zhou 1, Ian L. Dryden 1, Alexey Koloydenko 1, & Li Bai 2 1 School of Mathematical Sciences, Univ. of Nottingham 2 School of Computer Science and
Physics. Sunday, March 4, :30 a.m. 10:00 a.m.
Physics Sunday, March 4, 2018 9:30 a.m. 10:00 a.m. Social Q&A Use your phone, tablet, or laptop to Submit questions to speakers and moderators Answer interactive questions / audience response polls astro.org/refreshersocialqa
" #$ % &'( ) * +, -. /.
#% +#$ % &'( * "!":! -2 - " #$ % &'( * +, -..? @.0 # > = : ; < &+ + (CT #C 5 0, A( #C 5 ; 7 8. DEFB C AB " 4 5 20" #. "# G H5 D D I 88 : #C 5 2 8 822 :+ 24 : 8578 :.0 # "H L B M # "H 0? #" 5 2 0 % # "H
Bases of radioisotope diagnostic methods
Medical, pharmaceutical applications of radioisotopes Bases of radioisotope diagnostic methods Dr. István Voszka Basis of application: radioisotopes have identical behavior in the organism to corresponding
A Comparative Study of Current Clinical NLP Systems on Handling Abbreviations
A Comparative Study of Current Clinical NLP Systems on Handling Abbreviations Yonghui Wu 1 PhD, Joshua C. Denny 2 MD MS, S. Trent Rosenbloom 2 MD MPH, Randolph A. Miller 2 MD, Dario A. Giuse 2 Dr.Ing,
DIFFUSION MAGNETIC RESONANCE IMAGING
DIFFUSION MAGNETIC RESONANCE IMAGING from spectroscopy to imaging apparent diffusion coefficient ADC-Map anisotropy diffusion tensor (imaging) DIFFUSION NMR - FROM SPECTROSCOPY TO IMAGING Combining Diffusion
Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129 Xe MR imaging
J Appl Physiol 115: 850 860, 2013. First published July 11, 2013; doi:10.1152/japplphysiol.00092.2013. Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase
CROSS SECTIONAL STUDY & SAMPLING METHOD
CROSS SECTIONAL STUDY & SAMPLING METHOD Prof. Dr. Zaleha Md. Isa, BSc(Hons) Clin. Biochemistry; PhD (Public Health), Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia
AS to BS in Medical Dosimetry. Core Curriculum Course Descriptions
AS to BS in Medical Dosimetry Core Curriculum Course Descriptions MD301 RADIATION DOSIMETRY This course focuses on introducing radiation terminology used in radiation dosimetry. Fundamental dose calculation
1 Introduction. A Monte Carlo study
Current Directions in Biomedical Engineering 2017; 3(2): 281 285 Sebastian Richter*, Stefan Pojtinger, David Mönnich, Oliver S. Dohm, and Daniela Thorwarth Influence of a transverse magnetic field on the
The Future of Healthcare? W H A T D O E S T H E F U T U R E H O L D? The Empowered Consumer
: : The Future of Healthcare? W H A T D O E S T H E F U T U R E H O L D? The Empowered Consumer Dr. Anne Anne W. Snowdon, W. Snowdon, RN, BScN, Chair MSc, PhD World Health Innovation Network, Odette School
Sjoerd Verduyn Lunel (Utrecht University)
Universiteit Utrecht, February 9, 016 Wasserstein distances in the analysis of time series and dynamical systems Sjoerd Verduyn Lunel (Utrecht University) S.M.VerduynLunel@uu.nl Abstract A new approach
Properties of the nucleus. 9.1 Nuclear Physics. Isotopes. Stable Nuclei. Size of the nucleus. Size of the nucleus
Properties of the nucleus 9. Nuclear Physics Properties of nuclei Binding Energy Radioactive decay Natural radioactivity Consists of protons and neutrons Z = no. of protons (tomic number) N = no. of neutrons
Ball, Iain Keith (2011) Functional pulmonary MRI using hyperpolarised 3He. PhD thesis, University of Nottingham.
Ball, Iain Keith (2011) Functional pulmonary MRI using hyperpolarised 3He. PhD thesis, University of Nottingham. Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/12207/1/thesis.pdf
Nuclear Radiation. Natural Radioactivity. A person working with radioisotopes wears protective clothing and gloves and stands behind a shield.
Nuclear Radiation Natural Radioactivity A person working with radioisotopes wears protective clothing and gloves and stands behind a shield. 1 Radioactive Isotopes A radioactive isotope has an unstable
Conflicts of Interest
Analysis of Dependent Variables: Correlation and Simple Regression Zacariah Labby, PhD, DABR Asst. Prof. (CHS), Dept. of Human Oncology University of Wisconsin Madison Conflicts of Interest None to disclose
Longitudinal growth analysis of early childhood brain using deformation based morphometry
Longitudinal growth analysis of early childhood brain using deformation based morphometry Junki Lee 1, Yasser Ad-Dab'bagh 2, Vladimir Fonov 1, Alan C. Evans 1 and the Brain Development Cooperative Group
Lesbats, Clémentine (2017) Hyperpolarized noble gases as biomarkers for pulmonary pathology. PhD thesis, University of Nottingham.
Lesbats, Clémentine (2017) Hyperpolarized noble gases as biomarkers for pulmonary pathology. PhD thesis, University of Nottingham. Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/42321/1/clementine_lesbats_phd_thesis.pdf
Dirichlet process Bayesian clustering with the R package PReMiuM
Dirichlet process Bayesian clustering with the R package PReMiuM Dr Silvia Liverani Brunel University London July 2015 Silvia Liverani (Brunel University London) Profile Regression 1 / 18 Outline Motivation
Extending the results of clinical trials using data from a target population
Extending the results of clinical trials using data from a target population Issa Dahabreh Center for Evidence-Based Medicine, Brown School of Public Health Disclaimer Partly supported through PCORI Methods
PHY138Y Nuclear and Radiation
PHY138Y Nuclear and Radiation Professor Tony Key MP401 key@physics.utoronto.ca First Question Which of the following medical or dental procedures have you or a family member undergone? A. X-rays - for
Lecture PowerPoint. Chapter 31 Physics: Principles with Applications, 6 th edition Giancoli
Lecture PowerPoint Chapter 31 Physics: Principles with Applications, 6 th edition Giancoli 2005 Pearson Prentice Hall This work is protected by United States copyright laws and is provided solely for the
On ASSESSMENT EVIDENCE in CBME: Assessment, Strategies and Pitfalls
On ASSESSMENT EVIDENCE in CBME: Assessment, Strategies and Pitfalls Inf e r e n t i a l L e a p ASSESSMENT CONTEXT FUTURE CLINICAL PERFORMANCE LATENT ATTRIBUTES Inf e r e n t i a l L e a p Walter Tavares,
Plant and animal cells (eukaryotic cells) have a cell membrane, cytoplasm and genetic material enclosed in a nucleus.
4.1 Cell biology Cells are the basic unit of all forms of life. In this section we explore how structural differences between types of cells enables them to perform specific functions within the organism.
Probabilistic Causal Models
Probabilistic Causal Models A Short Introduction Robin J. Evans www.stat.washington.edu/ rje42 ACMS Seminar, University of Washington 24th February 2011 1/26 Acknowledgements This work is joint with Thomas
Undergraduate. Physics
Undergraduate Physics Studying Physics at Washington University If you have a strong interest in the sciences, you will want to consider physics as a major. As the most fundamental of all the sciences,
1999 10 33 10 Chin J Radiol October 1999 Vol 33 No. 10 655 (MCAO) MR ; (DWI) 45 MR DWI T 1 WI T 2 WI (01536 ) (TTC) 8 MCAO 30 DWI 4912 % 3 (4715 %) 18 T 2 WI 2 (214 015) DWI T 2 WI DWI DWI TTC ( t t =
Deformation Morphometry: Basics and Applications
Deformation Morphometry: Basics and Applications Valerie Cardenas Nicolson, Ph.D. Assistant Adjunct Professor NCIRE, UCSF, SFVA Center for Imaging of Neurodegenerative Diseases VA Challenge Clinical studies
Microwave Ablation and associated Dielectric Properties- Modelling, Measurements and Sensitivity Investigation
Microwave Ablation and associated Dielectric Properties- Modelling, Measurements and Sensitivity Investigation Mohammed Taj-Eldin, Punit Prakash WG1/WG3 Workshop on Dielectric Properties for Novel Medical
Differentiating Chemical Reactions from Nuclear Reactions
Differentiating Chemical Reactions from Nuclear Reactions 1 CHEMICAL Occurs when bonds are broken or formed. Atoms remained unchanged, though may be rearranged. Involves valence electrons Small energy
Sample Size and Power I: Binary Outcomes. James Ware, PhD Harvard School of Public Health Boston, MA
Sample Size and Power I: Binary Outcomes James Ware, PhD Harvard School of Public Health Boston, MA Sample Size and Power Principles: Sample size calculations are an essential part of study design Consider
Contrast Mechanisms in MRI. Michael Jay Schillaci
Contrast Mechanisms in MRI Michael Jay Schillaci Overview Image Acquisition Basic Pulse Sequences Unwrapping K-Space Image Optimization Contrast Mechanisms Static and Motion Contrasts T1 & T2 Weighting,
Online supplement. Absolute Value of Lung Function (FEV 1 or FVC) Explains the Sex Difference in. Breathlessness in the General Population
Online supplement Absolute Value of Lung Function (FEV 1 or FVC) Explains the Sex Difference in Breathlessness in the General Population Table S1. Comparison between patients who were excluded or included
Shape Anisotropy: Tensor Distance to Anisotropy Measure
Shape Anisotropy: Tensor Distance to Anisotropy Measure Yonas T. Weldeselassie, Saba El-Hilo and M. Stella Atkins Medical Image Analysis Lab, School of Computing Science, Simon Fraser University ABSTRACT
D-eigenvalues of diffusion kurtosis tensors
Journal of Computational and Applied Mathematics 221 (2008) 150 157 www.elsevier.com/locate/cam D-eigenvalues of diffusion kurtosis tensors Liqun Qi a,, Yiju Wang b, Ed X. Wu c a Department of Applied
Changes in apparent diffusion coefficient and T2 values in the lumbar intervertebral disc under short-time axial load. mm 2 /s Z=2.
19 31 2015 07 23 Chinese Journal of Tissue Engineering Research July 23, 2015 Vol.19, No.31 T2 ( 510120) 1 2 T2-map T2 (2013B021800236) MRI T1rho T2 T2 17 34 65 T2W T1WT2-mapping 40% 50% 10 min 2 15 min
A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes
IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 36, NO. 1, JANUARY 2017 343 A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes James C. Ross, Peter J. Castaldi, Michael
SAS macro to obtain reference values based on estimation of the lower and upper percentiles via quantile regression.
SESUG 2012 Poster PO-12 SAS macro to obtain reference values based on estimation of the lower and upper percentiles via quantile regression. Neeta Shenvi Department of Biostatistics and Bioinformatics,
(INCLUDING THIS FRONT PAGE)
I'IFIITIIBIFI UNIVERSITY OF SCIEI'ICE RITD TECHNOLOGY FACULTY OF HEALTH AND APPLIED SCIENCES DEPARTMENT OF NATURAL AND APPLIED SCIENCES QUALIFICATION: BACHELOR OF SCIENCE (MAJOR AND MINOR) QUALIFICATION
It is important. It is important. MTR: Imaging Clinical Trials. Isn t t it obvious? then why do we ask the question?
Isn t t it obvious? Image Treatment Response Assessment: How Important is Quantification? It is important Mitchell chnall MD, PhD Mathew J Wilson Professor of Radiology University of Pennsylvania Chair,
Analysis of Longitudinal Data. Patrick J. Heagerty PhD Department of Biostatistics University of Washington
Analysis of Longitudinal Data Patrick J Heagerty PhD Department of Biostatistics University of Washington Auckland 8 Session One Outline Examples of longitudinal data Scientific motivation Opportunities
Pulse Sequences: RARE and Simulations
Pulse Sequences: RARE and Simulations M229 Advanced Topics in MRI Holden H. Wu, Ph.D. 2018.04.19 Department of Radiological Sciences David Geffen School of Medicine at UCLA Class Business Final project
MAT 2379, Introduction to Biostatistics, Sample Calculator Questions 1. MAT 2379, Introduction to Biostatistics
MAT 2379, Introduction to Biostatistics, Sample Calculator Questions 1 MAT 2379, Introduction to Biostatistics Sample Calculator Problems for the Final Exam Note: The exam will also contain some problems
A. James O Malley, PhD, Kelly H. Zou, PhD, Julia R. Fielding, MD, Clare M. C. Tempany, MD. Acad Radiol 2001; 8:
Bayesian Regression Methodology for Estimating a Receiver Operating Characteristic Curve with Two Radiologic Applications: Prostate Biopsy and Spiral CT of Ureteral Stones 1 A. James O Malley, PhD, Kelly
Chapter 1: Introduction to Human Anatomy and Physiology. I. Introduction A. The interests of our earliest ancestors most likely concerned
Shier, Butler, and Lewis: Human Anatomy and Physiology, 11 th ed. Chapter 1: Introduction to Human Anatomy and Physiology Chapter 1: Introduction to Human Anatomy and Physiology I. Introduction A. The
UNIVERSITY OF SURREY
UNIVERSITY OF SURREY B.Sc. Undergraduate Programmes in Computing B.Sc. Undergraduate Programmes in Mathematical Studies Level HE3 Examination MODULE CS364 Artificial Intelligence Time allowed: 2 hours
8/1/2017. Introduction to Monte Carlo simulations at the (sub-)cellular scale: Concept and current status
MC-ADC ADC TOPAS 8/1/2017 Introduction to Monte Carlo simulations at the (sub-)cellular scale: Concept and current status Jan Schuemann Assistant Professor Head of the Multi-Scale Monte Carlo Modeling
Lecture PowerPoints. Chapter 31 Physics: Principles with Applications, 7th edition Giancoli
Lecture PowerPoints Chapter 31 Physics: Principles with Applications, 7th edition Giancoli This work is protected by United States copyright laws and is provided solely for the use of instructors in teaching
Accelerated MRI Image Reconstruction
IMAGING DATA EVALUATION AND ANALYTICS LAB (IDEAL) CS5540: Computational Techniques for Analyzing Clinical Data Lecture 15: Accelerated MRI Image Reconstruction Ashish Raj, PhD Image Data Evaluation and
Introduction to the Course and the Techniques. Jeffry R. Alger, PhD Ahmanson-Lovelace Brain Mapping Center Department of Neurology
Introduction to the Course and the Techniques Jeffry R. Alger, PhD Ahmanson-Lovelace Brain Mapping Center Department of Neurology (jralger@ucla.edu) CTSI Neuroimaging April 2013 Rationale for the Course
Regularized Nonrigid Registration of Lung CT Images by Preserving Tissue Volume and Vesselness Measure
Regularized Nonrigid Registration of Lung CT Images by Preserving Tissue Volume and Vesselness Measure Kunlin Cao 1,3, Kaifang Du 2,3, Kai Ding 2,3, Joseph M. Reinhardt 2,3,, and Gary E. Christensen 1,3
Curriculum Vitae. 75 Francis Street, Brigham and Women s Hospital, Boston, MA 02115, USA Tel: (O)
Jing Yuan Ph.D. Curriculum Vitae 75 Francis Street, Brigham and Women s Hospital, Boston, MA 02115, USA Tel: +1-617-525-3314 (O) E-mail: jyuan@bwh.harvard.edu General Information Date of Birth: August
Rician Noise Removal in Diffusion Tensor MRI
Rician Noise Removal in Diffusion Tensor MRI Saurav Basu, Thomas Fletcher, and Ross Whitaker University of Utah, School of Computing, Salt Lake City, UT 84112, USA Abstract. Rician noise introduces a bias
III. Proton-therapytherapy. Rome SB - 2/5 1
Outline Introduction: an historical review I Applications in medical diagnostics Particle accelerators for medicine Applications in conventional radiation therapy II III IV Hadrontherapy, the frontier
Bayesian Drug Disease Model with Stan Using published longitudinal data summaries in population models
Bayesian Drug Disease Model with Stan Using published longitudinal data summaries in population models S. Weber 1, B. Carpenter 2, D. Lee 2, F. Y. Bois 3, A. Gelman 2, A. Racine 1 (1) Novartis, Basel;